Page last updated: 2024-08-21

pyrazines and tyrosine

pyrazines has been researched along with tyrosine in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19903 (10.71)18.7374
1990's2 (7.14)18.2507
2000's15 (53.57)29.6817
2010's7 (25.00)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Kafoe, WF; Leonard, BE1
Leonard, BE1
Akhtar-Khavari, F; Khoyi, MA; Rezaei, E1
Katoh, I; Kyushiki, H; Sakamoto, Y; Yoshinaka, Y1
Bryant, SD; Lazarus, LH; Okada, Y; Taguchi, H; Tsukatani, M; Yokoi, T1
Christiansen, JS; Jørgensen, JO; Møller, N; Nielsen, S; Pedersen, SB1
Christiansen, JS; Hartmund, T; Jørgensen, JO; Møller, N; Nair, KS; Nielsen, S; Nørrelund, H1
Ferrer, T; Navarro-Polanco, RA; Sănchez-Chapula, JA; Sanguinetti, MC1
Christiansen, JS; Frystyk, J; Ivarsen, P; Jørgensen, JO; Møller, N; Nair, KS; Nielsen, S; Nørrelund, H1
Ambo, A; Bryant, SD; Jinsmaa, Y; Lazarus, LH; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y1
Anderson, KC; Chauhan, D; Hideshima, T; Ishitsuka, K; Podar, K; Richardson, PG; Sattler, M; Shringarpure, R; Simoncini, M; Tai, YT1
Chen, YC; Chou, DS; Hsiao, G; Lin, CH; Lin, JH; Lin, KH; Sheu, JR1
Ambo, A; Bryant, SD; Lazarus, LH; Li, T; Miyazaki, A; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y1
Ambo, A; Bryant, SD; Lazarus, LH; Li, T; Miyazaki, A; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y; Yokoi, T1
Christiansen, JS; Gjedde, S; Gjedsted, J; Gormsen, LC; Jørgensen, JO; Møller, N; Nørrelund, H; Schmitz, O1
Cai, Y; Chen, LE; Park, JW; Qi, WN; Urbaniak, JR1
Bökönyi, G; Fukushima, S; Horváth, A; Kéri, G; Miyazaki, A; Okada, Y; Szabó, E; Tsuda, Y; Vántus, T; Yokoi, T1
Callahan, LA; Supinski, GS; Vanags, J1
Inouye, S; Kato, S; Oba, Y; Ojika, M1
Fernández-Ballester, G; Ferrer-Montiel, A; Malkia, A; Pertusa, M; Viana, F1
Daunert, S; Ensor, M; Mehl, R; Rowe, L1
Aaron, KJ; Basnayake, K; Sanders, PW; Wang, PX; Ying, WZ1
Gupta, AK; Kailashiya, J; Kumar, N; Singh, SK; Verma, AK1
Barbieri, M; Boccardi, V; Esposito, A; Marfella, R; Pansini, A; Paolisso, G; Rizzo, MR1
Barreiro, E; Chacon-Cabrera, A; de Kier Joffé, ED; Diament, MJ; Fermoselle, C; Mateu-Jimenez, M; Sandri, M; Urtreger, AJ1
Dudem, S; Jain, N; Kalivendi, SV; Vangala, JR1
Liu, H; Lu, S; Lu, T; Pan, J; Qiao, X; Xiang, B; Yan, L; Yuan, H; Zhang, L; Zhang, Y1
Asadi, M; Warshel, A; Xie, WJ1

Trials

4 trial(s) available for pyrazines and tyrosine

ArticleYear
The effect of long-term pharmacological antilipolysis on substrate metabolism in growth hormone (GH)-substituted GH-deficient adults.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:7

    Topics: Adult; Body Composition; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Growth Hormone; Hormones; Human Growth Hormone; Humans; Hypolipidemic Agents; Lipoprotein Lipase; Lipoproteins; Male; Metabolism, Inborn Errors; Middle Aged; Phenylalanine; Pyrazines; Tyrosine

2002
Effects of lowering circulating free fatty acid levels on protein metabolism in adult growth hormone deficient patients.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2002, Volume: 12, Issue:6

    Topics: Adult; Area Under Curve; Blood Glucose; Dwarfism, Pituitary; Fatty Acids, Nonesterified; Female; Forearm; Growth Hormone; Humans; Hypolipidemic Agents; Lipolysis; Male; Middle Aged; Phenylalanine; Proteins; Pyrazines; Tyrosine; Urea

2002
The decisive role of free fatty acids for protein conservation during fasting in humans with and without growth hormone.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:9

    Topics: Adult; Amino Acids; Fasting; Fatty Acids, Nonesterified; Growth Hormone; Heparin; Hormone Antagonists; Human Growth Hormone; Humans; Hypolipidemic Agents; Lipolysis; Male; Microdialysis; Muscle, Skeletal; Phenylalanine; Proteins; Pyrazines; Somatostatin; Triglycerides; Tyrosine; Urea

2003
Decreased carotid atherosclerotic process by control of daily acute glucose fluctuations in diabetic patients treated by DPP-IV inhibitors.
    Atherosclerosis, 2013, Volume: 227, Issue:2

