pyrazole has been researched along with thiophenes in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T | 1 |
| Balsamo, A; Coletta, I; Guglielmotti, A; Landolfi, C; Mancini, F; Martinelli, A; Milanese, C; Minutolo, F; Nencetti, S; Orlandini, E; Pinza, M; Rapposelli, S; Rossello, A | 1 |
| Cai, H; Edwards, JP; Gu, Y; Jiang, W; Karlsson, L; Meduna, SP; Pio, BA; Sun, S; Thurmond, RL; Wei, J | 1 |
| Chang, CP; Chao, YS; Chiu, HH; Chu, CM; Chung, WL; Hsieh, WP; Hung, MS; Kuo, CW; Lin, Y; Shia, KS; Song, JS; Tai, CL; Tseng, SL; Tung, YS; Wu, CH | 1 |
| Bondock, S; Fadaly, W; Metwally, MA | 1 |
| Helal, MH; Mahmoud, Ael-S; Mohareb, RM; Shams, HZ | 1 |
| Bard, J; Barnes, K; Chopra, R; Erdei, J; Fan, KY; Gunawan, I; Hui, Y; Johnson, M; Malamas, MS; Pangalos, MN; Robichaud, A; Solvibile, W; Turner, J; Yan, Y; Zhou, P | 1 |
| Churruca, F; DomÃnguez, E; Hernández, S; Perea, M; SanMartin, R | 1 |
| Ishii, J; Kondo, A; Matsuda, F; Shirai, T | 1 |
| Dai, G; Jiang, H; Jin, Z; Liu, S; Lu, J; Wang, C; Wu, J | 1 |
| Altalbawy, FM; Edrees, MM; Gomha, SM | 1 |
| Bharath, S; Kumar, AD; Kumar, KA; Lokanath, NK; Mylarappa, BN; Naveen, S; Prabhudeva, MG | 1 |
| Che, J; Cheng, G; Dong, X; Hu, X; Hu, Y; Li, J; Wu, Y; Xu, L; Zhan, W; Zhou, Y | 1 |
| Alwan, ES; Mohareb, RM | 1 |
| El-Ansary, RA; Milad, YR; Mohareb, RM | 1 |
| Elmetwally, AM; Mohamed, AA; Mohareb, RM | 1 |
16 other study(ies) available for pyrazole and thiophenes
| Article | Year |
|---|---|
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase | 1981 |
Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring.
Topics: Amines; Animals; Binding Sites; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cyclopentanes; Dinoprostone; Humans; Isoenzymes; Isoxazoles; Macrophages; Membrane Proteins; Mice; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Structure-Activity Relationship; Thiophenes; U937 Cells | 2003 |
Pyrazole-based cathepsin S inhibitors with improved cellular potency.
Topics: Animals; Aza Compounds; Benzofurans; Carboxylic Acids; Cathepsins; Humans; Indoles; Molecular Structure; Protease Inhibitors; Pyrazoles; Structure-Activity Relationship; Thiophenes | 2007 |
Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antag
Topics: Animals; Binding Sites; Hydrophobic and Hydrophilic Interactions; Mice; Mice, Obese; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship; Thiophenes; Weight Loss | 2008 |
Synthesis and antimicrobial activity of some new thiazole, thiophene and pyrazole derivatives containing benzothiazole moiety.
Topics: Anti-Infective Agents; Bacteria; Benzothiazoles; Fungi; Microbial Sensitivity Tests; Pyrazoles; Thiophenes | 2010 |
Design and synthesis of novel antimicrobial acyclic and heterocyclic dyes and their precursors for dyeing and/or textile finishing based on 2-N-acylamino-4,5,6,7-tetrahydro-benzo[b]thiophene systems.
Topics: Acetamides; Ampicillin; Anti-Bacterial Agents; Antifungal Agents; Bacillus cereus; Bacillus subtilis; Candida albicans; Coloring Agents; Drug Design; Escherichia coli; Heterocyclic Compounds, 2-Ring; Materials Testing; Microbial Sensitivity Tests; Nitriles; Prodrugs; Pyrazoles; Pyrimidines; Textile Industry; Textiles; Thiazoles; Thiophenes | 2011 |
New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: exploring the S2' region.
Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Crystallography, X-Ray; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydantoins; Models, Molecular; Molecular Structure; Pyrazoles; Stereoisomerism; Structure-Activity Relationship; Thiophenes | 2011 |
Direct access to pyrazolo(benzo)thienoquinolines. Highly effective palladium catalysts for the intramolecular C-H heteroarylation of arenes.
Topics: Carbon; Catalysis; Hydrogen; Palladium; Pyrazoles; Quinolines; Thiophenes | 2013 |
Regulation of central carbon metabolism in Saccharomyces cerevisiae by metabolic inhibitors.
Topics: Acetone; Alcohol Dehydrogenase; Carbon; Enzyme Inhibitors; Ethanol; Fermentation; Glycerol; Metabolome; Pyrazoles; Saccharomyces cerevisiae; Succinate Dehydrogenase; Thiophenes | 2013 |
Novel fluorescent 1,8-naphthalimide derivatives containing thiophene and pyrazole moieties: synthesis by direct C-H arylation and evaluation of photophysical and electrochemical properties.
Topics: Benzene Derivatives; Electrochemistry; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Naphthalimides; Photochemistry; Pyrazoles; Quantum Theory; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet; Thiophenes | 2014 |
Synthesis and Characterization of Some New Bis-Pyrazolyl-Thiazoles Incorporating the Thiophene Moiety as Potent Anti-Tumor Agents.
Topics: Antineoplastic Agents; Carbon-13 Magnetic Resonance Spectroscopy; Cell Survival; Chemistry, Pharmaceutical; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Proton Magnetic Resonance Spectroscopy; Pyrazoles; Structure-Activity Relationship; Thiazoles; Thiophenes | 2016 |
Design and environmentally benign synthesis of novel thiophene appended pyrazole analogues as anti-inflammatory and radical scavenging agents: Crystallographic, in silico modeling, docking and SAR characterization.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Citrus; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Free Radical Scavengers; Humans; Models, Molecular; Molecular Structure; Oxidative Stress; Phospholipase A2 Inhibitors; Phospholipases A2; Pyrazoles; Structure-Activity Relationship; Thiophenes | 2017 |
Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors.
Topics: Administration, Oral; Animals; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; HCT116 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microsomes, Liver; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured | 2019 |
Heterocyclization of 2-(2-phenylhydrazono)cyclohexane-1,3-dione to Synthesis Thiophene, Pyrazole and 1,2,4-triazine Derivatives with Anti-Tumor and Tyrosine Kinase Inhibitions.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclization; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-pim-1; Pyrazoles; Structure-Activity Relationship; Thiophenes; Triazines | 2020 |
New Approaches for the Synthesis of Fused Thiophene, Pyrazole, Pyran and Pyridine Derivatives with Anti-Proliferative Together with c-Met Kinase and Prostate Cancer Cell Inhibitions.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Male; Molecular Structure; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrans; Pyrazoles; Pyridines; Structure-Activity Relationship; Thiophenes | 2021 |
Multi-Component Reactions of Cyclohexan-1,3-dione: Synthesis of Fused Pyran, Pyridine, Thiophene and Pyrazole Derivatives with c-Met, Anti-Proliferative Activities.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Protein Kinase Inhibitors; Pyrans; Pyrazoles; Pyridines; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship; Thiophenes | 2021 |