pyrazolanthrone has been researched along with u 0126 in 129 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 59 (45.74) | 29.6817 |
| 2010's | 63 (48.84) | 24.3611 |
| 2020's | 7 (5.43) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Akao, Y; Fujita, Y; Hamada, N; Ito, M; Itoh, T; Kiso, Y; Kitagawa, Y; Nozawa, Y; Ono, Y; Tanaka, A; Tomimori, N | 1 |
| Caballero, E; García-Cárceles, J; Gil, C; Martínez, A | 1 |
| Colburn, N; Fujii, M; Hou, DX; Kai, K; Li, JJ; Lin, S; Terahara, N; Wakamatsu, M; Young, MR | 1 |
| Coppens, A; Hooghe-Peters, E; Kooijman, R | 1 |
| Iovanna, JL; Lesavre, N; Malicet, C; Vasseur, S | 1 |
| Greene, SM; Headley, VV; Port, JD; Tanveer, R; Zweifach, A | 1 |
| Banerjee, S; Banerjee, SK; Saxena, NK; Sengupta, K | 1 |
| Kawashima, K; Nakajima, M; Negishi, Y; Tanaka, H | 1 |
| Ito, A; Miyata, Y; Sato, T; Yano, M | 1 |
| Matlis, S; Mooney, DJ; Nikolovski, J; Simmons, CA; Thornton, AJ | 1 |
| Chalothorn, D; Faber, JE; Jackson, LF; Lee, DC; Zhang, H | 1 |
| Dai, Y; Fukuoka, T; Katsura, H; Kobayashi, K; Mizushima, T; Noguchi, K; Obata, K; Tokunaga, A; Yamanaka, H | 1 |
| Barger, SW; Bodles, AM | 1 |
| Lee, YJ; Shukla, SD | 1 |
| Jung, YS; Kim, E; Lee, DH; Lim, H; Yi, KY; Yoo, SE | 1 |
| Fukuda, Y; Goto, M; Hayashi, Y; Oikawa, S; Terakawa, M; Tomimori, Y | 1 |
| Allshire, A; Anoopkumar-Dukie, S; Carey, JB; Conere, T | 1 |
| Lim, RW; Park, PH; Shukla, SD | 1 |
| Laham, R; Li, J; Luo, J; Rana, JS; Sellke, FW; Wu, G | 1 |
| Batty, S; Chow, EM; Der, SD; Kassam, A; Mogridge, J | 1 |
| Chang, SH; Chen, LM; Hsu, HH; Huang, CY; Hwang, JM; Kuo, WW; Lee, SD; Lin, JA; Lu, MC; Wang, CK; Wu, CC | 1 |
| Hiura, T; Ishikawa, M; Kanno, S; Kimura, K; Ohtake, T; Osanai, Y; Takeshita, M; Tomizawa, A; Ujibe, M; Uwai, K | 1 |
| Benvenisti-Zarom, L; Chen-Roetling, J; Regan, RF | 1 |
| Chayama, K; Kuwahara, K; Miyata, H; Sasaki, T; Serikawa, M | 1 |
| Hirasawa, N; Murakami, A; Ohgawara, R; Ohuchi, K; Torigoe, M | 1 |
| Cho, HS; Choi, MS; Hong, JT; Jung, HY; Jung, JK; Kim, Y; Lee, BC; Lee, SH; Pyo, HB; Yun, YP | 1 |
| Clough, RL; Stefanis, L | 1 |
| Montesano, R | 1 |
| Fuhrmann, R; Gandesiri, M; Kinne, RW; Kunisch, E; Roth, A; Winter, R | 1 |
| Chen, YP; Luo, Y; Rui, HL | 1 |
| Han, J; Jeong, YI; Jung, ID; Lee, CM; Lee, JS; Park, WS; Park, YM | 1 |
| Booth, JL; Chakrabarty, K; Coggeshall, KM; Duggan, ES; Metcalf, JP; Nagle, NN; Wu, W | 1 |
| Hatter, A; Liu, B; Zhang, P | 1 |
| De, A; Farassati, F; Frizelle, SP; Jacobson, BA; Janne, P; Kratzke, RA; Patel, MR; Thumma, SC; Whitson, BA | 1 |
| Alexis, NE; Bromberg, PA; Chen, X; Peden, DB; Wu, W | 1 |
| Fujita-Yoshigaki, J; Matsuki-Fukushima, M; Sugiya, H | 1 |
| Farivar, AS; McCourtie, AS; Merry, HE; Mulligan, MS; Wolf, PS | 1 |
| Fu, SM; Guan, SM; Liu, B; Shu, L; Wu, JZ; Xu, XL | 1 |
| Colvin, HP; Gerner, P; Haller, I; Klimaschewski, L; Lang, L; Lirk, P; Tomaselli, B | 1 |
| Ogata, T | 1 |
| Ding, Z; Masamune, A; Maubach, G; Zhuo, L | 1 |
| Bachleda, P; Dvorák, Z | 1 |
| Bao, Q; Cao, JL; Guan, XH; Ling, DY; Ruan, JP; Song, XJ; Yuan, Y; Zeng, YM; Zhang, LC | 1 |
| Barbeito, L; Casanova, G; Cassina, P; Fernandez, A; Latini, A; Olivera, S; Rosillo, JC; Wajner, M | 1 |
| Katayama, T; Minami, M; Tanaka, H; Uehara, T; Yoshida, T | 1 |
| Diffley, JM; Hammad, SM; Lyons, TJ; Sohn, M; Song, W; Wu, M | 1 |
| Figulla, HR; Foerster, M; Fritzenwanger, M; Jung, C; Meusel, K | 1 |
| Graham, CH; Renaud, SJ; Sullivan, R | 1 |
| Croons, V; De Meyer, GR; Herman, AG; Martinet, W; Timmermans, JP | 1 |
| Aarnes, H; Fonnum, F; Mariussen, E; Myhre, O; Reistad, T; Voie, OA | 1 |
| Inageda, K; Karube, H; Kurosu, H; Matsuoka, M; Nishitai, G | 1 |
| Klettner, A; Roider, J | 1 |
| Carrozzino, F; Féraille, E; Montesano, R; Pugnale, P | 1 |
| Asano, S; Itoh, M; Nishiwaki-Yasuda, K; Sekiguchi, S; Shibata, M; Suzuki, A | 1 |
| Kawanishi, M; Koizumi, K; Nishimura, M; Saiki, I; Sakurai, H; Shin, MS; Singhirunnusorn, P; Suzuki, S | 1 |
| Bulgheresi, S; Emami, C; Mittal, R; Prasadarao, NV | 1 |
| Chen, LM; Chen, YS; Fang, WK; Huang, CY; Ko, FY; Kuo, CH; Kuo, WW; Tsai, CH; Tsai, FJ; Wang, HL | 1 |
| Cho, KH; Chung, JH; Kim, S; Lee, J; Lee, Y; Oh, JH | 1 |
| Bala, M; Buechler, C; Kopp, A; Neumeier, M; Schäffler, A; Schölmerich, J | 1 |
| Herdegen, T; Klettner, A; Koinzer, S; Roider, J; Waetzig, V | 1 |
| Chan, DW; Chiu, P; Liu, VW; Ngan, HY; Wang, Y | 1 |
| Huang, J; Siragy, HM | 1 |
| Chen, DB; Feng, L; Liao, WX; Zheng, J | 1 |
| Do, EK; Kim, JH; Kim, KH; Kim, MY; Shin, SH; Song, HY | 1 |
| Battini, L; Flores, D; Gusella, GL; Rohatgi, R | 1 |
| Kline, K; Sanders, BG; Tiwary, R; Yu, W | 1 |
| Chen, H; Jin, WY; Ren, JY | 1 |
| Aarstad, HJ; Olofsson, J; Olsnes, C | 1 |
| Andersen, DC; Christensen, GL; Eskildsen, T; Gammeltoft, S; Hansen, JL; Jensen, HB; Jeppesen, PL; Nossent, AY; Schneider, M; Sheikh, SP | 1 |
| Aggarwal, S; Rao, RK; Samak, G | 1 |
| Alegret, M; Laguna, JC; Merlos, M; Piera, L; Pou, J; Rebollo, A; Roglans, N | 1 |
| Huang, JL; Jiang, CL; Ma, Q; Shen, XH; Wang, CC; Wang, X; Zhang, YL; Zhou, JR | 1 |
| Armstead, WM; Cines, DB; Higazi, AA; Kiessling, JW; Riley, J | 1 |
