pyrazines has been researched along with tyrosine in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.71) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 15 (53.57) | 29.6817 |
| 2010's | 7 (25.00) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Kafoe, WF; Leonard, BE | 1 |
| Leonard, BE | 1 |
| Akhtar-Khavari, F; Khoyi, MA; Rezaei, E | 1 |
| Katoh, I; Kyushiki, H; Sakamoto, Y; Yoshinaka, Y | 1 |
| Bryant, SD; Lazarus, LH; Okada, Y; Taguchi, H; Tsukatani, M; Yokoi, T | 1 |
| Christiansen, JS; Jørgensen, JO; Møller, N; Nielsen, S; Pedersen, SB | 1 |
| Christiansen, JS; Hartmund, T; Jørgensen, JO; Møller, N; Nair, KS; Nielsen, S; Nørrelund, H | 1 |
| Ferrer, T; Navarro-Polanco, RA; Sănchez-Chapula, JA; Sanguinetti, MC | 1 |
| Christiansen, JS; Frystyk, J; Ivarsen, P; Jørgensen, JO; Møller, N; Nair, KS; Nielsen, S; Nørrelund, H | 1 |
| Ambo, A; Bryant, SD; Jinsmaa, Y; Lazarus, LH; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y | 1 |
| Anderson, KC; Chauhan, D; Hideshima, T; Ishitsuka, K; Podar, K; Richardson, PG; Sattler, M; Shringarpure, R; Simoncini, M; Tai, YT | 1 |
| Chen, YC; Chou, DS; Hsiao, G; Lin, CH; Lin, JH; Lin, KH; Sheu, JR | 1 |
| Ambo, A; Bryant, SD; Lazarus, LH; Li, T; Miyazaki, A; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y | 1 |
| Ambo, A; Bryant, SD; Lazarus, LH; Li, T; Miyazaki, A; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y; Yokoi, T | 1 |
| Christiansen, JS; Gjedde, S; Gjedsted, J; Gormsen, LC; Jørgensen, JO; Møller, N; Nørrelund, H; Schmitz, O | 1 |
| Cai, Y; Chen, LE; Park, JW; Qi, WN; Urbaniak, JR | 1 |
| Bökönyi, G; Fukushima, S; Horváth, A; Kéri, G; Miyazaki, A; Okada, Y; Szabó, E; Tsuda, Y; Vántus, T; Yokoi, T | 1 |
| Callahan, LA; Supinski, GS; Vanags, J | 1 |
| Inouye, S; Kato, S; Oba, Y; Ojika, M | 1 |
| Fernández-Ballester, G; Ferrer-Montiel, A; Malkia, A; Pertusa, M; Viana, F | 1 |
| Daunert, S; Ensor, M; Mehl, R; Rowe, L | 1 |
| Aaron, KJ; Basnayake, K; Sanders, PW; Wang, PX; Ying, WZ | 1 |
| Gupta, AK; Kailashiya, J; Kumar, N; Singh, SK; Verma, AK | 1 |
| Barbieri, M; Boccardi, V; Esposito, A; Marfella, R; Pansini, A; Paolisso, G; Rizzo, MR | 1 |
| Barreiro, E; Chacon-Cabrera, A; de Kier Joffé, ED; Diament, MJ; Fermoselle, C; Mateu-Jimenez, M; Sandri, M; Urtreger, AJ | 1 |
| Dudem, S; Jain, N; Kalivendi, SV; Vangala, JR | 1 |
| Liu, H; Lu, S; Lu, T; Pan, J; Qiao, X; Xiang, B; Yan, L; Yuan, H; Zhang, L; Zhang, Y | 1 |
| Asadi, M; Warshel, A; Xie, WJ | 1 |
4 trial(s) available for pyrazines and tyrosine
| Article | Year |
|---|---|
The effect of long-term pharmacological antilipolysis on substrate metabolism in growth hormone (GH)-substituted GH-deficient adults.
Topics: Adult; Body Composition; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Growth Hormone; Hormones; Human Growth Hormone; Humans; Hypolipidemic Agents; Lipoprotein Lipase; Lipoproteins; Male; Metabolism, Inborn Errors; Middle Aged; Phenylalanine; Pyrazines; Tyrosine | 2002 |
Effects of lowering circulating free fatty acid levels on protein metabolism in adult growth hormone deficient patients.
Topics: Adult; Area Under Curve; Blood Glucose; Dwarfism, Pituitary; Fatty Acids, Nonesterified; Female; Forearm; Growth Hormone; Humans; Hypolipidemic Agents; Lipolysis; Male; Middle Aged; Phenylalanine; Proteins; Pyrazines; Tyrosine; Urea | 2002 |
The decisive role of free fatty acids for protein conservation during fasting in humans with and without growth hormone.
