pyridoxal phosphate has been researched along with deuterium in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (53.85) | 18.7374 |
| 1990's | 8 (20.51) | 18.2507 |
| 2000's | 6 (15.38) | 29.6817 |
| 2010's | 3 (7.69) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Christen, P; Kägi, JH; Pfister, K | 1 |
| Plapp, BV; Sogin, DC | 1 |
| Cooper, AJ | 1 |
| Choi, SY; Esaki, N; Soda, K; Yoshimura, T | 1 |
| Kagamiyama, H; Kuramitsu, S; Morino, Y; Tanase, S; Yano, T | 1 |
| Benecky, MJ; Copeland, RA; Feldhaus, R; Metzler, CM; Metzler, DE; Rava, RP; Scott, RD; Spiro, TG | 1 |
| Kiick, DM; Phillips, RS | 2 |
| Abell, LM; O'Leary, MH | 2 |
| Esaki, N; Soda, K | 1 |
| Bruice, TC; Shinkai, S | 1 |
| McPhie, P; Miles, EW | 1 |
| Graves, DJ; Jacobson, GR; Tu, JI | 1 |
| Flavin, M; Posner, BI | 2 |
| Barker, HA; Chirpich, TP; Costilow, RN; Zappia, V | 1 |
| Kobayashi, Y; Makino, K | 1 |
| Flavin, M; Guggenheim, S | 1 |
| Abeles, RH; Krongelb, M; Smith, TA | 1 |
| Sprinson, DB; Weliky, I | 1 |
| Asada, Y; Misono, H; Sawada, S; Soda, K; Suzuki, T; Tanizawa, K | 1 |
| Dye, JL; June, DS; Suelter, CH | 1 |
| Ballinger, MD; Frey, PA; LoBrutto, R; Reed, GH | 1 |
| Olson, GT; Silverman, RB | 1 |
| Fitzpatrick, TB; Mahon, MM; Malthouse, JP; Milne, JJ | 1 |
| Ferreira, GC; Gong, J; Hunter, GA | 1 |
| Fitzpatrick, TB; Malthouse, JP | 1 |
| Ro, HS; Wilson Miles, E | 1 |
| Chen, X; Dieckmann, T; Jin, X; Medhekar, R; Toney, MD; Zhou, X | 1 |
| Cook, PF; Daum, S; Tai, CH | 1 |
| Cash, MT; Miles, EW; Phillips, RS | 1 |
| Coats, BS; Davis, SR; Gregory, JF; Quinlivan, EP; Scheer, JB; Stacpoole, PW | 1 |
| Hewlins, MJ; John, RA; Markova, M; Peneff, C; Schirmer, T | 1 |
| Gilbert, LR; Gregory, JF; Keeling, C; Lamers, Y; Matthews, DE; O'Rourke, B; Stacpoole, PW | 1 |
| Loh, CT; Otting, G; Qi, R; Su, XC | 1 |
| Coats, B; Gregory, JF; Lamers, Y; Quinlivan, EP; Ralat, M; Stacpoole, PW | 1 |
| Blakeley, MP; Dajnowicz, S; Gerlits, O; Johnston, RC; Keen, DA; Kovalevsky, A; Mueser, TC; Parks, JM; Weiss, KL | 1 |
| Anufrieva, NV; Demidkina, TV; Faleev, NG; Fedorova, OS; Gogoleva, OI; Kuznetsov, NA; Kuznetsova, AA; Morozova, EA; Tsvetikova, MA | 1 |
1 trial(s) available for pyridoxal phosphate and deuterium
| Article | Year |
|---|---|
Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women.
Topics: Adult; Breath Tests; Carbon Isotopes; Cystathionine; Deuterium; Diet; DNA Methylation; Female; Humans; Kinetics; Leucine; Male; Methionine; Methylation; Monocytes; Postprandial Period; Pyridoxal Phosphate; Reproducibility of Results; Severity of Illness Index; Vitamin B 6; Vitamin B 6 Deficiency; Young Adult | 2011 |
38 other study(ies) available for pyridoxal phosphate and deuterium
| Article | Year |
|---|---|
Syncatalytic conformational changes in aspartate aminotransferase determined by hydrogen-deuterium exchange.
