pyrazole and thiazoles

pyrazole has been researched along with thiazoles in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.33)18.7374
1990's0 (0.00)18.2507
2000's6 (20.00)29.6817
2010's16 (53.33)24.3611
2020's7 (23.33)2.80

Authors

AuthorsStudies
Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T1
Fotsch, C; St Jean, DJ1
Abdel-Gawad, SM; El-Gaby, MS; Ghorab, MM1
Abdel Ghany, YS; Ashour, HM; Baraka, A; Bekhit, AA; Bekhit, Ael-D1
Kruse, CG; Lange, JH1
Almqvist, F; Sellstedt, M1
Gzella, A; Havrylyuk, D; Lesyk, R; Vasylenko, O; Zaprutko, L; Zimenkovsky, B1
Andrei, G; Balzarini, J; Baraka, MM; el-Sabbagh, OI; Ibrahim, SM; Pannecouque, C; Rashad, AA; Snoeck, R1
Helal, MH; Mahmoud, Ael-S; Mohareb, RM; Shams, HZ1
Beedkar, SD; Chobe, SS; Dawane, BS; Khobragade, CN; Yemul, OS1
Gangarajula, S; Ghosh, AK; Huang, X; Kulkarni, S; Pandey, S; Rao, KV; Tang, J; Xu, X1
Cui, HE; Gong, HB; Qiu, KM; Wang, HH; Xing, M; Yan, R; Zhu, HL1
Dawood, KM; El-Zahabi, HS; Eldebss, TM; Metz, P; Yousef, MH1
Atobe, M; Hayashi, T; Kasahara, K; Kawanishi, M; Miyoshi, S; Morimoto, A; Naganuma, K; Ohashi, S; Suzuki, H1
Ali, AR; El-Bendary, ER; Ghaly, MA; Shehata, IA1
Al-Harbi, NO; Amr, Ael-G; Bahashwan, SA; Fayed, AA; Ramadan, MA1
Bilcer, G; Brindisi, M; Devasamudram, T; Ghosh, AK; Huang, X; Koelsch, G; Lei, H; Mesecar, AD; Tang, J; Xu, X; Yen, YC1
Badawy, MA; Metwally, NH; Okpy, DS1
Duan, LM; Jia, CJ; Li, YL; Yu, HY1
Abdelall, EK; Kamel, GM1
Altalbawy, FM; Edrees, MM; Gomha, SM1
Byrappa, K; Kudva, AK; Kumar, MS; Nagananda, GS; Narayana, B; Salian, VV; Sarojini, BK1
Choi, YJ; Hong, JR; Keum, G; Nam, G1
Akbari, F; Didehban, K; Farhang, M1
Che, FS; Fujita, M; Hayashi, H; Kusajima, M; Maruyama-Nakashita, A; Mori, T; Nakashita, H; Tsukamoto, K; Ushiwatari, T; Yamakawa, H1
Cherukupalli, S; Du, X; Jia, H; Liu, X; Yu, J; Zhan, P1
Grant, G; Patel, B; Rudrawar, S; Zunk, M1
Abd-Allah, WH; Aboregela, AM; El-Behairy, MF; Lan, P; Marzouk, AA; Shaykoon, MSA; Taher, ES1
Kassu, M; Kim, C; Kirby, JE; Manetsch, R; Smith, KP1
Al-Aizari, FA; Almarhoon, ZM; Alsayari, A; Asiri, YI; Ghabbour, HA; Kheder, NA; Mabkhot, YN; Muhsinah, AB1

Reviews

1 review(s) available for pyrazole and thiazoles

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012

Other Studies

29 other study(ies) available for pyrazole and thiazoles

ArticleYear
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:10

    Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase

1981
Synthesis and antifungal activity of novel pyrano[2',3':4,5]thiazolo[2,3-b]quinazolines, pyrido[2',3':4,5]thiazolo[2,3-b]quinazolines and pyrazolo[2',3':4,5]thiazolo[2,3-b]quinazolines.
    Farmaco (Societa chimica italiana : 1989), 2000, Volume: 55, Issue:4

    Topics: Antifungal Agents; Aspergillus flavus; Aspergillus ochraceus; Candida albicans; Microbial Sensitivity Tests; Molecular Structure; Penicillium chrysogenum; Pyrans; Pyrazoles; Pyridines; Quinazolines; Thiazoles

2000
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Drug Design; Edema; Fungi; Granuloma; Humans; Male; Microbial Sensitivity Tests; Pyrazoles; Rats; Thiadiazoles; Thiazoles; Ulcer

2008
Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives.
    Chemical record (New York, N.Y.), 2008, Volume: 8, Issue:3

    Topics: Animals; Anti-Obesity Agents; CHO Cells; Cricetinae; Cricetulus; Humans; Imidazoles; Isomerism; Models, Chemical; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Solubility; Structure-Activity Relationship; Thiazoles; Triazoles; Water

