pyrazines has been researched along with transforming growth factor beta in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 13 (41.94) | 29.6817 |
| 2010's | 12 (38.71) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Adachi, M; Gohda, H; Harada, K; Ikeda, Y; Kawamata, H; Kinoshita, M; Nakashiro, K; Nishida, T; Ono, K; Sato, M; Yoshida, H | 1 |
| Antras-Ferry, J; Guillouzo, A; Langouët, S; Maheo, K; Morel, F | 1 |
| Kao, WW; Kawashima, Y; Kimura, M; Nakano, Y; Ohkawa, K; Ohnishi, Y; Ooshima, A; Saika, S; Yamanaka, O | 1 |
| Osaki, T; Ueta, E; Yamamoto, T; Yoneda, K | 1 |
| Adachi, M; Amuro, Y; Hada, T; Higashino, K; Ohkawa, T; Taguchi, T; Takahashi, M; Ueki, N | 1 |
| Iwabu, A; Kumashiro, H; Kusachi, S; Murakami, T; Ninomiya, Y; Nunoyama, H; Oka, T; Sano, I; Tsuji, T; Ueta, J | 1 |
| Ha, JR; Kang, KW; Kim, CW; Kim, ND; Kim, SG | 1 |
| Choi, SH; Ha, JR; Kang, KW; Kim, CW; Kim, SG | 1 |
| Bae, SK; Cho, MK; Kang, KW; Kim, CW; Kim, SG; Kim, YG; Lee, MG | 1 |
| Li, HL; Wang, WJ; Wang, XH; Yang, L | 1 |
| Chizzolini, C; Dayer, JM; Fineschi, S; Guerne, PA; Reith, W | 1 |
| Li, XS; Liu, LY; Wan, XQ | 1 |
| Anderson, KC; Hideshima, T; Ikeda, H; Ishitsuka, K; Jin, J; Kiziltepe, T; Moss, N; Ocio, EM; Okawa, Y; Pargellis, C; Podar, K; Raje, N; Richardson, PG; Vallet, S; Yasui, H | 1 |
| Lu, J; Qu, ZL; Ren, XY; Ruan, QR; Zhu, DH; Zhu, M | 1 |
| Argiroffo, CB; Bongiovanni, M; Chizzolini, C; Dayer, JM; Djaafar, S; Donati, Y; Ferrari-Lacraz, S; Fineschi, S; Goffin, L; Naso, F; Pache, JC | 1 |
| Asaoku, H; Katayama, Y; Kimura, A; Kubo, T; Kuroda, Y; Munemasa, S; Okikawa, Y; Sakai, A; Shimose, S | 1 |
| Liu, Y; Lu, M; Wang, F; Zhang, Y; Zhou, J | 1 |
| Jones, DR; Liu, Y; Nagji, AS; Taylor, MD; Theodosakis, N | 1 |
| Cho, YJ; Chung, EJ; Jung, SA; Kim, SW; Lee, JH; Moon, SW | 1 |
| Henderson, RA; McGhee, CN; Patel, D; Pradhan, MA; Vincent, AL | 1 |
| Chai, J; Jiang, Y; Li, Y; Luo, H; Xiao, X; You, Y; Zhou, Y; Zhu, H; Zuo, X | 1 |
| Alattar, M; Li, WP; Linder, G; Malek, R; Price, JD; Rother, KI; Tarbell, KV; Zimmermann, B | 1 |
| Lin, M; Luan, Y; Ma, Y; Wang, YB; Wang, YY; Zhang, X; Zhang, ZH; Zhu, XB | 1 |
| Boyer, JL; Harry, K; Luo, Y; Mennone, A; Soroka, CJ; Weerachayaphorn, J | 1 |
| Al-Salihi, M; Herhaus, L; Macartney, T; Sapkota, GP; Weidlich, S | 1 |
| Iyengar, R; Luker, GD; Luker, KE; Moudgil, P; Nyati, S; Rehemtulla, A; Stacer, AC | 1 |
| Li, J; Li, X; Shen, Y; Xiang, Y; Xing, N; Yang, H | 1 |
| Chirgwin, JM; Suvannasankha, A | 1 |
| Li, WL; Mao, CQ; Yan, S; Yang, L; Yue, J; Yue, YZ; Zeng, L | 1 |
| Sakai, M; Yoshimura, R | 1 |
| Ahn, KS; Blough, BE; Eng, H; Jung, YY; Kumar, AP; Mohan, CD; Namjoshi, OA; Narula, AS; Rangappa, KS; Sethi, G | 1 |
1 review(s) available for pyrazines and transforming growth factor beta
| Article | Year |
|---|---|
Role of bone-anabolic agents in the treatment of breast cancer bone metastases.