Topics: Animals; Aspartate Aminotransferases; Catalysis; Deuterium; Hydrogen; Kinetics; Ligands; Myocardium; Protein Conformation; Pyridoxal Phosphate; Swine | 1978 |
Activation and inactivation of horse liver alcohol dehydrogenase with pyridoxal compounds.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Chromatography, Gel; Chymotrypsin; Deuterium; Enzyme Activation; Ethanol; Horses; Kinetics; Liver; Peptide Fragments; Protein Binding; Pyridoxal; Pyridoxal Phosphate; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Trypsin | 1975 |
Proton magnetic resonance studies of glutamate-alanine transaminase-catalyzed deuterium exchange. Evidence for proton conservation during prototropic transfer from the alpha carbon of L-alanine to the C4-position of pyridoxal 5'-phosphate.
Topics: Alanine; Alanine Transaminase; Binding Sites; Chemical Phenomena; Chemistry; Deuterium; Fourier Analysis; Kinetics; Magnetic Resonance Spectroscopy; Protein Binding; Protein Conformation; Pyridoxal Phosphate; Temperature | 1976 |
Reaction mechanism of glutamate racemase, a pyridoxal phosphate-independent amino acid racemase.
Topics: Amino Acid Isomerases; Bacterial Proteins; Cysteine; Deuterium; Enzyme Activation; Glutamates; Glutamic Acid; Kinetics; Magnetic Resonance Spectroscopy; Pediococcus; Pyridoxal Phosphate; Sulfhydryl Compounds; Tritium | 1992 |
Role of Asp222 in the catalytic mechanism of Escherichia coli aspartate aminotransferase: the amino acid residue which enhances the function of the enzyme-bound coenzyme pyridoxal 5'-phosphate.
Topics: Aspartate Aminotransferases; Aspartic Acid; Base Sequence; Catalysis; Circular Dichroism; Deuterium; Escherichia coli; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyridoxal Phosphate; Spectrophotometry; Structure-Activity Relationship | 1992 |
Resonance Raman spectra of the pyridoxal coenzyme in aspartate aminotransferase. Evidence for pyridine protonation and a novel photochemical H/D exchange at the imine carbon atom.
Topics: Animals; Aspartate Aminotransferases; Deuterium; Imines; Myocardium; Photochemistry; Protons; Pyridines; Pyridoxal Phosphate; Schiff Bases; Spectrum Analysis, Raman; Swine | 1985 |
Mechanistic deductions from multiple kinetic and solvent deuterium isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Escherichia coli tryptophan indole-lyase.
Topics: Alanine; Binding, Competitive; Catalysis; Cysteine; Deuterium; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Lyases; Oxindoles; Pyridoxal Phosphate; Solvents; Tryptophan; Tryptophanase | 1988 |
Isotope effect studies of the pyridoxal 5'-phosphate dependent histidine decarboxylase from Morganella morganii.
Topics: Carbon Isotopes; Carboxy-Lyases; Deuterium; Glutamate Decarboxylase; Histidine Decarboxylase; Kinetics; Nitrogen Isotopes; Proteus; Pyridoxal Phosphate | 1988 |
Isotope effect studies of the pyruvate-dependent histidine decarboxylase from Lactobacillus 30a.
Topics: Carbon Isotopes; Carboxy-Lyases; Deuterium; Histidine Decarboxylase; Hydrogen-Ion Concentration; Kinetics; Lactobacillus; Nitrogen Isotopes; Pyridoxal Phosphate; Pyruvates; Pyruvic Acid; Schiff Bases | 1988 |
Mechanistic deductions from kinetic isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Erwinia herbicola and Citrobacter freundii tyrosine phenol-lyase.