| Du Pasquier, D; Dupré, A; Jessus, C | 1 |
| He, SZ; Jian, CX; Li, CJ; Liu, XC; Liu, XF | 1 |
| Barker, G; Lappas, M; Lim, R; Menon, R; Permezel, M; Rice, GE; Riley, C | 1 |
| Bae, SY; Cho, DH; Choe, JH; Choi, MY; Han, J; Kim, JH; Kim, JS; Kim, S; Koo, M; Lee, JE; Lee, SK; Nam, SJ; Yang, JH | 1 |
| Kim, CE; Kim, MH; Kim, SW | 1 |
| Aso, H; Hasegawa, Y; Imaizumi, K; Ito, S; Kondo, M; Mori, A; Morioka, M; Suganuma, N | 1 |
| He, W; Qu, T; Smith, AJ; Wang, H; Wang, Z; Yu, Q; Zhang, J | 1 |
| Fan, HQ; Li, Y; Wang, JG; Zou, J | 1 |
| Dai, QY; Gao, FH; Li, ZZ; Wu, HX; Xu, MD; Yao, HL; Zhang, Z | 1 |
| Arruebo, MP; Gonzalo, S; Grasa, L; Hernández, LV; Murillo, MD; Plaza, MÁ | 1 |
| Chotjumlong, P; Chruewkamlow, N; Kasinrerk, W; Krisanaprakornkit, S; Pata, S; Reutrakul, V | 1 |
| Ahmad, R; Chaudry, A; El Mabrouk, M; Sylvester, J; Zafarullah, M | 1 |
| Hintze, TH; Huang, A; Kaley, G; Sun, D; Yan, C; Yang, YM | 1 |
| Im, SY; Kim, HA; Kim, KJ; Lee, HK; Seo, KH | 1 |
| Kim, M; Noh, M; Shin, DW; Shin, H; Shin, JH | 1 |
| Hwangbo, C; Kim, N; Lee, JH; Lee, S | 1 |
| Chung, SW; Hwang, N; Kang, YH; Kwon, MY; Shin, DY; Woo, JM | 1 |
| Sakamoto, N; Sato, M; Song, G; Yuan, L | 1 |
| Chenyang, J; Jiajing, W; Jianchun, B; Jianhong, G; Xuezhong, L; Yan, Y; Yiran, Z; Zongping, L | 1 |
| Choi, NK; Hwang, YC; Jung, JY; Kim, SH; Kim, SM; Kim, WJ; Lim, HS; Woo, SM | 1 |
| Huang, HY; Lai, CH; Lee, CL; Leung, PC; Soong, YK; Wang, HS; Wu, HM | 1 |
| Atomi, K; Hayashi, H; Ikari, A; Sakai, H; Sugatani, J; Yamaguchi, M; Yamazaki, Y | 1 |
| Alain, LA; Huang, W; Luo, G; Wu, X | 1 |
| Chen, J; Guo, R; Huang, R; Li, S; Tian, L; Wu, K; Yan, H; You, Q | 1 |
| Chang, HH; Huang, YM; Juan, CC; Kao, CC; Kao, YH; Kuo, YC; Liu, CW; Tang, YC | 1 |
| Chen, YC; Chen, YH; Lin, HY; Shen, SC; Wu, MS; Yang, LY | 1 |
| Baek, MW; Chung, HJ; Jeong, YJ; Jung, JY; Kim, GM; Kim, SH; Kim, WJ; Park, HJ; Seong, KJ | 1 |
| He, WX; Kim, S; Kohli, MR; Luo, Z; Qu, T; Yu, Q | 1 |
| Ding, D; Jiang, C; Jin, C; Meng, X; Wang, C; You, X | 1 |
| Cooper, PR; Fu, L; He, W; Li, D; Luo, Z; Ma, F; Wang, Z; Yu, Q; Zhang, Y; Zhou, Z | 1 |
| Blank, V; Garcia-Santos, D; Gasiorek, JJ; Hui, ST; Mikhael, M; Ponka, P | 1 |
| Anisuzzaman, AS; Hayashi, H; Islam, MT; Khan, MR; Suzuki, Y; Taniguchi, T; Uwada, J; Yazawa, T | 1 |
| Bauer, D; Darling-Reed, S; Day, A; Flores-Rozas, H; Mazzio, E; Redmon, N; Reuben, JS; Sadrud-Din, S; Soliman, KF; Taka, E | 1 |
| Fukami, K; Kudo, K; Nakamura, Y; Sawada, M; Uchida, T; Yoneda, A | 1 |
| Ashley, AK; Hanneman, WH; Hinds, AI; Legare, ME; Tjalkens, RB | 1 |
| Chen, L; Dong, X; Huang, S; Liu, C; Liu, L; Wang, X; Xu, C; Zhang, H; Zhu, Y | 1 |
| Chen, WC; Li, L; Li, YH; Lu, ZY; Pang, Y; Xiao, HW; Xiao, Y; Xiao, ZF; Zhang, H | 1 |
| Choi, HJ; Choi, JY; Chung, TW; Ha, KT; Jung, YS; Kim, EY; Kim, HS; Lee, SO | 1 |
| Du, D; Li, Y; Liu, Y; Yin, Y; Zong, J | 1 |
| Arumugam, TV; Baik, SH; Chen, CL; Cheng, YL; Chunduri, P; Dheen, ST; Drummond, GR; Fann, DY; Jo, DG; Lim, YA; Lok, KZ; Sobey, CG | 1 |
| Liu, L; Wang, Y; Zhang, H; Zhang, N; Zhao, Z; Zhou, Y | 1 |
| Bae, H; Bazer, FW; Lim, W; Song, G | 1 |
| Hamilton, BJ; Stan, RV; Tse, D | 1 |
| Dai, L; Jin, L; Li, S; Li, T; Qian, Y; Zhou, J; Zhu, C | 1 |
| Fan, Z; Li, P; Mei, C; Wang, X; Zhang, M; Zhao, C | 1 |
| Bui, HTT; Kang, D; Kim, SE; Le, NH; Le, QA; Lee, S | 1 |
| Budach, W; Hüsemann, LC; Jänicke, RU; Piekorz, RP; Radine, C; Reese, A; Sohn, D | 1 |
| Chen, M; Cheng, X; Liu, Z | 1 |
| Li, H; Li, M; Liao, X; Wang, F; Yang, S; Zhao, C | 1 |
| Cai, WJ; Lan, CN; Shi, J; Yi, ZJ | 1 |
| Hayashi, Y; Hong, G; Izumi, S; Kudo, TA; Luo, YR; Matsuzawa, A; Nakai, J; Noguchi, T; Tanaka, T; Tominami, K; Wang, H | 1 |
| Fan, X; Gan, C; Qi, S; Qi, Z; Zhang, Y; Zhou, H | 1 |
1 review(s) available for pyrazolanthrone and u 0126
| Article | Year |
|---|---|
Kinase Inhibitors as Underexplored Antiviral Agents.
Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses | 2022 |
128 other study(ies) available for pyrazolanthrone and u 0126
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.
Topics: Animals; Apoptosis; Dioxoles; Heme Oxygenase-1; Hydrogen Peroxide; Lignans; NF-E2-Related Factor 2; PC12 Cells; Rats; Seedlings; Sesamum | 2011 |
Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms.
Topics: Animals; Anthocyanins; Anthracenes; Anticarcinogenic Agents; Butadienes; Cell Transformation, Neoplastic; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Structure-Activity Relationship; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2004 |
IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase.
Topics: Androstadienes; Anthracenes; Apoptosis; Butadienes; Cell Survival; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Hydrogen Peroxide; Imidazoles; Insulin-Like Growth Factor I; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor, IGF Type 1; RNA, Messenger; Wortmannin | 2003 |
p8 inhibits the growth of human pancreatic cancer cells and its expression is induced through pathways involved in growth inhibition and repressed by factors promoting cell growth.
