pyrazole has been researched along with thiazoles in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (20.00) | 29.6817 |
| 2010's | 16 (53.33) | 24.3611 |
| 2020's | 7 (23.33) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T | 1 |
| Fotsch, C; St Jean, DJ | 1 |
| Abdel-Gawad, SM; El-Gaby, MS; Ghorab, MM | 1 |
| Abdel Ghany, YS; Ashour, HM; Baraka, A; Bekhit, AA; Bekhit, Ael-D | 1 |
| Kruse, CG; Lange, JH | 1 |
| Almqvist, F; Sellstedt, M | 1 |
| Gzella, A; Havrylyuk, D; Lesyk, R; Vasylenko, O; Zaprutko, L; Zimenkovsky, B | 1 |
| Andrei, G; Balzarini, J; Baraka, MM; el-Sabbagh, OI; Ibrahim, SM; Pannecouque, C; Rashad, AA; Snoeck, R | 1 |
| Helal, MH; Mahmoud, Ael-S; Mohareb, RM; Shams, HZ | 1 |
| Beedkar, SD; Chobe, SS; Dawane, BS; Khobragade, CN; Yemul, OS | 1 |
| Gangarajula, S; Ghosh, AK; Huang, X; Kulkarni, S; Pandey, S; Rao, KV; Tang, J; Xu, X | 1 |
| Cui, HE; Gong, HB; Qiu, KM; Wang, HH; Xing, M; Yan, R; Zhu, HL | 1 |
| Dawood, KM; El-Zahabi, HS; Eldebss, TM; Metz, P; Yousef, MH | 1 |
| Atobe, M; Hayashi, T; Kasahara, K; Kawanishi, M; Miyoshi, S; Morimoto, A; Naganuma, K; Ohashi, S; Suzuki, H | 1 |
| Ali, AR; El-Bendary, ER; Ghaly, MA; Shehata, IA | 1 |
| Al-Harbi, NO; Amr, Ael-G; Bahashwan, SA; Fayed, AA; Ramadan, MA | 1 |
| Bilcer, G; Brindisi, M; Devasamudram, T; Ghosh, AK; Huang, X; Koelsch, G; Lei, H; Mesecar, AD; Tang, J; Xu, X; Yen, YC | 1 |
| Badawy, MA; Metwally, NH; Okpy, DS | 1 |
| Duan, LM; Jia, CJ; Li, YL; Yu, HY | 1 |
| Abdelall, EK; Kamel, GM | 1 |
| Altalbawy, FM; Edrees, MM; Gomha, SM | 1 |
| Byrappa, K; Kudva, AK; Kumar, MS; Nagananda, GS; Narayana, B; Salian, VV; Sarojini, BK | 1 |
| Choi, YJ; Hong, JR; Keum, G; Nam, G | 1 |
| Akbari, F; Didehban, K; Farhang, M | 1 |
| Che, FS; Fujita, M; Hayashi, H; Kusajima, M; Maruyama-Nakashita, A; Mori, T; Nakashita, H; Tsukamoto, K; Ushiwatari, T; Yamakawa, H | 1 |
| Cherukupalli, S; Du, X; Jia, H; Liu, X; Yu, J; Zhan, P | 1 |
| Grant, G; Patel, B; Rudrawar, S; Zunk, M | 1 |
| Abd-Allah, WH; Aboregela, AM; El-Behairy, MF; Lan, P; Marzouk, AA; Shaykoon, MSA; Taher, ES | 1 |
| Kassu, M; Kim, C; Kirby, JE; Manetsch, R; Smith, KP | 1 |
| Al-Aizari, FA; Almarhoon, ZM; Alsayari, A; Asiri, YI; Ghabbour, HA; Kheder, NA; Mabkhot, YN; Muhsinah, AB | 1 |
1 review(s) available for pyrazole and thiazoles
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
29 other study(ies) available for pyrazole and thiazoles
| Article | Year |
|---|---|
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase | 1981 |
Synthesis and antifungal activity of novel pyrano[2',3':4,5]thiazolo[2,3-b]quinazolines, pyrido[2',3':4,5]thiazolo[2,3-b]quinazolines and pyrazolo[2',3':4,5]thiazolo[2,3-b]quinazolines.
