pyrazines has been researched along with thiazoles in 71 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (8.45) | 18.7374 |
| 1990's | 10 (14.08) | 18.2507 |
| 2000's | 17 (23.94) | 29.6817 |
| 2010's | 29 (40.85) | 24.3611 |
| 2020's | 9 (12.68) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T | 1 |
| Fotsch, C; St Jean, DJ | 1 |
| Gwilt, M; Henderson, CG; Orme, J; Rourke, JD | 1 |
| Nare, B; Prichard, RK; Smith, JM | 1 |
| Kovárová, A; Krácmar, J; Krácmarová, J; Remsová, M | 1 |
| Buttery, RG; Guadagni, DG; Teranishi, R | 1 |
| Berk, S; Gisser, H | 1 |
| Foks, H; Sawlewicz, J | 1 |
| Bian, SS; Chen, YL; Lee, H | 1 |
| Batra, R; Kedderis, GL; Kim, SG; Novak, RF | 1 |
| Buxeraud, J; Comby, F; Lagorce, JF; Raby, C; Rousseau, A | 1 |
| Inoue, Y; Jinbo, Y; Kondo, H; Sakamoto, F; Taguchi, M; Tsukamoto, G | 1 |
| Collin, S; Hérent, MF; Pelosi, P | 1 |
| Kao, WW; Kawashima, Y; Kimura, M; Nakano, Y; Ohkawa, K; Ohnishi, Y; Ooshima, A; Saika, S; Yamanaka, O | 1 |
| Fujita, M; Higashino, K; Tsuchida, T | 1 |
| Caravatti, G; Furet, P; Gay, B; Rahuel, J | 1 |
| Blagosklonny, MV | 1 |
| Bouregeois, NM; Corbett, TH; Crantz, B; Hazeldine, ST; Horwitz, JP; Kushner, J; Palomino, E; Polin, L; White, K | 1 |
| Lee, KG; Ochi, H; Shibamoto, T; Yanagimoto, K | 1 |
| Adams, J; Altamirano, C; Berenson, JR; Borad, MJ; Frantzen, M; Friedman, JM; Ma, MH; Manyak, S; Mikail, A; Neeser, J; Parker, K; Roussos, E; Sjak-Shie, N; Vescio, RA; Wu, ZQ; Yang, HH | 1 |
| Anderson, KC; Mitsiades, CS; Mitsiades, N; Richardson, PG; Treon, SP | 1 |
| Case, BL; Clare, M; Dice, TA; Fenton, RL; Girard, TJ; Hayes, MJ; Jones, DE; Kurumbail, RG; Lachance, RM; Neumann, WL; Nicholson, NS; Parlow, JJ; South, MS; Stallings, WC; Stegeman, RA; Stevens, AM; Wood, RS | 1 |
| GRAY, AP; HEITMEIER, DE | 1 |
| Hasegawa, T; Kambayashi, Y; Kuwano, H; Nagamoto, H; Nakano, M; Sakurai, K; Saniabadi, AR; Takahashi, A; Tsukada, K | 1 |
| Cavaggioni, A; Mucignat-Caretta, C; Zagotto, G | 1 |
| Bonde, CG; Gaikwad, NJ | 1 |
| Cho, SW; Choi, KY; Park, CS | 1 |
| Aiello, F; Chen, X; Dayam, R; Deng, J; Garofalo, A; Neamati, N; Wu, Y | 1 |
| Scheinfeld, N | 1 |
| Jarois, T; Ju, D; Xie, Y; Xu, H | 1 |
| Delmore, JE; Hayden, P; Kotoula, V; McMillin, DW; McMullan, C; Mitsiades, CS; Mitsiades, N; Negri, J; Poulaki, V | 1 |
| Birgens, H; Brown, Pde N; Dalseg, AM; Dufva, IH; Hasselbalch, HC; Jensen, MK; Vangsted, A | 1 |
| Cambar, J; De Giorgi, F; Ichas, F; L'Azou, B; Passagne, I; Pédeboscq, S; Pometan, JP | 1 |
| Shiguang, Z; Tianhu, Z; Xinghan, L | 1 |
| Cheng, Y; Zhang, JH | 1 |
| Allan, EK; Bhatia, R; Chu, S; Crawford, L; Heaney, NB; Holyoake, TL; Irvine, AE; Jorgensen, HG; Kazmi, SM; Pellicano, F; Zhang, B | 1 |
| Bonde, CG; Gaikwad, NJ; Peepliwal, A | 1 |
| He, Q; Lin, M; Luo, P; Shen, J; Wang, Z; Yang, B; Zhu, D | 1 |
| Cho, YJ; Chung, EJ; Jung, SA; Kim, SW; Lee, JH; Moon, SW | 1 |
| Gong, Y; Liu, T; Meng, W; Xing, H | 1 |
| Gartel, AL; Pandit, B | 1 |
| Agyemang, D; Bardsley, K; Brown, S; Kraut, K; Psota-Kelty, L; Trinnaman, L | 1 |
