pyrazole and phenobarbital

pyrazole has been researched along with phenobarbital in 27 studies

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (37.04)	18.7374
1990's	14 (51.85)	18.2507
2000's	3 (11.11)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Berthou, F; Cauvin, JM; Deitrich, RA; Lucas, D; Ménez, JF	1
Khan, S; O'Brien, PJ; Quan, Z	1
Hahnemann, B; Honkakoski, P; Juvonen, R; Lang, MA; Mäenpää, J; Pasanen, M; Pelkonen, O; Raunio, H; Salonpää, P	1
Cederbaum, AI; Clejan, LA	1
Cederbaum, AI; Winters, DK	2
Aida, K; Negishi, M	1
Burnett, AK; Craft, JA; Lambard, SE; Wolf, CR	1
Elovaara, E; Gelboin, HV; Hietanen, E; Nakajima, T; Park, SS; Vainio, H	1
Gelboin, HV; Honkakoski, P; Järvinen, P; Juvonen, R; Kojo, A; Lang, MA; Park, SS; Pelkonen, O; Raunio, H; Vähäkangas, K	1
Brunk, G; Gold, B	1
Farber, J; Gold, B; Rogan, E	1
Cederbaum, AI; Feierman, DE	1
Kawanishi, T; Ohno, Y; Omori, Y; Takahashi, A; Takanaka, A	1
Dietz, D; Kornbrust, D	1
Kasuya, Y; Kawanishi, T; Ohno, Y; Omori, Y; Takahashi, A; Takanaka, A	1
Abdel-Tawab, GA; El-Bassiouni, EA; El-Sebae, AH; El-Sewedy, SM; El-Zoghby, SM; Mostafa, MH; Ramadan, M	1
Ingelman-Sundberg, M; Jörnvall, H	1
Bartsch, H; Kirby, GM; Lang, MA; Pelkonen, P; Wild, CP	1
Kharasch, ED; Thummel, KE	1
Geneste, O; Lang, MA; Raffalli, F	1
Commandeur, JN; Ploemen, JH; van Bladeren, P; van Ommen, B; Vermeulen, NP; Wormhoudt, LW	1
Elovaara, E; Lautala, P; Luukkanen, L; Taskinen, J; Vainio, H	1
De Curtis, V; Fabrizi, L; Gemma, S; Gervasi, P; Testai, E; Vittozzi, L	1
Strobel, H; Vasquez, H	1
Amato, G; Chiappe, C; De Rubertis, A; Gervasi, PG; Piegari, G	1
Bergström, U; Brittebo, EB; Fernández, EL; Franzén, A; Lang, M; Piras, E; Raffalli-Mathieu, F	1

