pyrazinoic acid has been researched along with pyrazinamide in 165 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 48 (29.09) | 18.7374 |
| 1990's | 25 (15.15) | 18.2507 |
| 2000's | 31 (18.79) | 29.6817 |
| 2010's | 48 (29.09) | 24.3611 |
| 2020's | 13 (7.88) | 2.80 |
| Authors | Studies |
|---|---|
| Chou, TS; Cynamon, MH; Gimi, RH; Klemens, SP; Welch, JT | 1 |
| Bergmann, KE; Cynamon, MH; Gimi, R; Gregor, LB; Gyenes, F; Han, HJ; Luciano, G; Rapolu, R; Sharpe, CA; Welch, JT | 1 |
| Arai, M; Jacobs, WR; Vilchèze, C; Welch, JT; Zimhony, O | 1 |
| Chung, WJ; Jacobs, WR; Ngo, SC; Sayahi, H; Welch, JT; Zimhony, O | 1 |
| Baughn, AD; Deng, J; Jacobs, WR; Riestra, A; Vilchèze, C; Welch, JT; Zimhony, O | 1 |
| Jacobs, WR; Sayahi, H; Shekhtman, A; Welch, JT; Zimhony, O | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Bolívar, BE; Welch, JT | 1 |
| Bohn, DL; Fanelli, GM; Zacchei, AG | 1 |
| Fanelli, GM; Weiner, IM | 1 |
| Roboz, J; Suzuki, R; Yü, TF | 1 |
| Frankfurt, SJ; Weinman, EJ | 1 |
| Foks, H; Manowska, W; Sienicka, J | 1 |
| Ellard, GA; Haslam, RM | 1 |
| Jung, DK; Jung, JS; Kim, YK; Lee, SH | 1 |
| Beyer, KH; Gelarden, RT; Jeszenka, EV; Passananti, GT; Vesell, ES | 1 |
| Guisan, B; Roch-Ramel, F; Werner, D | 1 |
| Shinosaki, T; Yonetani, Y | 2 |
| Crowle, AJ; Reller, LB; Salfinger, M | 1 |
| Kobayashi, M; Nagasawa, T; Yamada, H; Yanaka, N | 1 |
| Duwoos, H; Lacroix, C; Lafont, O; Phan Hoang, T; Tranvouez, JL | 1 |
| Czyźewska, K; Grzegorzewska, A; Knapowski, J | 1 |
| Flory, MA; Heifets, LB; Lindholm-Levy, PJ | 1 |
| MacDougall, ML; Wiegmann, TB | 1 |
| Czyzewska, K; Grzegorzewska, A; Knapowski, J; Stawny, B | 1 |
| Duwoos, H; Guyonnaud, C; Hoang, TP; Lacroix, C; Lafont, O; Laine, G; Nouveau, J | 1 |
| Kahn, AM; Weinman, EJ | 1 |
| Farinotti, R; Fessi, H; Kenouch, S; Méry, JP; Montes, C; Stamatakis, G; Trouvin, JH | 1 |
| Guyonnaud, C; Lacroix, C; Lafont, O; Laine, G; Menager, S; Poncet, P; Ray, M | 1 |
| Hada, T; Higashino, K; Moriwaki, Y; Takahashi, S; Yamamoto, T | 3 |
| Lacroix, C; Lafont, O; Langlois, B; Ménager, S | 1 |
| Bidiville, J; Roch-Ramel, F | 1 |
| Aihara, E; Hayama, T; Kokue, E; Koyanagi, M; Shimoda, M | 1 |
| Besseghir, K; Roch-Ramel, F | 1 |
| Acocella, G; Carlone, NA; Cuffini, AM; Forno-Pizzoglio, M | 1 |
| Abramson, RG; Lipkowitz, MS | 1 |
| Aronson, PS; Guggino, SE | 1 |
| Manganel, M; Murer, H; Roch-Ramel, F | 1 |
| Acocella, G; Conti, R; Grassi, C; Luisetti, M; Pozzi, E | 1 |
| Acocella, G; Carlone, NA; Cavallo, G; Cuffini, AM | 1 |
| Branham, S; Kahn, AM; Weinman, EJ | 1 |
| Iwaki, K; Yonetani, Y | 1 |
| Brokl, OH; Dantzler, WH | 1 |
| Acharyulu, GS; Gurumurthy, P; Kannapiran, M; Murthy, PV; Sarma, GR; Tripathy, SP | 1 |
| Perez-Gonzalez, M; Weiner, IM | 2 |
| Ferrier, B; Martin, M; Roch-Ramel, F | 1 |
| Beretta, E; Bernareggi, A; Ratti, B; Toselli, A | 1 |
| Fasold, H; Klöss, S; Rumrich, G; Ullrich, KJ | 1 |
| Duong, N; Gougoux, A; Lemieux, G; Moulin, B; Vinay, P | 1 |
| Roch-Ramel, F; Schäli, C | 1 |
| Gurumurthy, P; Nair, NG; Sarma, GR | 1 |
| Abramson, RG; Knorr, BA; Leal-Pinto, E; London, RD | 1 |
| Abramson, RG; Beck, JC; Knorr, BA | 1 |
| Cynamon, MH; Speirs, RJ; Welch, JT | 1 |
| Czyzewska, K; Grzegorzewska, AE; Szary, B | 1 |
| Mitchison, DA | 1 |
| Bergmann, KE; Cynamon, MH; Welch, JT | 1 |
| Guisan, B; Roch-Ramel, F; Schild, L | 1 |
| A-Rahim, YI; Beyer, KH; Vesell, ES | 1 |
| Diezi, J; Guisan, B; Roch-Ramel, F | 1 |
| André, D; Chabenat, C; Lafont, O; Mehmedagic, A; Ménager, S; Tharasse, C; Vérité, P | 2 |
| Scorpio, A; Sun, Z; Zhang, Y | 1 |
| Beyer, KH; Vesell, ES | 1 |
| Sun, Z; Zhang, Y | 1 |
| Nikaido, H; Scorpio, A; Sun, Z; Zhang, Y | 1 |
| Abramson, RG; Cohen, BE; Leal-Pinto, E | 1 |
| Furitsu, H; Iga, T; Kotaki, H; Sawada, Y; Yamada, H | 1 |
| Heinzmann, K; Kiener, A; Tinschert, A; Tschech, A | 1 |
| Draper, P | 1 |
| Cox, JS; Jacobs, WR; Vilchèze, C; Welch, JT; Zimhony, O | 1 |
| Bohme, GA; Boireau, A; Bouquerel, J; Damour, D; Debono, MW; Genevois-Borella, A; Hardy, JC; Hubert, P; Jimonet, P; Manfré, F; Mignani, S; Nemecek, P; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| DE Smet, KA; Fonteyne, PA; Jannes, G; Mestdagh, M; Mijs, W; Portaels, F; Realini, L; Rossau, R; Van den Eeckhout, E | 1 |
| Permar, S; Sun, Z; Zhang, Y | 1 |
| Barry, CE; Boshoff, HI; Mizrahi, V | 1 |
| Abramson, RG; Cohen, BE; Leal-Pinto, E; Lipkowitz, MS | 1 |
| Gisanrin, O; Guo, M; Schaller, A; Zhang, Y | 1 |
| Fukuwatari, T; Shibata, K; Sugimoto, E | 1 |
| Endou, H; Hosoya, T; Hosoyamada, M; Ichida, K; Kimura, H; Takeda, M; Utsunomiya, Y | 1 |
| Archana, A; Ramana, ChV; Sasikala, Ch | 1 |
| FERRARI, S; MORELLINI, M | 1 |
| AOKI, T; ITO, F; NISHIO, K | 1 |
| BERGER, L; GUTMAN, AB; STONE, DJ; WOLF, J; YU, TF | 1 |
| BERTONI, L; BONATI, F | 1 |
| CASALONE, G; GANZETTI, G; MANGIAROTTI, S | 1 |
| FOKS, H; SAWLEWICZ, J | 1 |
| ARTA, T; KAKEMI, K; KITAZAWA, S; KIYOTAKI, T | 1 |
| Scorpio, A; Sun, Z; Wade, MM; Zhang, H; Zhang, Y | 1 |
| Somoskovi, A; Sun, Z; Wade, MM; Zhang, Y | 1 |
| BUGIE, EJ; GREGORY, FJ; IRONSON, EJ; O'NEILL, RC; PFISTER, R; SOLOTOROVSKY, M | 1 |
| Deng, H; Deng, Q; Zhao, S; Zhou, L | 1 |
| Wade, MM; Zhang, Y | 1 |
| Hirano, T; Iseki, K; Itagaki, S; Kobayashi, M; Miyazaki, K; Shimamoto, S; Sugawara, M | 1 |
| Berkers, CR; Groll, M; Ovaa, H; Ploegh, HL | 1 |
| Bell, AT; Head-Gordon, M; Khaliullin, RZ | 1 |
| Iwanaga, T; Maeda, T; Ogihara, T; Sato, M; Tamai, I | 1 |
| Baska, RA; Behnia, K; Burford, NT; Carlson, KE; Cullen, MJ; Ellsworth, BA; Ewing, WR; Gerritz, SW; Huang, Q; Johnghar, S; Kang, L; Pelleymounter, MA; Pendri, A; Sun, C; Wang, Y; Washburn, WN; Yang, Y; Zhu, Y | 1 |
| Tsai, TH; Wu, JW | 1 |
| Dolezal, M; Mary, YS; Panicker, CY; Varghese, HT | 1 |
| Bouwman, E; Browne, WR; Feringa, BL; Hage, R; Marques-Gallego, P; Reedijk, J; Tanase, S | 1 |