| Briand, L; Scott, DJ; Taylor, AJ; Yabuki, M | 1 |
| Colado, E; de Queiroz Crusoe, E; Delgado, M; Fernandez-Lazaro, D; Garayoa, M; Garcia-Gomez, A; Gutierrez, NC; Lee, FY; Maiso, P; Martin-Sanchez, J; Ocio, EM; San-Segundo, L | 1 |
| Arshad Siddiqui, M; Belanger, DB; Bracken, JB; Curran, PJ; Malkowski, M; Miao, H; Shipps, GW; Wang, Y; Zeng, H | 1 |
| Li, Z; Liu, M; Liu, T; Luo, J; Qiu, WW; Tang, J; Xu, J; Yang, F | 1 |
| Fu, B; Li, Y; Liao, A; Liu, Z; Pan, H; Wang, H; Wang, X; Yang, W | 1 |
| Andriamanana, I; Duretz, B; Gana, I; Hulin, A | 1 |
| Akutsu, M; Furukawa, Y; Izumi, T; Kano, Y; Kikuchi, J; Nobuyoshi, M; Ohki, M; Park, SY; Shibayama, N; Sugiyama, K; Wada, T; Yamada, S | 1 |
| Chen, SS; Falchook, G; Fok, JY; Fu, S; Heymach, J; Hong, D; Janku, F; Kurzrock, R; Naing, A; Piha-Paul, S; Stephen, B; Tsimberidou, AM; Wheler, J | 1 |
| Bertomeu, T; Bucur, O; Dewar, R; Goganau, I; Khosravi-Far, R; Pennarun, B; Petrescu, SM; Stancu, AL | 1 |
| Bordignon-Luiz, MT; Burin, VM; de Revel, G; Marchand, S | 1 |
| Cui, L; Hierso, JC; Platon, M; Rampazzi, V; Rousselin, Y; Saeys, M; Wijaya, N | 1 |
| Anzaldi, M; Galietta, LJ; Mazzei, M; Mazzei, MT; Nieddu, E; Pedemonte, N; Pesce, E; Pollarolo, B; Schenone, S | 1 |
| Chen, S; Chen, W; Dong, Y; He, X; Liang, C; Ma, J; Zhang, B; Zhang, X | 1 |
| Abdildinova, A; Gong, YD; Yang, SJ | 1 |
| Gleyzer, N; Scarpulla, RC | 1 |
| Finkelmann, AR; Göller, AH; Schneider, G | 1 |
| Scott, A | 1 |
| El-Badry, YA; El-Hashash, MA; Sallam, MS | 1 |
| Drescher, K; Geneste, H; Jakob, C; Laplanche, L; Ochse, M; Torrent, M | 1 |
| Hou, L; Wang, X; Zhang, Y | 1 |
| Hocart, CH; Hu, Y; Peng, J; Yang, Y; Zhang, F; Zhao, H; Zhou, Y | 1 |
| Şimşek Yavuz, S; Ünal, S | 1 |
| Cherukupalli, S; Du, X; Jia, H; Liu, X; Yu, J; Zhan, P | 1 |
| Kumar, D; Trivedi, N; Verma, A | 1 |
| Wen, S; Xu, X; Yadav, AK; Yu, L | 1 |
| Assis, LC; da Cunha, EFF; de Almeida La Porta, F; de Castro Ramalho, T; de Castro, AA; de Jesus, JPA; Kuca, K; Nepovimova, E | 1 |
| Tsanni, A | 1 |
| Adom, AA; Aguirre-Alvarado, C; Aguirre-Gil, G; Bekker-Méndez, C; Cortes-Vazquez, MA; Cruz-Carbajal, AS; Dehbi, HM; Delgado-Pastelin, L; Escobedo, J; Favari-Perozzi, L; Gastine, S; González, YSP; Hoyo-Vadillo, C; Lowe, D; Mateos, E; Navarro-Gualito, MD; Owen, A; Smith, T; Standing, J; Villegas-Lara, B | 1 |
| Hayat, K; Ho, CT; Liu, M; Xu, H; Yu, J; Zhang, X; Zhou, T | 1 |
7 review(s) available for pyrazines and thiazoles
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
Novel biologically based therapies for Waldenstrom's macroglobulinemia.
Topics: Adjuvants, Immunologic; Anti-Bacterial Agents; Antineoplastic Agents; Boronic Acids; Bortezomib; Enzyme Inhibitors; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Protease Inhibitors; Pyrazines; Thalidomide; Thiazoles; Waldenstrom Macroglobulinemia | 2003 |
A review of deferasirox, bortezomib, dasatinib, and cyclosporine eye drops: possible uses and known side effects in cutaneous medicine.
