pyrazole and imidazole

pyrazole has been researched along with imidazole in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19904 (12.90)18.7374
1990's4 (12.90)18.2507
2000's8 (25.81)29.6817
2010's13 (41.94)24.3611
2020's2 (6.45)2.80

Authors

AuthorsStudies
Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T1
Fotsch, C; St Jean, DJ1
Carr, EP; Keeling, PW; Tipton, KF1
Fiorio, R; Gervasi, PG; Longo, V; Puccini, P1
Coon, MJ; Crump, BL; Koop, DR; Nordblom, GD1
Kasuya, Y; Kawanishi, T; Ohno, Y; Omori, Y; Takahashi, A; Takanaka, A1
Ingelman-Sundberg, M; Jörnvall, H1
McKinley-McKee, JS; Winberg, JO1
Been, MD; Perrotta, AT; Shih, I1
El-Azhary, AA1
Kulys, J; Tetianec, L; Ziemys, A1
Burini, A; Fackler, JP; Galassi, R; Mohamed, AA; Papa, F1
Abe, T; Ado, M; Agarwal, A; Dos Santos, O; Francisco, G; Li, Z; Lin, YI; Mansour, TS; Petersen, PJ; Shlaes, DM; Tsuyoshi, T; Ushirogochi, H; Venkatesan, AM; Weiss, WJ; Yang, Y1
Banfi, E; Laurini, E; Mamolo, MG; Scialino, G; Vio, L; Zampieri, D1
Berghofer, P; Fookes, CJ; Gregoire, MC; Greguric, I; Katsifis, A; Liu, X; Loc'h, C; Mattner, F; Pham, TQ; Shepherd, R1
Dhanalakshmi, T; Palaniandavar, M; Suresh, E1
Hamersak, Z; Minidis, AB; Svensson, MA; Vallin, KS; Wensbo Posaric, D1
Keith, JM1
Bethell, R; Bonneau, P; Bös, M; Bousquet, Y; Cordingley, MG; Coulombe, R; Deroy, P; Fader, LD; Faucher, AM; Gagnon, A; Goudreau, N; Grand-Maître, C; Guse, I; Hucke, O; Kawai, SH; Lacoste, JE; Landry, S; Lemke, CT; Malenfant, E; Mason, S; Morin, S; O'Meara, J; Simoneau, B; Titolo, S; Yoakim, C1
Evans, NL; Roberts, GM; Stavros, VG; Ullrich, S; Williams, CA; Yu, H1
Amaral, VF; Bernardino, AM; Canto-Cavalheiro, MM; de Carvalho, FT; de Léo, RM; dos Santos, MS; Leon, LL; Oliveira, ML1
Campayo, L; Cano, C; Gómez-Contreras, F; Marín, C; Navarro, P; Olmo, F; Ramírez-Macías, I; Sánchez-Moreno, M; Sanz, AM; Yunta, MJ1
Castiglione, F; Chiappe, C; Famulari, A; Mele, A; Mendola, D; Raos, G; Sanzone, A1
Atwal, K; Blanar, M; Caringal, Y; Conder, ML; Finlay, HJ; Harper, T; Hsueh, MM; Jiang, J; Kover, A; Levesque, P; Lloyd, J; Wexler, R; Xing, D1
Jin, CH; Kim, DK; Krishnaiah, M; Park, HJ; Park, SJ; Sheen, YY; Sreenu, D; Subrahmanyam, VB1
Bratoeff, E; Cabeza, M; Cortés, F; Garrido, M; Heuze, Y; Moreno, I; Posada, A; Sánchez-Márquez, A; Soriano, J1
Abrigach, F; Asehraou, A; Doucet, H; Khoutoul, M; Rokni, Y; Takfaoui, A; Touzani, R1
Guo, C; Wang, H1
Frömmel, J; Končitíková, R; Kopečný, D; Šebela, M; Soural, M1
Ghebreyessus, K; Sallee, A1
Li, W; Liu, G; Tang, Y; Wang, Z; Xu, X; Zhang, X; Zhao, P1

Reviews

1 review(s) available for pyrazole and imidazole

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012

Other Studies

30 other study(ies) available for pyrazole and imidazole

ArticleYear
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:10

    Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase

1981
The effects of histamine H2 receptor antagonists on the activity of horse liver alcohol dehydrogenase.
    Biochemical Society transactions, 1991, Volume: 19, Issue:1

    Topics: Alcohol Dehydrogenase; Animals; Binding, Competitive; Cimetidine; Fomepizole; Histamine H2 Antagonists; Horses; Imidazoles; Kinetics; Liver; Pyrazoles

1991
Effects of acetone administration on drug-metabolizing enzymes in mice: presence of a high-affinity diethylnitrosamine de-ethylase.
    Toxicology letters, 1990, Volume: 54, Issue:2-3

    Topics: Acetone; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Imidazoles; Kinetics; Male; Mice; Microsomes, Liver; Oxazines; Oxidoreductases; Pyrazoles

1990
Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid.
    Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:12