| Antipas, AS; Blumberg, LC; Brissette, WH; Brown, MF; Casavant, JM; Doty, JL; Driscoll, J; Harris, TM; Jones, CS; Li, Q; Linde, RG; Lira, PD; Marfat, A; McCurdy, SP; McElroy, E; Mitton-Fry, M; Munchhof, MJ; Reiter, LA; Ripp, SL; Shavnya, A; Thomasco, LM; Trevena, KA; Wolf-Gouveia, LA | 1 |
| Akashi, I; Hirano, T; Kagami, K; Oka, K | 1 |
| Datterl, B; Eller, GA; Habicht, D; Holzer, W | 1 |
| Anes, E; Constantino, L; Gómez, MJ; Simões, MF; Valente, E | 1 |
| Brandt, CA; Felli, VM; Fernandes, JP; Ferreira, EI; Pasqualoto, KF | 1 |
| Mamada, H; Nakanishi, T; Sato, M; Shirasaka, Y; Tamai, I; Wakayama, T | 1 |
| Barry, CE; Jiang, X; Lee, JS; Shi, W; Wang, H; Yuan, H; Zhang, W; Zhang, X; Zhang, Y | 1 |
| Bald, D; Haagsma, AC; Lill, H; Lu, P; Maaskant, JJ; Mol, S; Pham, H | 1 |
| Cole, ST | 1 |
| Fuentes, P; Gilman, RH; Gutiérrez, AH; Kirwan, D; Sheen, P; Zimic, M | 1 |
| Dolezal, M; Kesetovic, D; Zitko, J | 1 |
| Kang, HS; Kim, HJ; Kim, SY; Kim, YR; Kook, YH; Kwak, HK; Lee, J; Lee, JS; Lee, KH; Lee, MS; Maeng, YH; Min, SY; Park, SK; Yun, YJ | 1 |
| Cotrina, M; Fuentes, P; Gilman, RH; Gutierrez, A; Kirwan, D; Loli, S; Sheen, P; Zimic, M | 1 |
| Anzai, N; Nakanishi, T; Ohya, K; Shimada, S; Tamai, I | 1 |
| Feuerriegel, S; Köser, CU; Niemann, S; Richter, E | 1 |
| Guedes da Silva, MF; Kirillova, MV; Kozlov, YN; Pombeiro, AJ; Shul'pin, GB; Shvydkiy, NV; Sutradhar, M | 1 |
| Fuentes, P; Gilman, RH; Grandjean, L; Loli, S; Lozano, K; Sheen, P; Valencia, HJ; Zimic, M | 1 |
| Krátký, M; Novotná, E; Stolaříková, J; Vinšová, J | 1 |
| Kim, H; Mori, S; Rimbara, E; Shibayama, K | 1 |
| Baughn, AD; Dillon, NA; Peterson, ND; Rosen, BC | 2 |
| Bi, J; Cai, Q; Guo, C; Li, W; Liao, X; Lin, D; Lin, T; Liu, J; Liu, Y; Wang, H; Yang, J; Zhang, Q; Zhang, X; Zhao, Y | 1 |
| Dhillon, J; Durham, PG; Fourie, PB; German, N; Hickey, AJ; Mitchison, DA; Mortensen, N; Zhang, Y | 1 |
| Corrêa, MF; Fernandes, JP | 1 |
| Anes, E; Carmo, N; Constantino, L; Pires, D; Simões, MF; Testa, B; Valente, E | 1 |
| Sanyal, M; Shah, JV; Shah, PA; Sharma, P; Shrivastav, PS | 1 |
| Braunstein, MS; Durham, PG; Hickey, AJ; Welch, JT; Young, EF | 1 |
| Alland, D; Dartois, V; Lanoix, JP; Nuermberger, E; O'Brien, P; Pinn, M; Safi, H; Sarathy, J; Tasneen, R | 1 |
| Braunstein, MS; Durham, PG; Hayden, JD; Hickey, AJ; Malik, S; Perkowski, E; Welch, JT; Young, EF; Zhong, L | 1 |
| Fu, J; Guo, C; Huang, B; Liao, X; Lin, D; Wu, X | 1 |
| Al-Radadi, NS; Attia, MS | 1 |
| Cho, SH; Corrêa, MF; Felli, VMA; Fernandes, JPDS; Franzblau, SG; Miyata, M; Segretti, ND; Simões, CK | 1 |
| Caviedes, L; Coronel, J; Gilman, RH; Meinzen, C; Proaño, A; Sheen, P; Zimic, M | 1 |
| Dick, T; Gopal, P; Yee, M | 1 |
| Dartois, V; Dick, T; Gopal, P; Lanoix, JP; Li, L; Nuermberger, E; Rasic, G; Sarathy, J; Tasneen, R; Yee, M | 1 |
| De, A; Keshari, AK; Kumar, D; Kumar, U; Nath, S; Prakash, A; Rai, A; Raj, V; Rawat, A; Saha, S; Sahdev, AK; Samanta, A; Singh, AK | 1 |
| Chaturvedi, S; Dubey, D; Guleria, A; Keshari, AK; Kumar, D; Kumar, U; Prakash, A; Rai, A; Raj, V; Rawat, A; Saha, S; Singh, AK | 1 |
| Cai, X; Guo, J; Hameed, HMA; Lamichhane, G; Liu, J; Liu, Y; Mugweru, J; Njire, M; Nuermberger, E; Tan, S; Tan, Y; Wang, B; Wang, N; Yew, WW; Zhang, T | 1 |
| Cheng, LW; Chibale, K; Land, KM; Liu, N; Seldon, R; Smith, GS; Smith, PJ; Stringer, T; Tam, C; Warner, DF | 1 |
| Dartois, V; Dick, T; Gopal, P; Grüber, G; Kaya, F; Manimekalai, MSS; Nartey, W; Ragunathan, P; Sarathy, J; Setzer, C; Yee, M | 1 |
| Anthony, RM; den Hertog, AL; van Soolingen, D | 1 |
| Chen, J; Shi, W; Zhang, S; Zhang, W; Zhang, Y | 1 |
| Braunstein, M; Durham, PG; Hayden, JD; Hickey, AJ; Lin, FC; Miller, BK; Montgomery, SA; Rank, L; Welch, JT; Young, EF; Zulauf, KE | 1 |
| Fernandes, JPS; Torrecilhas, AC; Varela, MT; Vasconcelos, CI | 1 |
| Aono, A; Chikamatsu, K; Igarashi, Y; Mitarai, S; Murase, Y; Takaki, A; Yamada, H | 1 |
| Mugabo, P; Mulubwa, M | 1 |
| Afzal, MT; Ali, S; Khan, AS; Khan, MT; Malik, SI; Masood, N; Nadeem, T | 1 |
| Bakuradze, T; Buckel, L; Eisenbrand, G; Glaß-Theis, A; Kremer, JI; Pickard, S; Richling, E; Stadlmair, LF | 1 |
| Antiparra, R; Arteaga, H; Bueno, C; Campos, J; Duran, P; Gilman, RH; Huerta, R; Kirwan, DE; Monsalve, A; Sheen, P; Zimic, M | 1 |
| Li, X; Perez, LM; Sacchettini, JC; Shi, W; Sun, Q; Zhang, Y | 1 |
| Akopian, T; Bhushan, S; Dick, T; Gengenbacher, M; Gopal, P; Grüber, G; Kandror, O; Lim, TK; Lin, Q; Ragunathan, P; Rubin, EJ; Sarathy, JP; Shin, J; Yee, M; Zhu, J | 1 |
| Amzel, LM; Antiparra, R; Gilman, RH; Kirwan, DE; Lopez, JM; Maruenda, H; Saavedra, H; Sheen, P; Toscano, E; Vallejos-Sánchez, K; Zimic, M | 1 |
| Abbadi, BL; Bernardes-Génisson, V; Bizarro, CV; Carvalho, EM; Chauvin, R; de Freitas Paulo, T; de Morais Campos, R; do Nascimento, NRF; Ferreira, TLA; Lopes, LGF; Macchi, FS; Saquet, AS; Sousa, EHS | 1 |
| Campos, ML; Corrêa, MF; de Queiroz Aranha, CMS; DeGrandis, RA; Fernandes, JPS; Franchin, TB; Peccinini, RG; Ulian Silva, BC | 1 |
| Das, R; Mehta, DK | 1 |
| Crans, DC; Crick, DC; Fontes, FL; Peters, BJ | 1 |
| Alcántara, R; Angulo, N; Antiparra, R; Florentini, EA; Gilman, RH; Kirwan, D; Roncal, E; Sheen, P; Toscano, E; Vallejos, K; Zimic, M | 1 |
| Ali, M; Ali, SM; Boda, A; Das, SK; Dumpala, RMR; Kumar, A; Kumar, P; Rawat, N | 1 |
| Aldrich, CC; Baughn, AD; Brody, SI; Buonomo, JA; Cole, MS; Howe, MD; Lamont, EA; Minato, Y; Mishra, NK; Sharma, S; Thiede, JM | 1 |
| Aldrich, CC; Aragaw, WW; Cole, MS; Dick, T; Grüber, G; Harikishore, A; Hegde, PV; Jachak, G; Ragunathan, P; Sharma, S | 1 |
| Cialla-May, D; Jiménez-Avalos, G; Liu, C; Popp, J; Sheen, P; Zhang, WS; Zimic, M | 1 |
3 review(s) available for pyrazinoic acid and pyrazinamide
| Article | Year |
|---|---|
Urate transport in the proximal tubule: in vivo and vesicle studies.
