pyrazines has been researched along with urea in 43 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 20 (46.51) | 18.7374 |
1990's | 5 (11.63) | 18.2507 |
2000's | 11 (25.58) | 29.6817 |
2010's | 7 (16.28) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Foks, H; Janowiec, M | 1 |
Beyer, KH; Gelarden, RT; Vesell, ES | 1 |
Beyer, KH; Brown, LE; Gelarden, RT; Vary, JE; Vesell, ES | 1 |
Beyer, KH; Gelarden, RT | 1 |
Breckenridge, AM; Dollery, CT; George, CF | 1 |
Ford, EJ | 1 |
Beevers, DG; Brown, JJ; Davies, DL; Ferriss, JB; Fraser, R; Kremer, D; Lever, AF; Robertson, JI | 1 |
Degaute, JP; Demanet, JC; Fichefet, JP; Hubert, C; Paduart, P | 1 |
Kennedy, RD; MacFarlane, JP | 1 |
Brown, JJ; Davies, DL; Fraser, R; Kremer, D; Lever, AF; Robertson, JI | 1 |
Davidson, C; Gillebrand, IM | 1 |
Falase, AO; Salako, LA | 1 |
Naidoo, DN; Seedat, YK | 1 |
Antcliff, AC; Beevers, DG; Hamilton, M; Harpur, JE | 1 |
Hohenegger, M; Marktl, W; Selzer, H | 1 |
Irvine, RO; McKean, WI | 1 |
Capuzzi, R; Cohen, E; Hanifin, JW | 1 |
Avron, M; Hayyim, GB | 1 |
Accietto, F; Fedeli, G; Fenici, R; Ghirlanda, G; Greco, AV; Lucente, M | 1 |
Bolzano, K; Krempler, F; Sandhofer, F | 1 |
Eggena, P; Gibas, A | 1 |
Drayer, JI; Hoefnagels, WH; Kloppenborg, PW; Smals, AG | 1 |
Dytko, G; Kinter, LB; Smith, PL | 1 |
Beyer, KH; Gelarden, RT; Knutson, DW; Vary, JE; Vesell, ES; Ward, TD | 1 |
Fuller, RW; Hemrick-Luecke, SK | 1 |
Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
Christiansen, JS; Hartmund, T; Jørgensen, JO; Møller, N; Nair, KS; Nielsen, S; Nørrelund, H | 1 |
Christiansen, JS; Frystyk, J; Ivarsen, P; Jørgensen, JO; Møller, N; Nair, KS; Nielsen, S; Nørrelund, H | 1 |
Chen, Z; Credo, RB; Gwaltney, SL; Hasvold, LA; Kovar, P; Li, G; Lin, NH; Park, C; Patel, J; Rosenberg, SH; Sham, HL; Sowin, T; Tao, ZF; Wang, GT; Zhang, H | 1 |
Böhmer, V; Broda, F; Thondorf, I; Vysotsky, MO | 1 |
Christiansen, JS; Gjedde, S; Gjedsted, J; Gormsen, LC; Jørgensen, JO; Møller, N; Nørrelund, H; Schmitz, O | 1 |
Al-Moundhri, M; Al-Siyabi, S; Ali, BH; Annamalai, K; Eldin, MT; Nemmar, A | 1 |
Gilmour, BP; Navarro, HA; Runyon, SP; Zhang, Y | 1 |
Al-Husseini, I; Al-Salam, S; Ali, BH; Nemmar, A | 1 |
Cas, LD; Cotter, G; Gheorghiade, M; Metra, M; Sabbah, HN; Teerlink, JR; Zacà, V | 1 |
Blomgren, PA; Bourret, A; Brittelli, DR; Currie, KS; Danca, MD; Darrow, JW; DeSimone, RW; Elkin, LL; Eustice, DC; Gallion, SL; Hill-Drzewi, M; Kropf, JE; Lee, SH; Maciejewski, PM; Mitchell, SA; Pippin, DA; Xiong, JM | 1 |
Bölcskei, K; Dézsi, L; Horváth, C; Kis-Varga, A; Petho, G; Szentirmay, E; Szolcsányi, J; Tékus, V; Visegrády, A | 1 |
Bachmann, AS; Ibarra-Rivera, TR; Opoku-Ansah, J; Pirrung, MC | 1 |
de Vries, EG; Fehrmann, RS; Franke, L; Krajewska, M; Labib, S; Schoonen, PM; van Vugt, MA | 1 |
Bach, S; Bazin, MA; Evenou, P; Marchand, P; Marhadour, S; Piessard, S; Roussakis, C; Rousseau, B; Ruchaud, S; Tomasoni, C; Vaisberg, AJ | 1 |
Deng, O; Du, Z; Gao, J; Gorityala, S; Lai, J; Ma, Z; Susana, G; Xiong, X; Xu, Y; Yan, C; Yang, S; Zhang, J; Zhang, Y | 1 |
Hasvold, G; Hauge, S; Joel, M; Juzenas, P; Naucke, C; Rødland, GE; Stokke, T; Syljuåsen, RG | 1 |
Elkamhawy, A; Hassan, AHE; Lee, J; Pae, AN; Paik, S; Park, BG; Park, JE; Roh, EJ | 1 |
1 review(s) available for pyrazines and urea
Article | Year |
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Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond.