Topics: Alanine; Binding, Competitive; Citrobacter; Cysteine; Deuterium; Erwinia; Hydrogen-Ion Concentration; Kinetics; Lyases; Phenylalanine; Pyridoxal Phosphate; Tyrosine; Tyrosine Phenol-Lyase | 1988 |
Preparation of sulfur and selenium amino acids with microbial pyridoxal phosphate enzymes.
Topics: Amino Acids; Amino Acids, Sulfur; Bacteria; Carbon-Oxygen Lyases; Carbon-Sulfur Lyases; Cysteine Synthase; Deuterium; Isotope Labeling; Lyases; Multienzyme Complexes; Pyridoxal Phosphate; Saccharomyces cerevisiae Proteins; Selenium; Substrate Specificity; Tritium; Tryptophan Synthase | 1987 |
Model reactions which establish a facile reduction of pyridoxal phosphate and analogs by 1,4-dihydropyridines.
Topics: Alanine; Aldehydes; Cations, Divalent; Chemical Phenomena; Chemistry; Deuterium; Hydrogen; Hydrogen-Ion Concentration; Hydroquinones; Imines; Kinetics; Magnetic Resonance Spectroscopy; Methanol; Models, Chemical; Niacinamide; Oxidation-Reduction; Pyridines; Pyridoxal; Pyridoxal Phosphate; Spectrophotometry, Ultraviolet | 1973 |
Evidence for a rate-determining proton abstraction in the serine deaminase reaction of the beta 2 subunit of tryptophan synthetase.
Topics: Deuterium; Escherichia coli; Kinetics; L-Serine Dehydratase; Macromolecular Substances; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mathematics; Models, Chemical; Protons; Pyridoxal Phosphate; Schiff Bases; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tryptophan Synthase | 1974 |
Isotopic effects and inhibition of polysaccharide phosphorylase by 1,5-gluconolactone. Relationship to the catalytic mechanism.
Topics: Alkaline Phosphatase; Animals; Arsenic; Binding Sites; Catalysis; Chemical Phenomena; Chemistry; Deuterium; Drug Stability; Escherichia coli; Gluconates; Glucosyltransferases; Glycogen; Hexosephosphates; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lactones; Models, Chemical; Models, Structural; Muscles; Polysaccharides; Pyridoxal Phosphate; Rabbits; Ultracentrifugation | 1971 |
Cystathionine -synthase. Studies of hydrogen exchange reactions.
Topics: Alanine; Aminobutyrates; Catalysis; Chemical Phenomena; Chemistry; Cystathionine; Cysteine; Deuterium; Homoserine; Kinetics; Lyases; Magnetic Resonance Spectroscopy; Pyridoxal Phosphate; Salmonella; Serine; Succinates; Tritium | 1972 |
Cystathionine -synthase. The nature of intramolecular proton shifts in the elimination reaction.
Topics: Aluminum; Catalysis; Chemical Phenomena; Chemistry; Cystathionine; Deuterium; Homoserine; Isomerism; Isotope Labeling; Kinetics; Lyases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Optical Rotatory Dispersion; Protons; Pyridoxal; Pyridoxal Phosphate; Salmonella; Succinates; Sulfates | 1972 |
Lysine 2,3-aminomutase. Purification and properties of a pyridoxal phosphate and S-adenosylmethionine-activated enzyme.
Topics: Acetone; Amino Acids; Carbon Isotopes; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Clostridium; Cysteine; Deuterium; Dialysis; Drug Stability; Electrophoresis; Electrophoresis, Disc; Enzyme Activation; Hydrogen-Ion Concentration; Hydroxylamines; Intramolecular Transferases; Iron; Isomerases; Isoniazid; Kinetics; Lysine; Methionine; Methods; Molecular Weight; Nucleosides; Pyridoxal Phosphate; Pyridoxine; Streptomycin; Sulfhydryl Compounds; Temperature; Tritium | 1970 |
Proton magnetic resonance study of the interaction of pyridoxal 5-phosphate with tris(hydroxymethyl)aminomethane.
Topics: Deuterium; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Pyridoxal Phosphate; Tromethamine | 1970 |
Proton retention in the gamma-elimination reaction catalysed by cystathionine gamma-synthase.