    Topics: Adamantane; Atherosclerosis; Blood Glucose; Carotid Arteries; Carotid Artery Diseases; Carotid Intima-Media Thickness; Cytokines; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glycated Hemoglobin; Humans; Inflammation; Nitriles; Oxidative Stress; Prospective Studies; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Tyrosine; Vildagliptin

2013

Other Studies

24 other study(ies) available for pyrazines and tyrosine

ArticleYear
The effect of a new tetracyclic anti-depressant compound, Org GB 94, on the turnover of dopamine, noradrenalin and serotonin in the rat brain.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 206, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Carbon Radioisotopes; Dibenzazepines; Dopamine; Imipramine; In Vitro Techniques; Male; Norepinephrine; Pyrazines; Rats; Serotonin; Stimulation, Chemical; Time Factors; Tritium; Tryptophan; Tyramine; Tyrosine

1973
Some effects of a new tetracyclic anti-depressant compound, Org GB 94, on the metabolism of monoamines in the rat brain.
    Psychopharmacologia, 1974, Apr-23, Volume: 36, Issue:3

    Topics: Aminobutyrates; Animals; Antidepressive Agents; Behavior; Biogenic Amines; Brain; Brain Stem; Cerebral Cortex; Corpus Striatum; Dibenzazepines; Dopamine; Hydroxyindoleacetic Acid; Male; Mesencephalon; Mice; Norepinephrine; Normetanephrine; Pyrazines; Rats; Serotonin; Time Factors; Tryptamines; Tryptophan; Tyramine; Tyrosine

1974
Effects of amiloride on contractions and the release of tritium from rat vas deferens preloaded with [3H]-noradrenaline.
    British journal of pharmacology, 1981, Volume: 74, Issue:1

    Topics: Amiloride; Animals; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Norepinephrine; Potassium Chloride; Pyrazines; Rats; Tyrosine; Vas Deferens

1981
Alterations of the cytoskeletal organization in tumor cell lines by a cardiotonic drug, vesnarinone, through protein tyrosine phosphorylation.
    Experimental cell research, 1995, Volume: 219, Issue:1

    Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cardiotonic Agents; Catechols; Cell Communication; Cell Line; Cell Line, Transformed; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Genes, src; Humans; Immunoblotting; Lung Neoplasms; Mice; Nitriles; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Pyrazines; Quinolines; Tubulin; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Vimentin

1995
Amino acids and peptides. LII. Design and synthesis of opioid mimetics containing a pyrazinone ring and examination of their opioid receptor binding activity.
    Chemical & pharmaceutical bulletin, 1998, Volume: 46, Issue:9

    Topics: Amino Acids; Animals; Brain; Drug Design; Models, Molecular; Narcotics; Pyrazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Synaptosomes; Tyrosine

1998
Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain.
    Molecular pharmacology, 2003, Volume: 63, Issue:5

    Topics: Binding Sites; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Membrane Proteins; Phosphodiesterase Inhibitors; Point Mutation; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Structure, Tertiary; Pyrazines; Quinidine; Quinine; Quinolines; Trans-Activators; Transcriptional Regulator ERG; Tyrosine

2003
Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Guinea Pigs; Male; Mice; Molecular Mimicry; Morphine; Pain; Pyrazines; Receptors, Opioid, mu; Tyrosine

2004
Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib.
    Cancer research, 2004, Oct-15, Volume: 64, Issue:20

    Topics: Antineoplastic Agents; Bone Marrow; Boronic Acids; Bortezomib; Caveolin 1; Caveolins; Cell Line, Tumor; Cell Movement; Crk-Associated Substrate Protein; Endothelium, Vascular; Humans; Multiple Myeloma; Phosphorylation; Proteins; Pyrazines; Recombinant Proteins; Retinoblastoma-Like Protein p130; src-Family Kinases; Transfection; Tyrosine; Vascular Endothelial Growth Factor A

2004
Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats.
    Planta medica, 2006, Volume: 72, Issue:5

    Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Ligusticum; Male; Neuroprotective Agents; Neutrophils; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Pyrazines; Rats; Rats, Wistar; Respiratory Burst; Telencephalon; Tyrosine

2006
Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.
    Bioorganic & medicinal chemistry letters, 2006, Nov-15, Volume: 16, Issue:22

    Topics: Animals; Binding, Competitive; Models, Chemical; Narcotic Antagonists; Pyrazines; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Tyrosine

2006
Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.
    Bioorganic & medicinal chemistry letters, 2007, Nov-01, Volume: 17, Issue:21

    Topics: Analgesics, Opioid; Drug Design; Molecular Mimicry; Pyrazines; Tyrosine

2007
Dose-response effects of free fatty acids on amino acid metabolism and ureagenesis.
    Acta physiologica (Oxford, England), 2008, Volume: 192, Issue:3

    Topics: Adult; Dose-Response Relationship, Drug; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Forearm; Glucose Clamp Technique; Heparin; Human Growth Hormone; Humans; Lipid Metabolism; Lipolysis; Male; Phenylalanine; Pyrazines; Somatostatin; Tyrosine; Urea