Topics: Antifungal Agents; Aspergillus flavus; Aspergillus ochraceus; Candida albicans; Microbial Sensitivity Tests; Molecular Structure; Penicillium chrysogenum; Pyrans; Pyrazoles; Pyridines; Quinazolines; Thiazoles | 2000 |
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Drug Design; Edema; Fungi; Granuloma; Humans; Male; Microbial Sensitivity Tests; Pyrazoles; Rats; Thiadiazoles; Thiazoles; Ulcer | 2008 |
Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives.
Topics: Animals; Anti-Obesity Agents; CHO Cells; Cricetinae; Cricetulus; Humans; Imidazoles; Isomerism; Models, Chemical; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Solubility; Structure-Activity Relationship; Thiazoles; Triazoles; Water | 2008 |
Synthesis of a novel tricyclic peptidomimetic scaffold.
Topics: Molecular Conformation; Peptides, Cyclic; Pyrazoles; Pyridones; Thiazoles | 2008 |
Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Neoplasms; Pyrazoles; Thiazoles | 2009 |
Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; HeLa Cells; Humans; Microbial Sensitivity Tests; Pyrazoles; Structure-Activity Relationship; Thiazoles; Vero Cells; Viruses | 2009 |
Design and synthesis of novel antimicrobial acyclic and heterocyclic dyes and their precursors for dyeing and/or textile finishing based on 2-N-acylamino-4,5,6,7-tetrahydro-benzo[b]thiophene systems.
Topics: Acetamides; Ampicillin; Anti-Bacterial Agents; Antifungal Agents; Bacillus cereus; Bacillus subtilis; Candida albicans; Coloring Agents; Drug Design; Escherichia coli; Heterocyclic Compounds, 2-Ring; Materials Testing; Microbial Sensitivity Tests; Nitriles; Prodrugs; Pyrazoles; Pyrimidines; Textile Industry; Textiles; Thiazoles; Thiophenes | 2011 |
Novel thiazolo-pyrazolyl derivatives as xanthine oxidase inhibitors and free radical scavengers.
Topics: Allopurinol; Animals; Catalytic Domain; Drug Design; Enzyme Inhibitors; Free Radical Scavengers; Gout; Inhibitory Concentration 50; Models, Molecular; Pyrazoles; Rats; Thiazoles; Xanthine Oxidase | 2012 |
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Catalytic Domain; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Pyrazoles; Quinazolines; Structure-Activity Relationship; Thiazoles | 2012 |
Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors.
Topics: Animals; Binding Sites; Catalytic Domain; Cell Line; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Mice; Molecular Docking Simulation; Pyrazoles; Thiazoles | 2012 |
Synthesis of some new pyrazole-based 1,3-thiazoles and 1,3,4-thiadiazoles as anticancer agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Structure; Pyrazoles; Structure-Activity Relationship; Thiadiazoles; Thiazoles | 2013 |
SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists.
Topics: Humans; Protein Binding; Pyrazoles; Receptors, Prostaglandin E, EP1 Subtype; Structure-Activity Relationship; Thiazoles | 2013 |
Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo[2,1-b]thiazole derivatives bearing pyrazole moieties.
Topics: Antineoplastic Agents; Cell Line, Tumor; Computer Simulation; Drug Design; Drug Screening Assays, Antitumor; Humans; Imidazoles; Neoplasms; Pyrazoles; Thiazoles | 2014 |
Androgen receptor antagonists and anti-prostate cancer activities of some newly synthesized substituted fused pyrazolo-, triazolo- and thiazolo-pyrimidine derivatives.
Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; CHO Cells; Cricetulus; Humans; Lethal Dose 50; Male; Prostatic Neoplasms; Pyrazoles; Pyrimidines; Thiazoles; Triazoles | 2014 |
Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand.
Topics: Amyloid Precursor Protein Secretases; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Drug Design; Kinetics; Ligands; Molecular Dynamics Simulation; Protease Inhibitors; Protein Binding; Pyrazoles; Structure-Activity Relationship; Thiazoles | 2015 |
Synthesis and anticancer activity of some new thiopyrano[2,3-d]thiazoles incorporating pyrazole moiety.