Topics: Acute Disease; Cardiotonic Agents; Digoxin; Dobutamine; Etiocholanolone; Exercise Test; Heart Failure; Hemodynamics; Hospitals, Group Practice; Humans; Hydrazones; Prognosis; Pyrazines; Pyridazines; Quinolines; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Simendan; Treatment Outcome; Urea; Vasodilator Agents | 2009 |
7 trial(s) available for pyrazines and urea
Article | Year |
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Novel multivalent effects of pyrazinoylguanidine in patients with azotemia.
Topics: Adult; Aldosterone; Blood Pressure; Clinical Trials as Topic; Creatinine; Electrolytes; Female; Glomerular Filtration Rate; Guanidines; Humans; Male; Middle Aged; Pyrazines; Renin-Angiotensin System; Sodium; Urea; Uremia | 1990 |
Comparison of the potassium- retaining effects of amiloride and spironolactone in hypertensive patients with thiazide-induced hypokalaemia.
Topics: Adult; Aged; Amiloride; Blood Pressure; Body Weight; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle Aged; Pyrazines; Sodium; Spironolactone; Time Factors; Urea | 1973 |
The effects of amiloride during diuretic therapy in elderly subjects.
Topics: Administration, Oral; Aged; Amiloride; Calcium; Clinical Trials as Topic; Diuretics; Drug Combinations; Edema; Female; Humans; Hydrochlorothiazide; Hypokalemia; Male; Potassium; Pyrazines; Sodium; Urea; Uric Acid | 1972 |
Amiloride hydrochloride combined with hydrochlorothiazide in the control of hypertension and plasma potassium levels.
Topics: Alanine Transaminase; Amiloride; Aspartate Aminotransferases; Diuretics; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Pyrazines; Urea; Uric Acid | 1972 |
[A combination of methyldopa, hydrochlorothiazide and amiloride in the treatment of essential hypertension].
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Creatinine; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Placebos; Posture; Pulse; Pyrazines; Urea; Uric Acid | 1984 |
Effects of lowering circulating free fatty acid levels on protein metabolism in adult growth hormone deficient patients.
Topics: Adult; Area Under Curve; Blood Glucose; Dwarfism, Pituitary; Fatty Acids, Nonesterified; Female; Forearm; Growth Hormone; Humans; Hypolipidemic Agents; Lipolysis; Male; Middle Aged; Phenylalanine; Proteins; Pyrazines; Tyrosine; Urea | 2002 |
The decisive role of free fatty acids for protein conservation during fasting in humans with and without growth hormone.
Topics: Adult; Amino Acids; Fasting; Fatty Acids, Nonesterified; Growth Hormone; Heparin; Hormone Antagonists; Human Growth Hormone; Humans; Hypolipidemic Agents; Lipolysis; Male; Microdialysis; Muscle, Skeletal; Phenylalanine; Proteins; Pyrazines; Somatostatin; Triglycerides; Tyrosine; Urea | 2003 |
35 other study(ies) available for pyrazines and urea
Article | Year |
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[Pyrazine derivatives. XI. Synthesis and tuberculostatic activity of derivatives of pyrazineurea and pyrazinethiourea].
Topics: Antitubercular Agents; Chemical Phenomena; Chemistry; Pyrazines; Thiourea; Urea | 1978 |
Inhibition of urea transport across renal tubules by pyrazinoylguanidine and analogs.
Topics: Amiloride; Animals; Biological Transport, Active; Dogs; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Guanidines; Kidney Tubules; Potassium; Pyrazines; Sodium; Structure-Activity Relationship; Urea | 1992 |
Active transport of urea by mammalian kidney.
Topics: Amiloride; Animals; Biological Transport, Active; Diuresis; Dogs; Guanidines; Kidney; Mannitol; Pyrazines; Urea | 1988 |
Activity of gamma-glutamyl transpeptidase and other enzymes in the serum of sheep with liver or kidney damage.
Topics: Alcohol Oxidoreductases; Animals; Arginase; Aspartate Aminotransferases; Bilirubin; Brain; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; gamma-Glutamyltransferase; Glutamate Dehydrogenase; Indoles; Intestine, Small; Kidney; Kidney Diseases; Ligation; Liver; Liver Diseases; Male; Mercury Poisoning; Muscles; Mycotoxins; Myocardium; Pancreas; Pyrazines; Pyrroles; Sheep; Sheep Diseases; Urea | 1974 |
Spironolactone and amiloride in the treatment of low renin hyperaldosteronism and related syndromes.
