Page last updated: 2024-08-21

pyrazines and urea

pyrazines has been researched along with urea in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	20 (46.51)	18.7374
1990's	5 (11.63)	18.2507
2000's	11 (25.58)	29.6817
2010's	7 (16.28)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Foks, H; Janowiec, M	1
Beyer, KH; Gelarden, RT; Vesell, ES	1
Beyer, KH; Brown, LE; Gelarden, RT; Vary, JE; Vesell, ES	1
Beyer, KH; Gelarden, RT	1
Breckenridge, AM; Dollery, CT; George, CF	1
Ford, EJ	1
Beevers, DG; Brown, JJ; Davies, DL; Ferriss, JB; Fraser, R; Kremer, D; Lever, AF; Robertson, JI	1
Degaute, JP; Demanet, JC; Fichefet, JP; Hubert, C; Paduart, P	1
Kennedy, RD; MacFarlane, JP	1
Brown, JJ; Davies, DL; Fraser, R; Kremer, D; Lever, AF; Robertson, JI	1
Davidson, C; Gillebrand, IM	1
Falase, AO; Salako, LA	1
Naidoo, DN; Seedat, YK	1
Antcliff, AC; Beevers, DG; Hamilton, M; Harpur, JE	1
Hohenegger, M; Marktl, W; Selzer, H	1
Irvine, RO; McKean, WI	1
Capuzzi, R; Cohen, E; Hanifin, JW	1
Avron, M; Hayyim, GB	1
Accietto, F; Fedeli, G; Fenici, R; Ghirlanda, G; Greco, AV; Lucente, M	1
Bolzano, K; Krempler, F; Sandhofer, F	1
Eggena, P; Gibas, A	1
Drayer, JI; Hoefnagels, WH; Kloppenborg, PW; Smals, AG	1
Dytko, G; Kinter, LB; Smith, PL	1
Beyer, KH; Gelarden, RT; Knutson, DW; Vary, JE; Vesell, ES; Ward, TD	1
Fuller, RW; Hemrick-Luecke, SK	1
Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M	1
Christiansen, JS; Hartmund, T; Jørgensen, JO; Møller, N; Nair, KS; Nielsen, S; Nørrelund, H	1
Christiansen, JS; Frystyk, J; Ivarsen, P; Jørgensen, JO; Møller, N; Nair, KS; Nielsen, S; Nørrelund, H	1
Chen, Z; Credo, RB; Gwaltney, SL; Hasvold, LA; Kovar, P; Li, G; Lin, NH; Park, C; Patel, J; Rosenberg, SH; Sham, HL; Sowin, T; Tao, ZF; Wang, GT; Zhang, H	1
Böhmer, V; Broda, F; Thondorf, I; Vysotsky, MO	1
Christiansen, JS; Gjedde, S; Gjedsted, J; Gormsen, LC; Jørgensen, JO; Møller, N; Nørrelund, H; Schmitz, O	1
Al-Moundhri, M; Al-Siyabi, S; Ali, BH; Annamalai, K; Eldin, MT; Nemmar, A	1
Gilmour, BP; Navarro, HA; Runyon, SP; Zhang, Y	1
Al-Husseini, I; Al-Salam, S; Ali, BH; Nemmar, A	1
Cas, LD; Cotter, G; Gheorghiade, M; Metra, M; Sabbah, HN; Teerlink, JR; Zacà, V	1
Blomgren, PA; Bourret, A; Brittelli, DR; Currie, KS; Danca, MD; Darrow, JW; DeSimone, RW; Elkin, LL; Eustice, DC; Gallion, SL; Hill-Drzewi, M; Kropf, JE; Lee, SH; Maciejewski, PM; Mitchell, SA; Pippin, DA; Xiong, JM	1
Bölcskei, K; Dézsi, L; Horváth, C; Kis-Varga, A; Petho, G; Szentirmay, E; Szolcsányi, J; Tékus, V; Visegrády, A	1
Bachmann, AS; Ibarra-Rivera, TR; Opoku-Ansah, J; Pirrung, MC	1
de Vries, EG; Fehrmann, RS; Franke, L; Krajewska, M; Labib, S; Schoonen, PM; van Vugt, MA	1
Bach, S; Bazin, MA; Evenou, P; Marchand, P; Marhadour, S; Piessard, S; Roussakis, C; Rousseau, B; Ruchaud, S; Tomasoni, C; Vaisberg, AJ	1
Deng, O; Du, Z; Gao, J; Gorityala, S; Lai, J; Ma, Z; Susana, G; Xiong, X; Xu, Y; Yan, C; Yang, S; Zhang, J; Zhang, Y	1
Hasvold, G; Hauge, S; Joel, M; Juzenas, P; Naucke, C; Rødland, GE; Stokke, T; Syljuåsen, RG	1
Elkamhawy, A; Hassan, AHE; Lee, J; Pae, AN; Paik, S; Park, BG; Park, JE; Roh, EJ	1