Topics: Anthracenes; Basic Helix-Loop-Helix Transcription Factors; Butadienes; Cell Line, Tumor; Cell Proliferation; Culture Media; Culture Media, Serum-Free; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Vectors; Growth Inhibitors; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Nitriles; Pancreatic Neoplasms; Proto-Oncogene Proteins c-raf; Pyridines; ras Proteins; Retroviridae; RNA, Antisense; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Reciprocal regulation of beta-adrenergic receptor mRNA stability by mitogen activated protein kinase activation and inhibition.
Topics: 3' Untranslated Regions; Animals; Anisomycin; Anthracenes; Butadienes; Cell Line; Cricetinae; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heterogeneous-Nuclear Ribonucleoproteins; Imidazoles; Mitogen-Activated Protein Kinase Kinases; Nitriles; Nucleic Acid Synthesis Inhibitors; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Adrenergic, beta; RNA Stability; Signal Transduction | 2004 |
Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol.
Topics: Androstadienes; Anthracenes; Antibodies; Butadienes; Cell Division; Cell Movement; Cells, Cultured; Down-Regulation; Endothelial Cells; Estradiol; Estrogen Antagonists; Fulvestrant; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Receptors, Estrogen; RNA, Messenger; Thrombospondin 1; Time Factors; Wortmannin | 2004 |
p21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells.
Topics: Animals; Anthracenes; Butadienes; Cell Differentiation; Cell Line; Chondrocytes; Chondrogenesis; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Imidazoles; Insulin; Mice; Mitogen-Activated Protein Kinases; Nitriles; Pyridines; Signal Transduction | 2004 |
Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobi
Topics: Anthracenes; Antineoplastic Agents; Butadienes; Cell Line, Tumor; Collagenases; Enzyme Activation; Enzyme Precursors; Flavones; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; raf Kinases; ras Proteins; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1 | 2004 |
Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells.
Topics: Alkaline Phosphatase; Animals; Anthracenes; Butadienes; Calcification, Physiologic; Cattle; Cell Differentiation; Cell Line; Cell Proliferation; DNA; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nitriles; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Stress, Mechanical | 2004 |
Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anthracenes; Aorta, Thoracic; Bacterial Proteins; Benzopyrans; Butadienes; Catheterization; Cell Division; Dipeptides; ErbB Receptors; Flavonoids; Glycine; Hydroxamic Acids; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Organ Culture Techniques; Phenylephrine; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Thrombin; Tyrphostins | 2004 |
Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.
Topics: Animals; Anthracenes; Brain-Derived Neurotrophic Factor; Butadienes; Enzyme Activation; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Imidazoles; Ion Channels; JNK Mitogen-Activated Protein Kinases; Ligation; Lumbar Vertebrae; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons, Afferent; Nitriles; p38 Mitogen-Activated Protein Kinases; Physical Stimulation; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Rhizotomy; Spinal Nerves; Stress, Mechanical; TRPV Cation Channels | 2004 |
Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK.
Topics: Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Anthracenes; Blotting, Western; Butadienes; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; Microglia; Nitriles; Nitrites; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Time Factors | 2005 |
Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes.
Topics: Acetaldehyde; Acetylcysteine; Animals; Anthracenes; Apoptosis; Blotting, Western; Butadienes; Buthionine Sulfoximine; Caspase 3; Caspases; Cell Nucleus; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Ethanol; Genistein; Hepatocytes; Hydrogen Peroxide; Indoles; JNK Mitogen-Activated Protein Kinases; Male; Maleates; Maleimides; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors | 2005 |
KR-31378 protects cardiac H9c2 cells from chemical hypoxia-induced cell death via inhibition of JNK/p38 MAPK activation.
Topics: Animals; Anthracenes; Butadienes; Cell Death; Cell Hypoxia; Cell Line; Enzyme Activation; Guanidines; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Molecular Structure; Myocardium; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyrans; Pyridines; Reactive Oxygen Species | 2004 |
Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway.
Topics: Animals; Anthracenes; Blotting, Western; Butadienes; Butyric Acid; Cell Line, Tumor; Cell Movement; Chemotaxis; Chymases; Enzyme Inhibitors; Eosinophils; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mast Cells; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Pyridines; Receptors, G-Protein-Coupled; Serine Endopeptidases; Signal Transduction; Time Factors | 2005 |
Radical mediators and mitogen-activated protein kinase signaling in oxygen-dependent radiosensitivity of human tumor cell lines.
Topics: Acetylcysteine; Anthracenes; Antioxidants; Apoptosis; Ascorbic Acid; Butadienes; Cell Line, Tumor; Cell Proliferation; DNA Damage; Enzyme Inhibitors; Fluoresceins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Melatonin; Mitochondria; Nitriles; Nitrites; Oxazines; Oxygen; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Radiation Tolerance; Rhodamines; Spectrometry, Fluorescence; Xanthenes | 2005 |
Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: potential mechanism for gene expression.
Topics: Acetylation; Alcohol Dehydrogenase; Animals; Anthracenes; Butadienes; Ethanol; Gene Expression Regulation, Enzymologic; Hepatocytes; Histone Acetyltransferases; Histones; Imidazoles; Male; MAP Kinase Signaling System; Nitriles; Pyridines; Rats; Rats, Sprague-Dawley | 2005 |
Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells.
Topics: Anthracenes; Butadienes; Cells, Cultured; Cyclooxygenase 2; Endothelial Cells; Endothelium, Vascular; Gene Deletion; Humans; Imidazoles; MAP Kinase Kinase 4; Membrane Proteins; Neovascularization, Physiologic; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Small Interfering; Signal Transduction; Sulfonamides; Vascular Endothelial Growth Factor A | 2006 |
Inhibition of mitogen-activated protein kinase signalling by Bacillus anthracis lethal toxin causes destabilization of interleukin-8 mRNA.
Topics: 3' Untranslated Regions; Anthracenes; Antigens, Bacterial; Bacillus anthracis; Bacterial Toxins; Butadienes; Cells, Cultured; Endothelial Cells; Humans; Imidazoles; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Nitriles; Promoter Regions, Genetic; Pyridines; RNA Stability; RNA, Messenger; Signal Transduction | 2006 |
Porphyromonas gingivalis-related cardiac cell apoptosis was majorly co-activated by p38 and extracellular signal-regulated kinase pathways.
Topics: Animals; Anthracenes; Apoptosis; Butadienes; Calcineurin Inhibitors; Caspases; Cell Nucleus; Chromones; Cyclosporine; DNA Fragmentation; Enzyme Inhibitors; Fluorescent Dyes; Imidazoles; Indoles; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Myocardium; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas gingivalis; Pyridines; Rats | 2006 |
Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells.
Topics: Anthracenes; Apoptosis; Benzamidines; Butadienes; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; JNK Mitogen-Activated Protein Kinases; Leukemia, B-Cell; Nitriles; Oligopeptides; Ribonucleotide Reductases; Signal Transduction; Time Factors | 2006 |
Inhibition of the ERK/MAP kinase pathway attenuates heme oxygenase-1 expression and heme-mediated neuronal injury.
Topics: Animals; Anthracenes; Astrocytes; Butadienes; Cell Death; Cells, Cultured; Coculture Techniques; Culture Media, Serum-Free; Embryo, Mammalian; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Imidazoles; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Mice; Mitogen-Activated Protein Kinases; Neurons; Nitriles; Pyrimidines; Signal Transduction | 2006 |
The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines.
Topics: Anthracenes; Bile Duct Neoplasms; Butadienes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Clone Cells; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Quinazolines; Radiation-Sensitizing Agents | 2006 |
Involvement of MAP kinases in lipopolysaccharide-induced histamine production in RAW 264 cells.
Topics: Animals; Anthracenes; Butadienes; Cell Line; Extracellular Signal-Regulated MAP Kinases; Histamine; Histidine Decarboxylase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Messenger | 2006 |
Inhibitory effect of obovatol on nitric oxide production and activation of NF-kappaB/MAP kinases in lipopolysaccharide-treated RAW 264.7cells.
Topics: Animals; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Butadienes; Cell Line; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Lipopolysaccharides; Macrophages; Magnolia; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Phenyl Ethers | 2007 |
A novel pathway for transcriptional regulation of alpha-synuclein.
Topics: alpha-Synuclein; Animals; Anthracenes; Blotting, Western; Butadienes; Chromones; Enzyme Inhibitors; Fibroblast Growth Factor 2; Gene Expression Regulation; Humans; Imidazoles; Introns; JNK Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Nerve Growth Factor; Nitriles; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic | 2007 |
Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth.
