Compounds > pyrazines
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pyrazines and zaprinast

pyrazines has been researched along with zaprinast in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's9 (90.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Burns, F; Pyne, NJ2
Barnette, MS; Barone, FC; Fowler, PJ; Grous, M; Ormsbee, HS; Price, WJ1
Diocee, BK; Martin, W; Moodie, SA; Souness, JE1
Barnette, MS; Grous, M; Ormsbee, HS; Torphy, TJ1
Brown, AM; Hill, SJ; Stanley, C1
Barnette, M; Grous, M1
Dent, G; Liebig, S; Magnussen, H; Rabe, KF; Schudt, C; Tenor, H1
Hellewell, PG; Rossi, AG; Teixeira, MM; Williams, TJ1
Furman, BL; Pyne, NJ; Shafiee-Nick, R1

Other Studies

10 other study(ies) available for pyrazines and zaprinast

ArticleYear
Interaction of the catalytic subunit of protein kinase A with the lung type V cyclic GMP phosphodiesterase: modulation of non-catalytic binding sites.
    Biochemical and biophysical research communications, 1992, Dec-30, Volume: 189, Issue:3

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaline Phosphatase; Animals; Cyclic GMP; Enzyme Activation; Guinea Pigs; Isoenzymes; Kinetics; Lung; Macromolecular Substances; Protein Kinases; Purinones; Pyrazines; Pyrrolidinones; Rolipram

1992
Human lower oesophageal sphincter relaxation is associated with raised cyclic nucleotide content.
    Gut, 1991, Volume: 32, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cyclic AMP; Cyclic GMP; Electric Stimulation; Esophagogastric Junction; Humans; In Vitro Techniques; Muscle Relaxation; Nitroprusside; Nucleotides, Cyclic; Purinones; Pyrazines; Tetrodotoxin

1991
Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells.
    The Biochemical journal, 1990, Feb-15, Volume: 266, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Calcium; Cells, Cultured; Chromatography, Ion Exchange; Colforsin; Cyclic AMP; Cyclic GMP; Dipyridamole; Endothelium, Vascular; Isoquinolines; Kinetics; Purinones; Pyrazines; Pyrrolidinones; Rolipram; Swine; Tetrahydroisoquinolines

1990
Activation of cyclic AMP-dependent protein kinase during canine lower esophageal sphincter relaxation.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiotonic Agents; Dogs; Electric Stimulation; Enzyme Activation; Esophagogastric Junction; Female; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Protein Kinases; Purinones; Pyrazines

1990
Effect of isozyme-selective inhibitors of phosphodiesterase on histamine-stimulated cyclic AMP accumulation in guinea-pig hippocampus.
    Journal of neurochemistry, 1989, Volume: 52, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cerebral Cortex; Cyclic AMP; Female; Guinea Pigs; Hippocampus; Histamine; Isoenzymes; Male; Purinones; Pyrazines; Pyrrolidinones; Rolipram

1989
Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle.
    British journal of pharmacology, 1994, Volume: 111, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antigens; Colon; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Immunization; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyrrolidinones; Rolipram

1994
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
    The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoenzymes; Lung; Lung Neoplasms; Male; Middle Aged; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitroprusside; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rolipram; Vital Capacity

1993
Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig.
    British journal of pharmacology, 1994, Volume: 112, Issue:1

    Topics: Animals; Calmodulin; Cardiotonic Agents; Dermatitis; Edema; Eosinophils; Female; Guinea Pigs; In Vitro Techniques; Indium Radioisotopes; Isoenzymes; Male; Neutrophils; Passive Cutaneous Anaphylaxis; Phosphodiesterase Inhibitors; Purinones; Pyrazines; Pyrrolidinones; Rolipram; Skin

1994
Lung phosphodiesterase isoenzymes.
    Agents and actions. Supplements, 1993, Volume: 43

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Catalysis; Enzyme Activation; Guinea Pigs; Isoenzymes; Lung; Muscle, Smooth; Perfusion; Phosphoric Diester Hydrolases; Purinones; Pyrazines

1993
Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity.
    British journal of pharmacology, 1995, Volume: 115, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Thiophenes

1995