Topics: Antineoplastic Agents; Bone Density Conservation Agents; Bone Neoplasms; Boronic Acids; Bortezomib; Breast Neoplasms; Everolimus; Female; Humans; Oligopeptides; Osteoblasts; Parathyroid Hormone; Proteasome Inhibitors; Pyrazines; Recombinant Fusion Proteins; Sirolimus; Thiophenes; Transforming Growth Factor beta | 2014 |
1 trial(s) available for pyrazines and transforming growth factor beta
| Article | Year |
|---|---|
Effects of short-term sitagliptin treatment on immune parameters in healthy individuals, a randomized placebo-controlled study.
Topics: Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Down-Regulation; Glucagon-Like Peptide 1; Humans; Immunomodulation; Outcome Assessment, Health Care; Pyrazines; Sitagliptin Phosphate; T-Lymphocyte Subsets; Time Factors; Transforming Growth Factor beta; Triazoles; Up-Regulation | 2013 |
29 other study(ies) available for pyrazines and transforming growth factor beta
| Article | Year |
|---|---|
Induction of cyclin-dependent kinase inhibitor, p21WAF1, by treatment with 3,4-dihydro-6-[4-(3,4)-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinoline (vesnarinone) in a human salivary cancer cell line with mutant p53 gene.
Topics: Antineoplastic Agents; Carcinoma, Adenosquamous; Cell Differentiation; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Pyrazines; Quinolines; Salivary Gland Neoplasms; Transforming Growth Factor beta; Tumor Cells, Cultured | 1997 |
Modulation of glutathione S-transferase subunits A2, M1, and P1 expression by interleukin-1beta in rat hepatocytes in primary culture.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glutathione Transferase; Humans; Interleukin-1; Liver; Male; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiones; Thiophenes; Transforming Growth Factor beta | 1997 |
OPC-15161 suppresses the proliferation of Tenon's capsule fibroblasts and the production of type I collagen and fibronectin stimulated by TGF-beta1 in vitro.
Topics: Adult; Cell Count; Cell Division; Cells, Cultured; Connective Tissue; DNA Replication; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibronectins; Humans; Laminin; Male; Middle Aged; Procollagen; Pyrazines; Tetrazolium Salts; Thiazoles; Transforming Growth Factor beta | 1998 |
Induction of cyclin-dependent kinase inhibitor p21 in vesnarinone-induced differentiation of squamous cell carcinoma cells.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Differentiation; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; G1 Phase; Humans; Mouth Neoplasms; Phosphorylation; Promoter Regions, Genetic; Pyrazines; Quinolines; Retinoblastoma Protein; RNA, Messenger; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Inhibition of hyaluronan synthesis by vesnarinone in cultured human myofibroblasts.
Topics: Cell Line; Enzyme Inhibitors; Glucuronosyltransferase; Glycosyltransferases; Humans; Hyaluronan Synthases; Hyaluronic Acid; Membrane Proteins; Pyrazines; Quinolines; Transferases; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Xenopus Proteins | 2000 |
OPC-8212, a quinoline derivative, counteracts the reduction in type III collagen mRNA due to lipopolysaccharides in cultured rat cardiac fibroblasts.
Topics: Animals; Cardiotonic Agents; Collagen; Enzyme-Linked Immunosorbent Assay; Fibroblasts; In Vitro Techniques; Lipopolysaccharides; Myocardial Contraction; Myocardium; Pyrazines; Quinolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stimulation, Chemical; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2001 |
2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: role of inhibition of transforming growth factor-beta1 expression.
Topics: Animals; Dimethylnitrosamine; Enzyme Inhibitors; Liver; Liver Cirrhosis; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Transaminases; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Inhibition of dimethylnitrosamine-induced liver fibrosis by [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) in rats: suppression of transforming growth factor-beta1 and tumor necrosis factor-alpha expression.
Topics: Animals; Base Sequence; Dimethylnitrosamine; DNA Primers; Glyceraldehyde-3-Phosphate Dehydrogenases; Liver Cirrhosis, Experimental; Pyrazines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiones; Thiophenes; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2002 |
Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation.