Topics: Animals; Anthracenes; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Butadienes; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Female; Humans; Imidazoles; Mammary Glands, Animal; Mice; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Nitriles | 2007 |
Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by TNF alpha in early-passage synovial fibroblasts via TNF receptor-1: failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis.
Topics: Anthracenes; Arthritis, Rheumatoid; Blotting, Western; Butadienes; Case-Control Studies; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Imidazoles; MAP Kinase Kinase 4; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Nitriles; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Statistics, Nonparametric; Synovial Membrane; Tumor Necrosis Factor-alpha | 2007 |
[The role of MAPK/ERK1/2 signaling pathway in aldosterone stimulated transforming growth factor-beta1 synthesis in renal tubular epithelial cells].
Topics: Aldosterone; Anthracenes; Blotting, Western; Butadienes; Cells, Cultured; Dose-Response Relationship, Drug; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Kidney Tubules, Proximal; Mifepristone; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Pyridines; Signal Transduction; Time Factors; Transforming Growth Factor beta1 | 2006 |
Differential regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells.
Topics: Animals; Anthracenes; Bone Marrow Cells; Butadienes; Chromones; Dendritic Cells; Gene Expression; Gene Expression Regulation, Enzymologic; Imidazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Janus Kinase 1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Mice; Mice, Inbred Strains; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines | 2007 |
Human lung innate immune response to Bacillus anthracis spore infection.
Topics: Anthracenes; Anthrax; Bacillus anthracis; Butadienes; Chemokines; Cytokines; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Gene Expression Regulation; Humans; Imidazoles; Immunity, Innate; Immunohistochemistry; In Vitro Techniques; Lung; Macrophages, Alveolar; MAP Kinase Signaling System; Microscopy, Fluorescence; Nitriles; Pulmonary Alveoli; Pyridines; RNA, Messenger; Spores, Bacterial | 2007 |
Manganese chloride stimulates rat microglia to release hydrogen peroxide.
Topics: Animals; Animals, Newborn; Anthracenes; Butadienes; Cell Line; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Hydrogen Peroxide; Imidazoles; Manganese Compounds; Microglia; NADPH Oxidases; Nitriles; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Inbred F344; Time Factors | 2007 |
Ras pathway activation in malignant mesothelioma.
Topics: Adaptor Proteins, Signal Transducing; Anthracenes; Apoptosis; Blotting, Western; Butadienes; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; DNA, Neoplasm; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Mesothelioma; Mitogen-Activated Protein Kinase 3; Mutation; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Polymerase Chain Reaction; Repressor Proteins; Signal Transduction | 2007 |
Involvement of mitogen-activated protein kinases and NFkappaB in LPS-induced CD40 expression on human monocytic cells.
Topics: Animals; Anthracenes; Butadienes; CD40 Antigens; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Flow Cytometry; Humans; Imidazoles; Immunoblotting; Leupeptins; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Nitriles; Phosphorylation; Polysaccharides, Bacterial; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sulfones; Time Factors; Toll-Like Receptor 4 | 2008 |
Inhibition of Src and p38 MAP kinases suppresses the change of claudin expression induced on dedifferentiation of primary cultured parotid acinar cells.
Topics: Amylases; Animals; Anthracenes; Aquaporin 5; Butadienes; Cell Adhesion; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cell Shape; Cells, Cultured; Claudin-4; Claudins; Enzyme Activation; Extracellular Matrix; Imidazoles; Keratin-14; Male; Membrane Proteins; Nitriles; p38 Mitogen-Activated Protein Kinases; Parotid Gland; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction; src-Family Kinases; Tight Junctions; Time Factors; Vimentin | 2008 |
Stress-activated protein kinase inhibition to ameliorate lung ischemia reperfusion injury.
Topics: Animals; Anthracenes; Blotting, Western; Bronchoalveolar Lavage Fluid; Butadienes; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Immunohistochemistry; Inflammation Mediators; Lung Diseases; Male; Mitogen-Activated Protein Kinases; Nitriles; Oxidative Stress; Peroxidase; Phosphorylation; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Reperfusion Injury; Sensitivity and Specificity | 2008 |
Prevotella intermedia induces matrix metalloproteinase-9 expression in human periodontal ligament cells.
Topics: Adolescent; Anthracenes; Bacteroidaceae Infections; Butadienes; Cells, Cultured; Child; Culture Media, Conditioned; Electrophoresis, Polyacrylamide Gel; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Matrix Metalloproteinase 9; Nitriles; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Porphyromonas gingivalis; Prevotella intermedia; Protein Kinase Inhibitors; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2008 |
In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity.
Topics: Amides; Anesthetics, Local; Animals; Anthracenes; Bupivacaine; Butadienes; Cell Size; Cell Survival; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Ganglia, Spinal; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lidocaine; Membrane Potentials; Mitogen-Activated Protein Kinases; Neurons, Afferent; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Ropivacaine; Sodium Channels | 2008 |
Egr-1 mRNA induction by medium flow involves mRNA stabilization and is enhanced by the p38 inhibitor SB203580 in osteoblast-like cells.
Topics: Animals; Anthracenes; Butadienes; Cells, Cultured; Early Growth Response Protein 1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Imidazoles; MAP Kinase Kinase 4; Mechanotransduction, Cellular; Mice; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection | 2008 |
Glial fibrillary acidic protein promoter targets pancreatic stellate cells.
Topics: Animals; Anthracenes; Butadienes; Cell Line; Chromones; Enzyme Inhibitors; Gene Expression; Glial Fibrillary Acidic Protein; Lac Operon; Mice; Mice, Transgenic; Morpholines; Nitriles; Pancreas; Promoter Regions, Genetic; Transfection; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Vitamin A; Vitamins | 2009 |
Pharmacological inhibitors of JNK and ERK kinases SP600125 and U0126 are not appropriate tools for studies of drug metabolism because they activate aryl hydrocarbon receptor.
Topics: Anthracenes; Butadienes; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pharmaceutical Preparations; Pyridines; Receptors, Aryl Hydrocarbon | 2008 |
Activation of peripheral ephrinBs/EphBs signaling induces hyperalgesia through a MAPKs-mediated mechanism in mice.
Topics: Animals; Anthracenes; Butadienes; Dizocilpine Maleate; Ephrin-B1; Foot; Formaldehyde; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; MAP Kinase Signaling System; Mice; Nitriles; p38 Mitogen-Activated Protein Kinases; Physical Stimulation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Receptors, Eph Family; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Touch | 2008 |
Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: possible implications for GAI pathogenesis.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Animals, Newborn; Anthracenes; Antioxidants; Astrocytes; Brain; Brain Diseases, Metabolic, Inborn; Butadienes; Cell Count; Cell Proliferation; Cell Survival; Cells, Cultured; Glutarates; Immunohistochemistry; Membrane Potential, Mitochondrial; Mitochondria; Nitriles; Porphyrins; Rats; Rats, Sprague-Dawley | 2008 |
Neuronal injury induces cytokine-induced neutrophil chemoattractant-1 (CINC-1) production in astrocytes.
Topics: Animals; Anthracenes; Astrocytes; Butadienes; Cells, Cultured; Cerebral Cortex; Chemokine CXCL1; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Imidazoles; Immunochemistry; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Nitriles; Pyridines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2009 |
Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways.
Topics: Anthracenes; Apoptosis; Butadienes; Capillaries; Extracellular Signal-Regulated MAP Kinases; Glycation End Products, Advanced; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipoproteins, LDL; MAP Kinase Signaling System; Nitriles; p38 Mitogen-Activated Protein Kinases; Pericytes; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Retinal Vessels; Time Factors | 2009 |
Cardiotrophin-1 induces intercellular adhesion molecule-1 expression by nuclear factor kappaB activation in human umbilical vein endothelial cells.
Topics: Anthracenes; Butadienes; Cells, Cultured; Cytokines; Electrophoretic Mobility Shift Assay; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Gene Expression; Humans; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Polymerase Chain Reaction; Sesquiterpenes; Umbilical Veins | 2008 |
Tumour necrosis factor alpha stimulates the production of monocyte chemoattractants by extravillous trophoblast cells via differential activation of MAPK pathways.