Topics: Animals; Antineoplastic Agents; Benzoates; Boronic Acids; Bortezomib; Cyclosporine; Dasatinib; Deferasirox; Humans; Iron Chelating Agents; Ophthalmic Solutions; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Randomized Controlled Trials as Topic; Skin Diseases; Skin Neoplasms; Thiazoles; Triazoles | 2007 |
[Novel medical treatment modalities in hematology].
Topics: Aminoglycosides; Anemia, Hemolytic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Benzamides; Benzoates; Boronic Acids; Bortezomib; Carbazoles; Carrier Proteins; Cyclophosphamide; Dasatinib; Furans; Gemtuzumab; Hematologic Diseases; Humans; Hydrazines; Imatinib Mesylate; Immunologic Factors; Indoles; Lenalidomide; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Piperazines; Purpura, Thrombocytopenic; Pyrazines; Pyrazoles; Pyrimidines; Receptors, Fc; Recombinant Fusion Proteins; Rituximab; Thalidomide; Thiazoles; Thrombopoietin; Vidarabine | 2008 |
Antiviral treatment of COVID-19
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Humans; Hydroxychloroquine; Ivermectin; Lopinavir; Nitro Compounds; Pandemics; Pneumonia, Viral; Pyrazines; Ritonavir; SARS-CoV-2; Thiazoles | 2020 |
Possible treatment and strategies for COVID-19: review and assessment.
Topics: Adenosine Monophosphate; Alanine; Amides; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antiparasitic Agents; Antiviral Agents; Cannabinoids; Chloroquine; Complement Inactivating Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; COVID-19 Vaccines; Dexamethasone; Drug Combinations; Enzyme Inhibitors; Humans; Hydroxychloroquine; Immunization, Passive; Indoles; Interferons; Ivermectin; Lopinavir; Nitro Compounds; Pyrazines; Ritonavir; SARS-CoV-2; Teicoplanin; Tetracyclines; Thiazoles | 2020 |
Antiviral treatment in COVID-19: which is the most promising?-a narrative review.
Topics: Adenosine Monophosphate; Alanine; Amides; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azetidines; Chloroquine; COVID-19; COVID-19 Serotherapy; Drug Combinations; Humans; Hydroxychloroquine; Immunization, Passive; Indoles; Interferons; Ivermectin; Lopinavir; Nitro Compounds; Oseltamivir; Purines; Pyrazines; Pyrazoles; Ribavirin; Ritonavir; Sulfonamides; Thiazoles | 2021 |
2 trial(s) available for pyrazines and thiazoles
| Article | Year |
|---|---|
Revisiting clinical trials using EGFR inhibitor-based regimens in patients with advanced non-small cell lung cancer: a retrospective analysis of an MD Anderson Cancer Center phase I population.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Boronic Acids; Bortezomib; Carcinoma, Non-Small-Cell Lung; Cetuximab; Dasatinib; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Male; Middle Aged; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Quinazolines; Retrospective Studies; Sirolimus; Survival; Thiazoles; Treatment Outcome | 2013 |
Favipiravir and/or nitazoxanide: a randomized, double-blind, 2×2 design, placebo-controlled trial of early therapy in COVID-19 in health workers, their household members, and patients treated at IMSS (FANTAZE).
Topics: Amides; Antiviral Agents; COVID-19 Drug Treatment; Humans; Nitro Compounds; Pyrazines; SARS-CoV-2; Secondary Prevention; Thiazoles; Treatment Outcome | 2022 |
62 other study(ies) available for pyrazines and thiazoles
| Article | Year |
|---|---|
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase | 1981 |
Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Myocardial Ischemia; Piperidines; Potassium; Potassium Channels; Pyrazines; Pyridines; Sympatholytics; Thiazoles; Ventricular Fibrillation | 1992 |
Differential effects of oltipraz and its oxy-analogue on the viability of Schistosoma mansoni and the activity of glutathione S-transferase.
Topics: Animals; Dinitrochlorobenzene; Female; Glutathione; Glutathione Transferase; Kinetics; Male; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Tetrazolium Salts; Thiazoles; Thiones; Thiophenes | 1991 |
[UV-spectrophotometry in drug control. 41. Drug substances with chromophores and auxochromes in monocyclic compounds (pyrazolone, pyrazolidine, pyridazine, pyrimidine and pyrazine) and bicyclic compounds (benzoxazole, imidazole, benzthiazole and indene)].