Reviews

1 review(s) available for pyrazines and urea

Article	Year
Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond. Heart failure reviews, 2009, Volume: 14, Issue:4 Topics: Acute Disease; Cardiotonic Agents; Digoxin; Dobutamine; Etiocholanolone; Exercise Test; Heart Failure; Hemodynamics; Hospitals, Group Practice; Humans; Hydrazones; Prognosis; Pyrazines; Pyridazines; Quinolines; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Simendan; Treatment Outcome; Urea; Vasodilator Agents	2009

Article

Year

Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond.

Heart failure reviews, 2009, Volume: 14, Issue:4

Topics: Acute Disease; Cardiotonic Agents; Digoxin; Dobutamine; Etiocholanolone; Exercise Test; Heart Failure; Hemodynamics; Hospitals, Group Practice; Humans; Hydrazones; Prognosis; Pyrazines; Pyridazines; Quinolines; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Simendan; Treatment Outcome; Urea; Vasodilator Agents

2009

Trials

7 trial(s) available for pyrazines and urea

Article	Year
Novel multivalent effects of pyrazinoylguanidine in patients with azotemia. Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:5 Topics: Adult; Aldosterone; Blood Pressure; Clinical Trials as Topic; Creatinine; Electrolytes; Female; Glomerular Filtration Rate; Guanidines; Humans; Male; Middle Aged; Pyrazines; Renin-Angiotensin System; Sodium; Urea; Uremia	1990
Comparison of the potassium- retaining effects of amiloride and spironolactone in hypertensive patients with thiazide-induced hypokalaemia. Lancet (London, England), 1973, Dec-08, Volume: 2, Issue:7841 Topics: Adult; Aged; Amiloride; Blood Pressure; Body Weight; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle Aged; Pyrazines; Sodium; Spironolactone; Time Factors; Urea	1973
The effects of amiloride during diuretic therapy in elderly subjects. Age and ageing, 1972, Volume: 1, Issue:2 Topics: Administration, Oral; Aged; Amiloride; Calcium; Clinical Trials as Topic; Diuretics; Drug Combinations; Edema; Female; Humans; Hydrochlorothiazide; Hypokalemia; Male; Potassium; Pyrazines; Sodium; Urea; Uric Acid	1972
Amiloride hydrochloride combined with hydrochlorothiazide in the control of hypertension and plasma potassium levels. The British journal of clinical practice, 1972, Volume: 26, Issue:9 Topics: Alanine Transaminase; Amiloride; Aspartate Aminotransferases; Diuretics; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Pyrazines; Urea; Uric Acid	1972
[A combination of methyldopa, hydrochlorothiazide and amiloride in the treatment of essential hypertension]. Acta medica Austriaca, 1984, Volume: 11, Issue:2 Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Creatinine; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Placebos; Posture; Pulse; Pyrazines; Urea; Uric Acid	1984
Effects of lowering circulating free fatty acid levels on protein metabolism in adult growth hormone deficient patients. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2002, Volume: 12, Issue:6 Topics: Adult; Area Under Curve; Blood Glucose; Dwarfism, Pituitary; Fatty Acids, Nonesterified; Female; Forearm; Growth Hormone; Humans; Hypolipidemic Agents; Lipolysis; Male; Middle Aged; Phenylalanine; Proteins; Pyrazines; Tyrosine; Urea	2002
The decisive role of free fatty acids for protein conservation during fasting in humans with and without growth hormone. The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:9 Topics: Adult; Amino Acids; Fasting; Fatty Acids, Nonesterified; Growth Hormone; Heparin; Hormone Antagonists; Human Growth Hormone; Humans; Hypolipidemic Agents; Lipolysis; Male; Microdialysis; Muscle, Skeletal; Phenylalanine; Proteins; Pyrazines; Somatostatin; Triglycerides; Tyrosine; Urea	2003