Other Studies

27 other study(ies) available for pyrazole and phenobarbital

Article	Year
Differences in hepatic microsomal cytochrome P-450 isoenzyme induction by pyrazole, chronic ethanol, 3-methylcholanthrene, and phenobarbital in high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats. Alcoholism, clinical and experimental research, 1992, Volume: 16, Issue:5 Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenotype; Pyrazoles; Rats; Rats, Inbred Strains; Selection, Genetic; Species Specificity	1992
Role of cytochrome P-450IIE1 in N-nitroso-N-methylaniline induced hepatocyte cytotoxicity. Chemico-biological interactions, 1992, Aug-28, Volume: 83, Issue:3 Topics: Alcohols; Animals; Aryl Hydrocarbon Hydroxylases; Cell Survival; Chloroform; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Steroid Hydroxylases	1992
Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression. The Biochemical journal, 1992, Aug-15, Volume: 286 ( Pt 1) Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Western; Cell Nucleus; Cobalt; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Isoenzymes; Kinetics; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; Oligodeoxyribonucleotides; Phenobarbital; Polymerase Chain Reaction; Pyrazoles; RNA, Messenger; Steroid Hydroxylases	1992
Role of cytochrome P450 in the oxidation of glycerol by reconstituted systems and microsomes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1992, Jan-06, Volume: 6, Issue:2 Topics: Animals; Antibodies; Antibodies, Monoclonal; Antioxidants; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Glycerol; Kinetics; Miconazole; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidants; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Phenobarbital; Pyrazoles; Rats	1992
The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats. Alcohol and alcoholism (Oxford, Oxfordshire), 1992, Volume: 27, Issue:1 Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Fomepizole; Immunoblotting; Methylcholanthrene; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains	1992
Posttranscriptional regulation of coumarin 7-hydroxylase induction by xenobiotics in mouse liver: mRNA stabilization by pyrazole. Biochemistry, 1991, Aug-13, Volume: 30, Issue:32 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Cell Nucleus; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Enzymologic; Kinetics; Liver; Male; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Phenobarbital; Pyrazoles; RNA, Messenger; Transcription, Genetic; Xenobiotics	1991
The role of specific cytochromes P450 in the formation of 7,12-dimethylbenz(a)anthracene-protein adducts in rat liver microsomes in vitro. Biochemical pharmacology, 1991, Sep-27, Volume: 42, Issue:8 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azo Compounds; Benzoflavones; Blotting, Western; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Isoenzymes; Metyrapone; Microsomes, Liver; Phenobarbital; Pyrazoles; Rats; Troleandomycin	1991
Oxidation of glycerol to formaldehyde by rat liver microsomes. Effects of cytochrome P-450 inducing agents. Biochemical pharmacology, 1990, Feb-15, Volume: 39, Issue:4 Topics: Acetone; Aldehyde Oxidoreductases; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Fomepizole; Formaldehyde; Glycerol; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NAD; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains	1990
Immunochemical characterization of cytochrome P-450 isozymes responsible for benzene oxidation in the rat liver. Carcinogenesis, 1989, Volume: 10, Issue:9 Topics: Animals; Benzene; Cytochrome P-450 Enzyme System; Ethanol; Fasting; Isoenzymes; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Reference Values	1989
Mouse hepatic cytochrome P-450 isozyme induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, pyrazole, and phenobarbital. Biochemical pharmacology, 1988, Nov-01, Volume: 37, Issue:21 Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cytochrome P-450 Enzyme System; Enzyme Induction; Glutamate-Cysteine Ligase; Isoenzymes; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Phenobarbital; Pyrazoles; Pyridines	1988
The effect of pyrazole, phenobarbital, ethanol and 3-methylcholanthrene pretreatment on the in vivo and in vitro genotoxicity of N-nitrosopyrrolidine. Carcinogenesis, 1988, Volume: 9, Issue:6 Topics: Animals; DNA Damage; Ethanol; Liver; Male; Methylcholanthrene; Mutagenicity Tests; Mutagens; Mutation; N-Nitrosopyrrolidine; Nitrosamines; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Salmonella typhimurium	1988
An investigation of the metabolism of N-nitroso-N-methylaniline by phenobarbital- and pyrazole-induced Sprague-Dawley rat liver and esophagus derived S-9. Chemico-biological interactions, 1987, Volume: 61, Issue:3 Topics: Animals; Biotransformation; Electrochemistry; Enzyme Induction; Esophagus; In Vitro Techniques; Liver; Male; Mutagenicity Tests; Mutagens; Nitrosamines; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Subcellular Fractions	1987
Increased sensitivity of the microsomal oxidation of ethanol to inhibition by pyrazole and 4-methylpyrazole after chronic ethanol treatment. Biochemical pharmacology, 1987, Oct-01, Volume: 36, Issue:19 Topics: Animals; Cytochrome P-450 Enzyme System; Ethanol; Fomepizole; Male; Methylcholanthrene; Microsomes; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains	1987
Different effects of chemicals on metabolism of N-nitrosamines in rat liver. IARC scientific publications, 1987, Issue:84 Topics: Animals; Dimethylnitrosamine; Ethanol; Liver; Methylcholanthrene; Nitrosamines; Phenobarbital; Pyrazoles; Rats	1987