Topics: Anthracenes; Butadienes; Cell Line; Cell Movement; Chemokine CCL2; Chemokine CCL5; Collagen; Culture Media, Conditioned; Drug Combinations; Enzyme Inhibitors; Female; Humans; Imidazoles; In Vitro Techniques; Laminin; Macrophages; MAP Kinase Signaling System; Monocytes; Nitriles; Pregnancy; Proteoglycans; Pyridines; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Trophoblasts; Tumor Necrosis Factor-alpha | 2009 |
The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.
Topics: Animals; Anisomycin; Anthracenes; Aorta; Apoptosis; Butadienes; Carotid Arteries; Carotid Stenosis; Cell Line, Tumor; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Macrophages; Macrophages, Alveolar; Mice; Mitogen-Activated Protein Kinases; Myocytes, Smooth Muscle; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rabbits; Tunica Intima; Tunica Media | 2009 |
Effects of polychlorinated biphenyls on the neutrophil NADPH oxidase system.
Topics: Anthracenes; Aroclors; Butadienes; Cyclosporine; Environmental Pollutants; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Luminescent Measurements; NADPH Oxidases; Neutrophil Activation; Neutrophils; Nitriles; Pyridines; Respiratory Burst; Tacrolimus | 2009 |
NaF activates MAPKs and induces apoptosis in odontoblast-like cells.
Topics: Animals; Anthracenes; Apoptosis; Butadienes; Caspase 3; Cell Culture Techniques; Cell Line; Cell Survival; DNA Fragmentation; Enzyme Activators; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Nitriles; Nucleosomes; Odontoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Sodium Fluoride; Time Factors | 2009 |
Constitutive and oxidative-stress-induced expression of VEGF in the RPE are differently regulated by different Mitogen-activated protein kinases.
Topics: Animals; Anthracenes; Blotting, Western; Butadienes; Cell Culture Techniques; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Organ Culture Techniques; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Retinal Pigment Epithelium; Swine; tert-Butylhydroperoxide; Vascular Endothelial Growth Factor A | 2009 |
Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression.
Topics: Animals; Anthracenes; Butadienes; Cell Line; Dogs; Epithelium; Female; Imidazoles; Mammary Glands, Animal; MAP Kinase Kinase 4; Membrane Proteins; Mice; Nitriles; p38 Mitogen-Activated Protein Kinases | 2009 |
Effects of prostaglandin D2 on Na-dependent phosphate transport activity and its intracellular signaling mechanism in osteoblast-like cells.
Topics: 3T3 Cells; Animals; Anthracenes; Butadienes; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Imidazoles; Mice; Morpholines; Naphthalenes; Nitriles; Osteoblasts; Phosphates; Prostaglandin D2; Pyridines; Signal Transduction; Sirolimus; Sodium | 2009 |
TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling.
Topics: Anthracenes; Butadienes; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Imidazoles; Lactones; MAP Kinase Kinase Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinazolines; Resorcinols; RNA, Small Interfering; Serine; Signal Transduction; Threonine; Tumor Necrosis Factor-alpha | 2009 |
Enterobacter sakazakii targets DC-SIGN to induce immunosuppressive responses in dendritic cells by modulating MAPKs.
Topics: Animals; Anthracenes; Bacterial Outer Membrane Proteins; Butadienes; Cell Adhesion Molecules; Cell Survival; Cronobacter sakazakii; Dendritic Cells; Enterobacteriaceae Infections; Enzyme Inhibitors; Epithelial Cells; Flavonoids; HeLa Cells; Humans; Imidazoles; Interleukin-10; Lectins, C-Type; Lipopolysaccharides; Lymphocyte Activation; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase Kinases; Nitriles; Pyridines; Rats; Receptors, Cell Surface; Transfection; Transforming Growth Factor beta | 2009 |
The proliferation and migration effects of huangqi on RSC96 Schwann cells.
Topics: Animals; Anthracenes; Astragalus Plant; Astragalus propinquus; Blotting, Western; Butadienes; Cell Line; Cell Movement; Cell Proliferation; Cell Survival; Cyclin A; Cyclin D1; Cyclin E; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Inhibitors; Fibroblast Growth Factor 2; Imidazoles; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Models, Biological; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Schwann Cells; Urokinase-Type Plasminogen Activator | 2009 |
Induction of tissue inhibitor of matrix metalloproteinase-2 by cholesterol depletion leads to the conversion of proMMP-2 into active MMP-2 in human dermal fibroblasts.
Topics: Anthracenes; Butadienes; Cells, Cultured; Child; Child, Preschool; Cholesterol; Cyclodextrins; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Immunoblotting; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 2; Microscopy, Electron, Transmission; Nitriles; Tissue Inhibitor of Metalloproteinase-2 | 2010 |
Toll-like receptor ligands cause proinflammatory and prodiabetic activation of adipocytes via phosphorylation of extracellular signal-regulated kinase and c-Jun N-terminal kinase but not interferon regulatory factor-3.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Adult; Animals; Anthracenes; Butadienes; Chemokine CCL2; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Inflammation; Insulin; Interferon Regulatory Factor-3; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mice; Myeloid Differentiation Factor 88; Nitriles; Phosphorylation; RNA, Messenger; Toll-Like Receptors | 2010 |
Deferoxamine mesylate is toxic for retinal pigment epithelium cells in vitro, and its toxicity is mediated by p38.
Topics: Animals; Anthracenes; Blotting, Western; Butadienes; Cell Death; Cells, Cultured; Deferoxamine; Dose-Response Relationship, Drug; Hydrogen Peroxide; Imidazoles; Iron Chelating Agents; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Retinal Pigment Epithelium; Swine; Trypan Blue | 2010 |
Differential functions of growth factor receptor-bound protein 7 (GRB7) and its variant GRB7v in ovarian carcinogenesis.
Topics: Alternative Splicing; Anthracenes; Blotting, Western; Butadienes; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; GRB7 Adaptor Protein; Green Fluorescent Proteins; Humans; Immunohistochemistry; Microscopy, Confocal; Middle Aged; Mitogen-Activated Protein Kinases; Neoplasm Staging; Nitriles; Ovarian Neoplasms; Protein Isoforms; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transfection | 2010 |
Regulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways.
Topics: Animals; Anthracenes; Butadienes; Cell Line; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Glucose; Indoles; MAP Kinase Kinase Kinases; Mesangial Cells; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Phenols; Phosphorylation; Promoter Regions, Genetic; Prorenin Receptor; Protein Binding; Proto-Oncogene Proteins c-raf; Rats; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription Factor AP-1 | 2010 |
Deciphering mechanisms controlling placental artery endothelial cell migration stimulated by vascular endothelial growth factor.
Topics: Androstadienes; Animals; Anthracenes; Arteries; Butadienes; Caveolin 1; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Electrophoresis, Polyacrylamide Gel; Endothelial Cells; Enzyme Inhibitors; Female; Focal Adhesion Protein-Tyrosine Kinases; Imidazoles; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide Synthase Type III; Nitriles; Nitrogen Oxides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Placenta; Pregnancy; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Sheep; Signal Transduction; src-Family Kinases; Vascular Endothelial Growth Factor A; Wortmannin | 2010 |
Platelet-activating factor receptor mediates oxidized low density lipoprotein-induced migration of bone marrow-derived mesenchymal stem cells.
Topics: Anthracenes; Becaplermin; Bone Marrow Cells; Butadienes; Cell Movement; Humans; Imidazoles; Lipoproteins, LDL; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyridines; Receptors, G-Protein-Coupled; RNA Interference; RNA, Small Interfering | 2010 |
Fluid shear stress induces renal epithelial gene expression through polycystin-2-dependent trafficking of extracellular regulated kinase.
Topics: Animals; Anthracenes; Blotting, Western; Butadienes; Cell Line; Chemokine CCL2; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Fluorescent Antibody Technique; Gene Expression Regulation; JNK Mitogen-Activated Protein Kinases; Kidney Tubules, Collecting; Mice; Mitogen-Activated Protein Kinases; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; Rheology; RNA Interference; Stress, Mechanical; TRPP Cation Channels | 2011 |
α-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways.
