pyrazolone has been researched along with pyridine* in 2 studies
2 other study(ies) available for pyrazolone and pyridine
| Article | Year |
|---|---|
Evaluation of an analytical method for cyanogenic compounds in beans and surveillance of cyanogenic compounds in beans.
The performance characteristics of an analytical method for cyanogenic compounds were evaluated. Specifically, we tested the trueness, repeatability and intermediate precision of the method using a spectrophotometric-based detection system for 4-pyridinecarboxylic acid and pyrazolone after steam distillation. The pH adjustment of the distillate was revealed to affect the trueness of the measurements. A pH of approximately 6 was found to be optimal. The targeted quantitation limit of the cyanide ion was set to 5 mg/kg. The performance of the method was evaluated using beans spiked with cyanide ion at one to two times the quantitation limit (5-10 mg/kg). The trueness of the method was between 78-90%, and the repeatability and intermediate precision were between RSD 1.2% to 6.0%. A surveillance of cyanogenic compounds in beans retailed in Japan was then carried out. All the results were below the quantitation limit of 5 mg/kg. Topics: Cyanides; Fabaceae; Food Analysis; Hydrogen-Ion Concentration; Japan; Pyrazolones; Pyridines; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry | 2011 |
Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as K(ATP) channel openers.
In search of a novel chemotype of K(ATP) channel openers a series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones was synthesized. It was found that cyclopentanone in the left hand portion of the molecule was 4-fold more potent than cyclohexanone. Introduction of gem-dimethyl groups as well as incorporation of oxygen in the cyclohexanone ring in the left hand portion of the molecule increased the potency 10-fold. In the right hand portion of the molecule, the NH-group of the pyrazolone can be effectively substituted by oxygen increasing the activity 5-fold. Incorporation of a methyl group adjacent to the dihydropyridine (DHP) nitrogen not only significantly boosted activity, but also provided an additional benefit of increased metabolic stability. In vitro tests on the tissue from pig bladder strips provided further confirmation of K(ATP) activity of these compounds. Topics: Animals; Cells, Cultured; Guinea Pigs; Humans; In Vitro Techniques; Membrane Proteins; Oxazolone; Potassium Channels; Pyrazoles; Pyrazolones; Pyridines; Structure-Activity Relationship; Swine | 2004 |