Other Studies

35 other study(ies) available for pyrazines and urea

Article	Year
[Pyrazine derivatives. XI. Synthesis and tuberculostatic activity of derivatives of pyrazineurea and pyrazinethiourea]. Acta poloniae pharmaceutica, 1978, Volume: 35, Issue:5 Topics: Antitubercular Agents; Chemical Phenomena; Chemistry; Pyrazines; Thiourea; Urea	1978
Inhibition of urea transport across renal tubules by pyrazinoylguanidine and analogs. Pharmacology, 1992, Volume: 44, Issue:3 Topics: Amiloride; Animals; Biological Transport, Active; Dogs; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Guanidines; Kidney Tubules; Potassium; Pyrazines; Sodium; Structure-Activity Relationship; Urea	1992
Active transport of urea by mammalian kidney. Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:11 Topics: Amiloride; Animals; Biological Transport, Active; Diuresis; Dogs; Guanidines; Kidney; Mannitol; Pyrazines; Urea	1988
Activity of gamma-glutamyl transpeptidase and other enzymes in the serum of sheep with liver or kidney damage. Journal of comparative pathology, 1974, Volume: 84, Issue:2 Topics: Alcohol Oxidoreductases; Animals; Arginase; Aspartate Aminotransferases; Bilirubin; Brain; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; gamma-Glutamyltransferase; Glutamate Dehydrogenase; Indoles; Intestine, Small; Kidney; Kidney Diseases; Ligation; Liver; Liver Diseases; Male; Mercury Poisoning; Muscles; Mycotoxins; Myocardium; Pancreas; Pyrazines; Pyrroles; Sheep; Sheep Diseases; Urea	1974
Spironolactone and amiloride in the treatment of low renin hyperaldosteronism and related syndromes. Clinical science and molecular medicine. Supplement, 1973, Volume: 45 Suppl 1 Topics: Adrenocortical Hyperfunction; Amiloride; Angiotensin II; Body Water; Corticosterone; Diuretics; Extracellular Space; Humans; Hyperaldosteronism; Hypertension; Plasma Volume; Potassium; Pyrazines; Renin; Secretory Rate; Sodium; Spironolactone; Urea	1973
Tolerance and side-effects of the association hydrochlorothiazide-amiloride in long-term treatment of arterial hypertension. Acta clinica Belgica, 1974, Volume: 29, Issue:5 Topics: Adult; Aged; Amiloride; Calcium; Creatinine; Drug Combinations; Drug Tolerance; Humans; Hydrochlorothiazide; Hypercalcemia; Hypertension; Hypocalcemia; Middle Aged; Potassium; Pyrazines; Sodium; Time Factors; Urea; Uric Acid	1974
Amiloride in primary hyperaldosteronism with chronic peptic ulceration. British medical journal, 1973, Apr-28, Volume: 2, Issue:5860 Topics: Aged; Amiloride; Bicarbonates; Blood Pressure; Body Water; Chlorides; Chronic Disease; Diuretics; Female; Humans; Hyperaldosteronism; Hypertension; Peptic Ulcer; Potassium; Pyrazines; Sodium; Spironolactone; Urea	1973
Use of amiloride as a potassium conserving agent in severe cardiac disease. British heart journal, 1973, Volume: 35, Issue:4 Topics: Adult; Aged; Amiloride; Bicarbonates; Chlorides; Diuretics; Female; Furosemide; Heart Diseases; Humans; Male; Middle Aged; Potassium; Pyrazines; Sodium; Time Factors; Urea	1973
A comparison of moduretic and hydrochlorothiazide in the treatment of hypertension in African patients. East African medical journal, 1973, Volume: 50, Issue:1 Topics: Adult; Aged; Amiloride; Blood Pressure; Diuretics; Electrolytes; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium Chloride; Pyrazines; Urea; Uric Acid	1973
Evaluation of amiloride combined with hydrochlorothiazide (Moduretic) in the treatment of hypertension. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Jul-21, Volume: 47, Issue:28 Topics: Adult; Aged; Amiloride; Benzothiadiazines; Diuretics; Drug Combinations; Female; Guanethidine; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Potassium; Propranolol; Pyrazines; Urea; Uremia	1973
Potassium-escape-phenomenon in rats during continuous application of amiloride. 3. Influence of acid and alkali loading. Pharmacology, 1971, Volume: 6, Issue:5 Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Amiloride; Ammonium Chloride; Animals; Bicarbonates; Diuresis; Diuretics; Hydrogen-Ion Concentration; Male; Nephrectomy; Potassium; Pyrazines; Rats; Rats, Inbred Strains; Sodium; Sodium Chloride; Urea	1971