Topics: 1-Phosphatidylinositol 4-Kinase; alpha-Tocopherol; Androstadienes; Anthracenes; Antioxidants; Apoptosis; Blotting, Western; Breast Neoplasms; Butadienes; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Immunosuppressive Agents; Insulin Receptor Substrate Proteins; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Nitriles; Phosphorylation; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Wortmannin | 2011 |
[Simvastatin suppress lipopolysaccharides induced upregulation of lipoprotein associated phospholipase A(2) expression in macrophages via inactivation of p38MAPK pathway].
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Anthracenes; Butadienes; Cells, Cultured; Humans; Imidazoles; Lipopolysaccharides; Macrophages; Monocytes; Nitriles; p38 Mitogen-Activated Protein Kinases; Phospholipases A2; Phosphorylation; Pyridines; RNA, Messenger; Simvastatin | 2010 |
MAPKs ERK and p38, but not JNK phosphorylation, modulate IL-6 and TNF-α secretion following OK-432 in vitro stimulation of purified human monocytes.
Topics: Anthracenes; Antineoplastic Agents; Butadienes; Cells, Cultured; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Picibanil; Pyridines; Teichoic Acids; Tumor Necrosis Factor-alpha | 2011 |
Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes.
Topics: Angiotensin II; Anthracenes; Butadienes; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gq-G11; HEK293 Cells; Humans; Imidazoles; MicroRNAs; Myocytes, Cardiac; Nitriles; Pyridines; Receptor, Angiotensin, Type 1; Signal Transduction | 2011 |
ERK is involved in EGF-mediated protection of tight junctions, but not adherens junctions, in acetaldehyde-treated Caco-2 cell monolayers.
Topics: Acetaldehyde; Actins; Adherens Junctions; Anthracenes; beta Catenin; Butadienes; Caco-2 Cells; Cadherins; Claudin-3; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Inulin; Membrane Proteins; Nitriles; Occludin; Permeability; Phosphoproteins; Pyridines; Tight Junctions; Zonula Occludens-1 Protein | 2011 |
Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages.
Topics: Amino Acid Chloromethyl Ketones; Anthracenes; Antithrombins; Blotting, Western; Butadienes; Cell Line; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Enzyme Inhibitors; Flavonoids; Gene Expression; Glycoproteins; Hirudins; Humans; JNK Mitogen-Activated Protein Kinases; Lipoproteins, VLDL; Macrophages; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Nitrobenzenes; Reverse Transcriptase Polymerase Chain Reaction; Sesquiterpenes; Signal Transduction; Sulfonamides; Thrombin; Time Factors | 2011 |
Enhanced phosphorylation of MAPKs by NE promotes TNF-α production by macrophage through α adrenergic receptor.
Topics: Adrenergic alpha-Antagonists; Animals; Anthracenes; Butadienes; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Nitriles; Norepinephrine; p38 Mitogen-Activated Protein Kinases; Phentolamine; Phosphorylation; Pyridines; Receptors, Adrenergic, alpha; Tumor Necrosis Factor-alpha | 2012 |
tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK.
Topics: Animals; Animals, Newborn; Anthracenes; Brain Injuries; Butadienes; Drug Interactions; Female; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; N-Methylaspartate; Nitriles; Oligopeptides; Papaverine; Peptides; Pia Mater; Pyridines; Swine; Tissue Plasminogen Activator; Up-Regulation; Vasoconstriction; Vasodilation | 2011 |
Unfertilized Xenopus eggs die by Bad-dependent apoptosis under the control of Cdk1 and JNK.
Topics: Animals; Anthracenes; Apoptosis; bcl-Associated Death Protein; Blotting, Western; Butadienes; Caspases; CDC2 Protein Kinase; Cyclin B; Cytochromes c; Female; JNK Mitogen-Activated Protein Kinases; Mitochondria; Mitogen-Activated Protein Kinase 3; Models, Biological; Molecular Sequence Data; Nitriles; Oocytes; Ovum; Phosphorylation; Progesterone; Time Factors; Xenopus laevis; Xenopus Proteins | 2011 |
IL-33 is induced by amyloid-β stimulation and regulates inflammatory cytokine production in retinal pigment epithelium cells.
Topics: Amyloid beta-Peptides; Anthracenes; Butadienes; Cell Line; Humans; Imidazoles; Inflammation; Interleukin-1 Receptor-Like 1 Protein; Interleukin-1beta; Interleukin-33; Interleukin-6; Interleukin-8; Interleukins; JNK Mitogen-Activated Protein Kinases; Macular Degeneration; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitriles; Peptide Fragments; Pyridines; Receptors, Cell Surface; Retinal Pigment Epithelium; Sulfones; Tumor Necrosis Factor-alpha | 2012 |
MAPK and AP-1 proteins are increased in term pre-labour fetal membranes overlying the cervix: regulation of enzymes involved in the degradation of fetal membranes.
Topics: Anthracenes; Butadienes; Cervix Uteri; Extracellular Signal-Regulated MAP Kinases; Extraembryonic Membranes; Female; Gentian Violet; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pregnancy; Pyridines; Quaternary Ammonium Compounds; Transcription Factor AP-1 | 2011 |
Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells.
Topics: Anthracenes; Breast Neoplasms; Butadienes; Cell Line, Tumor; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Matrix Metalloproteinase 9; Nitriles; Phosphorylation; RNA, Messenger; Signal Transduction; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1 | 2012 |
Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells.
Topics: Anthracenes; Butadienes; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Flavanones; Glucose; Hesperidin; Humans; Hyperglycemia; Imidazoles; Intercellular Adhesion Molecule-1; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Resveratrol; Stilbenes; Up-Regulation; Veins | 2011 |
Prostaglandin E2 enhances interleukin-8 production via EP4 receptor in human pulmonary microvascular endothelial cells.
Topics: Acute Lung Injury; Anthracenes; Butadienes; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelial Cells; Humans; Imidazoles; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Lung; MAP Kinase Signaling System; Methyl Ethers; Microvessels; Naphthalenes; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenylbutyrates; Pyridines; Receptors, Prostaglandin E, EP4 Subtype; Respiratory Distress Syndrome; RNA, Messenger; Thionucleotides | 2012 |
Lipopolysaccharide enhances decorin expression through the Toll-like receptor 4, myeloid differentiating factor 88, nuclear factor-kappa B, and mitogen-activated protein kinase pathways in odontoblast cells.
Topics: Animals; Anthracenes; Blotting, Western; Butadienes; Cell Line; Decorin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; I-kappa B Kinase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Luciferases; Luminescent Agents; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Myeloid Differentiation Factor 88; NF-kappa B p50 Subunit; Nitriles; Odontoblasts; p38 Mitogen-Activated Protein Kinases; Pyridines; Real-Time Polymerase Chain Reaction; Time Factors; Toll-Like Receptor 2; Toll-Like Receptor 4; Up-Regulation | 2012 |
Effects of dihydropyridine calcium channel blockers on oxidized low-density lipoprotein induced proliferation and oxidative stress of vascular smooth muscle cells.
Topics: Amlodipine; Anthracenes; Butadienes; Calcium Channel Blockers; Cell Proliferation; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipoproteins, LDL; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Time Factors | 2012 |
Monocyte chemoattractant protein-1 mediates angiotensin II-induced vascular smooth muscle cell proliferation via SAPK/JNK and ERK1/2.
Topics: Angiotensin II; Animals; Anthracenes; Aorta, Thoracic; Benzoxazines; Butadienes; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, CCR2 | 2012 |
Mitogen activated protein kinases blockade improves lipopolysaccharide-induced ileal motor disturbances.
Topics: Acetylcholine; Animals; Anthracenes; Biomarkers; Butadienes; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ileum; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rabbits | 2012 |
CD99 ligation induces intercellular cell adhesion molecule-1 expression and secretion in human gingival fibroblasts.
Topics: 12E7 Antigen; Anthracenes; Antibodies, Monoclonal; Antigens, CD; Butadienes; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Culture Media, Conditioned; Endothelial Cells; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flow Cytometry; Gingiva; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukocytes; Leupeptins; MAP Kinase Signaling System; NF-kappa B; NF-kappa B p50 Subunit; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines | 2013 |
Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases.
Topics: Anthracenes; Butadienes; Cartilage, Articular; Cells, Cultured; Chondrocytes; Curcumin; Endopeptidases; Gene Expression Regulation; Humans; Imidazoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Lipoxygenases; Masoprocol; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Pyrrolidines; RNA, Messenger; Thiocarbamates; Transcription Factor AP-1 | 2012 |
Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice.