    Topics: Acetone; Animals; Butanols; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Imidazoles; Isoenzymes; Isoniazid; Male; Microsomes, Liver; Pyrazoles; Rabbits; Trichloroethylene

1985
Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats.
    Archives of toxicology, 1984, Volume: 56, Issue:1

    Topics: Aminoacetonitrile; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzoflavones; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Imidazoles; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Monoamine Oxidase; Niacinamide; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Inbred Strains; Tranylcypromine

1984
Induction of the ethanol-inducible form of rabbit liver microsomal cytochrome P-450 by inhibitors of alcohol dehydrogenase.
    Biochemical and biophysical research communications, 1984, Oct-30, Volume: 124, Issue:2

    Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Amino Acid Sequence; Amino Acids; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Imidazoles; Immunodiffusion; Male; Microsomes, Liver; Phenobarbital; Pyrazoles; Rabbits

1984
Drosophila melanogaster alcohol dehydrogenase: mechanism of aldehyde oxidation and dismutation.
    The Biochemical journal, 1998, Feb-01, Volume: 329 ( Pt 3)

    Topics: Acetates; Alcohol Dehydrogenase; Aldehydes; Animals; Binding, Competitive; Drosophila melanogaster; Imidazoles; Kinetics; NAD; Oxidation-Reduction; Pyrazoles; Substrate Specificity; Triazines

1998
Imidazole rescue of a cytosine mutation in a self-cleaving ribozyme.
    Science (New York, N.Y.), 1999, Oct-01, Volume: 286, Issue:5437

    Topics: Binding Sites; Catalysis; Cytosine; Hepatitis Delta Virus; Hydrogen-Ion Concentration; Imidazoles; Magnesium Chloride; Manganese; Mutagenesis; Point Mutation; Protons; Pyrazoles; RNA, Catalytic; Temperature

1999
A coupled-cluster study of the structure and vibrational spectra of pyrazole and imidazole.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2003, Volume: 59, Issue:9

    Topics: Imidazoles; Pyrazoles; Spectrum Analysis

2003
Probing Aspergillus niger glucose oxidase with pentacyanoferrate(III) aza- and thia-complexes.
    Journal of inorganic biochemistry, 2006, Volume: 100, Issue:10

    Topics: Aspergillus niger; Benzimidazoles; Ferric Compounds; Glucose Oxidase; Histidine; Imidazoles; Models, Chemical; Models, Molecular; Oxidation-Reduction; Pyrazoles; Pyridines; Structure-Activity Relationship; Thiadiazoles; Triazoles

2006
Gold(I) and silver(I) mixed-metal trinuclear complexes: dimeric products from the reaction of gold(I) carbeniates or benzylimidazolates with silver(I) 3,5-diphenylpyrazolate.
    Inorganic chemistry, 2006, Sep-18, Volume: 45, Issue:19

    Topics: Crystallography, X-Ray; Dimerization; Gold; Gold Compounds; Hydrocarbons; Imidazoles; Methane; Models, Molecular; Molecular Structure; Pyrazoles; Silver; Silver Compounds

2006
5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases.
    Bioorganic & medicinal chemistry, 2008, Feb-15, Volume: 16, Issue:4

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Heterocyclic Compounds, 3-Ring; Imidazoles; Lactams; Microbial Sensitivity Tests; Pyrazoles; Structure-Activity Relationship

2008
Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives.
    Bioorganic & medicinal chemistry, 2008, Apr-15, Volume: 16, Issue:8

    Topics: Anti-Bacterial Agents; Antifungal Agents; Candida albicans; Hydrogen; Imidazoles; Magnetic Resonance Spectroscopy; Molecular Structure; Mycobacterium tuberculosis; Pyrazoles; Structure-Activity Relationship

2008
Synthesis and biological evaluation of substituted [18F]imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography.
    Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13

    Topics: Animals; Femur; Fluorine Radioisotopes; Imidazoles; Ligands; Molecular Structure; Olfactory Bulb; Organ Specificity; Positron-Emission Tomography; Pyrazoles; Pyridines; Pyrimidines; Rats; Receptors, GABA-A; Structure-Activity Relationship

2008
Synthesis, structure, spectra and reactivity of iron(III) complexes of imidazole and pyrazole containing ligands as functional models for catechol dioxygenases.
    Dalton transactions (Cambridge, England : 2003), 2009, Oct-21, Issue:39

    Topics: Catechol 1,2-Dioxygenase; Crystallography, X-Ray; Imidazoles; Iron; Kinetics; Ligands; Molecular Conformation; Pyrazoles

2009
Efficient chemoenzymatic dynamic kinetic resolution of 1-heteroaryl ethanols.
    The Journal of organic chemistry, 2009, Dec-18, Volume: 74, Issue:24

    Topics: Biocatalysis; Enzymes, Immobilized; Ethanol; Fungal Proteins; Heterocyclic Compounds; Hydrogenation; Imidazoles; Isoxazoles; Kinetics; Lipase; Molecular Dynamics Simulation; Oxadiazoles; Pyrazoles; Ruthenium; Stereoisomerism