Topics: Absorption; Animals; Basement Membrane; Bicarbonates; Biological Transport, Active; Chlorides; Dogs; Humans; Hydroxides; Hydroxyl Radical; Infant, Newborn; Isomerism; Kidney Tubules, Proximal; Lactates; Lactic Acid; Microvilli; Models, Biological; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rats; Species Specificity; Uric Acid | 1985 |
Antimycobacterial evaluation of pyrazinoic acid reversible derivatives.
Topics: Animals; Anti-Bacterial Agents; Cell Line; Cell Survival; Drug Design; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium; Prodrugs; Pyrazinamide; Structure-Activity Relationship | 2011 |
Pyrazinamide and Pyrazinoic Acid Derivatives Directed to Mycobacterial Enzymes Against Tuberculosis.
Topics: Animals; Anti-Bacterial Agents; Humans; Mycobacterium tuberculosis; Prodrugs; Pyrazinamide; Tuberculosis | 2016 |
1 trial(s) available for pyrazinoic acid and pyrazinamide
| Article | Year |
|---|---|
Studies on pyrazinoylguanidine. 7. Effects of single oral doses in normal human subjects.
Topics: Adult; Blood Glucose; Cross-Over Studies; Fatty Acids, Nonesterified; Guanidines; Hormones; Humans; Hypolipidemic Agents; Lipids; Male; Pyrazinamide; Pyrazines; Single-Blind Method | 1999 |
161 other study(ies) available for pyrazinoic acid and pyrazinamide
| Article | Year |
|---|---|
Antimycobacterial activity of a series of pyrazinoic acid esters.
Topics: Animals; Antitubercular Agents; Esters; Hydrogen-Ion Concentration; Mice; Mycobacterium; Mycobacterium avium; Mycobacterium bovis; Mycobacterium tuberculosis; Pyrazinamide | 1992 |
Pyrazinoic acid esters with broad spectrum in vitro antimycobacterial activity.
Topics: Anti-Bacterial Agents; Esters; Microbial Sensitivity Tests; Mycobacterium; Pyrazinamide; Structure-Activity Relationship | 1995 |
Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli.
Topics: Bacterial Proteins; Fatty Acid Synthases; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide; Structure-Activity Relationship; Tuberculosis | 2007 |
Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs.
Topics: Bacterial Proteins; Cell-Free System; Fatty Acid Synthases; Humans; Inhibitory Concentration 50; Kinetics; Mass Spectrometry; Molecular Structure; Mycobacterium tuberculosis; NADP; Oxidation-Reduction; Pyrazinamide; Reproducibility of Results; Substrate Specificity | 2007 |
Mutually exclusive genotypes for pyrazinamide and 5-chloropyrazinamide resistance reveal a potential resistance-proofing strategy.
Topics: Antitubercular Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Genotype; Mutation; Mycobacterium bovis; Mycobacterium smegmatis; Mycobacterium tuberculosis; Pyrazinamide | 2010 |
Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase I.
Topics: Bacterial Proteins; Binding Sites; Binding, Competitive; Crystallography, X-Ray; Enzyme Inhibitors; Fatty Acid Synthases; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Mycobacterium tuberculosis; NADP; Pyrazinamide; Stereoisomerism; Structure-Activity Relationship | 2011 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Studies of the Binding of Modest Modulators of the Human Enzyme, Sirtuin 6, by STD NMR.
Topics: Binding Sites; Crystallography, X-Ray; Humans; Kinetics; Magnetic Resonance Imaging; Niacinamide; Protein Binding; Pyrazinamide; Sirtuins; Thermodynamics | 2017 |
Renal excretion of a slauretic-uricosuric agent (MK-196) and interaction with a urate-retaining drug, pyrazinoate, in the chimpanzee.
Topics: Acetazolamide; Animals; Diuresis; Drug Interactions; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Indans; Indenes; Kidney; Male; p-Aminohippuric Acid; Pan troglodytes; Probenecid; Pyrazinamide; Pyrazines; Sodium Chloride; Time Factors; Uric Acid; Uricosuric Agents | 1977 |
Urate excretion: drug interactions.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Glomerular Filtration Rate; Haplorhini; Male; Models, Biological; p-Aminohippuric Acid; Pan troglodytes; Probenecid; Pyrazinamide; Salicylates; Ultrafiltration; Uric Acid; Uricosuric Agents | 1979 |
Mass fragmentographic determination of pyrazinamide and its metabolites in serum and urine.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Methods; Pyrazinamide; Pyrazines | 1978 |
Pyrazinoic acid and urate transport in the rat.
Topics: Animals; Glomerular Filtration Rate; Kidney Tubules, Proximal; Male; Metabolic Clearance Rate; Pyrazinamide; Rats; Uric Acid | 1978 |
[Synthesis and tuberculostatic activity of some derivatives of pyrazine-2-carboxylic acid].
Topics: Antitubercular Agents; Chemical Phenomena; Chemistry; Mycobacterium tuberculosis; Pyrazinamide; Pyrazines | 1976 |
Observations on the reduction of the renal elimination of urate in man caused by the administration of pyrazinamide.
Topics: Humans; Male; Pyrazinamide; Pyrazines; Time Factors; Uric Acid | 1976 |
Urate excretion by the cat kidney.
Topics: Animals; Cats; Female; Kidney; Male; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1992 |
Pharmacokinetics of pyrazinoyl-guanidine, 3-aminopyrazinoyl-guanidine and their corresponding pyrazinoic acid metabolites in humans and dogs.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Drug Stability; Guanidines; Half-Life; Humans; Hydrolysis; Molecular Structure; Pyrazinamide; Pyrazines; Uremia | 1992 |
Urate transport in the proximal tubule of human kidney.
Topics: Biological Transport; Humans; Kidney Cortex; Kidney Tubules, Proximal; Kinetics; Lactates; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1991 |
Hyperuricemia induced by the uricosuric drug probenecid in rats.
Topics: Allopurinol; Animals; Hepatectomy; Hypoxanthines; Inulin; Kidney Function Tests; Male; Oxonic Acid; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Uric Acid; Xanthines | 1991 |
Pyrazinamide and pyrazinoic acid activity against tubercle bacilli in cultured human macrophages and in the BACTEC system.
Topics: Amidohydrolases; Cells, Cultured; Culture Media; Humans; Hydrogen-Ion Concentration; Macrophages; Mycobacterium bovis; Mycobacterium tuberculosis; Pyrazinamide | 1990 |
Nitrilase-catalyzed production of pyrazinoic acid, an antimycobacterial agent, from cyanopyrazine by resting cells of Rhodococcus rhodochrous J1.
Topics: Aminohydrolases; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pyrazinamide; Pyrazines; Rhodococcus; Spectrophotometry, Infrared; Temperature | 1990 |
Pharmacokinetics of pyrazinamide and its metabolites in patients with hepatic cirrhotic insufficiency.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Liver Cirrhosis; Liver Function Tests; Male; Pyrazinamide | 1990 |
Change in the transport of uric acid under the influence of pyrazinoic acid: in vitro studies with human and rabbit peritoneum.
Topics: Adult; Animals; Biological Transport, Active; Female; Humans; In Vitro Techniques; Male; Peritoneum; Pyrazinamide; Rabbits; Species Specificity; Uric Acid | 1989 |
Does pyrazinoic acid as an active moiety of pyrazinamide have specific activity against Mycobacterium tuberculosis?
Topics: Culture Media; Hydrogen-Ion Concentration; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide | 1989 |
Urate excretion by the isolated perfused rat kidney and modification by drugs.