Topics: Animals; CCAAT-Enhancer-Binding Proteins; Extracellular Matrix; Liver; Liver Cirrhosis, Experimental; Liver Regeneration; Models, Biological; Pyrazines; Rats; RNA, Messenger; Survival Analysis; Thiones; Thiophenes; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
[Effect of ligustrazine on airway remodeling in asthmatic rats].
Topics: Animals; Anti-Asthmatic Agents; Asthma; Collagen Type III; Disease Models, Animal; Drugs, Chinese Herbal; Immunohistochemistry; Male; Muscle, Smooth, Vascular; Ovalbumin; Pyrazines; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 2004 |
Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.
Topics: Acetylcysteine; Anthracenes; Boronic Acids; Bortezomib; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; Fibroblasts; Fibrosis; Genes, jun; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Matrix Metalloproteinase 1; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Pyrazines; RNA Polymerase II; RNA, Messenger; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Up-Regulation | 2006 |
[The effects of tetramethylpyrazine in combination with rhein on proliferation and apoptosis in human liver cell L-02 induced by TGFb1 and TG].
Topics: Anthraquinones; Apoptosis; Cell Proliferation; Cells, Cultured; Hepatocytes; Humans; Pyrazines; Transforming Growth Factor beta; Triglycerides | 2006 |
BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth.
Topics: Antineoplastic Agents, Hormonal; Apoptosis; Benzoquinones; Boronic Acids; Bortezomib; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Cytotoxicity Tests, Immunologic; Dexamethasone; Drug Resistance, Neoplasm; HSP90 Heat-Shock Proteins; Humans; Immunoblotting; Interleukin-6; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Multiple Myeloma; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazines; Pyrazoles; Signal Transduction; Stem Cells; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2007 |
Tetramethylpyrazine inhibits agiontensin II-induced nuclear factor-kappaB activation and bone morphogenetic protein-2 downregulation in rat vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Atherosclerosis; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Immunohistochemistry; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Pyrazines; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 2007 |
In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis.
Topics: Animals; Bleomycin; Boronic Acids; Bortezomib; Cells, Cultured; Collagen Type I; Fibrosis; Hydroxyproline; Leupeptins; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proteasome Inhibitors; Protein Serine-Threonine Kinases; Pulmonary Fibrosis; Pyrazines; Scleroderma, Systemic; Signal Transduction; Skin; Transforming Growth Factor beta | 2008 |
Osteoprogenitor differentiation is not affected by immunomodulatory thalidomide analogs but is promoted by low bortezomib concentration, while both agents suppress osteoclast differentiation.
Topics: Alkaline Phosphatase; Apoptosis; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Boronic Acids; Bortezomib; Cell Differentiation; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Immunologic Factors; Lenalidomide; Multiple Myeloma; Osteoblasts; Osteoclasts; Pyrazines; Thalidomide; Transforming Growth Factor beta | 2008 |
[Effect of tetramethylpyrazine on expression of Smad7 and SnoN in rats with UUO].
Topics: Animals; Body Weight; Collagen; Gene Expression Regulation; Kidney; Male; Nerve Tissue Proteins; Peptide Fragments; Procollagen; Pyrazines; Rats; Smad7 Protein; Transcription Factors; Transforming Growth Factor beta; Ureteral Obstruction | 2009 |
Combined proteasome and histone deacetylase inhibition attenuates epithelial-mesenchymal transition through E-cadherin in esophageal cancer cells.
Topics: Adenocarcinoma; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cadherins; Carcinoma, Squamous Cell; Cell Death; Cell Line, Tumor; Cell Movement; Epithelial Cells; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mesoderm; Neoplasm Invasiveness; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; RNA, Messenger; Spheroids, Cellular; Time Factors; Transfection; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Up-Regulation; Vorinostat | 2010 |
Potentiation of bortezomib-induced apoptosis by TGF-beta in cultured human Tenon's fibroblasts: contribution of the PI3K/Akt signaling pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Boronic Acids; Bortezomib; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Fibroblasts; Flow Cytometry; Gene Expression Regulation; Genes, bcl-2; Humans; Phosphatidylinositol 3-Kinases; Phosphorylation; Protease Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tenon Capsule; Tetrazolium Salts; Thiazoles; Time Factors; Transforming Growth Factor beta; Tumor Suppressor Protein p53 | 2010 |
Heavy-chain amyloidosis in TGFBI-negative and gelsolin-negative atypical lattice corneal dystrophy.