Evaluation of amiloride combined with hydrochlorothiazide in the treatment of congestive heart failure. The New Zealand medical journal, 1970, Volume: 72, Issue:459 Topics: Aged; Amidines; Body Weight; Diuretics; Drug Synergism; Female; Heart Failure; Humans; Hydrochlorothiazide; Male; Middle Aged; Potassium; Pyrazines; Sodium; Time Factors; Urea	1970
A reinvestigation of the reaction of monosodium urea with various substituted pyrazinecarboxylate esters. Journal of medicinal chemistry, 1970, Volume: 13, Issue:5 Topics: Chemical Phenomena; Chemistry; Esters; Pyrazines; Sodium; Urea	1970
Cytochrome b of isolated chloroplasts. European journal of biochemistry, 1970, Volume: 14, Issue:2 Topics: Adenosine Triphosphate; Chloroplasts; Cytochromes; Darkness; Electron Transport; Hydrogen-Ion Concentration; Light; Nitriles; Oxidation-Reduction; Phenylhydrazines; Phlorhizin; Photochemistry; Plants; Pyrazines; Quaternary Ammonium Compounds; Spectrophotometry; Tyrothricin; Uncoupling Agents; Urea	1970
[Clinical experience concerning the action of a new oral antidiabetic drug: glidiazinamide]. Minerva medica, 1971, Jul-21, Volume: 62, Issue:57 Topics: Adult; Aged; Cholesterol; Cyclohexanes; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Lipid Metabolism; Male; Middle Aged; Pyrazines; Sulfones; Urea	1971
Inhibition of urea-linked water flux and [14C]urea transport across the toad bladder by amiloride. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1981, Volume: 167, Issue:1 Topics: Amiloride; Animals; Biological Transport, Active; Bufo marinus; Inulin; Osmosis; Permeability; Pyrazines; Urea; Urinary Bladder; Vasopressins; Water	1981
Spironolactone and amiloride in hypertensive patients with and without aldosterone excess. Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:3 Topics: Adult; Amiloride; Blood Pressure; Body Weight; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Renin; Spironolactone; Urea	1980
Urea transport in toad skin (Bufo marinus) The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1 Topics: Amiloride; Animals; Arginine Vasopressin; Biological Transport; Bufo marinus; Guanidines; Hydrogen-Ion Concentration; Kinetics; Ouabain; Phloretin; Pyrazines; Skin; Sodium Chloride; Urea; Urinary Bladder	1993
Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency. Journal of clinical pharmacology, 1993, Volume: 33, Issue:6 Topics: Adult; Aged; Blood Glucose; Cholesterol; Electrolytes; Female; Guanidines; Humans; Hydrochlorothiazide; Male; Middle Aged; Pyrazines; Renal Insufficiency; Single-Blind Method; Triglycerides; Urea	1993
Involvement of 5-HT2A receptors in the elevation of rat serum corticosterone concentrations by quipazine and MK-212. European journal of pharmacology, 1996, Sep-12, Volume: 311, Issue:2-3 Topics: Animals; Corticosterone; Fluorobenzenes; Indoles; Male; Piperidines; Pyrazines; Quipazine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Urea	1996
4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity. Bioorganic & medicinal chemistry letters, 2000, May-15, Volume: 10, Issue:10 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Isoquinolines; Mice; Mice, Inbred DBA; Pyrazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles; Urea	2000
Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors. Bioorganic & medicinal chemistry letters, 2006, Apr-15, Volume: 16, Issue:8 Topics: Antibiotics, Antineoplastic; Cell Cycle; Checkpoint Kinase 1; Crystallography, X-Ray; Doxorubicin; Humans; Inhibitory Concentration 50; Nitriles; Protein Kinase Inhibitors; Protein Kinases; Pyrazines; Tumor Cells, Cultured; Urea	2006
Orientational preferences of aromatic guests in dimeric capsules of tetraurea calix[4]arenes--MD and NMR studies. Organic & biomolecular chemistry, 2006, Jun-21, Volume: 4, Issue:12 Topics: Benzene Derivatives; Binding, Competitive; Calixarenes; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Phenols; Pyrazines; Pyridines; Substrate Specificity; Thermodynamics; Urea	2006
Dose-response effects of free fatty acids on amino acid metabolism and ureagenesis. Acta physiologica (Oxford, England), 2008, Volume: 192, Issue:3 Topics: Adult; Dose-Response Relationship, Drug; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Forearm; Glucose Clamp Technique; Heparin; Human Growth Hormone; Humans; Lipid Metabolism; Lipolysis; Male; Phenylalanine; Pyrazines; Somatostatin; Tyrosine; Urea	2008
Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the Chinese herb Ligusticum wallichi. Experimental biology and medicine (Maywood, N.J.), 2008, Volume: 233, Issue:7 Topics: Animals; Antineoplastic Agents; Cisplatin; Creatinine; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutathione; Kidney; Ligusticum; Lipid Peroxidation; Male; Necrosis; Pyrazines; Rats; Rats, Wistar; Superoxide Dismutase; Urea	2008
Identifying structural features on 1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones critical for Neuropeptide S antagonist activity. Bioorganic & medicinal chemistry letters, 2008, Jul-15, Volume: 18, Issue:14 Topics: Calcium; Carbon; Chemistry, Pharmaceutical; Drug Design; Humans; Kinetics; Models, Chemical; Neuropeptides; Nitrogen; Oxygen; Pyrazines; Structure-Activity Relationship; Urea	2008
Comparative protective effect of N-acetyl cysteine and tetramethylpyrazine in rats with gentamicin nephrotoxicity. Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Body Weight; Creatinine; Gentamicins; Kidney Cortex; Male; Protective Agents; Protein Synthesis Inhibitors; Pyrazines; Rats; Rats, Wistar; Urea; Urodynamics	2009
Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4. Bioorganic & medicinal chemistry letters, 2009, Dec-15, Volume: 19, Issue:24 Topics: Angiogenesis Inhibitors; Cell Line, Tumor; Humans; Imidazoles; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrazines; Receptor, EphB4; Urea	2009
Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath. European journal of pharmacology, 2010, Sep-01, Volume: 641, Issue:2-3 Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Pain; Pyrazines; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea	2010
Syringolin B-inspired proteasome inhibitor analogue TIR-203 exhibits enhanced biological activity in multiple myeloma and neuroblastoma. Pharmaceutical biology, 2012, Volume: 50, Issue:1 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Humans; Multiple Myeloma; Neuroblastoma; Peptides, Cyclic; Proteasome Inhibitors; Pyrazines; Urea	2012
ATR inhibition preferentially targets homologous recombination-deficient tumor cells. Oncogene, 2015, Volume: 34, Issue:26 Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Survival; Checkpoint Kinase 1; Drug Resistance, Neoplasm; HeLa Cells; Homologous Recombination; Humans; MCF-7 Cells; Molecular Targeted Therapy; Neoplasms; Protein Kinases; Pyrazines; Signal Transduction; Sulfones; Thiophenes; Urea	2015
Discovery of Novel (Imidazo[1,2-a]pyrazin-6-yl)ureas as Antiproliferative Agents Targeting P53 in Non-small Cell Lung Cancer Cell Lines. Anticancer research, 2016, Volume: 36, Issue:4 Topics: Animals; Antineoplastic Agents; BALB 3T3 Cells; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Imidazoles; Lung Neoplasms; Mice; Pyrazines; Tumor Suppressor Protein p53; Urea	2016
Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress. Oncotarget, 2016, Jun-07, Volume: 7, Issue:23 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; DNA Repair; Homologous Recombination; Humans; MCF-7 Cells; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrazines; Radiation Tolerance; Radiation-Sensitizing Agents; Thiophenes; Urea	2016
Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading. Oncotarget, 2017, Feb-14, Volume: 8, Issue:7 Topics: A549 Cells; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinases; DNA Damage; DNA Replication; Drug Synergism; Flow Cytometry; Humans; Nuclear Proteins; Phenylurea Compounds; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazines; Pyrazoles; Pyrimidines; Pyrimidinones; S Phase; Thiophenes; Urea	2017
Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease. European journal of medicinal chemistry, 2018, Sep-05, Volume: 157 Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Hippocampus; Humans; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Models, Molecular; Molecular Structure; Neural Stem Cells; Neuroprotective Agents; Pyrazines; Structure-Activity Relationship; Urea	2018