Topics: Animals; Furosemide; Glomerular Filtration Rate; Kidney; Natriuresis; Oxonic Acid; Perfusion; Probenecid; Pyrazinamide; Rats; Salicylates; Salicylic Acid; Uric Acid | 1989 |
[Human peritoneum in vitro: changes in urate transport after administration of pyrazinoic acid].
Topics: Adult; Aged; Biological Transport; Depression, Chemical; Female; Humans; In Vitro Techniques; Male; Middle Aged; Models, Biological; Peritoneum; Pyrazinamide; Uric Acid | 1989 |
Stop-flow studies on tubular transport of uric acid in rats.
Topics: Animals; Kidney; Male; Metabolic Clearance Rate; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Stereoisomerism; Sulfonamides; Ticrynafen; Uric Acid | 1989 |
Pharmacokinetics of pyrazinamide and its metabolites in healthy subjects.
Topics: Chromatography, High Pressure Liquid; Half-Life; Humans; Male; Pyrazinamide | 1989 |
Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure.
Topics: Adult; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pyrazinamide; Renal Dialysis; Tuberculosis, Pulmonary; Uremia | 1988 |
[Microdetermination of pyrazinamide and its metabolites (pyrazinoic acid, 5-hydroxypyrazinoic acid, 5-hydroxypyrazinamide and pyrazinuric acid) in plasma and urine with liquid chromatography].
Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Indicators and Reagents; Pyrazinamide; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1987 |
Study of the metabolism of pyrazinamide using a high-performance liquid chromatographic analysis of urine samples.
Topics: Allopurinol; Chromatography, High Pressure Liquid; Humans; Pyrazinamide; Xanthine Oxidase; Xanthines | 1987 |
5-Hydroxypyrazinamide, a human metabolite of pyrazinamide.
Topics: Adult; Biotransformation; Humans; Male; Pyrazinamide | 1987 |
[Simultaneous microdetermination of pyrazinamide and pyrazinoic acid by liquid chromatography].
Topics: Acetonitriles; Chromatography, Liquid; Humans; Microchemistry; Pyrazinamide | 1987 |
In vitro conversion of pyrazinamide into 5-hydroxypyrazinamide and that of pyrazinoic acid into 5-hydroxypyrazinoic acid by xanthine oxidase from human liver.
Topics: Humans; Liver; NAD; Pyrazinamide; Xanthine Oxidase | 1987 |
Competition of organic anions for furosemide and p-aminohippurate secretion in the rabbit.
Topics: Aminohippuric Acids; Animals; Biological Transport; Female; Furosemide; Glomerular Filtration Rate; In Vitro Techniques; Indomethacin; Kidney; Male; Natriuresis; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rabbits; Time Factors; Tritium | 1986 |
Possible active tubular secretion of sulfamonomethoxine and its metabolites in pigs.
Topics: Acetylation; Animals; Diuresis; Kidney Tubules; Kinetics; Male; Probenecid; Pyrazinamide; Sulfamonomethoxine; Sulfanilamides; Swine; Swine, Miniature | 1986 |
Pyrazinoate transport in the isolated perfused rabbit proximal tubule.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Absorption; Animals; Biological Transport; Epithelium; Ethoxzolamide; Female; In Vitro Techniques; Kidney Tubules, Proximal; Lactates; Lactic Acid; Male; Ouabain; p-Aminohippuric Acid; Pyrazinamide; Rabbits | 1986 |
Killing of macrophage-ingested mycobacteria by rifampicin, pyrazinamide, and pyrazinoic acid alone and in combination.
Topics: Animals; Antitubercular Agents; Drug Combinations; Macrophages; Male; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Phagocytosis; Pyrazinamide; Rifampin | 1985 |
Carrier-mediated concentrative urate transport in rat renal membrane vesicles.
Topics: Animals; Biological Transport; Copper; Diffusion; Hydrogen-Ion Concentration; Kidney; Male; Microvilli; Osmolar Concentration; Oxonic Acid; Pyrazinamide; Rats; Uric Acid | 1985 |
Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes.
Topics: Animals; Biological Transport, Active; Dogs; Hydrogen-Ion Concentration; Kidney Cortex; Lactates; Lactic Acid; Membranes; Microvilli; Models, Biological; Niacin; Nigericin; Pyrazinamide; Sodium; Uric Acid; Valinomycin | 1985 |
Sodium-pyrazinoate cotransport in rabbit renal brush border membrane vesicles.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Freezing; Glucose; Kidney Cortex; Kinetics; Microvilli; Pyrazinamide; Rabbits; Sodium; Tritium | 1985 |
Pharmacokinetic studies on antituberculosis regimens in humans. I. Absorption and metabolism of the compounds used in the initial intensive phase of the short-course regimens: single administration study.
Topics: Absorption; Antitubercular Agents; Humans; Isoniazid; Kinetics; Male; Pyrazinamide; Rifampin; Streptomycin | 1985 |
The penetration of rifampicin, pyrazinamide, and pyrazinoic acid into mouse macrophages.
Topics: Animals; Binding Sites; Biological Transport; Cells, Cultured; Dose-Response Relationship, Drug; Macrophages; Male; Mice; Mice, Inbred BALB C; Pyrazinamide; Rifampin | 1985 |
Mechanism of urate and p-aminohippurate transport in rat renal microvillus membrane vesicles.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Aminohippuric Acids; Animals; Biological Transport; Carbon Radioisotopes; Cell Membrane; Furosemide; Hydrogen-Ion Concentration; Kidney Cortex; Kinetics; Microvilli; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Tritium; Uric Acid | 1983 |
Decreased renal excretion of uric acid following diuretic administration in rats.
Topics: Animals; Diuretics; Furosemide; Insulin; Male; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Trichlormethiazide; Uric Acid | 1984 |
Lack of effect of low [Ca2+], La3+, and pyrazinoate on urate transport by isolated, perfused snake renal tubules.
Topics: Animals; Biological Transport, Active; Calcium; Female; In Vitro Techniques; Kidney Tubules; Lanthanum; Male; Perfusion; Pyrazinamide; Snakes; Uric Acid | 1984 |
Role of rifampicin in arthralgia induced by pyrazinamide.
Topics: Drug Therapy, Combination; Humans; Joint Diseases; Pain; Pyrazinamide; Rifampin; Tuberculosis, Pulmonary; Uric Acid | 1983 |
Effects of p-aminohippurate and pyrazinoate on urate excretion in Cebus monkeys.
Topics: Aminohippuric Acids; Animals; Cebus; Dose-Response Relationship, Drug; Female; Male; p-Aminohippuric Acid; Pyrazinamide; Uric Acid | 1984 |
Effects of pyrazinoate and p-aminohippurate on renal urate excretion by the dog and guinea pig.
Topics: Aminohippuric Acids; Animals; Dogs; Female; Glomerular Filtration Rate; Guinea Pigs; Kidney Tubules; Male; p-Aminohippuric Acid; Pyrazinamide; Species Specificity; Uric Acid | 1983 |
Effects of p-aminohippurate and pyrazinoate on the renal excretion of salicylate in the rat: a micropuncture study.
Topics: Aminohippuric Acids; Animals; Bicarbonates; Kidney Tubules; Male; p-Aminohippuric Acid; Pyrazinamide; Rats; Rats, Inbred Strains; Salicylates | 1983 |
HPLC assay of pyrazinoic acid in human plasma in the presence of pyrazinamide and other antituberculosis drugs using an automatic sampler.
Topics: Antitubercular Agents; Chromatography, High Pressure Liquid; Humans; Pyrazinamide | 1982 |
Reabsorption of monocarboxylic acids in the proximal tubule of the rat kidney. III. Specificity for aromatic compounds.
Topics: Absorption; Animals; Benzene Derivatives; Benzoates; Biological Transport; Carboxylic Acids; Cinnamates; Kidney Tubules, Proximal; Lactates; Male; Nicotinic Acids; Pyrazinamide; Rats; Rats, Inbred Strains | 1982 |
Net urate reabsorption in the Dalmatian coach hound with a note on automated measurement of urate in species with low plasma urate.
Topics: Absorption; Animals; Dogs; Glomerular Filtration Rate; Hemodynamics; Kidney; Kidney Tubules, Proximal; p-Aminohippuric Acid; Pyrazinamide; Species Specificity; Uric Acid | 1982 |
Uptake of [3H]PAH and [14C]urate into isolated proximal tubular segments of the pig kidney.
Topics: Aminohippuric Acids; Animals; Biological Transport, Active; Female; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Swine; Uric Acid | 1981 |
Methods for the estimation of pyrazinamide and pyrazinoic acid in body fluids.
Topics: Body Fluids; Humans; Pyrazinamide | 1980 |
Reconstitution of hepatic uricase in planar lipid bilayer reveals a functional organic anion channel.
Topics: Animals; Anions; Ion Channels; Lipid Bilayers; Liver; Oxonic Acid; Pyrazinamide; Rats; Swine; Urate Oxidase | 1995 |
Classical and channel-like urate transporters in rabbit renal brush border membranes.