Topics: Acetic Acid; Antineoplastic Agents; Binding Sites; Cell Survival; Crystallography, X-Ray; Cycloaddition Reaction; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Conformation; Molecular Docking Simulation; Polyethylene Glycols; Protein Structure, Tertiary; Pyrans; Pyrazoles; Temperature; Thiazoles; Tubulin | 2015 |
Design and discovery of 2-(4-(1H-tetrazol-5-yl)-1H-pyrazol-1-yl)-4-(4-phenyl)thiazole derivatives as cardiotonic agents via inhibition of PDE3.
Topics: Animals; Binding Sites; Cardiotonic Agents; Catalytic Domain; Cyclic Nucleotide Phosphodiesterases, Type 3; Drug Design; Drug Evaluation, Preclinical; Humans; Male; Molecular Docking Simulation; Phosphodiesterase 3 Inhibitors; Protein Binding; Pyrazoles; Rats; Rats, Wistar; Thiazoles; Toxicity Tests | 2015 |
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 15-Lipoxygenase; Cattle; Celecoxib; Chemistry Techniques, Synthetic; Cyclization; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Male; Pyrazoles; Rats; Stereoisomerism; Thiazoles; Ulcer | 2016 |
Synthesis and Characterization of Some New Bis-Pyrazolyl-Thiazoles Incorporating the Thiophene Moiety as Potent Anti-Tumor Agents.
Topics: Antineoplastic Agents; Carbon-13 Magnetic Resonance Spectroscopy; Cell Survival; Chemistry, Pharmaceutical; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Proton Magnetic Resonance Spectroscopy; Pyrazoles; Structure-Activity Relationship; Thiazoles; Thiophenes | 2016 |
Spectroscopic, single crystal X-ray, Hirshfeld, in vitro and in silico biological evaluation of a new series of potent thiazole nucleus integrated with pyrazoline scaffolds.
Topics: Anti-Infective Agents; Antifungal Agents; Antioxidants; Bacteria; Biphenyl Compounds; Computer Simulation; Crystallography, X-Ray; Fungi; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Conformation; Molecular Docking Simulation; Picrates; Pyrazoles; Spectroscopy, Fourier Transform Infrared; Static Electricity; Thiazoles | 2017 |
Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Diabetic Neuropathies; Disease Models, Animal; Half-Life; Humans; Inhibitory Concentration 50; Male; Microsomes, Liver; Neuralgia; Pyrazoles; Rats; Structure-Activity Relationship; Thiazoles | 2017 |
Solubility of solid intermediate of pharmaceutical compounds in pure organic solvents using semi-empirical models.
Topics: Aldehydes; Models, Chemical; Nitroimidazoles; Phenylenediamines; Pyrazoles; Solubility; Solvents; Thermodynamics; Thiazoles | 2020 |
Characterization of plant immunity-activating mechanism by a pyrazole derivative.
Topics: Arabidopsis; Arabidopsis Proteins; Ascomycota; Disease Resistance; Intramolecular Transferases; Oryza; Plant Diseases; Plants, Genetically Modified; Pseudomonas syringae; Pyrazoles; Salicylic Acid; Signal Transduction; Solanum lycopersicum; Thiazoles | 2020 |
Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors.
Topics: Antiviral Agents; Capsid Proteins; Dose-Response Relationship, Drug; Drug Design; Hepatitis B e Antigens; Hepatitis B virus; Microbial Sensitivity Tests; Molecular Structure; Pyrazines; Pyrazoles; Pyridines; Pyrimidines; Structure-Activity Relationship; Thiazoles; Virus Replication | 2020 |
Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity.
Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Design; HEK293 Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Pyrazoles; Structure-Activity Relationship; Thiazoles | 2021 |
Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Apoptosis; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Edema; Formaldehyde; Male; Models, Molecular; Molecular Structure; Pyrazoles; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship; Thiazoles | 2021 |
Pyrazole-Thiazole Core-Containing Analogs Exhibit Adjunctive Activity with Meropenem against Carbapenem-Resistant Enterobacteriaceae (CRE).
Topics: Anti-Bacterial Agents; Carbapenem-Resistant Enterobacteriaceae; Dose-Response Relationship, Drug; Meropenem; Microbial Sensitivity Tests; Molecular Structure; Pyrazoles; Structure-Activity Relationship; Thiazoles | 2021 |
Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-
Topics: Anti-Bacterial Agents; Antineoplastic Agents; HCT116 Cells; Hep G2 Cells; Humans; Pyrazoles; Thiazoles | 2021 |