2008
Proteasome inhibitor attenuates skeletal muscle reperfusion injury by blocking the pathway of nuclear factor-kappaB activation.
    Plastic and reconstructive surgery, 2007, Volume: 120, Issue:7

    Topics: Animals; Blood Vessels; Boronic Acids; Bortezomib; Drug Evaluation, Preclinical; Intercellular Adhesion Molecule-1; Intracellular Signaling Peptides and Proteins; Laser-Doppler Flowmetry; Male; Mice; Microscopy, Video; Muscle, Skeletal; NF-kappa B p50 Subunit; Nitric Oxide Synthase Type II; Protease Inhibitors; Proteasome Inhibitors; Proteins; Pyrazines; Random Allocation; Reperfusion Injury; Surgical Flaps; Tyrosine

2007
New cyclic somatostatin analogues containing a pyrazinone ring: importance of Tyr for antiproliferative activity.
    Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23

    Topics: Amino Acid Sequence; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Pyrazines; Receptors, Somatostatin; Somatostatin; Stereoisomerism; Structure-Activity Relationship; Tyrosine

2008
Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction.
    American journal of physiology. Lung cellular and molecular physiology, 2009, Volume: 296, Issue:6

    Topics: Animals; Atrophy; Boronic Acids; Bortezomib; Caspase 3; Cysteine Proteinase Inhibitors; Diaphragm; Endotoxemia; Enzyme Activation; Leupeptins; Male; Muscle Contraction; Muscle Weakness; Oligopeptides; Organ Size; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Sepsis; Tyrosine

2009
Biosynthesis of coelenterazine in the deep-sea copepod, Metridia pacifica.
    Biochemical and biophysical research communications, 2009, Dec-18, Volume: 390, Issue:3

    Topics: Animals; Copepoda; Imidazoles; Luminescent Agents; Phenylalanine; Pyrazines; Tyrosine

2009
Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.
    Molecular pain, 2009, Nov-03, Volume: 5

    Topics: Animals; Capsaicin; Clotrimazole; Cold Temperature; Humans; Imidazoles; Ion Channel Gating; Menthol; Mice; Models, Molecular; Molecular Dynamics Simulation; Mutant Proteins; Mutation; Phenotype; Pyrazines; Pyridines; Structure-Activity Relationship; TRPM Cation Channels; Tyrosine

2009
Modulating the bioluminescence emission of photoproteins by in vivo site-directed incorporation of non-natural amino acids.
    ACS chemical biology, 2010, May-21, Volume: 5, Issue:5

    Topics: Aequorin; Amino Acid Substitution; Amino Acids; Escherichia coli; Imidazoles; Luminescent Measurements; Luminescent Proteins; Mutagenesis, Site-Directed; Pyrazines; Tyrosine

2010
Immunoglobulin light chains activate nuclear factor-κB in renal epithelial cells through a Src-dependent mechanism.
    Blood, 2011, Jan-27, Volume: 117, Issue:4

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Epithelial Cells; Humans; I-kappa B Kinase; Immunoglobulin Light Chains; Kidney; NF-kappa B; Phosphorylation; Pyrazines; Signal Transduction; src-Family Kinases; Tyrosine

2011
Sitagliptin: anti-platelet effect in diabetes and healthy volunteers.
    Platelets, 2012, Volume: 23, Issue:8

    Topics: Adult; Aged; Blood Platelets; Blood Proteins; Calcium; Case-Control Studies; Cells, Cultured; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazines; Sitagliptin Phosphate; Thrombin; Triazoles; Tyrosine

2012
Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness.
    Journal of cellular physiology, 2014, Volume: 229, Issue:11

    Topics: Animals; Autophagy; Boronic Acids; Bortezomib; Butadienes; Cachexia; Cell Line, Tumor; Inflammation; Lung Neoplasms; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle Proteins; Muscle Weakness; Muscle, Skeletal; NF-kappa B; Nitriles; Oxidation-Reduction; Proteolysis; Pyrazines; Signal Transduction; Sulfasalazine; Tyrosine; Weight Gain

2014
Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy.
    The Journal of biological chemistry, 2014, May-02, Volume: 289, Issue:18

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Epidermal Growth Factor; HEK293 Cells; HeLa Cells; Humans; Neoplasms; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Subunits; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; STAT3 Transcription Factor; Tyrosine; Up-Regulation

2014
Insight into the key features for ligand binding in Y1230 mutated c-Met kinase domain by molecular dynamics simulations.
    Journal of biomolecular structure & dynamics, 2018, Volume: 36, Issue:8

    Topics: Binding Sites; Crizotinib; Humans; Hydrogen Bonding; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Mutation; Protein Binding; Protein Domains; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrazines; Triazoles; Tyrosine

2018
Exploring the Role of Chemical Reactions in the Selectivity of Tyrosine Kinase Inhibitors.
    Journal of the American Chemical Society, 2022, 09-14, Volume: 144, Issue:36

    Topics: Agammaglobulinaemia Tyrosine Kinase; Benzamides; Protein Kinase Inhibitors; Pyrazines; Tyrosine

2022