pyrazines has been researched along with trichostatin a in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, J; Callery, MP; Demirjian, A; Marasco, W; Sui, J; Vollmer, CM | 1 |
| Alvarez, S; Barrero, M; Cabrero, JR; Fernández, G; Gordon-Alonso, M; Muñoz-Fernández, MA; Naranjo-Suárez, S; Sánchez-Madrid, F; Serrador, JM; Ursa, A; Valenzuela-Fernández, A; Yáñez-Mo, M | 1 |
| Bai, J; Callery, MP; Demirjian, A; Marasco, W; Sui, J | 1 |
| Adjei, AA; Atadja, P; Friday, BB; Sarkaria, J; Wigle, D; Yang, L; Yu, C | 1 |
| Chang, I; Chen, X; Guan, J; Han, D; Kim, J; Wang, CY | 1 |
| Chen, T; Fang, Y; Hu, Y; Jiang, X; Ma, D; Ma, Q; Meng, L; Tian, Y; Wang, B; Wang, S; Wu, P; Xia, X; Xu, G; Zhang, Q; Zhou, J | 1 |
| Ciccarelli, B; Fulciniti, M; Gong, P; Hatjiharissi, E; Hunter, ZR; Ioakimidis, L; Liu, X; Maghsoudi, K; Munshi, NC; O'Connor, OA; Patterson, CJ; Sheehy, P; Sun, JY; Treon, SP; Tseng, H; Xu, L; Yang, G; Zhou, Y; Zhu, B | 1 |
| Balsas, P; Galán-Malo, P; Marzo, I; Naval, J | 1 |
| Brown, CO; Fitzgerald, MP; Goel, A; Salem, K; Schibler, J; Singh, N; Zhan, F | 1 |
| Gurocak, S; Kiliccioglu, I; Konac, E; Varol, N; Yucel Bilen, C | 1 |
10 other study(ies) available for pyrazines and trichostatin a
| Article | Year |
|---|---|
Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Benzoquinones; Boronic Acids; Bortezomib; Cell Line, Tumor; Doxorubicin; Drug Synergism; Gene Expression Regulation, Neoplastic; Gene Silencing; HSP90 Heat-Shock Proteins; Humans; Hydroxamic Acids; Lactams, Macrocyclic; Membrane Glycoproteins; Pancreatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Quinones; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2005 |
Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection.
Topics: Acetylation; Aminobenzoates; CD4-Positive T-Lymphocytes; Cell Fusion; Cell Line, Tumor; Gene Silencing; HeLa Cells; Histone Deacetylase 6; Histone Deacetylases; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Hydroxamic Acids; Jurkat Cells; Pyrazines; RNA, Small Nuclear; Transfection; Tubulin | 2005 |
Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Boronic Acids; Bortezomib; Caspases; Cell Line, Tumor; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; NF-kappa B; Pancreatic Neoplasms; Poly(ADP-ribose) Polymerases; Protease Inhibitors; Proteasome Inhibitors; Pyrazines | 2006 |
Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Boronic Acids; Bortezomib; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Glioma; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Mitochondria; Panobinostat; Proteasome Inhibitors; Protein Transport; Pyrazines; RNA, Small Interfering | 2008 |
PS-341 and histone deacetylase inhibitor synergistically induce apoptosis in head and neck squamous cell carcinoma cells.
Topics: Acetylation; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Northern; Blotting, Western; Boronic Acids; Bortezomib; Carcinoma, Squamous Cell; Caspases; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Head and Neck Neoplasms; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Mice; Mice, Nude; Proto-Oncogene Proteins c-bcl-2; Pyrazines; RNA Interference; Xenograft Model Antitumor Assays | 2010 |
Synergistic efficacy in human ovarian cancer cells by histone deacetylase inhibitor TSA and proteasome inhibitor PS-341.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Cytochromes c; Drug Resistance, Neoplasm; Drug Synergism; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Ovarian Neoplasms; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; RNA Interference; Time Factors | 2011 |
Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bone Marrow; Boronic Acids; Bortezomib; Cell Cycle; Cell Line, Tumor; Cell Survival; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Immunoblotting; Male; Polymerase Chain Reaction; Pyrazines; Waldenstrom Macroglobulinemia | 2011 |
Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Caspase 3; Cell Line, Tumor; Drug Resistance, Neoplasm; Flow Cytometry; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Multiple Myeloma; Polyploidy; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2012 |
Scavenger receptor class A member 3 (SCARA3) in disease progression and therapy resistance in multiple myeloma.
Topics: Antineoplastic Agents; Azacitidine; Boronic Acids; Bortezomib; Cell Line; Cell Line, Tumor; Decitabine; Dexamethasone; Disease Progression; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Heat-Shock Proteins; Humans; Hydrogen Peroxide; Hydroxamic Acids; Multiple Myeloma; Oligonucleotide Array Sequence Analysis; Oxidants; Prognosis; Pyrazines; Radiation, Ionizing; Reverse Transcriptase Polymerase Chain Reaction; Scavenger Receptors, Class A | 2013 |
Apoptotic effects of proteasome and histone deacetylase inhibitors in prostate cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Caspase 3; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; NF-kappa B; Prostatic Neoplasms; Pyrazines | 2014 |