Topics: Adult; Amino Acids; Fasting; Fatty Acids, Nonesterified; Growth Hormone; Heparin; Hormone Antagonists; Human Growth Hormone; Humans; Hypolipidemic Agents; Lipolysis; Male; Microdialysis; Muscle, Skeletal; Phenylalanine; Proteins; Pyrazines; Somatostatin; Triglycerides; Tyrosine; Urea | 2003 |
Decreased carotid atherosclerotic process by control of daily acute glucose fluctuations in diabetic patients treated by DPP-IV inhibitors.
Topics: Adamantane; Atherosclerosis; Blood Glucose; Carotid Arteries; Carotid Artery Diseases; Carotid Intima-Media Thickness; Cytokines; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glycated Hemoglobin; Humans; Inflammation; Nitriles; Oxidative Stress; Prospective Studies; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Tyrosine; Vildagliptin | 2013 |
24 other study(ies) available for pyrazines and tyrosine
| Article | Year |
|---|---|
The effect of a new tetracyclic anti-depressant compound, Org GB 94, on the turnover of dopamine, noradrenalin and serotonin in the rat brain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Carbon Radioisotopes; Dibenzazepines; Dopamine; Imipramine; In Vitro Techniques; Male; Norepinephrine; Pyrazines; Rats; Serotonin; Stimulation, Chemical; Time Factors; Tritium; Tryptophan; Tyramine; Tyrosine | 1973 |
Some effects of a new tetracyclic anti-depressant compound, Org GB 94, on the metabolism of monoamines in the rat brain.
Topics: Aminobutyrates; Animals; Antidepressive Agents; Behavior; Biogenic Amines; Brain; Brain Stem; Cerebral Cortex; Corpus Striatum; Dibenzazepines; Dopamine; Hydroxyindoleacetic Acid; Male; Mesencephalon; Mice; Norepinephrine; Normetanephrine; Pyrazines; Rats; Serotonin; Time Factors; Tryptamines; Tryptophan; Tyramine; Tyrosine | 1974 |
Effects of amiloride on contractions and the release of tritium from rat vas deferens preloaded with [3H]-noradrenaline.
Topics: Amiloride; Animals; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Norepinephrine; Potassium Chloride; Pyrazines; Rats; Tyrosine; Vas Deferens | 1981 |
Alterations of the cytoskeletal organization in tumor cell lines by a cardiotonic drug, vesnarinone, through protein tyrosine phosphorylation.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cardiotonic Agents; Catechols; Cell Communication; Cell Line; Cell Line, Transformed; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Genes, src; Humans; Immunoblotting; Lung Neoplasms; Mice; Nitriles; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Pyrazines; Quinolines; Tubulin; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Vimentin | 1995 |
Amino acids and peptides. LII. Design and synthesis of opioid mimetics containing a pyrazinone ring and examination of their opioid receptor binding activity.
Topics: Amino Acids; Animals; Brain; Drug Design; Models, Molecular; Narcotics; Pyrazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Synaptosomes; Tyrosine | 1998 |
Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain.
Topics: Binding Sites; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Membrane Proteins; Phosphodiesterase Inhibitors; Point Mutation; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Structure, Tertiary; Pyrazines; Quinidine; Quinine; Quinolines; Trans-Activators; Transcriptional Regulator ERG; Tyrosine | 2003 |
Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Guinea Pigs; Male; Mice; Molecular Mimicry; Morphine; Pain; Pyrazines; Receptors, Opioid, mu; Tyrosine | 2004 |
Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib.
Topics: Antineoplastic Agents; Bone Marrow; Boronic Acids; Bortezomib; Caveolin 1; Caveolins; Cell Line, Tumor; Cell Movement; Crk-Associated Substrate Protein; Endothelium, Vascular; Humans; Multiple Myeloma; Phosphorylation; Proteins; Pyrazines; Recombinant Proteins; Retinoblastoma-Like Protein p130; src-Family Kinases; Transfection; Tyrosine; Vascular Endothelial Growth Factor A | 2004 |
Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Ligusticum; Male; Neuroprotective Agents; Neutrophils; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Pyrazines; Rats; Rats, Wistar; Respiratory Burst; Telencephalon; Tyrosine | 2006 |
Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.
Topics: Animals; Binding, Competitive; Models, Chemical; Narcotic Antagonists; Pyrazines; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Tyrosine | 2006 |
Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.
Topics: Analgesics, Opioid; Drug Design; Molecular Mimicry; Pyrazines; Tyrosine | 2007 |
Dose-response effects of free fatty acids on amino acid metabolism and ureagenesis.