2008
Synthesis of a novel tricyclic peptidomimetic scaffold.
    Organic letters, 2008, Sep-18, Volume: 10, Issue:18

    Topics: Molecular Conformation; Peptides, Cyclic; Pyrazoles; Pyridones; Thiazoles

2008
Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Neoplasms; Pyrazoles; Thiazoles

2009
Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:9

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; HeLa Cells; Humans; Microbial Sensitivity Tests; Pyrazoles; Structure-Activity Relationship; Thiazoles; Vero Cells; Viruses

2009
Design and synthesis of novel antimicrobial acyclic and heterocyclic dyes and their precursors for dyeing and/or textile finishing based on 2-N-acylamino-4,5,6,7-tetrahydro-benzo[b]thiophene systems.
    Molecules (Basel, Switzerland), 2011, Jul-26, Volume: 16, Issue:8

    Topics: Acetamides; Ampicillin; Anti-Bacterial Agents; Antifungal Agents; Bacillus cereus; Bacillus subtilis; Candida albicans; Coloring Agents; Drug Design; Escherichia coli; Heterocyclic Compounds, 2-Ring; Materials Testing; Microbial Sensitivity Tests; Nitriles; Prodrugs; Pyrazoles; Pyrimidines; Textile Industry; Textiles; Thiazoles; Thiophenes

2011
Novel thiazolo-pyrazolyl derivatives as xanthine oxidase inhibitors and free radical scavengers.
    International journal of biological macromolecules, 2012, May-01, Volume: 50, Issue:4

    Topics: Allopurinol; Animals; Catalytic Domain; Drug Design; Enzyme Inhibitors; Free Radical Scavengers; Gout; Inhibitory Concentration 50; Models, Molecular; Pyrazoles; Rats; Thiazoles; Xanthine Oxidase

2012
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors.
    Bioorganic & medicinal chemistry letters, 2012, Sep-01, Volume: 22, Issue:17

    Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Catalytic Domain; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Pyrazoles; Quinazolines; Structure-Activity Relationship; Thiazoles

2012
Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Animals; Binding Sites; Catalytic Domain; Cell Line; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Mice; Molecular Docking Simulation; Pyrazoles; Thiazoles

2012
Synthesis of some new pyrazole-based 1,3-thiazoles and 1,3,4-thiadiazoles as anticancer agents.
    European journal of medicinal chemistry, 2013, Volume: 70

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Structure; Pyrazoles; Structure-Activity Relationship; Thiadiazoles; Thiazoles

2013
SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists.
    Bioorganic & medicinal chemistry letters, 2013, Dec-15, Volume: 23, Issue:24

    Topics: Humans; Protein Binding; Pyrazoles; Receptors, Prostaglandin E, EP1 Subtype; Structure-Activity Relationship; Thiazoles

2013
Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo[2,1-b]thiazole derivatives bearing pyrazole moieties.
    European journal of medicinal chemistry, 2014, Mar-21, Volume: 75

    Topics: Antineoplastic Agents; Cell Line, Tumor; Computer Simulation; Drug Design; Drug Screening Assays, Antitumor; Humans; Imidazoles; Neoplasms; Pyrazoles; Thiazoles

2014
Androgen receptor antagonists and anti-prostate cancer activities of some newly synthesized substituted fused pyrazolo-, triazolo- and thiazolo-pyrimidine derivatives.
    International journal of molecular sciences, 2014, Nov-24, Volume: 15, Issue:11

    Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; CHO Cells; Cricetulus; Humans; Lethal Dose 50; Male; Prostatic Neoplasms; Pyrazoles; Pyrimidines; Thiazoles; Triazoles

2014
Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand.
    Bioorganic & medicinal chemistry letters, 2015, Feb-01, Volume: 25, Issue:3

    Topics: Amyloid Precursor Protein Secretases; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Drug Design; Kinetics; Ligands; Molecular Dynamics Simulation; Protease Inhibitors; Protein Binding; Pyrazoles; Structure-Activity Relationship; Thiazoles

2015
Synthesis and anticancer activity of some new thiopyrano[2,3-d]thiazoles incorporating pyrazole moiety.
    Chemical & pharmaceutical bulletin, 2015, Volume: 63, Issue:7

    Topics: Acetic Acid; Antineoplastic Agents; Binding Sites; Cell Survival; Crystallography, X-Ray; Cycloaddition Reaction; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Conformation; Molecular Docking Simulation; Polyethylene Glycols; Protein Structure, Tertiary; Pyrans; Pyrazoles; Temperature; Thiazoles; Tubulin

2015
Design and discovery of 2-(4-(1H-tetrazol-5-yl)-1H-pyrazol-1-yl)-4-(4-phenyl)thiazole derivatives as cardiotonic agents via inhibition of PDE3.
    Bioorganic & medicinal chemistry, 2015, Sep-15, Volume: 23, Issue:18