Topics: Benzothiazoles; Benzoxazoles; Imidazoles; Pharmaceutical Preparations; Pyrazines; Pyrazoles; Pyridazines; Pyrimidines; Spectrophotometry, Ultraviolet; Thiazoles | 1988 |
Odor quality and chemical structure in fruit and vegetable flavors.
Topics: Aldehydes; Chemical Phenomena; Chemistry; Fruit; Ketones; Odorants; Pyrazines; Structure-Activity Relationship; Thiazoles; Vegetables | 1974 |
Radiation chemistry of nitrogen and sulfur heterocyclics.
Topics: Chromatography, Gas; Free Radicals; Heterocyclic Compounds; Imidazoles; Nitrogen; Pyrazines; Pyrazoles; Pyrimidines; Pyrroles; Radiochemistry; Sulfur; Tetrazoles; Thiazoles; Thiophenes; Triazines; Triazoles | 1973 |
[Synthesis of 2- and 4-pyrazinylthiazole derivatives].
Topics: Antitubercular Agents; Pyrazines; Thiazoles | 1968 |
Genotoxicity of 1,3-dithiane and 1,4-dithiane in the CHO/SCE assay and the Salmonella/microsomal test.
Topics: Animals; Biotransformation; CHO Cells; Cricetinae; Furans; Heterocyclic Compounds; Imidazoles; Maillard Reaction; Mutagenicity Tests; Mutagens; Pyrazines; Pyridines; Pyrroles; Salmonella typhimurium; Sister Chromatid Exchange; Sulfur Compounds; Thiazoles; Thiophenes | 1994 |
Induction of rat liver microsomal epoxide hydrolase by thiazole and pyrazine: hydrolysis of 2-cyanoethylene oxide.
Topics: Animals; Base Sequence; Carcinogens; DNA; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Epoxide Hydrolases; Ethylene Oxide; Gene Amplification; Hydrolysis; Kinetics; Male; Microsomes, Liver; Molecular Sequence Data; Nucleic Acid Hybridization; Polymerase Chain Reaction; Pyrazines; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Sodium Dodecyl Sulfate; Thiazoles | 1993 |
Synthesis and antithyroid activity of pyridine, pyrimidine and pyrazine derivatives of thiazole-2-thiol and 2-thiazoline-2-thiol.
Topics: Animals; Antithyroid Agents; Male; Pyrazines; Pyridines; Pyrimidines; Rats; Rats, Wistar; Thiazoles; Thyrotropin; Thyroxine | 1993 |
Synthesis and antibacterial activity of thiazolopyrazine-incorporated tetracyclic quinolone antibacterial agents. 2.
Topics: 4-Quinolones; Animals; Anti-Infective Agents; Gram-Negative Bacteria; Gram-Positive Bacteria; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Microbial Sensitivity Tests; Molecular Structure; Optical Rotation; Pyrazines; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles | 1994 |
Affinities of nutty and green-smelling pyrazines and thiazoles to odorant-binding proteins, in relation with their lipophilicity.
Topics: Animals; Binding, Competitive; Cattle; Chemical Phenomena; Chemistry, Physical; Humans; Kinetics; Odorants; Pyrazines; Receptors, Odorant; Swine; Thiazoles | 1995 |
OPC-15161 suppresses the proliferation of Tenon's capsule fibroblasts and the production of type I collagen and fibronectin stimulated by TGF-beta1 in vitro.
Topics: Adult; Cell Count; Cell Division; Cells, Cultured; Connective Tissue; DNA Replication; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibronectins; Humans; Laminin; Male; Middle Aged; Procollagen; Pyrazines; Tetrazolium Salts; Thiazoles; Transforming Growth Factor beta | 1998 |
Effect of vesnarinone in combination with anti-cancer drugs on lung cancer cell lines.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cell Division; Cisplatin; Coloring Agents; Deoxycytidine; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; Flow Cytometry; Gemcitabine; Humans; Lung Neoplasms; Pyrazines; Quinolines; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1999 |
Structure-based design of a non-peptidic antagonist of the SH2 domain of GRB2.
Topics: Adaptor Proteins, Signal Transducing; Computer Simulation; Drug Design; Enzyme-Linked Immunosorbent Assay; GRB2 Adaptor Protein; Inhibitory Concentration 50; Models, Molecular; Molecular Mimicry; Molecular Structure; Peptides; Phosphates; Phosphoproteins; Proteins; Pyrazines; src Homology Domains; Structure-Activity Relationship; Thiazoles | 1999 |
Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Boronic Acids; Bortezomib; Cell Cycle; Cell Survival; Cyclosporins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Flavonoids; Hematopoietic Stem Cells; HL-60 Cells; Humans; Jurkat Cells; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Oligopeptides; Paclitaxel; Piperidines; Poly(ADP-ribose) Polymerases; Pyrazines; Substrate Specificity; Thiazoles | 2001 |
II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469).