Topics: Adult; Dose-Response Relationship, Drug; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Forearm; Glucose Clamp Technique; Heparin; Human Growth Hormone; Humans; Lipid Metabolism; Lipolysis; Male; Phenylalanine; Pyrazines; Somatostatin; Tyrosine; Urea | 2008 |
Proteasome inhibitor attenuates skeletal muscle reperfusion injury by blocking the pathway of nuclear factor-kappaB activation.
Topics: Animals; Blood Vessels; Boronic Acids; Bortezomib; Drug Evaluation, Preclinical; Intercellular Adhesion Molecule-1; Intracellular Signaling Peptides and Proteins; Laser-Doppler Flowmetry; Male; Mice; Microscopy, Video; Muscle, Skeletal; NF-kappa B p50 Subunit; Nitric Oxide Synthase Type II; Protease Inhibitors; Proteasome Inhibitors; Proteins; Pyrazines; Random Allocation; Reperfusion Injury; Surgical Flaps; Tyrosine | 2007 |
New cyclic somatostatin analogues containing a pyrazinone ring: importance of Tyr for antiproliferative activity.
Topics: Amino Acid Sequence; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Pyrazines; Receptors, Somatostatin; Somatostatin; Stereoisomerism; Structure-Activity Relationship; Tyrosine | 2008 |
Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction.
Topics: Animals; Atrophy; Boronic Acids; Bortezomib; Caspase 3; Cysteine Proteinase Inhibitors; Diaphragm; Endotoxemia; Enzyme Activation; Leupeptins; Male; Muscle Contraction; Muscle Weakness; Oligopeptides; Organ Size; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Sepsis; Tyrosine | 2009 |
Biosynthesis of coelenterazine in the deep-sea copepod, Metridia pacifica.
Topics: Animals; Copepoda; Imidazoles; Luminescent Agents; Phenylalanine; Pyrazines; Tyrosine | 2009 |
Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.
Topics: Animals; Capsaicin; Clotrimazole; Cold Temperature; Humans; Imidazoles; Ion Channel Gating; Menthol; Mice; Models, Molecular; Molecular Dynamics Simulation; Mutant Proteins; Mutation; Phenotype; Pyrazines; Pyridines; Structure-Activity Relationship; TRPM Cation Channels; Tyrosine | 2009 |
Modulating the bioluminescence emission of photoproteins by in vivo site-directed incorporation of non-natural amino acids.
Topics: Aequorin; Amino Acid Substitution; Amino Acids; Escherichia coli; Imidazoles; Luminescent Measurements; Luminescent Proteins; Mutagenesis, Site-Directed; Pyrazines; Tyrosine | 2010 |
Immunoglobulin light chains activate nuclear factor-κB in renal epithelial cells through a Src-dependent mechanism.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Epithelial Cells; Humans; I-kappa B Kinase; Immunoglobulin Light Chains; Kidney; NF-kappa B; Phosphorylation; Pyrazines; Signal Transduction; src-Family Kinases; Tyrosine | 2011 |
Sitagliptin: anti-platelet effect in diabetes and healthy volunteers.
Topics: Adult; Aged; Blood Platelets; Blood Proteins; Calcium; Case-Control Studies; Cells, Cultured; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazines; Sitagliptin Phosphate; Thrombin; Triazoles; Tyrosine | 2012 |
Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness.
Topics: Animals; Autophagy; Boronic Acids; Bortezomib; Butadienes; Cachexia; Cell Line, Tumor; Inflammation; Lung Neoplasms; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle Proteins; Muscle Weakness; Muscle, Skeletal; NF-kappa B; Nitriles; Oxidation-Reduction; Proteolysis; Pyrazines; Signal Transduction; Sulfasalazine; Tyrosine; Weight Gain | 2014 |
Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Epidermal Growth Factor; HEK293 Cells; HeLa Cells; Humans; Neoplasms; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Subunits; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; STAT3 Transcription Factor; Tyrosine; Up-Regulation | 2014 |
Insight into the key features for ligand binding in Y1230 mutated c-Met kinase domain by molecular dynamics simulations.
Topics: Binding Sites; Crizotinib; Humans; Hydrogen Bonding; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Mutation; Protein Binding; Protein Domains; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrazines; Triazoles; Tyrosine | 2018 |
Exploring the Role of Chemical Reactions in the Selectivity of Tyrosine Kinase Inhibitors.
Topics: Agammaglobulinaemia Tyrosine Kinase; Benzamides; Protein Kinase Inhibitors; Pyrazines; Tyrosine | 2022 |