Topics: Adrenocortical Hyperfunction; Amiloride; Angiotensin II; Body Water; Corticosterone; Diuretics; Extracellular Space; Humans; Hyperaldosteronism; Hypertension; Plasma Volume; Potassium; Pyrazines; Renin; Secretory Rate; Sodium; Spironolactone; Urea | 1973 |
Tolerance and side-effects of the association hydrochlorothiazide-amiloride in long-term treatment of arterial hypertension.
Topics: Adult; Aged; Amiloride; Calcium; Creatinine; Drug Combinations; Drug Tolerance; Humans; Hydrochlorothiazide; Hypercalcemia; Hypertension; Hypocalcemia; Middle Aged; Potassium; Pyrazines; Sodium; Time Factors; Urea; Uric Acid | 1974 |
Amiloride in primary hyperaldosteronism with chronic peptic ulceration.
Topics: Aged; Amiloride; Bicarbonates; Blood Pressure; Body Water; Chlorides; Chronic Disease; Diuretics; Female; Humans; Hyperaldosteronism; Hypertension; Peptic Ulcer; Potassium; Pyrazines; Sodium; Spironolactone; Urea | 1973 |
Use of amiloride as a potassium conserving agent in severe cardiac disease.
Topics: Adult; Aged; Amiloride; Bicarbonates; Chlorides; Diuretics; Female; Furosemide; Heart Diseases; Humans; Male; Middle Aged; Potassium; Pyrazines; Sodium; Time Factors; Urea | 1973 |
A comparison of moduretic and hydrochlorothiazide in the treatment of hypertension in African patients.
Topics: Adult; Aged; Amiloride; Blood Pressure; Diuretics; Electrolytes; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium Chloride; Pyrazines; Urea; Uric Acid | 1973 |
Evaluation of amiloride combined with hydrochlorothiazide (Moduretic) in the treatment of hypertension.
Topics: Adult; Aged; Amiloride; Benzothiadiazines; Diuretics; Drug Combinations; Female; Guanethidine; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Potassium; Propranolol; Pyrazines; Urea; Uremia | 1973 |
Potassium-escape-phenomenon in rats during continuous application of amiloride. 3. Influence of acid and alkali loading.
Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Amiloride; Ammonium Chloride; Animals; Bicarbonates; Diuresis; Diuretics; Hydrogen-Ion Concentration; Male; Nephrectomy; Potassium; Pyrazines; Rats; Rats, Inbred Strains; Sodium; Sodium Chloride; Urea | 1971 |
Evaluation of amiloride combined with hydrochlorothiazide in the treatment of congestive heart failure.
Topics: Aged; Amidines; Body Weight; Diuretics; Drug Synergism; Female; Heart Failure; Humans; Hydrochlorothiazide; Male; Middle Aged; Potassium; Pyrazines; Sodium; Time Factors; Urea | 1970 |
A reinvestigation of the reaction of monosodium urea with various substituted pyrazinecarboxylate esters.
Topics: Chemical Phenomena; Chemistry; Esters; Pyrazines; Sodium; Urea | 1970 |
Cytochrome b of isolated chloroplasts.
Topics: Adenosine Triphosphate; Chloroplasts; Cytochromes; Darkness; Electron Transport; Hydrogen-Ion Concentration; Light; Nitriles; Oxidation-Reduction; Phenylhydrazines; Phlorhizin; Photochemistry; Plants; Pyrazines; Quaternary Ammonium Compounds; Spectrophotometry; Tyrothricin; Uncoupling Agents; Urea | 1970 |
[Clinical experience concerning the action of a new oral antidiabetic drug: glidiazinamide].
Topics: Adult; Aged; Cholesterol; Cyclohexanes; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Lipid Metabolism; Male; Middle Aged; Pyrazines; Sulfones; Urea | 1971 |
Inhibition of urea-linked water flux and [14C]urea transport across the toad bladder by amiloride.
Topics: Amiloride; Animals; Biological Transport, Active; Bufo marinus; Inulin; Osmosis; Permeability; Pyrazines; Urea; Urinary Bladder; Vasopressins; Water | 1981 |
Spironolactone and amiloride in hypertensive patients with and without aldosterone excess.
Topics: Adult; Amiloride; Blood Pressure; Body Weight; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Renin; Spironolactone; Urea | 1980 |
Urea transport in toad skin (Bufo marinus)
Topics: Amiloride; Animals; Arginine Vasopressin; Biological Transport; Bufo marinus; Guanidines; Hydrogen-Ion Concentration; Kinetics; Ouabain; Phloretin; Pyrazines; Skin; Sodium Chloride; Urea; Urinary Bladder | 1993 |
Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency.