Topics: Animals; Antineoplastic Agents; Benzoxazoles; Drug Screening Assays, Antitumor; Mice; Neoplasm Transplantation; Propionates; Pyrazines; Pyridines; Quinazolines; Quinolines; Quinoxalines; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazines; Tumor Cells, Cultured | 2002 |
Antioxidative activity of heterocyclic compounds found in coffee volatiles produced by Maillard reaction.
Topics: Aldehydes; Antioxidants; Coffee; Furans; Heterocyclic Compounds; Maillard Reaction; Pyrazines; Pyrroles; Thiazoles; Thiophenes; Volatilization | 2002 |
The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents.
Topics: Active Transport, Cell Nucleus; Adenoviridae; Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Division; Cell Nucleus; Cell Survival; Cysteine Endopeptidases; Cytosol; Dose-Response Relationship, Drug; Genes, Dominant; Humans; I-kappa B Proteins; Melphalan; Microscopy, Fluorescence; Multienzyme Complexes; Multiple Myeloma; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Proteasome Endopeptidase Complex; Pyrazines; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Tumor Cells, Cultured; Ubiquitin | 2003 |
Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
Topics: Antithrombin III; Binding Sites; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Drug Design; Factor VIIa; Fibrinolytic Agents; Humans; Inhibitory Concentration 50; Models, Molecular; Pyrazines; Recombinant Proteins; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thiazoles; Thrombin; Thromboplastin | 2003 |
BETA-HYDROXYPHENETHYLAMINO DERIVATIVES OF VARIOUS NITROGEN HETEROCYCLES.
Topics: Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antipyretics; Chemistry, Pharmaceutical; Hypnotics and Sedatives; Muscle Relaxants, Central; Nitrogen; Pharmacology; Phenethylamines; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Research; Thiazoles; Triazines; Triazoles | 1964 |
Effects of OPC-6535 on lipopolysaccharide-induced acute liver injury in the rat: involvement of superoxide and tumor necrosis factor-alpha from hepatic macrophages.
Topics: Animals; Chemokine CXCL1; Chemokines, CXC; Imidazoles; Intercellular Signaling Peptides and Proteins; Lipopolysaccharides; Liver; Luminescent Measurements; Macrophages; Male; Nitroblue Tetrazolium; Perfusion; Peroxidase; Pyrazines; Rats; Rats, Wistar; Superoxides; Thiazoles; Tumor Necrosis Factor-alpha | 2003 |
Absolute configuration of 2-sec-butyl-4,5-dihydrothiazole in male mouse urine.
Topics: Animals; Behavior, Animal; Chromatography, Gas; Competitive Behavior; Male; Mice; Pheromones; Protein Binding; Pyrazines; Stereoisomerism; Thiazoles | 2003 |
Synthesis and preliminary evaluation of some pyrazine containing thiazolines and thiazolidinones as antimicrobial agents.
Topics: Anti-Bacterial Agents; Drug Evaluation, Preclinical; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Pyrazines; Species Specificity; Thiazoles | 2004 |
A new putative cyclic nucleotide-gated channel gene, cng-3, is critical for thermotolerance in Caenorhabditis elegans.
Topics: Alcohols; Aldehydes; Amino Acid Sequence; Animals; Caenorhabditis elegans; Chemotaxis; Cyclic Nucleotide-Gated Cation Channels; Gene Deletion; Gene Expression; Genome Components; Heat-Shock Response; Ion Channels; Molecular Sequence Data; Phylogeny; Protein Subunits; Pyrazines; Recombinant Proteins; Sequence Alignment; Smell; Thiazoles | 2004 |
Discovery of small molecule integrin alphavbeta3 antagonists as novel anticancer agents.
Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Databases, Factual; Drug Screening Assays, Antitumor; Furans; Humans; Imidazoles; Integrin alphaVbeta3; Models, Molecular; Molecular Conformation; Pyrazines; Pyridazines; Radioligand Assay; Structure-Activity Relationship; Thiazoles | 2006 |
Diminished feedback regulation of proteasome expression and resistance to proteasome inhibitors in breast cancer cells.