Topics: Animals; Biological Transport; Carrier Proteins; Copper; Diffusion; Female; Ion Channels; Kidney Tubules, Proximal; Male; Membrane Potentials; Microvilli; Oxonic Acid; Pyrazinamide; Rabbits; Urea | 1994 |
Activity of n-propyl pyrazinoate against pyrazinamide-resistant Mycobacterium tuberculosis: investigations into mechanism of action of and mechanism of resistance to pyrazinamide.
Topics: Amidohydrolases; Antibiotics, Antitubercular; Drug Resistance, Microbial; Esterases; Microbial Sensitivity Tests; Mycobacterium; Mycobacterium tuberculosis; Niacin; Pyrazinamide; Structure-Activity Relationship | 1995 |
Pyrazinoic acid decreases peritoneal transfer rates.
Topics: Albumins; Biological Transport; Humans; In Vitro Techniques; Peritoneum; Pyrazinamide; Urea; Uric Acid | 1995 |
Pyrazinamide--on the antituberculosis drug frontline.
Topics: Amidohydrolases; Animals; Antitubercular Agents; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Humans; Mice; Pyrazinamide; Tuberculosis | 1996 |
Quantitative structure-activity relationships for the in vitro antimycobacterial activity of pyrazinoic acid esters.
Topics: AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Esters; Humans; Microbial Sensitivity Tests; Mycobacterium; Mycobacterium avium; Mycobacterium Infections; Mycobacterium tuberculosis; Pyrazinamide; Structure-Activity Relationship; Tuberculosis | 1996 |
Indirect coupling of urate and p-aminohippurate transport to sodium in human brush-border membrane vesicles.
Topics: Aged; Biological Transport; Humans; Kidney; Microvilli; Middle Aged; p-Aminohippuric Acid; Pyrazinamide; Sodium; Sodium Lactate; Uric Acid | 1996 |
Studies on pyrazinoylguanidine. 2. Comparative drug and dose effects on glucose and lipid metabolism in streptozotocin-induced diabetic rats.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glyburide; Guanidines; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Metabolism; Male; Metformin; Pyrazinamide; Pyrazines; Rats; Rats, Sprague-Dawley; Streptozocin | 1996 |
Effects of uricosuric and antiuricosuric agents on urate transport in human brush-border membrane vesicles.
Topics: Aged; Benzbromarone; Biological Transport; Biphenyl Compounds; Carbon Radioisotopes; Diuretics; Ethambutol; Humans; Imidazoles; Kidney Cortex; Kidney Neoplasms; Kinetics; Losartan; Microvilli; Middle Aged; Probenecid; Pyrazinamide; Salicylates; Salicylic Acid; Sulfinpyrazone; Tetrazoles; Ticrynafen; Uric Acid; Uricosuric Agents | 1997 |
Determination of pyrazinamide and its main metabolites in rat urine by high-performance liquid chromatography.
Topics: Animals; Antitubercular Agents; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Pyrazinamide; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 1997 |
The pncA gene from naturally pyrazinamide-resistant Mycobacterium avium encodes pyrazinamidase and confers pyrazinamide susceptibility to resistant M. tuberculosis complex organisms.
Topics: Amidohydrolases; Amino Acid Sequence; Antitubercular Agents; Base Sequence; Biological Transport, Active; Cloning, Molecular; DNA Primers; Drug Resistance, Microbial; Escherichia coli; Genes, Bacterial; Humans; Molecular Sequence Data; Mycobacterium; Mycobacterium avium Complex; Pyrazinamide; Sequence Homology, Amino Acid; Species Specificity | 1997 |
Reduced pyrazinamidase activity and the natural resistance of Mycobacterium kansasii to the antituberculosis drug pyrazinamide.
Topics: Amidohydrolases; Amino Acid Sequence; Antitubercular Agents; Blotting, Southern; Cloning, Molecular; Drug Resistance, Microbial; Microbial Sensitivity Tests; Molecular Sequence Data; Mycobacterium avium; Mycobacterium kansasii; Nicotinamidase; Pyrazinamide; Transformation, Bacterial | 1999 |
Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide.
Topics: Amidohydrolases; Antitubercular Agents; Biological Transport; Drug Resistance, Microbial; Hydrogen-Ion Concentration; Mycobacterium smegmatis; Mycobacterium tuberculosis; Pyrazinamide | 1999 |
Functional analysis and molecular modeling of a cloned urate transporter/channel.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cattle; Cloning, Molecular; Lipid Bilayers; Models, Molecular; Molecular Sequence Data; Organic Anion Transporters; Oxonic Acid; Pyrazinamide; Rats; Receptors, Purinergic P1; Sequence Homology, Amino Acid; Structure-Activity Relationship; Urate Oxidase; Uric Acid; Xanthine | 1999 |
Mechanism of the uricosuric action of E3040, a drug used to treat inflammatory bowel disease II: study using DBA/2N mice.
Topics: Animals; Benzothiazoles; Gastrointestinal Agents; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred DBA; Pyrazinamide; Pyridines; Thiazoles; Uric Acid; Uricosuric Agents | 1999 |
Novel regioselective hydroxylations of pyridine carboxylic acids at position C2 and pyrazine carboxylic acids at position C3.
Topics: Biotransformation; Carboxylic Acids; Culture Media; Gram-Negative Aerobic Rods and Cocci; Hydroxylation; Niacin; Nicotinic Acids; Pyrazinamide; Pyridines; Spectrophotometry, Ultraviolet; Time Factors | 2000 |
Lipid biochemistry takes a stand against tuberculosis.
Topics: Acetyltransferases; Antitubercular Agents; Bacterial Proteins; Drug Therapy, Combination; Fatty Acid Synthase, Type II; Fatty Acid Synthases; Humans; Isoniazid; Multienzyme Complexes; Prodrugs; Pyrazinamide; Tuberculosis, Pulmonary | 2000 |
Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis.
Topics: Animals; Antitubercular Agents; Bacterial Proteins; Enzyme Inhibitors; Fatty Acid Synthases; Humans; Mycobacterium tuberculosis; Prodrugs; Pyrazinamide; Tuberculosis, Pulmonary | 2000 |
Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Combinatorial Chemistry Techniques; Disease Models, Animal; Excitatory Amino Acid Antagonists; Imidazoles; Inhibitory Concentration 50; Male; Mice; Oocytes; Pyrazinamide; Pyrazines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship | 2001 |
Correlation of pncA sequence with pyrazinamide resistance level in BACTEC for 21 mycobacterium tuberculosis clinical isolates.
Topics: Amidohydrolases; Antitubercular Agents; Biomarkers; Drug Resistance, Microbial; Humans; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Prodrugs; Pyrazinamide | 2000 |
Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide.
Topics: Antitubercular Agents; Cell Survival; Colony Count, Microbial; Culture Media; Drug Interactions; Drug Resistance, Bacterial; Humans; Hydrogen-Ion Concentration; Ionophores; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide; Reserpine; Serum Albumin, Bovine; Time Factors; Tuberculosis; Valinomycin | 2002 |
Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.
Topics: Antitubercular Agents; Bacterial Proteins; Fatty Acid Synthases; Fatty Acids; Hydrogen-Ion Concentration; Mycobacterium tuberculosis; Pyrazinamide | 2002 |
Functional analysis and molecular model of the human urate transporter/channel, hUAT.
Topics: Adenosine; Amino Acid Sequence; Binding Sites; Biological Transport; Carrier Proteins; Glucose; Glycophorins; Humans; Ion Channel Gating; Lactose; Membrane Potentials; Models, Molecular; Molecular Sequence Data; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Protein Structure, Tertiary; Pyrazinamide; Ribose; Urate Oxidase | 2002 |
Escherichia coli genes involved in resistance to pyrazinoic acid, the active component of the tuberculosis drug pyrazinamide.
Topics: Amidohydrolases; Antitubercular Agents; Cloning, Molecular; Culture Media; DNA Transposable Elements; Drug Resistance, Microbial; Escherichia coli; Genes, Bacterial; Mutation; Mycobacterium tuberculosis; Nicotinamidase; Pyrazinamide; Transformation, Bacterial | 2002 |
Investigation of the effects of concomitant caffeine administration on the metabolic disposition of pyrazinamide in rats.
Topics: Animals; Antitubercular Agents; Caffeine; Drug Interactions; Female; Pyrazinamide; Rats; Rats, Sprague-Dawley; Urination | 2002 |
Growth-promoting activity of pyrazinoic acid, a putative active compound of antituberculosis drug pyrazinamide, in niacin-deficient rats through the inhibition of ACMSD activity.