Topics: Adult; Aged; Blood Glucose; Cholesterol; Electrolytes; Female; Guanidines; Humans; Hydrochlorothiazide; Male; Middle Aged; Pyrazines; Renal Insufficiency; Single-Blind Method; Triglycerides; Urea | 1993 |
Involvement of 5-HT2A receptors in the elevation of rat serum corticosterone concentrations by quipazine and MK-212.
Topics: Animals; Corticosterone; Fluorobenzenes; Indoles; Male; Piperidines; Pyrazines; Quipazine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Urea | 1996 |
4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Isoquinolines; Mice; Mice, Inbred DBA; Pyrazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles; Urea | 2000 |
Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.
Topics: Antibiotics, Antineoplastic; Cell Cycle; Checkpoint Kinase 1; Crystallography, X-Ray; Doxorubicin; Humans; Inhibitory Concentration 50; Nitriles; Protein Kinase Inhibitors; Protein Kinases; Pyrazines; Tumor Cells, Cultured; Urea | 2006 |
Orientational preferences of aromatic guests in dimeric capsules of tetraurea calix[4]arenes--MD and NMR studies.
Topics: Benzene Derivatives; Binding, Competitive; Calixarenes; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Phenols; Pyrazines; Pyridines; Substrate Specificity; Thermodynamics; Urea | 2006 |
Dose-response effects of free fatty acids on amino acid metabolism and ureagenesis.
Topics: Adult; Dose-Response Relationship, Drug; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Forearm; Glucose Clamp Technique; Heparin; Human Growth Hormone; Humans; Lipid Metabolism; Lipolysis; Male; Phenylalanine; Pyrazines; Somatostatin; Tyrosine; Urea | 2008 |
Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the Chinese herb Ligusticum wallichi.
Topics: Animals; Antineoplastic Agents; Cisplatin; Creatinine; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutathione; Kidney; Ligusticum; Lipid Peroxidation; Male; Necrosis; Pyrazines; Rats; Rats, Wistar; Superoxide Dismutase; Urea | 2008 |
Identifying structural features on 1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones critical for Neuropeptide S antagonist activity.
Topics: Calcium; Carbon; Chemistry, Pharmaceutical; Drug Design; Humans; Kinetics; Models, Chemical; Neuropeptides; Nitrogen; Oxygen; Pyrazines; Structure-Activity Relationship; Urea | 2008 |
Comparative protective effect of N-acetyl cysteine and tetramethylpyrazine in rats with gentamicin nephrotoxicity.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Body Weight; Creatinine; Gentamicins; Kidney Cortex; Male; Protective Agents; Protein Synthesis Inhibitors; Pyrazines; Rats; Rats, Wistar; Urea; Urodynamics | 2009 |
Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4.
Topics: Angiogenesis Inhibitors; Cell Line, Tumor; Humans; Imidazoles; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrazines; Receptor, EphB4; Urea | 2009 |
Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Pain; Pyrazines; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea | 2010 |
Syringolin B-inspired proteasome inhibitor analogue TIR-203 exhibits enhanced biological activity in multiple myeloma and neuroblastoma.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Humans; Multiple Myeloma; Neuroblastoma; Peptides, Cyclic; Proteasome Inhibitors; Pyrazines; Urea | 2012 |
ATR inhibition preferentially targets homologous recombination-deficient tumor cells.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Survival; Checkpoint Kinase 1; Drug Resistance, Neoplasm; HeLa Cells; Homologous Recombination; Humans; MCF-7 Cells; Molecular Targeted Therapy; Neoplasms; Protein Kinases; Pyrazines; Signal Transduction; Sulfones; Thiophenes; Urea | 2015 |
Discovery of Novel (Imidazo[1,2-a]pyrazin-6-yl)ureas as Antiproliferative Agents Targeting P53 in Non-small Cell Lung Cancer Cell Lines.
Topics: Animals; Antineoplastic Agents; BALB 3T3 Cells; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Imidazoles; Lung Neoplasms; Mice; Pyrazines; Tumor Suppressor Protein p53; Urea | 2016 |
Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; DNA Repair; Homologous Recombination; Humans; MCF-7 Cells; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrazines; Radiation Tolerance; Radiation-Sensitizing Agents; Thiophenes; Urea | 2016 |
Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading.
Topics: A549 Cells; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinases; DNA Damage; DNA Replication; Drug Synergism; Flow Cytometry; Humans; Nuclear Proteins; Phenylurea Compounds; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazines; Pyrazoles; Pyrimidines; Pyrimidinones; S Phase; Thiophenes; Urea | 2017 |
Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Hippocampus; Humans; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Models, Molecular; Molecular Structure; Neural Stem Cells; Neuroprotective Agents; Pyrazines; Structure-Activity Relationship; Urea | 2018 |