Topics: Cysteine; Deuterium; Dinitrophenols; Hydrazines; Hydro-Lyases; Hydrogen; Keto Acids; Magnetic Resonance Spectroscopy; Protons; Pyridoxal Phosphate; Serine; Succinates; Tritium; Water | 1968 |
The formation of an enzyme-bound beta-carbanion in the enzymic conversion of L-homoserine to alpha-ketobutyrate.
Topics: Aminobutyrates; Animals; Butyrates; Deuterium; Hydro-Lyases; Hydroxybutyrates; Infrared Rays; Keto Acids; Liver; Magnetic Resonance Spectroscopy; Models, Chemical; Pyridoxal Phosphate; Rats; Spectrum Analysis | 1968 |
The conversion of ethanolamine to acetate in mammalian tissues.
Topics: Acetaldehyde; Acetates; Amino Alcohols; Ammonia; Animals; Carbon Isotopes; Deuterium; Male; Phenylbutyrates; Pyridoxal Phosphate; Rats | 1969 |
Stereochemistry of meso-alpha,epsilon-diaminopimelate decarboxylase reaction: the first evidence for pyridoxal 5'-phosphate dependent decarboxylation with inversion of configuration.
Topics: Bacillus; Bacterial Proteins; Cadaverine; Carboxy-Lyases; Deuterium; Kinetics; Lysine; Piperidines; Pyridoxal Phosphate; Radioisotope Dilution Technique | 1981 |
Equilibrium and kinetic study of interaction of amino acid inhibitors with tryptophanase: mechanism of quinonoid formation.
Topics: Alanine; Deuterium; Escherichia coli; Ethionine; Hydrogen-Ion Concentration; Kinetics; Lyases; Protein Binding; Pyridoxal Phosphate; Quinones; Spectrophotometry; Tryptophanase | 1981 |
Pulsed electron paramagnetic resonance studies of the lysine 2,3-aminomutase substrate radical: evidence for participation of pyridoxal 5'-phosphate in a radical rearrangement.
Topics: Amino Acid Isomerases; Anions; Chlorides; Clostridium; Deuterium; Electron Spin Resonance Spectroscopy; Free Radicals; Intramolecular Transferases; Lysine; Models, Chemical; Pyridoxal Phosphate; Sulfates | 1995 |
Inactivation of gamma-aminobutyric acid aminotransferase by L-3-chloroalanine hydroxamate.
Topics: 4-Aminobutyrate Transaminase; Alanine; Animals; Buffers; Cyclohexanecarboxylic Acids; Cycloserine; Deuterium; Prodrugs; Pyridoxal Phosphate; Swine; Time Factors | 1995 |
Kinetic analysis of the exchange of the alpha-protons of amino acids by pyridoxal-phosphate-dependent enzymes.
Topics: Deuterium; Enzymes; Glycine Hydroxymethyltransferase; Hydrogen; Kinetics; Mathematics; Models, Theoretical; Pyridoxal Phosphate; Schiff Bases; Tryptophan Synthase | 1996 |
Aspartate-279 in aminolevulinate synthase affects enzyme catalysis through enhancing the function of the pyridoxal 5'-phosphate cofactor.
Topics: 5-Aminolevulinate Synthetase; Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Conserved Sequence; Deuterium; DNA Primers; In Vitro Techniques; Kinetics; Mice; Mutagenesis, Site-Directed; Point Mutation; Pyridoxal Phosphate; Recombinant Proteins | 1998 |
A substrate-induced change in the stereospecificity of the serine-hydroxymethyltransferase-catalysed exchange of the alpha-protons of amino acids--evidence for a second catalytic site.