Topics: Animals; Antitubercular Agents; Carboxy-Lyases; Diet; Eating; Injections, Intraperitoneal; Kidney; Kynurenic Acid; Liver; Male; NAD; Niacin; Pyrazinamide; Rats; Rats, Wistar; Tryptophan; Weight Gain; Xanthurenates | 2002 |
Urate transport via human PAH transporter hOAT1 and its gene structure.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Biological Transport; Blotting, Western; Carbon Radioisotopes; Cell Line; Cloning, Molecular; Exons; Female; Gene Library; Gout; Humans; Kidney; Kidney Diseases; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Probenecid; Protein Structure, Tertiary; Pyrazinamide; Sodium Salicylate; Uric Acid; Uricosuric Agents | 2003 |
Augmentation of H2 photoproduction in Rhodopseudomonas palustris by N-heterocyclic aromatic compounds.
Topics: Acetylene; Bacteria; Heterocyclic Compounds; Hydrocarbons, Aromatic; Hydrogen; Picolines; Pyrazinamide; Quality Control; Rhodopseudomonas | 2003 |
[Activity of pyrazinamide (pyrazine-2-carboxylic acid amide) in experimental tuberculosis of the cavy].
Topics: Amides; Guinea Pigs; Niacin; Nicotinic Acids; Pyrazinamide; Tuberculosis | 1956 |
[Research on the metabolic fate of pyrazinamide; pyrazinoic acid formation by liver homogenates in vitro].
Topics: In Vitro Techniques; Liver; Niacin; Nicotinic Acids; Pyrazinamide; Research | 1957 |
Effect of pyrazinamide and pyrazinoic acid on urate clearance and other discrete renal functions.
Topics: Humans; Kidney Function Tests; Niacin; Nicotinic Acids; Pyrazinamide; Uric Acid; Urinary Tract Physiological Phenomena | 1957 |
[Basic derivatives of pyrazine-2-carboxylic acid with antimycobacterial action. Microbiological and pharmacological study].
Topics: Anti-Bacterial Agents; Humans; Pyrazinamide; Tuberculosis | 1962 |
[Experimental and clinical research on the antitubercular activity of the N-(4-morpholinomethyl)-amide of pyrazinecarboxylic acid].
Topics: Amides; Antitubercular Agents; Humans; Pyrazinamide; Tuberculosis | 1962 |
[N-OXIDES OF 2-PYRAZINECARBOXYLIC ACID].
Topics: Chemistry, Pharmaceutical; Oxides; Pyrazinamide; Pyrazines; Research | 1964 |
[Studies on the synthesis of pyrazinoic acid derivatives. II. Derivatives of 3-aminopyrazinoic acid].
Topics: Pyrazinamide | 1961 |
Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid.
Topics: Antitubercular Agents; Azides; Dicyclohexylcarbodiimide; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Mycobacterium tuberculosis; Pyrazinamide; Rotenone | 2003 |
Iron enhances the antituberculous activity of pyrazinamide.
Topics: Antitubercular Agents; Calcium; Culture Media; Drug Synergism; Hydrogen-Ion Concentration; Iron; Magnesium; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide; Zinc | 2004 |
Pyrazinoic acid amide; an agent active against experimental murine tuberculosis.
Topics: Amides; Animals; Humans; Mice; Niacin; Nicotinic Acids; Pyrazinamide; Tuberculosis | 1952 |
A mixed matrix of 3-hydroxypicolinic acid and pyrazinecarboxylic acid for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of oligodeoxynucleotides.
Topics: Base Sequence; DNA; Molecular Sequence Data; Oligodeoxyribonucleotides; Picolinic Acids; Pyrazinamide; Reproducibility of Results; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
Anaerobic incubation conditions enhance pyrazinamide activity against Mycobacterium tuberculosis.
Topics: Adenosine Triphosphatases; Anaerobiosis; Antitubercular Agents; Colony Count, Microbial; Electron Transport; Energy Metabolism; Enzyme Inhibitors; Isoniazid; Mycobacterium tuberculosis; Nitrates; Oxygen; Pyrazinamide; Rifampin | 2004 |
Phenolsulfonphthalein transport by potential-sensitive urate transport system.
Topics: Animals; Biological Transport; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Membrane; Chlorides; Dose-Response Relationship, Drug; Ionophores; Kidney; Male; Mannitol; Membrane Potentials; Microvilli; Phenolsulfonphthalein; Potassium Chloride; Probenecid; Pyrazinamide; Rats; Rats, Wistar; Time Factors; Uric Acid; Valinomycin | 2005 |
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.
Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Catalytic Domain; Crystallization; Leucine; Mammals; Models, Molecular; Peptides; Phenylalanine; Proteasome Endopeptidase Complex; Protein Structure, Quaternary; Pyrazinamide; Pyrazines; Structure-Activity Relationship; Substrate Specificity; Yeasts | 2006 |
A density functional theory study of the mechanism of free radical generation in the system vanadate/PCA/H2O2.
Topics: Adsorption; Free Radicals; Hydrogen; Hydrogen Peroxide; Kinetics; Models, Molecular; Models, Theoretical; Pyrazinamide; Vanadates; Vanadium | 2005 |
Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Dose-Response Relationship, Drug; Female; Imidazoles; Losartan; Organic Anion Transporters; Organic Cation Transport Proteins; Pyrazinamide; Tetrazoles; Uric Acid; Valine; Valsartan; Xenopus laevis | 2007 |
Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.
Topics: Amides; Animals; Pyrazinamide; Rats; Receptor, Cannabinoid, CB1; Structure-Activity Relationship | 2007 |
Effect of silibinin on the pharmacokinetics of pyrazinamide and pyrazinoic acid in rats.
Topics: Animals; Antioxidants; Antitubercular Agents; Area Under Curve; Bile; Brain; Chromatography, High Pressure Liquid; Half-Life; Liver; Male; Microdialysis; Pyrazinamide; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Silybin; Silymarin; Tissue Distribution | 2007 |
Vibrational spectroscopic studies and ab initio calculations of a substituted amide of pyrazine-2-carboxylic acid--C12H10ClN3O.
Topics: Models, Molecular; Molecular Conformation; Molecular Structure; Pyrazinamide; Spectrophotometry, Infrared; Vibration | 2008 |
Mechanistic implications of the active species involved in the oxidation of hydrocarbons by iron complexes of pyrazine-2-carboxylic acid.
Topics: Catalysis; Electrochemistry; Hydrocarbons; Hydrogen Peroxide; Iron; Molecular Structure; Organometallic Compounds; Oxidation-Reduction; Pyrazinamide; Solutions; Spectrophotometry, Ultraviolet; Time Factors | 2008 |
The identification of orally bioavailable thrombopoietin agonists.
Topics: Administration, Oral; Animals; Benzoates; Biological Availability; Caco-2 Cells; Humans; Hydrazines; Piperidines; Pyrazinamide; Pyrazoles; Pyrimidines; Rats; Receptors, Thrombopoietin | 2009 |
Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats.
Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Drug Induced Liver Injury; Chlorogenic Acid; Coffee; Galactosamine; Interleukin-10; Lipopolysaccharides; Liver Diseases; Male; Niacin; Pyrazinamide; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2009 |
Derivatives of pyrazinecarboxylic acid: 1H, 13C and 15N NMR spectroscopic investigations.
Topics: Carbon Isotopes; Hydrogen; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Pyrazinamide; Stereoisomerism | 2009 |
Lipophilic pyrazinoic acid amide and ester prodrugs stability, activation and activity against M. tuberculosis.
Topics: Amides; Animals; Antitubercular Agents; Buffers; Cell Line; Chromatography, High Pressure Liquid; Drug Stability; Esters; Humans; Hydrolysis; In Vitro Techniques; Indicators and Reagents; Lipids; Liver; Macrophages; Microbial Sensitivity Tests; Mycobacterium smegmatis; Mycobacterium tuberculosis; Phagocytosis; Prodrugs; Pyrazinamide; Rats; Solubility; Solutions; Spectrophotometry, Ultraviolet | 2009 |
QSAR modeling of a set of pyrazinoate esters as antituberculosis prodrugs.
Topics: Algorithms; Antitubercular Agents; Drug Design; Esters; Least-Squares Analysis; Microbial Sensitivity Tests; Models, Molecular; Mycobacterium tuberculosis; Prodrugs; Pyrazinamide; Quantitative Structure-Activity Relationship | 2010 |
Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.
Topics: Animals; Anion Transport Proteins; Benzbromarone; Biological Transport; Epithelial Cells; Female; Humans; Immunohistochemistry; Kidney; Kinetics; Lactates; Male; Microvilli; Oocytes; Pyrazinamide; Rats; Rats, Sprague-Dawley; Rats, Wistar; Uric Acid; Xenopus laevis | 2011 |
Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis.
Topics: Amidohydrolases; Amino Acid Sequence; Antitubercular Agents; Bacterial Proteins; Drug Resistance, Bacterial; Molecular Sequence Data; Mutant Proteins; Mutation; Mycobacterium tuberculosis; Prodrugs; Protein Binding; Protein Biosynthesis; Protein Structure, Tertiary; Pyrazinamide; Ribosomal Proteins; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Transfer | 2011 |
Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity, and cellular ATP levels.
Topics: Adenosine Triphosphate; Antitubercular Agents; Cell Membrane; Mycobacterium bovis; Proton-Motive Force; Pyrazinamide | 2011 |
Microbiology. Pyrazinamide--old TB drug finds new target.
