pyridine and gdc 0449
pyridine has been researched along with gdc 0449 in 2 studies
Research
Studies (2)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Chen, YH; Deese, A; Hop, CE; Khojasteh, SC; Mulder, T; Reynolds, M; Rudewicz, PJ; Solon, E; Takahashi, R; Wong, H; Yue, Q | 1 |
| Castanedo, G; Chen, JZ; Hop, CE; Jia, W; Khojasteh, SC; Liu, L; Ly, J; Lyssikatos, J; Ma, S; Messick, K; Mulder, T; Takahashi, R; Wong, H; Yue, Q | 1 |
Other Studies
2 other study(ies) available for pyridine and gdc 0449
| Article | Year |
|---|---|
Absorption, distribution, metabolism, and excretion of [¹⁴C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring opening.
Topics: Absorption; Administration, Oral; Anilides; Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dogs; Feces; Female; Hedgehog Proteins; Male; Metabolic Clearance Rate; Pyridines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Signal Transduction; Species Specificity; Structure-Activity Relationship; Tissue Distribution | 2011 |
Investigations into the mechanisms of pyridine ring cleavage in vismodegib.
Topics: Anilides; Animals; Biotransformation; Chromatography, High Pressure Liquid; Dogs; Hedgehog Proteins; Humans; In Vitro Techniques; Liver; Macaca fascicularis; Male; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Oxidation-Reduction; Perfusion; Pyridines; Rats; Rats, Sprague-Dawley | 2014 |