Effects of pretreatment with pyrazole and inducers of mixed function oxidases on DNA repair elicited by dimethylnitrosamine in rat hepatocytes in vivo and in vitro. Chemico-biological interactions, 1985, Dec-17, Volume: 56, Issue:1 Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP2E1; DDT; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Enzyme Induction; Liver; Male; Methyl Methanesulfonate; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains	1985
Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats. Archives of toxicology, 1984, Volume: 56, Issue:1 Topics: Aminoacetonitrile; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzoflavones; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Imidazoles; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Monoamine Oxidase; Niacinamide; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Inbred Strains; Tranylcypromine	1984
Effect of some xenobiotics on kynurenine hydrolase and kynurenine aminotransferase of mouse liver. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 1983, Volume: 18, Issue:3 Topics: Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinogens; Chlorodiphenyl (54% Chlorine); Chlorpromazine; Female; Hydrolases; Liver; Lyases; Methylcholanthrene; Mice; Phenobarbital; Pyrazoles; Transaminases	1983
Induction of the ethanol-inducible form of rabbit liver microsomal cytochrome P-450 by inhibitors of alcohol dehydrogenase. Biochemical and biophysical research communications, 1984, Oct-30, Volume: 124, Issue:2 Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Amino Acid Sequence; Amino Acids; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Imidazoles; Immunodiffusion; Male; Microsomes, Liver; Phenobarbital; Pyrazoles; Rabbits	1984
Metabolism of nitrosamines and aflatoxin B1 by hamster liver CYP2A enzymes. Chemico-biological interactions, 1994, Volume: 93, Issue:1 Topics: Aflatoxin B1; Animals; Blotting, Western; Coumarins; Cricetinae; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Female; Kinetics; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Phenobarbital; Pyrazoles; Steroid Hydroxylases	1994
Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance? Anesthesia and analgesia, 1993, Volume: 76, Issue:5 Topics: Alfentanil; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Liver; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Pyrazoles; Rats; Rats, Sprague-Dawley	1993
Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization. The Biochemical journal, 1996, Feb-01, Volume: 313 ( Pt 3) Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Binding Sites; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; DNA, Complementary; Drug Stability; Liver; Male; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Molecular Sequence Data; Molecular Weight; Phenobarbital; Poly A; Pyrazoles; RNA-Binding Proteins; RNA, Messenger; Subcellular Fractions	1996
Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats. Chemico-biological interactions, 1996, Jan-05, Volume: 99, Issue:1-3 Topics: Acetaldehyde; Adenosine; Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethylene Dibromide; Hydrogen-Ion Concentration; Hypnotics and Sedatives; Isoenzymes; Kinetics; Male; Microsomes, Liver; Molecular Structure; NADP; Phenobarbital; Pyrazoles; Rats; Rats, Wistar; Temperature	1996
Characterization of 1-hydroxypyrene as a novel marker substrate of 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase(s). Pharmacology & toxicology, 1997, Volume: 80, Issue:3 Topics: Acetone; Animals; Carcinogens; Chromatography, High Pressure Liquid; Creosote; Enzyme Induction; Enzyme Inhibitors; Glucuronates; Glucuronosyltransferase; Magnetic Resonance Spectroscopy; Male; Methylcholanthrene; Methylenebis(chloroaniline); Microsomes, Liver; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Pyrazoles; Pyrenes; Rats; Rats, Wistar; Substrate Specificity	1997
The role of different cytochrome P450 isoforms in in vitro chloroform metabolism. Journal of biochemical toxicology, 1996, Volume: 11, Issue:6 Topics: Acetone; Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Biotransformation; Chloroform; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dexamethasone; Drug Synergism; Enzyme Induction; Isoenzymes; Male; Microsomes, Liver; Phenobarbital; Pyrazoles; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	1996
Role of cytochrome P450 in DNA damage produced by treatment of colon cells with 1,2-dimethylhydrazine. International journal of oncology, 2001, Volume: 18, Issue:3 Topics: 1,2-Dimethylhydrazine; Benz(a)Anthracenes; Carcinogens; Colon; Cytochrome P-450 Enzyme System; DNA; DNA Damage; Enzyme Activators; Glutathione; Guanine; Humans; Hypnotics and Sedatives; Methyltransferases; Phenobarbital; Pyrazoles	2001
Stereochemical aspects in the 4-vinylcyclohexene biotransformation with rat liver microsomes and purified cytochrome P450s: diepoxide formation and hydrolysis. Chemical research in toxicology, 2003, Volume: 16, Issue:1 Topics: Animals; Biotransformation; Chromatography, Gas; Cyclohexanes; Cyclohexenes; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Epoxy Compounds; Hydrolysis; Isoenzymes; Male; Microsomes, Liver; Molecular Conformation; Phenobarbital; Pyrazoles; Rats; Rats, Sprague-Dawley	2003
Cell-specific expression of CYP2A5 in the mouse respiratory tract: effects of olfactory toxicants. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2003, Volume: 51, Issue:11 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Environmental Pollutants; Enzyme Induction; Female; Immunohistochemistry; In Situ Hybridization; Male; Methimazole; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Nasolacrimal Duct; Nitriles; Olfactory Mucosa; Phenobarbital; Pyrazoles; Respiratory System; Salivary Glands	2003