Topics: Apoptosis; Boronic Acids; Bortezomib; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Feedback, Physiological; Humans; Leupeptins; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Temperature; Tetrazolium Salts; Thiazoles | 2008 |
Bcl-2 overexpression in thyroid carcinoma cells increases sensitivity to Bcl-2 homology 3 domain inhibition.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Boronic Acids; Bortezomib; Carcinoma; Carcinoma, Medullary; Cell Line, Tumor; Colorimetry; Doxorubicin; Genes, bcl-2; Humans; Membrane Potentials; Oncogene Protein v-akt; Protease Inhibitors; Pyrazines; RNA, Neoplasm; Tetrazolium Salts; Thiazoles; Thyroid Neoplasms; Transcription, Genetic | 2007 |
Cytotoxic and apoptotic effects of bortezomib and gefitinib compared to alkylating agents on human glioblastoma cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Boronic Acids; Bortezomib; Brain Neoplasms; Carboplatin; Carmustine; Cell Line, Tumor; Dacarbazine; Dose-Response Relationship, Drug; ErbB Receptors; Flow Cytometry; Gefitinib; Glial Fibrillary Acidic Protein; Glioblastoma; Immunohistochemistry; Indicators and Reagents; Mice; Proteasome Inhibitors; Pyrazines; Quinazolines; Rats; Temozolomide; Tetrazolium Salts; Thiazoles | 2008 |
Bmf is upregulated by PS-341-mediated cell death of glioma cells through JNK phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; DNA Fragmentation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioma; Humans; MAP Kinase Kinase 4; Phosphorylation; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Tetrazolium Salts; Thiazoles | 2010 |
The [3 + 2] cycloaddition reaction of thiazole carbene-derived C-C-Se 1,3-dipoles: a concise and highly efficient strategy for the construction of multifunctional dihydroselenophenes and selenopheno[2,3-b]pyrazines.
Topics: Alkenes; Alkynes; Catalysis; Cyclization; Methane; Pyrazines; Thiazoles | 2009 |
Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells.
Topics: Animals; Antigens, CD34; Apoptosis; Boronic Acids; Bortezomib; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Dasatinib; Drug Synergism; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, SCID; Mutant Proteins; Proteasome Inhibitors; Pyrazines; Pyrimidines; Thiazoles; Time Factors; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2010 |
Synthesis and antimycobacterial activity of azetidine-, quinazoline-, and triazolo-thiadiazole-containing pyrazines.
Topics: Antitubercular Agents; Azetidines; Cell Wall; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Permeability; Pyrazines; Quinazolines; Structure-Activity Relationship; Thiadiazoles; Thiazoles | 2010 |
Bortezomib induces apoptosis in human neuroblastoma CHP126 cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Boronic Acids; Bortezomib; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression; Humans; Indicators and Reagents; Neuroblastoma; NF-kappa B; Oncogene Protein p21(ras); Poly(ADP-ribose) Polymerases; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles; Up-Regulation | 2010 |
Potentiation of bortezomib-induced apoptosis by TGF-beta in cultured human Tenon's fibroblasts: contribution of the PI3K/Akt signaling pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Boronic Acids; Bortezomib; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Fibroblasts; Flow Cytometry; Gene Expression Regulation; Genes, bcl-2; Humans; Phosphatidylinositol 3-Kinases; Phosphorylation; Protease Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tenon Capsule; Tetrazolium Salts; Thiazoles; Time Factors; Transforming Growth Factor beta; Tumor Suppressor Protein p53 | 2010 |
An investigation of reversal of imatinib resistance in the Bcr-Abl positive imatinib-resistant cell line K562r by dasatinib, nilotinib, rapamycin and bortezomib.
Topics: Antineoplastic Agents; Benzamides; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; K562 Cells; Piperazines; Pyrazines; Pyrimidines; Signal Transduction; Sirolimus; Thiazoles; TOR Serine-Threonine Kinases; Up-Regulation | 2011 |
Thiazole antibiotic thiostrepton synergize with bortezomib to induce apoptosis in cancer cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; HCT116 Cells; Humans; Neoplasms; Pyrazines; Thiazoles; Thiostrepton | 2011 |
Identification of 2-ethyl-4-methyl-3-thiazoline and 2-isopropyl-4-methyl-3-thiazoline for the first time in nature by the comprehensive analysis of sesame seed oil.
Topics: Flame Ionization; Food Handling; Furans; Gas Chromatography-Mass Spectrometry; Guaiacol; Hot Temperature; Humans; Limit of Detection; Magnetic Resonance Spectroscopy; Maillard Reaction; Molecular Structure; Odorants; Pyrazines; Seeds; Sensation; Sesame Oil; Sesamum; Taste; Thiazoles | 2011 |
Dynamics of odorant binding to thin aqueous films of rat-OBP3.
Topics: Animals; Benzaldehydes; Binding Sites; Binding, Competitive; Calorimetry; Kinetics; Odorants; Pyrazines; Rats; Receptors, Odorant; Recombinant Proteins; Thermodynamics; Thiazoles; Water | 2011 |
Transcriptomic rationale for the synergy observed with dasatinib + bortezomib + dexamethasone in multiple myeloma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle; Cell Proliferation; Cells, Cultured; Dasatinib; Dexamethasone; Drug Synergism; Gene Expression Profiling; Humans; Multiple Myeloma; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Thiazoles; Transcriptome | 2012 |
Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors.
