pyridine and gdc 0449

pyridine has been researched along with gdc 0449 in 2 studies

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chen, YH; Deese, A; Hop, CE; Khojasteh, SC; Mulder, T; Reynolds, M; Rudewicz, PJ; Solon, E; Takahashi, R; Wong, H; Yue, Q	1
Castanedo, G; Chen, JZ; Hop, CE; Jia, W; Khojasteh, SC; Liu, L; Ly, J; Lyssikatos, J; Ma, S; Messick, K; Mulder, T; Takahashi, R; Wong, H; Yue, Q	1

Other Studies

2 other study(ies) available for pyridine and gdc 0449

Article	Year
Absorption, distribution, metabolism, and excretion of [¹⁴C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring opening. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:6 Topics: Absorption; Administration, Oral; Anilides; Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dogs; Feces; Female; Hedgehog Proteins; Male; Metabolic Clearance Rate; Pyridines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Signal Transduction; Species Specificity; Structure-Activity Relationship; Tissue Distribution	2011
Investigations into the mechanisms of pyridine ring cleavage in vismodegib. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:3 Topics: Anilides; Animals; Biotransformation; Chromatography, High Pressure Liquid; Dogs; Hedgehog Proteins; Humans; In Vitro Techniques; Liver; Macaca fascicularis; Male; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Oxidation-Reduction; Perfusion; Pyridines; Rats; Rats, Sprague-Dawley	2014

Article

Year

Absorption, distribution, metabolism, and excretion of [¹⁴C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring opening.

Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:6

Topics: Absorption; Administration, Oral; Anilides; Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dogs; Feces; Female; Hedgehog Proteins; Male; Metabolic Clearance Rate; Pyridines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Signal Transduction; Species Specificity; Structure-Activity Relationship; Tissue Distribution

2011

Investigations into the mechanisms of pyridine ring cleavage in vismodegib.

Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:3

Topics: Anilides; Animals; Biotransformation; Chromatography, High Pressure Liquid; Dogs; Hedgehog Proteins; Humans; In Vitro Techniques; Liver; Macaca fascicularis; Male; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Oxidation-Reduction; Perfusion; Pyridines; Rats; Rats, Sprague-Dawley

2014