pyrazolone and pyrroline

pyrazolone has been researched along with pyrroline* in 1 studies

Other Studies

1 other study(ies) available for pyrazolone and pyrroline

Article	Year
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives. Bioorganic & medicinal chemistry letters, 2020, 12-15, Volume: 30, Issue:24 The P2X3 receptor is an attractive target for the treatment of pain and chronic coughing, and thus P2X3 antagonists have been developed as new therapeutic drugs. We previously reported selective P2X3 receptor antagonists by derivatization of hit compound 1. As a result, we identified hit compound 3, the structure of which was similar to hit compound 1. On the basis of SAR studies of hit compound 1, we modified hit compound 3 and compound 42 was identified as having analgesic efficacy by oral administration. Topics: Drug Discovery; Humans; Molecular Docking Simulation; Purinergic P2X Receptor Antagonists; Pyrazolones; Pyrroles; Receptors, Purinergic P2X3; Structure-Activity Relationship	2020

Article

Year

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives.

Bioorganic & medicinal chemistry letters, 2020, 12-15, Volume: 30, Issue:24

The P2X3 receptor is an attractive target for the treatment of pain and chronic coughing, and thus P2X3 antagonists have been developed as new therapeutic drugs. We previously reported selective P2X3 receptor antagonists by derivatization of hit compound 1. As a result, we identified hit compound 3, the structure of which was similar to hit compound 1. On the basis of SAR studies of hit compound 1, we modified hit compound 3 and compound 42 was identified as having analgesic efficacy by oral administration.

Topics: Drug Discovery; Humans; Molecular Docking Simulation; Purinergic P2X Receptor Antagonists; Pyrazolones; Pyrroles; Receptors, Purinergic P2X3; Structure-Activity Relationship

2020