pyrenophorol and pyrenophorin
pyrenophorol has been researched along with pyrenophorin* in 3 studies
Other Studies
3 other study(ies) available for pyrenophorol and pyrenophorin
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Antifungal metabolites from fungal endophytes of Pinus strobus.
The extracts of five foliar fungal endophytes isolated from Pinus strobus (eastern white pine) that showed antifungal activity in disc diffusion assays were selected for further study. From these strains, the aliphatic polyketide compound 1 and three related sesquiterpenes 2-4 were isolated and characterized. Compound 2 is reported for the first time as a natural product and the E/Z conformational isomers 3 and 4 were hitherto unknown. Additionally, the three known macrolides; pyrenophorol (5), dihydropyrenophorin (6), and pyrenophorin (7) were isolated and identified. Their structures were elucidated by spectroscopic analyses including 2D NMR, HRMS and by comparison to literature data where available. The isolated compounds 1, 2, and 5 were antifungal against both the rust Microbotryum violaceum and Saccharomyces cerevisae. Topics: Antifungal Agents; Ascomycota; Base Sequence; Basidiomycota; Endophytes; Heterocyclic Compounds; Ketones; Lactones; Macrolides; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Sequence Data; Pinus; Plant Leaves; Polyketides; Saccharomyces; Sequence Analysis, DNA; Sesquiterpenes | 2011 |
Comparative toxicity of the phytotoxins (8R,16R)-(-)-pyrenophorin and (5S,8R,13S,16R)-(-)-pyrenophorol on aquatic organisms.
The acute toxicities of the fungal phytotoxins (8R,16R)-(-)-pyrenophorin and (5S,8R,13S,16R)-(-)-pyrenophorol on Vibrio fischeri, Oscillatoria perornata, Pseudokirchneriella subcapitata, Lemna minor and Artemia fransiscana were evaluated. (8R,16R)-(-)-pyrenophorin was more toxic than (5S,8R,13S,16R)-(-)-pyrenophorol to V. fischeri, O. perornata, L. minor and A. fransiscana. The highest acute toxicity of (8R,16R)-(-)-pyrenophorin was exhibited on V. fischeri (5 min median effective concentration of 3.57 M 10(-5)) whereas the corresponding value for (5S,8R,13S,16R)-(-)-pyrenophorol was 801 M 10(-5). P. subcapitata exhibited a lack of sensitivity (median inhibitory concentration of >10 M 10(-5)) to both phytotoxins. Topics: Animals; Araceae; Artemia; Bacteria; Heterocyclic Compounds; Ketones; Lactones; Water Pollutants, Chemical | 2007 |
Bioactivity of the fungal metabolite (8R,16R)-(-)-pyrenophorin on graminaceous plants.
A secondary metabolite was isolated from cultures of a Drechslera avenae pathotype with host specificity to Avena sterilis and identified as the macrodiolide (8R,16R)-(-)-pyrenophorin (8,16-dimethyl-1,9-dioxa-cyclohexadeca-3,11-diene-2,5,10,13-tetraone). A considerable yield of the substance was obtained after 8-12 days of incubation at temperatures of 15-20 degrees C. The compound at a concentration of 60 microM inhibited seed germination of wild oats (Avena sterilis, A. fatua), oat (A. sativa), wheat (Triticum aestivum), and barley (Hordeum vulgare). Root growth of pregerminated seeds of the graminaceous plants was stimulated, remained unaffected, or was inhibited by pyrenophorin at 10-30, 31-50, and >51 microM, respectively. The metabolite caused abnormal chlorophyll retention in leaf sections of all five graminaceous plants, but seedling cuttings partially immersed in 1000 microM solutions remained unaffected. The rate of chlorophyll dissipation was decreased by half in leaf sections treated with pyrenophorin at 320 microM compared with the control. These findings are discussed and compared with data on the production and bioactivity of the macrodiolide (5S,8R,13S,16R)-(-)-pyrenophorol, which has a similar stereochemical configuration. Topics: Ascomycota; Avena; Chlorophyll; Germination; Hordeum; Lactones; Plant Leaves; Plant Roots; Poaceae; Seeds; Triticum | 2005 |