    Topics: Animals; Binding Sites; Cardiotonic Agents; Catalytic Domain; Cyclic Nucleotide Phosphodiesterases, Type 3; Drug Design; Drug Evaluation, Preclinical; Humans; Male; Molecular Docking Simulation; Phosphodiesterase 3 Inhibitors; Protein Binding; Pyrazoles; Rats; Rats, Wistar; Thiazoles; Toxicity Tests

2015
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.
    European journal of medicinal chemistry, 2016, Aug-08, Volume: 118

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 15-Lipoxygenase; Cattle; Celecoxib; Chemistry Techniques, Synthetic; Cyclization; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Male; Pyrazoles; Rats; Stereoisomerism; Thiazoles; Ulcer

2016
Synthesis and Characterization of Some New Bis-Pyrazolyl-Thiazoles Incorporating the Thiophene Moiety as Potent Anti-Tumor Agents.
    International journal of molecular sciences, 2016, Sep-07, Volume: 17, Issue:9

    Topics: Antineoplastic Agents; Carbon-13 Magnetic Resonance Spectroscopy; Cell Survival; Chemistry, Pharmaceutical; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Proton Magnetic Resonance Spectroscopy; Pyrazoles; Structure-Activity Relationship; Thiazoles; Thiophenes

2016
Spectroscopic, single crystal X-ray, Hirshfeld, in vitro and in silico biological evaluation of a new series of potent thiazole nucleus integrated with pyrazoline scaffolds.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2017, Mar-05, Volume: 174

    Topics: Anti-Infective Agents; Antifungal Agents; Antioxidants; Bacteria; Biphenyl Compounds; Computer Simulation; Crystallography, X-Ray; Fungi; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Conformation; Molecular Docking Simulation; Picrates; Pyrazoles; Spectroscopy, Fourier Transform Infrared; Static Electricity; Thiazoles

2017
Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives.
    Bioorganic & medicinal chemistry, 2017, 09-01, Volume: 25, Issue:17

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Diabetic Neuropathies; Disease Models, Animal; Half-Life; Humans; Inhibitory Concentration 50; Male; Microsomes, Liver; Neuralgia; Pyrazoles; Rats; Structure-Activity Relationship; Thiazoles

2017
Solubility of solid intermediate of pharmaceutical compounds in pure organic solvents using semi-empirical models.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020, Feb-15, Volume: 143

    Topics: Aldehydes; Models, Chemical; Nitroimidazoles; Phenylenediamines; Pyrazoles; Solubility; Solvents; Thermodynamics; Thiazoles

2020
Characterization of plant immunity-activating mechanism by a pyrazole derivative.
    Bioscience, biotechnology, and biochemistry, 2020, Volume: 84, Issue:7

    Topics: Arabidopsis; Arabidopsis Proteins; Ascomycota; Disease Resistance; Intramolecular Transferases; Oryza; Plant Diseases; Plants, Genetically Modified; Pseudomonas syringae; Pyrazoles; Salicylic Acid; Signal Transduction; Solanum lycopersicum; Thiazoles

2020
Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors.
    European journal of medicinal chemistry, 2020, Sep-15, Volume: 202

    Topics: Antiviral Agents; Capsid Proteins; Dose-Response Relationship, Drug; Drug Design; Hepatitis B e Antigens; Hepatitis B virus; Microbial Sensitivity Tests; Molecular Structure; Pyrazines; Pyrazoles; Pyridines; Pyrimidines; Structure-Activity Relationship; Thiazoles; Virus Replication

2020
Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity.
    Bioorganic & medicinal chemistry letters, 2021, 05-01, Volume: 39

    Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Design; HEK293 Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Pyrazoles; Structure-Activity Relationship; Thiazoles

2021
Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment.
    Bioorganic chemistry, 2021, Volume: 111

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Apoptosis; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Edema; Formaldehyde; Male; Models, Molecular; Molecular Structure; Pyrazoles; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship; Thiazoles

2021
Pyrazole-Thiazole Core-Containing Analogs Exhibit Adjunctive Activity with Meropenem against Carbapenem-Resistant Enterobacteriaceae (CRE).
    ChemMedChem, 2021, 09-16, Volume: 16, Issue:18

    Topics: Anti-Bacterial Agents; Carbapenem-Resistant Enterobacteriaceae; Dose-Response Relationship, Drug; Meropenem; Microbial Sensitivity Tests; Molecular Structure; Pyrazoles; Structure-Activity Relationship; Thiazoles

2021
Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-
    Molecules (Basel, Switzerland), 2021, Sep-04, Volume: 26, Issue:17

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; HCT116 Cells; Hep G2 Cells; Humans; Pyrazoles; Thiazoles

2021