Topics: Adaptor Proteins, Signal Transducing; Animals; Aurora Kinases; Breast Neoplasms; Computer Simulation; Dasatinib; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Design; Drug Discovery; Drug Screening Assays, Antitumor; Female; Humans; Imidazoles; Inhibitory Concentration 50; Melanocytes; Mice; Molecular Targeted Therapy; Neoplasm Proteins; Oncogenes; Phenotype; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogenes; Pyrazines; Pyrimidines; RNA-Binding Proteins; Structure-Activity Relationship; Thiazoles | 2011 |
Synthesis and biological evaluation of heterocyclic ring-fused betulinic acid derivatives as novel inhibitors of osteoclast differentiation and bone resorption.
Topics: Acid Phosphatase; Animals; Betulinic Acid; Bone Density Conservation Agents; Bone Resorption; Cathepsin K; Cell Differentiation; Cell Line; Cell Proliferation; Crystallography, X-Ray; Female; Isoenzymes; Isoxazoles; Mice; Mice, Inbred C57BL; Osteoclasts; Ovariectomy; Pentacyclic Triterpenes; Pyrazines; Pyrazoles; Pyrimidines; RANK Ligand; Rats; Structure-Activity Relationship; Tartrate-Resistant Acid Phosphatase; Thiazoles; Triterpenes | 2012 |
The proteasome inhibitor bortezomib reverses P-glycoprotein-mediated leukemia multi-drug resistance through the NF-kappaB pathway.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Boronic Acids; Bortezomib; Cell Survival; Coloring Agents; Drug Resistance, Neoplasm; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; I-kappa B Proteins; Indicators and Reagents; K562 Cells; NF-kappa B; Polymerase Chain Reaction; Proteasome Inhibitors; Pyrazines; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Thiazoles; Transcription Factor RelA | 2012 |
Simultaneous analysis of anticancer agents bortezomib, imatinib, nilotinib, dasatinib, erlotinib, lapatinib, sorafenib, sunitinib and vandetanib in human plasma using LC/MS/MS.
Topics: Antineoplastic Agents; Benzamides; Boronic Acids; Bortezomib; Chromatography, Liquid; Dasatinib; Erlotinib Hydrochloride; Humans; Imatinib Mesylate; Indoles; Lapatinib; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Pyrazines; Pyrimidines; Pyrroles; Quinazolines; Reproducibility of Results; Sorafenib; Sunitinib; Tandem Mass Spectrometry; Thiazoles | 2013 |
Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding.
Topics: Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Discovery; Humans; Immunoblotting; Neoplasms; Piperazines; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Tetrazolium Salts; Thiazoles | 2013 |
Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells.
Topics: Benzamides; Boronic Acids; Bortezomib; Caspases; Cell Death; Cell Line, Tumor; Dasatinib; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Fusion Proteins, bcr-abl; Heterocyclic Compounds, 2-Ring; Humans; Imatinib Mesylate; JNK Mitogen-Activated Protein Kinases; Leukemia; Mitosis; Models, Biological; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Pteridines; Pyrazines; Pyrimidines; Signal Transduction; STAT5 Transcription Factor; Thiazoles | 2013 |
Development and validation of method for heterocyclic compounds in wine: optimization of HS-SPME conditions applying a response surface methodology.
Topics: Factor Analysis, Statistical; Furans; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Maillard Reaction; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Microextraction; Temperature; Thiazoles; Thiophenes; Wine | 2013 |
Thioetherification of chloroheteroarenes: a binuclear catalyst promotes wide scope and high functional-group tolerance.
Topics: Catalysis; Furans; Halogenation; Ligands; Models, Molecular; Palladium; Phenols; Phosphines; Pyrazines; Pyridines; Quinolines; Sulfhydryl Compounds; Sulfides; Thiazoles | 2014 |
The search for a common structural moiety among selected pharmacological correctors of the mutant CFTR chloride channel.
Topics: Anisoles; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Deletion; Humans; Models, Molecular; Molecular Conformation; Piperazines; Purines; Pyrazines; Sildenafil Citrate; Sulfonamides; Thiazoles; Vasodilator Agents | 2014 |
Bortezomib enhances the therapeutic efficacy of dasatinib by promoting c-KIT internalization-induced apoptosis in gastrointestinal stromal tumor cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptotic Protease-Activating Factor 1; Biomarkers, Tumor; Blotting, Western; Boronic Acids; Bortezomib; Cell Cycle; Cell Proliferation; Dasatinib; Drug Synergism; Fluorescent Antibody Technique; Gastrointestinal Stromal Tumors; HSP90 Heat-Shock Proteins; Humans; Immunoprecipitation; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrazines; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Thiazoles; Tumor Cells, Cultured | 2015 |
Solid-Phase Parallel Synthesis of N-Substituted-2-aminothiazolo[4,5-b]pyrazine Derivatives via Tandem Reaction of Isothiocyanate Terminated Resin with o-Bromo-2-Aminopyrazines.