2009
One-step conversion of azine N-oxides to alpha-1,2,4-triazolo-, 1,2,3-triazolo, imidazolo-, and pyrazoloheteroarenes.
    The Journal of organic chemistry, 2010, Apr-16, Volume: 75, Issue:8

    Topics: Cyclic N-Oxides; Imidazoles; Pyrazoles; Triazoles

2010
Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.
    Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

    Topics: Anti-HIV Agents; Benzodiazepinones; Capsid Proteins; Drug Evaluation, Preclinical; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Pyrazoles; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2011
Exploring ultrafast H-atom elimination versus photofragmentation pathways in pyrazole following 200 nm excitation.
    The journal of physical chemistry. A, 2012, Mar-22, Volume: 116, Issue:11

    Topics: Adenine; DNA; Histidine; Imidazoles; Kinetics; Photochemical Processes; Protons; Pyrazoles; Thermodynamics; Ultraviolet Rays

2012
Synthesis and antileishmanial evaluation of 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives.
    Bioorganic & medicinal chemistry letters, 2011, Dec-15, Volume: 21, Issue:24

    Topics: Animals; Antiprotozoal Agents; Imidazoles; Leishmania; Leishmaniasis; Mice; Pyrazoles; Structure-Activity Relationship

2011
In vitro leishmanicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against Leishmania infantum and Leishmania braziliensis species.
    The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:2

    Topics: Animals; Antiprotozoal Agents; Cell Survival; Female; Humans; Imidazoles; Leishmania braziliensis; Leishmania infantum; Macrophages; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Parasitic Sensitivity Tests; Phthalazines; Pyrazoles; Structure-Activity Relationship; Superoxide Dismutase

2012
Pyrazolium- versus imidazolium-based ionic liquids: structure, dynamics and physicochemical properties.
    The journal of physical chemistry. B, 2013, Jan-17, Volume: 117, Issue:2

    Topics: Anions; Cations; Electric Conductivity; Hydrogen Bonding; Imidazoles; Ionic Liquids; Magnetic Resonance Spectroscopy; Pyrazoles; Viscosity

2013
Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists.
    Bioorganic & medicinal chemistry letters, 2013, Mar-15, Volume: 23, Issue:6

    Topics: Animals; Cell Line; Imidazoles; Isomerism; Kv1.5 Potassium Channel; Mice; Potassium Channel Blockers; Potassium Channels; Protein Binding; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Triazoles

2013
4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole and -pyrazole derivatives as potent and selective inhibitors of transforming growth factor-β type I receptor kinase.
    Bioorganic & medicinal chemistry, 2014, May-01, Volume: 22, Issue:9

    Topics: Binding Sites; Catalytic Domain; Cell Line; Humans; Imidazoles; Molecular Docking Simulation; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Structure-Activity Relationship

2014
Biological activity of pyrazole and imidazole-dehydroepiandrosterone derivatives on the activity of 17β-hydroxysteroid dehydrogenase.
    Journal of enzyme inhibition and medicinal chemistry, 2016, Volume: 31, Issue:1

    Topics: 17-Hydroxysteroid Dehydrogenases; Animals; Cricetinae; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Imidazoles; Male; Middle Aged; Molecular Structure; Prostate; Pyrazoles; Structure-Activity Relationship

2016
In vitro screening, homology modeling and molecular docking studies of some pyrazole and imidazole derivatives.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 103

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Antifungal Agents; Crystallography, X-Ray; Escherichia coli; Fusarium; Humans; Imidazoles; Molecular Docking Simulation; Protein Structure, Secondary; Pyrazoles; Staphylococcus aureus; Structure-Activity Relationship

2018
Enantioselective γ-Addition of Pyrazole and Imidazole Heterocycles to Allenoates Catalyzed by Chiral Phosphine.
    Angewandte Chemie (International ed. in English), 2019, 02-25, Volume: 58, Issue:9

    Topics: Alkadienes; Catalysis; Cycloaddition Reaction; Heterocyclic Compounds; Imidazoles; Molecular Structure; Phosphines; Pyrazoles

2019
Oxidation of imidazole- and pyrazole-derived aldehydes by plant aldehyde dehydrogenases from the family 2 and 10.
    Chemico-biological interactions, 2019, May-01, Volume: 304

    Topics: Aldehyde Dehydrogenase; Aldehydes; Imidazoles; Molecular Structure; Oxidation-Reduction; Pisum sativum; Pyrazoles; Solanum lycopersicum; Zea mays

2019
Photoresponsive Zn
    Dalton transactions (Cambridge, England : 2003), 2020, Aug-14, Volume: 49, Issue:30

    Topics: Coordination Complexes; Hydrogels; Imidazoles; Molecular Structure; Phenylalanine; Photochemical Processes; Pyrazoles; Zinc

2020
In Silico Prediction of CYP2C8 Inhibition with Machine-Learning Methods.
    Chemical research in toxicology, 2021, 08-16, Volume: 34, Issue:8

    Topics: Computer Simulation; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Drug Discovery; Humans; Imidazoles; Machine Learning; Molecular Docking Simulation; Pyrazoles

2021