pyrazole has been researched along with isoxazoles in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 11 (61.11) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Fotsch, C; St Jean, DJ | 1 |
| Horvath, JJ; Witmer, CM; Witz, G | 1 |
| Balsamo, A; Coletta, I; Guglielmotti, A; Landolfi, C; Mancini, F; Martinelli, A; Milanese, C; Minutolo, F; Nencetti, S; Orlandini, E; Pinza, M; Rapposelli, S; Rossello, A | 1 |
| Kobayashi, K; Mohamed Ahmed, MS; Mori, A | 1 |
| Boys, ML; Chen, BB; Duffin, T; Engleman, VW; Finn, MB; Freeman, SK; Hanneke, ML; Keene, JL; Khilevich, A; Klover, JA; Nickols, GA; Nickols, MA; Penning, TD; Rader, RK; Russell, MA; Settle, SL; Shannon, KE; Steininger, CN; Wang, Y; Westlin, MM; Westlin, WF | 1 |
| Hamersak, Z; Minidis, AB; Svensson, MA; Vallin, KS; Wensbo Posaric, D | 1 |
| Alami, M; Audisio, D; Brion, JD; Dubus, E; Ijjaali, I; Messaoudi, S; Petitet, F; Peyrat, JF | 1 |
| Giridhar, R; Hartmann, RW; Haupenthal, J; Sabale, PM; Yadav, MR; Zimmer, C | 1 |
| Kumar, RA; Rajendra Prasad, KJ; Yamuna, E; Zeller, M | 1 |
| Keerthi, VS; Mayadevi, M; Omkumar, RV; Rajasekharan, KN; Sherin, DR | 1 |
| Chelucci, G; Loriga, G; Pinna, G; Pinna, GA | 1 |
| Basu, G; Bhattacharyya, B; Chakrabarti, P; Chakraborti, G; Chakraborti, S; Das, A; Dhar, G; Dwivedi, V; Poddar, A; Surolia, A | 1 |
| Jain, N; Kamal, A; Kumar, GB; Polepalli, S; Reddy, VS; Shaik, AB; Vishnuvardhan, MV | 1 |
| Dang, TT; Ejaz, SA; Hung, TQ; Iqbal, J; Langer, P; Lecka, J; Ngo, TN; Sévigny, J | 1 |
| Bharath Kumar, G; Jain, N; Kamal, A; Khan, I; Rao, BB; Shaik, AB | 1 |
| Gan, X; Li, P; Yang, Z | 1 |
| Akinola, LS; Damaj, MI; Deba, F; Hamouda, AK; Munoz, K; Ramos, K; Vannoy, M | 1 |
| Bugarčić, Z; Davidović, G; Janković, N; Joksimović, N | 1 |
2 review(s) available for pyrazole and isoxazoles
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
2,4-Diketo esters: Crucial intermediates for drug discovery.
Topics: Acylation; Anti-Infective Agents; Antineoplastic Agents; Antiviral Agents; Chemistry, Pharmaceutical; Esters; Humans; Isoxazoles; Keto Acids; Models, Molecular; Molecular Structure; Pyrazoles; Pyrrolidinones; Structure-Activity Relationship | 2020 |
16 other study(ies) available for pyrazole and isoxazoles
| Article | Year |
|---|---|
Nephrotoxicity of the 1:1 acrolein-glutathione adduct in the rat.
Topics: Acrolein; Animals; Disulfiram; Glutathione; Isoxazoles; Kidney Diseases; Kidney Tubules, Proximal; Male; Probenecid; Pyrazoles; Rats; Rats, Sprague-Dawley | 1992 |
Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring.
Topics: Amines; Animals; Binding Sites; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cyclopentanes; Dinoprostone; Humans; Isoenzymes; Isoxazoles; Macrophages; Membrane Proteins; Mice; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Structure-Activity Relationship; Thiophenes; U937 Cells | 2003 |
One-pot construction of pyrazoles and isoxazoles with palladium-catalyzed four-component coupling.