Topics: Amino Acids; Bacterial Proteins; Binding Sites; Borohydrides; Butyrates; Caproates; Carbon Isotopes; Catalysis; Deuterium; Escherichia coli; Glycine; Glycine Hydroxymethyltransferase; Kinetics; Molecular Conformation; Pentanoic Acids; Protons; Pyridoxal Phosphate; Schiff Bases; Substrate Specificity; Tetrahydrofolates | 1998 |
Catalytic mechanism of the tryptophan synthase alpha(2)beta(2) complex. Effects of pH, isotopic substitution, and allosteric ligands.
Topics: Alanine; Allosteric Regulation; Catalytic Domain; Deuterium; Glycine; Hydrogen-Ion Concentration; Indoles; Ligands; Models, Chemical; Oxindoles; Pyridoxal Phosphate; Salmonella typhimurium; Serine; Tryptophan Synthase | 1999 |
Rapid kinetic and isotopic studies on dialkylglycine decarboxylase.
Topics: Alanine; Aminoisobutyric Acids; Carbon Isotopes; Carboxy-Lyases; Decarboxylation; Deuterium; Enzyme Activation; Isoenzymes; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Protons; Pyridoxal Phosphate; Pyruvic Acid; Transaminases | 2001 |
Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.
Topics: Alanine; Aspartic Acid; Binding Sites; Catalysis; Circular Dichroism; Cysteine Synthase; Deuterium; Hydrogen Bonding; Kinetics; Mutagenesis, Site-Directed; Pyridines; Pyridoxal Phosphate; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Substrate Specificity | 2003 |
The reaction of indole with the aminoacrylate intermediate of Salmonella typhimurium tryptophan synthase: observation of a primary kinetic isotope effect with 3-[(2)H]indole.
Topics: Acrylates; Binding Sites; Deuterium; Deuterium Exchange Measurement; Enzyme Activation; Flow Injection Analysis; Indoles; Isotope Labeling; Kinetics; Multienzyme Complexes; Protein Binding; Protein Subunits; Pyridoxal Phosphate; Salmonella typhimurium; Tryptophan Synthase | 2004 |
Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men.
Topics: Adult; Carbon Isotopes; Deuterium; Female; Glycine; Homocysteine; Humans; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pyridoxal Phosphate; Serine; Vitamin B 6 | 2005 |
Determinants of substrate specificity in omega-aminotransferases.
Topics: Amino Acids; Aminobutyrates; Binding Sites; Biochemistry; Crystallography, X-Ray; Deuterium; DNA; Glutamic Acid; Humans; Isoleucine; Ketoglutaric Acids; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Ornithine; Ornithine-Oxo-Acid Transaminase; Protein Binding; Pyridoxal Phosphate; Recombinant Fusion Proteins; Spectrophotometry; Substrate Specificity; Time Factors; Transaminases; Tyrosine | 2005 |
Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women.
Topics: Adult; Analysis of Variance; Area Under Curve; Carbon Isotopes; Deuterium; Diet; Erythrocytes; Female; Glutathione; Humans; Kinetics; Male; Pyridoxal Phosphate; Statistics, Nonparametric; Vitamin B 6; Vitamin B 6 Deficiency; Young Adult | 2009 |
Suppression of isotope scrambling in cell-free protein synthesis by broadband inhibition of PLP enymes for selective 15N-labelling and production of perdeuterated proteins in H2O.
Topics: Cell-Free System; Deuterium; Isotope Labeling; Lysine; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Protein Biosynthesis; Proteins; Pyridoxal Phosphate; Water | 2011 |
Direct visualization of critical hydrogen atoms in a pyridoxal 5'-phosphate enzyme.
Topics: Aspartate Aminotransferases; Catalysis; Catalytic Domain; Crystallography; Deuterium; Dimerization; Escherichia coli; Hydrogen; Neutrons; Pyridoxal Phosphate; Schiff Bases | 2017 |
Analyses of pre-steady-state kinetics and isotope effects of the γ-elimination reaction catalyzed by Citrobacter freundii methionine γ-lyase.
Topics: Amino Acids; Carbon-Sulfur Lyases; Catalysis; Citrobacter freundii; Deuterium; Imines; Kinetics; Methionine; Nitriles; Phosphates; Protons; Pyridoxal Phosphate | 2022 |