Page last updated: 2024-08-21

pyrazines and theophylline

pyrazines has been researched along with theophylline in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199014 (45.16)18.7374
1990's13 (41.94)18.2507
2000's4 (12.90)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Anderson, WH; Fitzpatrick, DF; Hwang, DP; Krzanowski, JJ; Polson, JB; Szentivanyi, A1
Candia, OA1
Brink, A; Fuder, H; Meincke, M; Tauber, U1
Bonnet, PA; Boucard, M; Chapat, JP; Laurent, F; Mani, JC; Michel, A; Rechencq, E; Sablayrolles, C1
Chiou, WF; Wu, CC; Yen, MH1
Giles, RE; Hwang, TF; Kau, ST; Keith, RA; Murthy, VS; Salama, AI; Wurm, R; Zagar, ME1
Salako, LA; Smith, AJ1
Bentley, PJ1
Mandel, LR1
Rigal, J; Savelli, A1
Carrère, J1
Bonnafous, JC; Chapat, JP; Francoise, MA; Levallois, C; Mani, JC; Sablayrolles, C1
Barnett, A; Chiu, PJ; Tetzloff, G1
Angelucci, R; Briatico-Vangosa, G; Lovisolo, PP; Orsini, G; Ronchi, R; Valzelli, G1
Hosokawa, T; Kojima, M; Mori, T; Yabuuchi, Y; Yamashita, S1
Archer, K; Buchheit, KH; Cook, SJ; Elliott, KR; Foster, RW; Fozard, JR; Martin, A; Miller, AJ; Müller, T; Small, RC1
Chen, HM; Lin, CI; Tao, PL; Wei, J; Wu, SL1
Bonnet, PA; Boucard, M; Chapat, JP; Laurent, F; Michel, A1
A-Rahim, YI; Beyer, KH; Kimball, SR; Rannels, SL; Vesell, ES1
Funaya, H; Hori, M; Kitakaze, M; Minamino, T; Mori, H; Node, K; Shinozaki, Y1
Anderson, DR; Chen, Q; Matsugi, T1
Nagai, H; Tanaka, H; Uno, T1
Sawada, M; Suzumura, A; Takayanagi, T; Tamaru, T; Yoshikawa, M1
Han, KS; Lee, MG1
Fredholm, BB; Lindström, K1
Fujii, S; Ito, Ki; Kaneko, K; Kato, H; Kuroda, Y1
Fujii, S; Ito, KL; Kaneko, K; Kato, H; Kuroda, Y; Sasaki, H; Yamazaki, Y; Yoshioka, M1
Fujii, S; Ito, K; Itoh, S; Kato, H; Kuroda, Y; Sasaki, H; Yamazaki, Y1
Choo, EF; Mayo, G; Shyr, Y; Sofowora, GG; Wilkinson, GR1
DOULL, J; PLZAK, V; ROOT, M1
Chapple, S; Collins, C; Fairman, DA1

Other Studies

31 other study(ies) available for pyrazines and theophylline

ArticleYear
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle.
    Biochemical pharmacology, 1979, Apr-15, Volume: 28, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Airway Resistance; Animals; Caffeine; Dogs; Etazolate; Female; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyrazines; Theophylline; Trachea; Triazoles

1979
Reduction of chloride fluxes by amiloride across the short-circuited frog skin.
    The American journal of physiology, 1978, Volume: 234, Issue:5

    Topics: Amiloride; Animals; Anura; Chlorides; Depression, Chemical; Drug Interactions; Electric Conductivity; In Vitro Techniques; Membrane Potentials; Models, Biological; Pyrazines; Rana catesbeiana; Rana pipiens; Skin; Sodium; Theophylline

1978
Purinoceptor-mediated modulation by endogenous and exogenous agonists of stimulation-evoked [3H]noradrenaline release on rat iris.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:4

    Topics: Adenosine; Animals; Electric Stimulation; In Vitro Techniques; Iris; Male; Norepinephrine; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Synaptic Transmission; Theophylline; Xanthines