Topics: Catalysis; Hydralazine; Isoxazoles; Molecular Structure; Palladium; Pyrazoles | 2005 |
Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists.
Topics: Animals; Cell Line; Humans; Integrin alphaVbeta3; Isoxazoles; Mice; Molecular Structure; Pyrazoles; Rats; Structure-Activity Relationship | 2006 |
Efficient chemoenzymatic dynamic kinetic resolution of 1-heteroaryl ethanols.
Topics: Biocatalysis; Enzymes, Immobilized; Ethanol; Fungal Proteins; Heterocyclic Compounds; Hydrogenation; Imidazoles; Isoxazoles; Kinetics; Lipase; Molecular Dynamics Simulation; Oxadiazoles; Pyrazoles; Ruthenium; Stereoisomerism | 2009 |
Assessing the chemical diversity of an hsp90 database.
Topics: Antineoplastic Agents; Binding Sites; Computational Biology; Databases, Protein; HSP90 Heat-Shock Proteins; Isoxazoles; Ligands; Molecular Structure; Principal Component Analysis; Purines; Pyrazoles; Structure-Activity Relationship | 2010 |
Synthesis of some novel androstanes as potential aromatase inhibitors.
Topics: Androstanes; Aromatase Inhibitors; Humans; Isoxazoles; Kinetics; Protein Binding; Pyrazoles; Structure-Activity Relationship | 2011 |
Synthesis, antimicrobial, antimycobacterial and structure-activity relationship of substituted pyrazolo-, isoxazolo-, pyrimido- and mercaptopyrimidocyclohepta[b]indoles.
Topics: Anti-Bacterial Agents; Hydrogen Bonding; Indoles; Isoxazoles; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Mycobacterium tuberculosis; Pyrazoles; Pyrimidines; Software; Structure-Activity Relationship | 2012 |
Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Curcumin; Isoxazoles; Microwaves; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Pyrazoles; Rats; Recombinant Proteins | 2012 |
Synthesis of tricyclic condensed rings incorporating the pyrazole or isoxazole moieties bonded to a 4-piperidinyl substituent.
Topics: Antipsychotic Agents; Hydrazines; Hydroxylamine; Isoxazoles; Molecular Structure; Piperidones; Pyrazoles | 2013 |
Stable and potent analogues derived from the modification of the dicarbonyl moiety of curcumin.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Proliferation; Curcumin; Flow Cytometry; Free Radical Scavengers; Humans; Isoxazoles; Ketones; Lung Neoplasms; Models, Chemical; Molecular Conformation; Molecular Structure; Pyrazoles; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured | 2013 |
Synthesis of (Z)-(arylamino)-pyrazolyl/isoxazolyl-2-propenones as tubulin targeting anticancer agents and apoptotic inducers.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Pyrazoles; Structure-Activity Relationship; Tubulin | 2015 |
Efficient one-pot synthesis of 5-perfluoroalkylpyrazoles by cyclization of hydrazone dianions.
Topics: Agrochemicals; Alkaline Phosphatase; Animals; Anions; Chemistry, Organic; Chlorocebus aethiops; COS Cells; Cyclization; Enzyme Inhibitors; Humans; Hydrazones; Isoxazoles; Pharmaceutical Preparations; Pyrazoles; Pyrophosphatases; Structure-Activity Relationship | 2015 |
Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cinnamates; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Isoxazoles; Molecular Structure; Polymerization; Pyrazoles; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2015 |
Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity.
Topics: Antiviral Agents; Chemistry Techniques, Synthetic; Drug Design; Hydrazones; Isoxazoles; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Pyrazoles; Structure-Activity Relationship; Tobacco Mosaic Virus | 2018 |
Examining the Effects of (α4)3(β2)2 Nicotinic Acetylcholine Receptor-Selective Positive Allosteric Modulator on Acute Thermal Nociception in Rats.
Topics: Allosteric Regulation; Animals; Hot Temperature; Hydrocarbons, Brominated; Isoxazoles; Male; Nicotinic Agonists; Nociception; Pain Threshold; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2020 |