Topics: Animals; Anthracenes; Butadienes; Diabetes Mellitus, Type 2; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mitogen-Activated Protein Kinases; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Leptin; Resveratrol; Signal Transduction; Stilbenes; Superoxides | 2012 |
PTEN/MAPK pathways play a key role in platelet-activating factor-induced experimental pulmonary tumor metastasis.
Topics: Androstadienes; Animals; Anthracenes; Butadienes; Cell Line; Humans; Imidazoles; Lung Neoplasms; MAP Kinase Signaling System; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyridines; Wortmannin | 2012 |
Tensile stimuli increase nerve growth factor in human dermal fibroblasts independent of tension-induced TGFβ production.
Topics: Anthracenes; Antibodies, Neutralizing; Butadienes; Chromones; Fibroblasts; Humans; Morpholines; Nerve Growth Factor; Nitriles; RNA, Messenger; Signal Transduction; Skin; Stress, Mechanical; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Up-Regulation | 2013 |
Eupatolide inhibits PDGF-induced proliferation and migration of aortic smooth muscle cells through ROS-dependent heme oxygenase-1 induction.
Topics: Acetylcysteine; Animals; Anthracenes; Aorta; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Imidazoles; Inula; Male; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-E2-Related Factor 2; Nitriles; Platelet-Derived Growth Factor; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes | 2013 |
Human retinal pigment epithelial cells express the long pentraxin PTX3.
Topics: Anthracenes; Butadienes; C-Reactive Protein; Cell Line; Cytokines; Gene Expression; Humans; Imidazoles; Inflammation Mediators; Interferon-gamma; Interleukin-1beta; MAP Kinase Signaling System; NF-kappa B; Nitriles; Pyridines; Retinal Pigment Epithelium; RNA, Messenger; Serum Amyloid P-Component; Signal Transduction; Sulfones; Tumor Necrosis Factor-alpha | 2013 |
Low-level shear stress induces human mesenchymal stem cell migration through the SDF-1/CXCR4 axis via MAPK signaling pathways.
Topics: Anthracenes; Benzylamines; Butadienes; Cell Movement; Cell- and Tissue-Based Therapy; Cells, Cultured; Chemokine CXCL12; Cyclams; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Heterocyclic Compounds; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, CXCR4; Stress, Mechanical; Wound Healing | 2013 |
Oxidative stress and mitogen-activated protein kinase pathways involved in cadmium-induced BRL 3A cell apoptosis.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Butadienes; Cadmium; Cell Line; Extracellular Signal-Regulated MAP Kinases; Glutathione Peroxidase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Malondialdehyde; Mitogen-Activated Protein Kinases; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2013 |
Effect of nifedipine on the differentiation of human dental pulp cells cultured with mineral trioxide aggregate.
Topics: Adult; Aluminum Compounds; Anthracenes; Butadienes; Calcium; Calcium Channel Blockers; Calcium Compounds; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cells, Cultured; Culture Media; Dental Pulp; Drug Combinations; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Nifedipine; Nitriles; Odontoblasts; Oxides; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Pyridines; Root Canal Filling Materials; Sialoglycoproteins; Silicates; Tooth Calcification | 2013 |
Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2.
Topics: Anthracenes; Butadienes; Carcinoma; Cell Line, Tumor; Cell Movement; Endometrial Neoplasms; Enzyme Activation; Female; Gene Knockdown Techniques; Gonadotropin-Releasing Hormone; Humans; Hydroxamic Acids; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Nitriles; Phosphorylation; Receptors, LHRH | 2013 |
Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation.
Topics: Animals; Anthracenes; Base Sequence; Butadienes; Cell Nucleus; Claudin-4; Cycloheximide; Dogs; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Free Radical Scavengers; Hydrogen Peroxide; Hypertonic Solutions; JNK Mitogen-Activated Protein Kinases; Kidney Tubules, Collecting; Madin Darby Canine Kidney Cells; Models, Biological; Molecular Sequence Data; NADPH Oxidases; Nitriles; Osmolar Concentration; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Sp1 Transcription Factor; Up-Regulation | 2013 |
Hypoxia induces connexin 43 dysregulation by modulating matrix metalloproteinases via MAPK signaling.
Topics: Animals; Anthracenes; Butadienes; Cell Hypoxia; Cell Survival; Cells, Cultured; Chromones; Connexin 43; Down-Regulation; Doxycycline; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Morpholines; Myocytes, Cardiac; NF-kappa B; Nitriles; Phenylenediamines; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Rats; Transcription Factor AP-1 | 2013 |
Naringin inhibits ROS-activated MAPK pathway in high glucose-induced injuries in H9c2 cardiac cells.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Butadienes; Cell Line; Cell Survival; Enzyme Inhibitors; Flavanones; Fruit; Glucose; Hyperglycemia; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Pyridines; Rats; Reactive Oxygen Species | 2014 |
Endothelin-1 stimulates resistin gene expression.
Topics: 3T3-L1 Cells; Adipose Tissue; Androstadienes; Animals; Anthracenes; Butadienes; Chromones; Dactinomycin; Endothelin-1; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Morpholines; Nitriles; Oligopeptides; Piperidines; Proto-Oncogene Proteins c-akt; Resistin; Signal Transduction; STAT3 Transcription Factor; Tyrphostins; Wortmannin | 2014 |
Reactive oxygen species-dependent nitric oxide production in reciprocal interactions of glioma and microglial cells.
Topics: Anthracenes; Butadienes; Cell Line, Tumor; Cell Survival; Chemokine CCL2; Coculture Techniques; Culture Media, Conditioned; Gene Expression Regulation, Neoplastic; Glioma; Humans; JNK Mitogen-Activated Protein Kinases; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2014 |
Nitric oxide induces apoptosis in human gingival fibroblast through mitochondria-dependent pathway and JNK activation.
Topics: Anthracenes; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Butadienes; Cell Survival; Cells, Cultured; Cytochromes c; Enzyme Inhibitors; Fibroblasts; Gingiva; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Membrane Potentials; Mitochondria; Nitric Oxide; Nitriles; Nitroprusside; Pyridines; Signal Transduction | 2015 |
Biodentine induces human dental pulp stem cell differentiation through mitogen-activated protein kinase and calcium-/calmodulin-dependent protein kinase II pathways.
Topics: Adolescent; Adult; Alkaline Phosphatase; Anthracenes; Benzylamines; Butadienes; Calcium Compounds; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Culture Techniques; Cell Differentiation; Dental Pulp; Extracellular Matrix Proteins; Humans; Imidazoles; Integrin-Binding Sialoprotein; MAP Kinase Signaling System; NF-kappa B; Nitriles; Odontoblasts; Osteocalcin; Phosphoproteins; Protein Kinase Inhibitors; Pulp Capping and Pulpectomy Agents; Pyridines; Pyrrolidines; Sialoglycoproteins; Signal Transduction; Silicates; Stem Cells; Sulfonamides; Thiocarbamates; Young Adult | 2014 |
Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway.
Topics: Animals; Animals, Newborn; Anthracenes; Butadienes; Cell Hypoxia; Flavonoids; Gene Expression Regulation; Heart Ventricles; Hepatocyte Growth Factor; JNK Mitogen-Activated Protein Kinases; Microfilament Proteins; Myocytes, Cardiac; Nitriles; Oxygen; Primary Cell Culture; Protein Kinase Inhibitors; Rats; RNA, Messenger; Signal Transduction | 2014 |
The effects of LPS on adhesion and migration of human dental pulp stem cells in vitro.
Topics: Adolescent; Adult; Anthracenes; Benzylamines; Butadienes; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Chemokine CXCL12; Chemotactic Factors; Cyclams; Dental Pulp; Escherichia coli; Extracellular Signal-Regulated MAP Kinases; Heterocyclic Compounds; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Signaling System; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrrolidines; Receptors, CXCR4; Signal Transduction; Stem Cells; Thiocarbamates; Young Adult | 2014 |
Thioredoxin-interacting protein regulates the differentiation of murine erythroid precursors.
Topics: Animals; Anthracenes; Butadienes; Carrier Proteins; Cell Differentiation; Cell Line; Cell Line, Tumor; Erythroblasts; Erythropoiesis; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Heme; Imidazoles; Immunoblotting; Iron; JNK Mitogen-Activated Protein Kinases; Leukemia, Erythroblastic, Acute; Mice, Inbred C57BL; Mice, Knockout; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Thioredoxins | 2015 |
Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice.