Topics: Antitubercular Agents; Bacterial Proteins; Mycobacterium tuberculosis; Prodrugs; Protein Biosynthesis; Pyrazinamide; Ribosomal Proteins; RNA, Bacterial; RNA, Messenger; RNA, Transfer | 2011 |
Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance.
Topics: Amidohydrolases; Antitubercular Agents; Bacterial Proteins; Drug Resistance, Bacterial; Humans; Membrane Transport Proteins; Mutation; Mycobacterium tuberculosis; Public Health; Pyrazinamide | 2012 |
Patterns of pncA mutations in drug-resistant Mycobacterium tuberculosis isolated from patients in South Korea.
Topics: Adult; Amidohydrolases; Antitubercular Agents; Bacterial Proteins; Base Sequence; DNA Mutational Analysis; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tuberculosis; Female; Genotype; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Molecular Sequence Data; Mutation; Mycobacterium tuberculosis; Phenotype; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; Pyrazinamide; Republic of Korea; Tuberculosis, Multidrug-Resistant | 2012 |
A new approach for pyrazinamide susceptibility testing in Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Biological Transport; Biotransformation; Drug Resistance, Bacterial; Humans; Kinetics; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide; Regression Analysis; Reproducibility of Results; Sensitivity and Specificity; Tuberculosis, Pulmonary | 2012 |
Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate.
Topics: Animals; Benzbromarone; Cells, Cultured; Dogs; Fluorescent Antibody Technique; Glucose Transport Proteins, Facilitative; Humans; Kidney; Lactic Acid; Madin Darby Canine Kidney Cells; Niacin; Oocytes; Organic Anion Transporters; Organic Cation Transport Proteins; Pyrazinamide; Uric Acid; Uricosuric Agents; Vasodilator Agents; Xenopus laevis | 2013 |
Mycobacterium canettii is intrinsically resistant to both pyrazinamide and pyrazinoic acid.
Topics: Amidohydrolases; Antitubercular Agents; Drug Resistance, Bacterial; Genes, Bacterial; Microbial Sensitivity Tests; Mutation; Mycobacterium; Pyrazinamide; Ribosomal Proteins | 2013 |
A new binuclear oxovanadium(V) complex as a catalyst in combination with pyrazinecarboxylic acid (PCA) for efficient alkane oxygenation by H2O2.
Topics: Alkanes; Catalysis; Hydrogen Peroxide; Hydroxyl Radical; Molecular Structure; Organometallic Compounds; Oxidation-Reduction; Oxygen; Pyrazinamide; Vanadium | 2013 |
pncA gene expression and prediction factors on pyrazinamide resistance in Mycobacterium tuberculosis.
Topics: Amidohydrolases; Antitubercular Agents; Drug Resistance, Bacterial; Genes, Bacterial; Humans; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Promoter Regions, Genetic; Pyrazinamide; RNA, Bacterial; RNA, Messenger | 2013 |
Salicylanilide pyrazinoates inhibit in vitro multidrug-resistant Mycobacterium tuberculosis strains, atypical mycobacteria and isocitrate lyase.
Topics: Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Isocitrate Lyase; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nontuberculous Mycobacteria; Pyrazinamide; Salicylanilides | 2014 |
Biochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamide.
Topics: Enzyme Inhibitors; Kinetics; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mutation; Mycobacterium tuberculosis; Pentosyltransferases; Protein Conformation; Pyrazinamide; Quinolinic Acid | 2014 |
Pantothenate and pantetheine antagonize the antitubercular activity of pyrazinamide.
Topics: Antitubercular Agents; beta-Alanine; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Niacinamide; Pantetheine; Pantothenic Acid; Pyrazinamide | 2014 |
Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide.
Topics: Antitubercular Agents; Crystallography, X-Ray; Microbial Sensitivity Tests; Molecular Structure; Mutation; Mycobacterium tuberculosis; Protein Structure, Tertiary; Pyrazinamide; Ribosomal Proteins; RNA, Bacterial; Sequence Alignment; Thermodynamics | 2015 |
Spray Dried Aerosol Particles of Pyrazinoic Acid Salts for Tuberculosis Therapy. [Corrected].
Topics: Administration, Inhalation; Antitubercular Agents; Desiccation; Dry Powder Inhalers; Humans; Nanoparticles; Nasal Sprays; Particle Size; Powder Diffraction; Pyrazinamide; Salts; Tuberculosis; X-Ray Diffraction | 2015 |
Uncoupling Environmental pH and Intrabacterial Acidification from Pyrazinamide Susceptibility in Mycobacterium tuberculosis.
Topics: Amidohydrolases; Antitubercular Agents; Drug Resistance, Bacterial; Gene Expression; Genes, Reporter; Green Fluorescent Proteins; Hydrazones; Hydrogen-Ion Concentration; Microbial Sensitivity Tests; Monensin; Mycobacterium tuberculosis; Proton Ionophores; Protons; Pyrazinamide | 2015 |
Esters of Pyrazinoic Acid Are Active against Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Other Naturally Resistant Mycobacteria In Vitro and Ex Vivo within Macrophages.
Topics: Alcohols; Antitubercular Agents; Cell Line; Cell Survival; Drug Resistance, Bacterial; Esters; Humans; Macrophages; Microbial Sensitivity Tests; Moraxella bovis; Mycobacterium; Mycobacterium avium Complex; Mycobacterium tuberculosis; Prodrugs; Pyrazinamide | 2015 |
An improved LC-MS/MS method for the simultaneous determination of pyrazinamide, pyrazinoic acid and 5-hydroxy pyrazinoic acid in human plasma for a pharmacokinetic study.
Topics: Calibration; Chromatography, Liquid; Humans; Pyrazinamide; Quality Control; Reference Standards; Tandem Mass Spectrometry | 2016 |
A dry powder combination of pyrazinoic acid and its n-propyl ester for aerosol administration to animals.
Topics: Administration, Inhalation; Administration, Intranasal; Animals; Drug Combinations; Drug Compounding; Dry Powder Inhalers; Particle Size; Powders; Pyrazinamide | 2016 |
High Systemic Exposure of Pyrazinoic Acid Has Limited Antituberculosis Activity in Murine and Rabbit Models of Tuberculosis.
Topics: Animals; Antitubercular Agents; Female; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide; Rabbits; Tuberculosis | 2016 |
Inhaled Pyrazinoic Acid Esters for the Treatment of Tuberculosis.
Topics: Administration, Inhalation; Aerosols; Animals; Antitubercular Agents; Esters; Guinea Pigs; Male; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide; Treatment Outcome; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2016 |
(1)H, (15)N, (13)C resonance assignments for pyrazinoic acid binding domain of ribosomal protein S1 from Mycobacterium tuberculosis.
Topics: Bacterial Proteins; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular; Protein Domains; Pyrazinamide; Ribosomal Proteins | 2016 |
Nano optical sensor binuclear Pt-2-pyrazinecarboxylic acid -bipyridine for enhancement of the efficiency of 3-nitrotyrosine biomarker for early diagnosis of liver cirrhosis with minimal hepatic encephalopathy.
Topics: Adult; Biomarkers; Early Diagnosis; Equipment Design; Equipment Failure Analysis; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Luminescent Measurements; Male; Middle Aged; Optical Devices; Platinum; Pyrazinamide; Reproducibility of Results; Sensitivity and Specificity; Transducers; Tyrosine | 2016 |
Antimycobacterial activity of pyrazinoate prodrugs in replicating and non-replicating Mycobacterium tuberculosis.
Topics: Animals; Antitubercular Agents; Cell Proliferation; Chlorocebus aethiops; Dose-Response Relationship, Drug; Esters; Inhibitory Concentration 50; Microbial Sensitivity Tests; Microbial Viability; Molecular Structure; Mycobacterium tuberculosis; Prodrugs; Pyrazinamide; Structure-Activity Relationship; Vero Cells | 2016 |
A quantitative adaptation of the Wayne test for pyrazinamide resistance.
Topics: Adult; Antitubercular Agents; Area Under Curve; Calibration; Drug Resistance, Bacterial; Female; Humans; Male; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Predictive Value of Tests; Pyrazinamide; Reference Standards; Reproducibility of Results; ROC Curve; Spectrophotometry; Sputum; Tuberculosis, Pulmonary | 2016 |
Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Mutation; Mutation, Missense; Mycobacterium tuberculosis; Pyrazinamide | 2017 |
In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.
Topics: Animals; Antitubercular Agents; Bacterial Proteins; Carboxy-Lyases; Culture Media; Disease Models, Animal; Drug Resistance, Bacterial; Female; Gene Expression; Genome, Bacterial; Heat-Shock Proteins; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mutation, Missense; Mycobacterium tuberculosis; Polyketide Synthases; Pyrazinamide; Selection, Genetic; Sequence Analysis, DNA; Tuberculosis | 2017 |
Ameliorative effects of pyrazinoic acid against oxidative and metabolic stress manifested in rats with dimethylhydrazine induced colonic carcinoma.