1992
Synthesis and antibronchospastic activity of 8-alkoxy- and 8-(alkylamino)imidazo[1,2-a]pyrazines.
    Journal of medicinal chemistry, 1992, Sep-04, Volume: 35, Issue:18

    Topics: Animals; Bronchodilator Agents; Imidazoles; In Vitro Techniques; Male; Mice; Motor Activity; Phosphodiesterase Inhibitors; Pyrazines; Structure-Activity Relationship; Theophylline

1992
A possible mechanism of action of tetramethylpyrazine on vascular smooth muscle in rat aorta.
    European journal of pharmacology, 1989, Oct-10, Volume: 169, Issue:2-3

    Topics: Animals; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenethylamines; Potassium; Pyrazines; Rats; Rats, Inbred Strains; Theophylline; Vasodilation

1989
Insurmountable beta receptor blockade by ICI 147,798 in rabbits.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Heart Rate; Male; Propranolol; Pyrazines; Rabbits; Receptors, Adrenergic, beta; Theophylline

1989
Effects of amiloride on active sodium transport by the isolated frog skin: evidence concerning site of action.
    British journal of pharmacology, 1970, Volume: 38, Issue:4

    Topics: Animals; Anura; Biological Transport, Active; Cyclic AMP; Diuretics; Electric Conductivity; In Vitro Techniques; Membrane Potentials; Oxygen Consumption; Pyrazines; Skin; Sodium; Theophylline; Vasopressins

1970
Sodium and water movement across the urinary bladder of a urodele amphibian (th mudpuppy Necturus maculosus): studies and vasotocin and aldosterone.
    General and comparative endocrinology, 1971, Volume: 16, Issue:2

    Topics: Aldosterone; Amphotericin B; Animals; Anura; Biological Transport; Caffeine; Cyclic AMP; Diuretics; In Vitro Techniques; Membrane Potentials; Ouabain; Peptides; Physiology, Comparative; Pituitary Hormones, Posterior; Pyrazines; Seasons; Sodium; Theophylline; Urinary Bladder; Urodela; Vasotocin; Water

1971
Inhibition of cyclic 3',5'-adenosine monophosphate phosphodiesterase by substituted imidazopyrazines.
    Biochemical pharmacology, 1971, Volume: 20, Issue:12

    Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Bronchodilator Agents; Carbon Isotopes; Cattle; Cyclic AMP; Female; Glycerol; Heart; Imidazoles; In Vitro Techniques; Lung; Myocardium; Norepinephrine; Pancreas; Phosphoric Monoester Hydrolases; Pyrazines; Rabbits; Rats; Structure-Activity Relationship; Theophylline; Uterus; Vasodilator Agents

1971
[Study of clinical and encephalographic action of 1035 MD in child neuropsychiatry. Apropos of 33 cases followed during a year].
    Revue de neuropsychiatrie infantile et d'hygiene mentale de l'enfance, 1974, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Alpha Rhythm; Amino Alcohols; Child; Child Behavior Disorders; Cinnamates; Drug Combinations; Electroencephalography; Humans; Intellectual Disability; Piperazines; Psychometrics; Pyrazines; Theophylline; Vasodilator Agents

1974
[Restructuring action of Sureptil in anxio-depressive components of involutive states].
    Annales medico-psychologiques, 1970, Volume: 2, Issue:3

    Topics: Aged; Amino Alcohols; Bipolar Disorder; Cinnamates; Depressive Disorder, Major; Humans; Middle Aged; Psychological Tests; Psychoses, Alcoholic; Pyrazines; Theophylline; Vasodilator Agents

1970
Theophylline-like properties of xanthine analogs.
    Biochemical pharmacology, 1984, Jul-15, Volume: 33, Issue:14

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Adult; Animals; Female; Humans; In Vitro Techniques; Male; Mice; Pyrazines; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Thymidine; Xanthines