Topics: Amyloid; Amyloidosis; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Corneal Dystrophies, Hereditary; Dexamethasone; DNA Mutational Analysis; Extracellular Matrix Proteins; Gelsolin; Glucocorticoids; Humans; Immunoglobulin Heavy Chains; Male; Mass Spectrometry; Melphalan; Microscopy, Confocal; Middle Aged; Mutation; Nephrotic Syndrome; Paraproteinemias; Pyrazines; Sequence Analysis, Protein; Transforming Growth Factor beta | 2011 |
MicroRNA-21 in scleroderma fibrosis and its function in TGF-β-regulated fibrosis-related genes expression.
Topics: Animals; Bleomycin; Boronic Acids; Bortezomib; Cells, Cultured; Female; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Mice; Mice, Inbred DBA; MicroRNAs; Molecular Targeted Therapy; Pyrazines; RNA, Small Interfering; Scleroderma, Diffuse; Signal Transduction; Skin; Smad7 Protein; Transforming Growth Factor beta | 2013 |
Proteasome inhibitor PS-341 attenuates flow-induced pulmonary arterial hypertension.
Topics: Animals; Blotting, Western; Boronic Acids; Bortezomib; Disease Models, Animal; Gene Expression Profiling; Hypertension, Pulmonary; Immunohistochemistry; Lung; Male; NF-kappa B; Proliferating Cell Nuclear Antigen; Proteasome Inhibitors; Pyrazines; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Smad Proteins; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vascular Remodeling | 2014 |
Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.
Topics: Angiogenic Proteins; Animals; Bile; Bile Acids and Salts; Bile Ducts; Cholestasis, Extrahepatic; Glutathione; Ligation; Male; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; NF-E2-Related Factor 2; Pyrazines; Thiones; Thiophenes; Transforming Growth Factor beta | 2014 |
OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.
Topics: Animals; Boronic Acids; Bortezomib; Cell Line, Tumor; Cysteine Endopeptidases; Deubiquitinating Enzymes; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; Humans; Mice; Phosphoproteins; Phosphorylation; Primary Cell Culture; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Pyrazines; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Ubiquitin; Ubiquitination | 2013 |
NanoLuc reporter for dual luciferase imaging in living animals.
Topics: Animals; Breast Neoplasms; Cell Line; Disease Progression; Female; Heterografts; Imidazoles; Luciferases; Luciferases, Firefly; Luminescent Measurements; Mice; Molecular Imaging; Neoplasm Transplantation; Pyrazines; Signal Transduction; Substrate Specificity; Transfection; Transforming Growth Factor beta | 2013 |
[Effect of tetramethylpyrazine and rat CTGF miRNA plasmids on connective tissue growth factor, transforming growth factor-beta in high glucose stimulated hepatic stellate cells].
Topics: Animals; Cells, Cultured; Collagen Type I; Connective Tissue Growth Factor; Culture Media; Glucose; Hepatic Stellate Cells; MicroRNAs; Plasmids; Pyrazines; Rats; RNA, Messenger; Transfection; Transforming Growth Factor beta | 2014 |
Effect of ligustrazine nanoparticles nano spray on transforming growth factor-β/Smad signal pathway of rat peritoneal mesothelial cells induced by tumor necrosis factor-α.
Topics: Animals; Collagen Type I; Epithelium; Fibronectins; Male; Nanoparticles; Particle Size; Peritoneal Cavity; Pyrazines; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2016 |
Mechanotransduction-Targeting Drugs Attenuate Stiffness-Induced Hepatic Stellate Cell Activation in Vitro.
Topics: Actins; Adenosine Triphosphate; Animals; Benzamides; Cells, Cultured; Colchicine; Collagen Type I; Hepatic Stellate Cells; Imidazoles; Integrins; Male; Mechanotransduction, Cellular; Paclitaxel; Piperazines; Pyrazines; Quinoxalines; Rats, Sprague-Dawley; Roscovitine; Sulfonamides; Transforming Growth Factor beta; Tubulin Modulators | 2021 |
2,3,5,6-Tetramethylpyrazine Targets Epithelial-Mesenchymal Transition by Abrogating Manganese Superoxide Dismutase Expression and TGFβ-Driven Signaling Cascades in Colon Cancer Cells.
Topics: Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Epithelial-Mesenchymal Transition; Glycogen Synthase Kinase 3; Humans; Phosphatidylinositol 3-Kinases; Pyrazines; Superoxide Dismutase; Transforming Growth Factor beta | 2022 |