Topics: Animals; Apoptosis; Carcinoma; Cell Proliferation; Colonic Neoplasms; Dimethylhydrazines; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Oxidative Stress; Pyrazinamide; Rats; Stress, Physiological | 2017 |
Metabolomics approach discriminates toxicity index of pyrazinamide and its metabolic products, pyrazinoic acid and 5-hydroxy pyrazinoic acid.
Topics: Administration, Oral; Animals; Antitubercular Agents; Biomarkers; Biotransformation; Chemical and Drug Induced Liver Injury; Liver; Male; Metabolomics; Microscopy, Electron, Scanning; Multivariate Analysis; Oxidative Stress; Proton Magnetic Resonance Spectroscopy; Pyrazinamide; Rats, Wistar; Risk Assessment; Time Factors; Toxicity Tests | 2018 |
Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Chromatography, High Pressure Liquid; DNA, Single-Stranded; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide; Pyrophosphatases | 2017 |
Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes.
Topics: Aldehydes; Animals; Anti-Bacterial Agents; Antiparasitic Agents; CHO Cells; Coordination Complexes; Cricetulus; Ferrous Compounds; Humans; Iridium; Isoniazid; Isonicotinic Acids; Metallocenes; Mycobacterium tuberculosis; Plasmodium falciparum; Pyrazinamide; Rhodium; Ruthenium; Trichomonas vaginalis | 2017 |
Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD.
Topics: Antitubercular Agents; Binding Sites; Carbon; Carboxy-Lyases; Coenzyme A; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Models, Molecular; Mycobacterium bovis; Mycobacterium tuberculosis; NAD; Protein Binding; Protein Conformation; Pyrazinamide | 2017 |
'Happy the man, who, studying nature's laws, Thro' known effects can trace the secret cause.' Do we have enough pieces to solve the pyrazinamide puzzle?
Topics: Drug Resistance, Bacterial; Humans; Hydrogen-Ion Concentration; Mycobacterium tuberculosis; Pyrazinamide | 2018 |
Identification of Novel Mutations in LprG (
Topics: Antitubercular Agents; Bacterial Proteins; Drug Resistance, Bacterial; Lipoproteins; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide | 2018 |
Efficacy of pyrazinoic acid dry powder aerosols in resolving necrotic and non-necrotic granulomas in a guinea pig model of tuberculosis.
Topics: Aerosols; Animals; Antitubercular Agents; Bacterial Load; Disease Models, Animal; Drug Therapy, Combination; Dry Powder Inhalers; Granuloma, Respiratory Tract; Guinea Pigs; Male; Mycobacterium tuberculosis; Necrosis; Pyrazinamide; Respiratory Tract Absorption; Rifampin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2018 |
Pyrazinoates as antiparasitic agents against Trypanosoma cruzi.
Topics: Antiparasitic Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; HeLa Cells; Humans; Molecular Structure; Parasitic Sensitivity Tests; Pyrazinamide; Structure-Activity Relationship; THP-1 Cells; Trypanosoma cruzi | 2018 |
A simplified pyrazinamidase test for pyrazinamide drug susceptibility in Mycobacterium tuberculosis.
Topics: Amidohydrolases; Antitubercular Agents; Culture Media; Diagnostic Tests, Routine; Drug Resistance, Bacterial; Enzyme Assays; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide; Sensitivity and Specificity | 2018 |
Population Pharmacokinetic Modelling of Pyrazinamide and Pyrazinoic Acid in Patients with Multi-Drug Resistant Tuberculosis.
Topics: Adolescent; Adult; Antitubercular Agents; Chromatography, Liquid; Female; Humans; Male; Middle Aged; Pyrazinamide; Tandem Mass Spectrometry; Tuberculosis, Multidrug-Resistant; Young Adult | 2019 |
Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan.
Topics: Adolescent; Adult; Aged; Amidohydrolases; Antitubercular Agents; Child; Drug Resistance, Bacterial; Humans; Microbial Sensitivity Tests; Middle Aged; Mutation; Mycobacterium tuberculosis; Pakistan; Pyrazinamide; Sensitivity and Specificity; Sequence Analysis, DNA; Tuberculosis | 2019 |
Alkylpyrazines from Coffee are Extensively Metabolized to Pyrazine Carboxylic Acids in the Human Body.
Topics: Adult; Carboxylic Acids; Chromatography, High Pressure Liquid; Coffee; Female; Healthy Volunteers; Humans; Male; Pyrazinamide; Pyrazines; Spectrometry, Mass, Electrospray Ionization | 2019 |
Metallochaperones Are Needed for Mycobacterium tuberculosis and Escherichia coli Nicotinamidase-Pyrazinamidase Activity.
Topics: Antitubercular Agents; Drug Resistance, Bacterial; Escherichia coli; Metallochaperones; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nicotinamidase; Pyrazinamide | 2020 |
The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD.
Topics: Amidohydrolases; Antitubercular Agents; Bacterial Proteins; Carboxy-Lyases; Crystallography, X-Ray; Drug Resistance, Bacterial; Hydrogen Bonding; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Mutation; Mycobacterium tuberculosis; Pyrazinamide; Tuberculosis | 2020 |
Pyrazinamide triggers degradation of its target aspartate decarboxylase.
Topics: Antitubercular Agents; Bacterial Proteins; Carboxy-Lyases; Drug Resistance, Bacterial; Endopeptidase Clp; Heat-Shock Proteins; Humans; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Proteolysis; Pyrazinamide; Tuberculosis | 2020 |
Mycobacterium tuberculosis ribosomal protein S1 (RpsA) and variants with truncated C-terminal end show absence of interaction with pyrazinoic acid.
Topics: Antitubercular Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tuberculosis; Humans; Mutation; Mycobacterium tuberculosis; Pyrazinamide; Ribosomal Proteins; RNA, Bacterial | 2020 |
Pentacyanoferrate(II) complex of pyridine-4- and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities.
Topics: Amidohydrolases; Antitubercular Agents; Coordination Complexes; Drug Discovery; Electron Spin Resonance Spectroscopy; Ferrous Compounds; Hydrogen Peroxide; Hydroxamic Acids; Iron; Ligands; Mycobacterium tuberculosis; Nitrogen Oxides; Oxidation-Reduction; Pyrazinamide; Vasodilation | 2020 |
Assessment of the Physicochemical Properties and Stability for Pharmacokinetic Prediction of Pyrazinoic Acid Derivatives.
Topics: 1-Octanol; Animals; Cell Line; Drug Stability; Humans; Hydrogen-Ion Concentration; Microsomes, Liver; Permeability; Pyrazinamide; Rats; Water | 2020 |
Evaluation and Docking Study of Pyrazine Containing 1, 3, 4-Oxadiazoles Clubbed with Substituted Azetidin-2-one: A New Class of Potential Antimicrobial and Antitubercular.
Topics: Antifungal Agents; Antitubercular Agents; Aspergillus niger; Azetidines; Candida albicans; Drug Evaluation, Preclinical; Humans; Microbial Sensitivity Tests; Molecular Docking Simulation; Mycobacterium tuberculosis; Mycoses; Oxadiazoles; Pyrazinamide; Tuberculosis | 2021 |
The Acid-Base Equilibrium of Pyrazinoic Acid Drives the pH Dependence of Pyrazinamide-Induced
Topics: Acid-Base Equilibrium; Antitubercular Agents; Mycobacterium tuberculosis; Pyrazinamide | 2020 |
Immunological detection of pyrazine-2-carboxylic acid for the detection of pyrazinamide resistance in Mycobacterium tuberculosis.
Topics: Animals; Antibodies; Antitubercular Agents; Drug Resistance, Bacterial; Enzyme-Linked Immunosorbent Assay; Immunoconjugates; Inhibitory Concentration 50; Mycobacterium tuberculosis; Pyrazinamide; Rabbits; Serum Albumin, Bovine; Toxicity Tests | 2020 |
Characterization of Thorium-Pyrazinoic acid complexation and its decorporation efficacy in human cells and blood.
Topics: Animals; Chelating Agents; Humans; Pyrazinamide; Thermodynamics; Thorium | 2021 |
Cephem-Pyrazinoic Acid Conjugates: Circumventing Resistance in Mycobacterium tuberculosis.
Topics: Antitubercular Agents; beta-Lactams; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide; Tuberculosis | 2022 |
Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.
Topics: Amidohydrolases; Antitubercular Agents; Carboxylic Acids; Drug Resistance, Bacterial; Humans; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Pyrazinamide; Structure-Activity Relationship; Tuberculosis | 2022 |
Prussian blue (PB) modified gold nanoparticles as a SERS-based sensing platform for capturing and detection of pyrazinoic acid (POA).
Topics: Drug Resistance, Bacterial; Gold; Metal Nanoparticles; Microbial Sensitivity Tests; Pyrazinamide | 2024 |