1984
Effects of SCH 32651 on resting and stimulated acid secretion in guinea-pig isolated fundic mucosa.
    British journal of pharmacology, 1984, Volume: 83, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Bucladesine; Drug Interactions; Gastric Acid; Gastric Fundus; Gastric Mucosa; Guinea Pigs; Histamine; Imidazoles; In Vitro Techniques; Male; Methacholine Compounds; Potassium; Pyrazines; Theophylline; Time Factors

1984
Pharmacological profile of a new anti-lipolytic agent: 5-methyl-pyrazine-2-carboxylic acid 4-oxide (acipimox) (1) I - Mechanism of action.
    Pharmacological research communications, 1981, Volume: 13, Issue:2

    Topics: Adipose Tissue; Animals; Bucladesine; Fatty Acids, Nonesterified; Lipolysis; Male; Nicotinic Acids; Norepinephrine; Oxidative Phosphorylation; Pyrazines; Rats; Theophylline

1981
In vitro and in vivo studies of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212), a novel positive inotropic drug, in various animals.
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:3A

    Topics: Aminopyridines; Amrinone; Animals; Blood Pressure; Cardiotonic Agents; Cardiovascular System; Cats; Dobutamine; Dogs; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Phentolamine; Pindolol; Pyrazines; Quinolines; Rabbits; Rats; Sodium-Potassium-Exchanging ATPase; Theophylline

1984
Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40.
    British journal of pharmacology, 1995, Volume: 114, Issue:1

    Topics: Animals; Cyclic AMP; Electric Stimulation; Electrophysiology; Female; Guinea Pigs; Imidazoles; Isoproterenol; Male; Nifedipine; Parasympatholytics; Pyrazines; Quinine; Theophylline; Trachea

1995
The role of cyclic AMP and phosphodiesterase activity in the mechanism of action of tetramethylpyrazine on human and dog cardiac and dog coronary arterial tissues.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:11

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Action Potentials; Animals; Coronary Vessels; Cyclic AMP; Dogs; Epinephrine; Female; Heart; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardium; Purkinje Fibers; Pyrazines; Theophylline; Vasodilator Agents

1993
Pharmacological activities of imidazo[1,2-alpha]pyrazine derivatives.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:12

    Topics: Adenosine; Animals; Calcium; Cardiovascular Agents; Cattle; Diuresis; Guinea Pigs; Heart Atria; Heart Rate; Ileum; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myocardial Contraction; Parasympatholytics; Phosphodiesterase Inhibitors; Pyrazines; Rabbits; Rats; Rats, Wistar; Theophylline; Trachea

1995
Studies on pyrazinoylguanidine. 4. Upregulation of phosphodiesterase activity in rat adipose tissue and downregulation of gluconeogenesis and adenosine 3',5'-monophosphate concentrations in perfused rat liver.
    Pharmacology, 1996, Volume: 53, Issue:4

    Topics: Adipocytes; Adipose Tissue; Animals; Cell Membrane; Cyclic AMP; Down-Regulation; Gluconeogenesis; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Liver; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Rats; Rats, Sprague-Dawley; Theophylline; Up-Regulation

1996
Vesnarinone limits infarct size via adenosine-dependent mechanisms in the canine heart.
    Circulation, 1997, Apr-15, Volume: 95, Issue:8

    Topics: 5'-Nucleotidase; Adenosine; Adenosine Diphosphate; Animals; Cardiotonic Agents; Dipyridamole; Dogs; Enzyme Activation; Enzyme Inhibitors; Infusions, Intra-Arterial; Ion Channel Gating; Myocardial Infarction; Myocardial Reperfusion Injury; Potassium Channels; Pyrazines; Quinolines; Receptors, Purinergic P1; Theophylline

1997
Adenosine-induced relaxation of cultured bovine retinal pericytes.
    Investigative ophthalmology & visual science, 1997, Volume: 38, Issue:13

    Topics: Adenosine; Animals; Capillaries; Cattle; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Purinergic P1 Receptor Antagonists; Pyrazines; Receptors, Purinergic P1; Retinal Vessels; Theophylline; Vasodilator Agents; Xanthines