Topics: Animals; Anthracenes; Butadienes; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Intestinal Secretions; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Membrane Potentials; Mice; Muscarinic Agonists; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines | 2015 |
Diallyl disulfide inhibits TNFα induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling.
Topics: Allyl Compounds; Anthracenes; Anticarcinogenic Agents; Butadienes; Cell Line, Tumor; Chemokine CCL2; Disulfides; Garlic; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Macrophages; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; NF-kappa B p50 Subunit; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Tumor Necrosis Factor-alpha | 2015 |
Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis.
Topics: Animals; Anthracenes; Butadienes; Cell Line; Gene Expression Regulation; Imidazoles; Interleukin-1beta; Lipopolysaccharides; Macrophages; Mice; Mice, Knockout; Mutation; Nitriles; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C delta; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Receptors, IgG; RNA, Small Interfering; Signal Transduction; Toll-Like Receptor 4 | 2016 |
DJ-1 mutation decreases astroglial release of inflammatory mediators.
Topics: Animals; Anthracenes; Astrocytes; Butadienes; Cyclooxygenase 2; Dinoprostone; Imidazoles; Inflammation Mediators; Lipopolysaccharides; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Primary Cell Culture; Protein Deglycase DJ-1; Pyridines; Tumor Necrosis Factor-alpha | 2016 |
Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A.
Topics: Animals; Anthracenes; Apoptosis; Butadienes; Cadmium; Genes, jun; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Neurons; Nitriles; PC12 Cells; Phosphorylation; Protein Phosphatase 2; Rats; Reactive Oxygen Species; Signal Transduction; Sirolimus | 2016 |
TNF-α enhances vascular cell adhesion molecule-1 expression in human bone marrow mesenchymal stem cells via the NF-κB, ERK and JNK signaling pathways.
Topics: Anthracenes; Biomarkers; Butadienes; Cell Adhesion; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Immunophenotyping; JNK Mitogen-Activated Protein Kinases; Mesenchymal Stem Cells; NF-kappa B; Nitriles; Phosphorylation; Signal Transduction; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2016 |
Water-extracted Perilla frutescens increases endometrial receptivity though leukemia inhibitory factor-dependent expression of integrins.
Topics: Anthracenes; Butadienes; Cell Adhesion; Cells, Cultured; Endometrium; Female; Humans; Imidazoles; Integrin beta Chains; Leukemia Inhibitory Factor; Leukemia Inhibitory Factor Receptor alpha Subunit; MAP Kinase Signaling System; Nitriles; Perilla frutescens; Plant Extracts; Plant Leaves; Plant Roots; Pyridines; RNA, Small Interfering; Signal Transduction | 2016 |
CD147 induces up-regulation of vascular endothelial growth factor in U937-derived foam cells through PI3K/AKT pathway.
Topics: Anthracenes; Atherosclerosis; Basigin; Butadienes; Chromones; Flow Cytometry; Foam Cells; Gene Expression Regulation; Gene Silencing; Humans; Imidazoles; Lipoproteins, LDL; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; U937 Cells; Up-Regulation; Vascular Endothelial Growth Factor A | 2016 |
Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anthracenes; Apoptosis Regulatory Proteins; Brain; Brain Ischemia; Butadienes; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Inflammasomes; Mice; Neurons; NF-kappa B; Nitriles; NLR Family, Pyrin Domain-Containing 3 Protein; Pyridines; Signal Transduction; Stroke; Sulfones | 2018 |
37LRP induces invasion in hypoxic lung adenocarcinoma cancer cells A549 through the JNK/ERK/c-Jun signaling cascade.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Anthracenes; Butadienes; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; MAP Kinase Kinase 4; MAP Kinase Signaling System; Nitriles; Phosphorylation; Receptors, Laminin | 2017 |
Ephrin A1 promotes proliferation of bovine endometrial cells with abundant expression of proliferating cell nuclear antigen and cyclin D1 changing the cell population at each stage of the cell cycle.
Topics: Animals; Anthracenes; Butadienes; Cattle; Cell Cycle; Cell Line; Cell Proliferation; Cyclin D1; Endometrium; Endoplasmic Reticulum Stress; Ephrin-A1; Extracellular Signal-Regulated MAP Kinases; Female; Interferon Type I; JNK Mitogen-Activated Protein Kinases; Nitriles; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Pregnancy; Pregnancy Proteins; Proliferating Cell Nuclear Antigen; Receptor, EphA2; Receptor, EphA4; Wortmannin | 2019 |
Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK1-dependent and p38, JNK and PI3K/Akt-independent manner.
Topics: Anthracenes; Autocrine Communication; Axitinib; Butadienes; Flavonoids; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Indazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Membrane Proteins; Nitriles; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Small Interfering; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2019 |
STRIP2 silencing inhibits vascular smooth muscle cell proliferation and migration via P38-AKT-MMP-2 signaling pathway.
Topics: Acetates; Alkaloids; Animals; Anthracenes; Axin Protein; Benzopyrans; Butadienes; Cell Line; Cell Movement; Cell Proliferation; Cytoskeletal Proteins; Gene Expression Regulation; Gene Knockdown Techniques; Gene Silencing; Imidazoles; Matrix Metalloproteinase 2; Mice; Mitomycin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines | 2019 |
MAPK Pathway Inhibitors Attenuated Hydrogen Peroxide Induced Damage in Neural Cells.
Topics: Animals; Anthracenes; Butadienes; Cell Survival; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Imidazoles; Mice; Mitogen-Activated Protein Kinase Kinases; Neurodegenerative Diseases; Neurons; Nitriles; Oxidative Stress; PC12 Cells; Primary Cell Culture; Pyridines; Rats; Reactive Oxygen Species | 2019 |
Synergistic apoptosis of human gastric cancer cells by bortezomib and TRAIL.
Topics: Aged; Anthracenes; Apoptosis; Bortezomib; Butadienes; Caspases; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Middle Aged; Nitriles; p21-Activated Kinases; Receptors, TNF-Related Apoptosis-Inducing Ligand; Stomach Neoplasms; TNF-Related Apoptosis-Inducing Ligand | 2019 |
The microtubule targeting agents eribulin and paclitaxel activate similar signaling pathways and induce cell death predominantly in a caspase-independent manner.
Topics: Anthracenes; Butadienes; Caspase 3; Cell Cycle; Cell Death; Cell Line, Tumor; Furans; Humans; Ketones; Microtubules; Mitogen-Activated Protein Kinases; Nitriles; Paclitaxel; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2020 |
MicroRNA-294 Promotes Cell Proliferation, Migration and Invasion in SMMC-7721 Hepatoma Carcinoma Cells by Activating the JNK/ERK Signaling Pathway.
Topics: Aged; Anthracenes; Butadienes; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; MicroRNAs; Middle Aged; Neoplasm Invasiveness; Nitriles; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Up-Regulation | 2020 |
L‑carnitine attenuates TGF‑β1‑induced EMT in retinal pigment epithelial cells via a PPARγ‑dependent mechanism.
Topics: Anilides; Anthracenes; Butadienes; Carnitine; Cell Movement; Cells, Cultured; Epithelial Cells; Epithelial-Mesenchymal Transition; Humans; MAP Kinase Signaling System; Models, Biological; NF-kappa B; Nitriles; PPAR gamma; Retinal Pigment Epithelium; Smad Proteins; Transforming Growth Factor beta1 | 2021 |
MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy.
Topics: Animals; Anthracenes; Autophagy; Butadienes; Disease Models, Animal; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osteoarthritis; Protein Kinase Inhibitors; Pyridines; Rabbits; Severity of Illness Index | 2021 |
SP600125 Enhances Temperature-Controlled Repeated Thermal Stimulation-Induced Neurite Outgrowth in PC12-P1F1 Cells.
Topics: Animals; Butadienes; Neuronal Outgrowth; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Rats; Temperature | 2022 |
[Eriocitrin suppresses proliferation and migration of hepatocellular carcinoma SMMC-7721 cells by promoting ROS production and activating the MAPK pathway].
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Poly(ADP-ribose) Polymerase Inhibitors; Reactive Oxygen Species | 2023 |