Topics: Cyclization; Isothiocyanates; Molecular Docking Simulation; Molecular Structure; Pyrazines; Solid-Phase Synthesis Techniques; Thiazoles | 2016 |
Concerted Action of PGC-1-related Coactivator (PRC) and c-MYC in the Stress Response to Mitochondrial Dysfunction.
Topics: Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Tumor; Glycogen Synthase Kinase 3 beta; Heterocyclic Compounds, 3-Ring; Humans; Mitochondria; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Pyrazines; Signal Transduction; Stress, Physiological; Sulfonamides; Thiazoles; Transcription Factors | 2016 |
Site of Metabolism Prediction Based on ab initio Derived Atom Representations.
Topics: Cytochrome P-450 Enzyme System; Drug Discovery; Machine Learning; Models, Molecular; Molecular Structure; Organic Chemicals; Pyrazines; Pyridines; Quantum Theory; Thiazoles | 2017 |
Drug therapy: On the treatment trail for ALS.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Benzamides; C9orf72 Protein; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Edaravone; Genetic Therapy; Humans; Imidazoles; Mesenchymal Stem Cells; Motor Neurons; Neuroglia; Off-Label Use; Oligoribonucleotides, Antisense; Piperidines; Precision Medicine; Pyrazines; Pyridines; Riluzole; RNAi Therapeutics; Stem Cell Transplantation; Superoxide Dismutase; Thiazoles; United States; United States Food and Drug Administration | 2017 |
Efficient 1,3,4-Thiadiazole-4,5-dihydropyridazin-3(2H)-ones as Antimicrobial Agents.
Topics: Anti-Bacterial Agents; Antifungal Agents; Dose-Response Relationship, Drug; Fungi; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Molecular Structure; Pyrazines; Structure-Activity Relationship; Thiazoles | 2018 |
Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors.
Topics: Animals; Dose-Response Relationship, Drug; Heterocyclic Compounds, 2-Ring; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Rats; Structure-Activity Relationship; Thiazoles | 2019 |
Characterization of the Volatile Compounds and Taste Attributes of Sesame Pastes Processed at Different Temperatures.
Topics: Alkenes; Food Handling; Food Quality; Gas Chromatography-Mass Spectrometry; Hot Temperature; Ketones; Odorants; Pyrazines; Sesamum; Solid Phase Microextraction; Taste; Thiazoles; Volatile Organic Compounds | 2019 |
Headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry with selected ion monitoring for the determination of four food flavoring compounds and its application in identifying artificially scented rice.
Topics: Flavoring Agents; Food Analysis; Gas Chromatography-Mass Spectrometry; Odorants; Oryza; Pyrazines; Pyridines; Reproducibility of Results; Solid Phase Microextraction; Thiazoles | 2020 |
Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors.
Topics: Antiviral Agents; Capsid Proteins; Dose-Response Relationship, Drug; Drug Design; Hepatitis B e Antigens; Hepatitis B virus; Microbial Sensitivity Tests; Molecular Structure; Pyrazines; Pyrazoles; Pyridines; Pyrimidines; Structure-Activity Relationship; Thiazoles; Virus Replication | 2020 |
Effect of drug metabolism in the treatment of SARS-CoV-2 from an entirely computational perspective.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; Drug Design; Drug Discovery; Humans; Metabolic Networks and Pathways; Molecular Docking Simulation; Nitro Compounds; Pyrazines; Pyrrolidines; Ribavirin; SARS-CoV-2; Thiazoles | 2021 |
African scientists race to test COVID drugs - but face major hurdles.
Topics: Africa; Amides; Amodiaquine; Artesunate; Atazanavir Sulfate; Carbamates; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Drug Approval; Drug Evaluation, Preclinical; Drug Repositioning; Drug Therapy, Combination; Humans; Hydroxylamines; Imidazoles; Ivermectin; Naphthyridines; Nitro Compounds; Pregnenediones; Pyrazines; Pyrrolidines; Ritonavir; Sample Size; Thiazoles; Valine; World Health Organization | 2021 |
Formation Priority of Pyrazines and 2-Acetylthiazole Dependent on the Added Cysteine and Fragments of Deoxyosones during the Thermal Process of the Glycine-Ribose Amadori Compound.
Topics: Cysteamine; Cysteine; Glycine; Glyoxal; Magnesium Oxide; Maillard Reaction; Pyrazines; Pyruvaldehyde; Ribose; Thiazoles | 2022 |