1997
Effects of isoenzyme selective phosphodiesterase inhibitors on bacterial lipopolysaccharide-induced bronchial hyperreactivity in guinea pigs.
    General pharmacology, 1998, Volume: 30, Issue:2

    Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cilostazol; Guinea Pigs; Isoenzymes; Lipopolysaccharides; Male; Neutrophils; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Quinolines; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha

1998
Effects of phosphodiesterase inhibitors on cytokine production by microglia.
    Multiple sclerosis (Houndmills, Basingstoke, England), 1999, Volume: 5, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Anti-Ulcer Agents; Cilostazol; Colforsin; Dipyridamole; DNA Primers; Gene Expression Regulation, Enzymologic; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha; Vinca Alkaloids; Xanthines

1999
Effect of a new chemoprotective agent, 2-(allylthio)pyrazine, on the pharmacokinetics of intravenous theophylline in rats.
    International journal of pharmaceutics, 1999, Jul-20, Volume: 184, Issue:2

    Topics: Animals; Area Under Curve; Biotransformation; Bronchodilator Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Infusions, Intravenous; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Theophylline

1999
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors.
    European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3

    Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Caffeine; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Tritium; Xanthines

1999
Effects of adenosine receptors on the synaptic and EPSP-spike components of long-term potentiation and depotentiation in the guinea-pig hippocampus.
    The Journal of physiology, 1999, Dec-01, Volume: 521 Pt 2

    Topics: Action Potentials; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Excitatory Postsynaptic Potentials; Guinea Pigs; Hippocampus; Long-Term Potentiation; Male; Neuronal Plasticity; Organ Culture Techniques; Pyrazines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Synaptic Transmission; Theophylline

1999
Endogenous adenosine regulates the effects of low-frequency stimulation on the induction of long-term potentiation in CA1 neurons of guinea pig hippocampal slices.
    Neuroscience letters, 2000, Jan-28, Volume: 279, Issue:2

    Topics: Adenosine; Afferent Pathways; Animals; Electric Stimulation; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Purinergic P1 Receptor Antagonists; Pyramidal Cells; Pyrazines; Receptors, Purinergic P1; Theophylline

2000
Effects of A1 and A2 adenosine receptor antagonists on the induction and reversal of long-term potentiation in guinea pig hippocampal slices of CA1 neurons.
    Cellular and molecular neurobiology, 2000, Volume: 20, Issue:3

    Topics: Action Potentials; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Dendrites; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Guinea Pigs; Hippocampus; Long-Term Potentiation; Neuronal Plasticity; Organ Culture Techniques; Pyramidal Cells; Pyrazines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Theophylline

2000
In vivo inhibition of human CYP1A2 activity by oltipraz.
    Cancer chemotherapy and pharmacology, 2001, Volume: 47, Issue:6

    Topics: Adult; Antineoplastic Agents; Caffeine; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Female; Humans; Male; Methylation; Pyrazines; Theophylline; Thiones; Thiophenes

2001
PHARMACOLOGICAL OR TOXICOLOGICAL COMPOUNDS AS PROTECTIVE OR THERAPEUTIC AGENTS AGAINST RADIATION INJURY IN EXPERIMENTAL ANIMALS. II. THE INFLUENCE OF VARIOUS CHEMICAL COMPOUNDS ON RADIATION LETHALITY IN MICE. REP NO. 51.
    Quarterly progress report. United States. Air Force. Radiation Laboratory, University of Chicago, 1964, Apr-15, Volume: 51

    Topics: Animals; Animals, Laboratory; Cresols; Cyanides; Indoles; Pharmacology; Pyrazines; Radiation Injuries; Radiation-Protective Agents; Research; Statistics as Topic; Theophylline; Thiourea

1964
Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation?
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:12

    Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dihydralazine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Models, Biological; NADP; Paroxetine; Pyrazines; Resveratrol; Stilbenes; Theophylline; Thiones; Thiophenes

2007