pyrazines has been researched along with theophylline in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (45.16) | 18.7374 |
| 1990's | 13 (41.94) | 18.2507 |
| 2000's | 4 (12.90) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, WH; Fitzpatrick, DF; Hwang, DP; Krzanowski, JJ; Polson, JB; Szentivanyi, A | 1 |
| Candia, OA | 1 |
| Brink, A; Fuder, H; Meincke, M; Tauber, U | 1 |
| Bonnet, PA; Boucard, M; Chapat, JP; Laurent, F; Mani, JC; Michel, A; Rechencq, E; Sablayrolles, C | 1 |
| Chiou, WF; Wu, CC; Yen, MH | 1 |
| Giles, RE; Hwang, TF; Kau, ST; Keith, RA; Murthy, VS; Salama, AI; Wurm, R; Zagar, ME | 1 |
| Salako, LA; Smith, AJ | 1 |
| Bentley, PJ | 1 |
| Mandel, LR | 1 |
| Rigal, J; Savelli, A | 1 |
| Carrère, J | 1 |
| Bonnafous, JC; Chapat, JP; Francoise, MA; Levallois, C; Mani, JC; Sablayrolles, C | 1 |
| Barnett, A; Chiu, PJ; Tetzloff, G | 1 |
| Angelucci, R; Briatico-Vangosa, G; Lovisolo, PP; Orsini, G; Ronchi, R; Valzelli, G | 1 |
| Hosokawa, T; Kojima, M; Mori, T; Yabuuchi, Y; Yamashita, S | 1 |
| Archer, K; Buchheit, KH; Cook, SJ; Elliott, KR; Foster, RW; Fozard, JR; Martin, A; Miller, AJ; Müller, T; Small, RC | 1 |
| Chen, HM; Lin, CI; Tao, PL; Wei, J; Wu, SL | 1 |
| Bonnet, PA; Boucard, M; Chapat, JP; Laurent, F; Michel, A | 1 |
| A-Rahim, YI; Beyer, KH; Kimball, SR; Rannels, SL; Vesell, ES | 1 |
| Funaya, H; Hori, M; Kitakaze, M; Minamino, T; Mori, H; Node, K; Shinozaki, Y | 1 |
| Anderson, DR; Chen, Q; Matsugi, T | 1 |
| Nagai, H; Tanaka, H; Uno, T | 1 |
| Sawada, M; Suzumura, A; Takayanagi, T; Tamaru, T; Yoshikawa, M | 1 |
| Han, KS; Lee, MG | 1 |
| Fredholm, BB; Lindström, K | 1 |
| Fujii, S; Ito, Ki; Kaneko, K; Kato, H; Kuroda, Y | 1 |
| Fujii, S; Ito, KL; Kaneko, K; Kato, H; Kuroda, Y; Sasaki, H; Yamazaki, Y; Yoshioka, M | 1 |
| Fujii, S; Ito, K; Itoh, S; Kato, H; Kuroda, Y; Sasaki, H; Yamazaki, Y | 1 |
| Choo, EF; Mayo, G; Shyr, Y; Sofowora, GG; Wilkinson, GR | 1 |
| DOULL, J; PLZAK, V; ROOT, M | 1 |
| Chapple, S; Collins, C; Fairman, DA | 1 |
31 other study(ies) available for pyrazines and theophylline
| Article | Year |
|---|---|
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Airway Resistance; Animals; Caffeine; Dogs; Etazolate; Female; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyrazines; Theophylline; Trachea; Triazoles | 1979 |
Reduction of chloride fluxes by amiloride across the short-circuited frog skin.
Topics: Amiloride; Animals; Anura; Chlorides; Depression, Chemical; Drug Interactions; Electric Conductivity; In Vitro Techniques; Membrane Potentials; Models, Biological; Pyrazines; Rana catesbeiana; Rana pipiens; Skin; Sodium; Theophylline | 1978 |
Purinoceptor-mediated modulation by endogenous and exogenous agonists of stimulation-evoked [3H]noradrenaline release on rat iris.
Topics: Adenosine; Animals; Electric Stimulation; In Vitro Techniques; Iris; Male; Norepinephrine; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Synaptic Transmission; Theophylline; Xanthines | 1992 |
Synthesis and antibronchospastic activity of 8-alkoxy- and 8-(alkylamino)imidazo[1,2-a]pyrazines.
Topics: Animals; Bronchodilator Agents; Imidazoles; In Vitro Techniques; Male; Mice; Motor Activity; Phosphodiesterase Inhibitors; Pyrazines; Structure-Activity Relationship; Theophylline | 1992 |
A possible mechanism of action of tetramethylpyrazine on vascular smooth muscle in rat aorta.
Topics: Animals; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenethylamines; Potassium; Pyrazines; Rats; Rats, Inbred Strains; Theophylline; Vasodilation | 1989 |
Insurmountable beta receptor blockade by ICI 147,798 in rabbits.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Heart Rate; Male; Propranolol; Pyrazines; Rabbits; Receptors, Adrenergic, beta; Theophylline | 1989 |
Effects of amiloride on active sodium transport by the isolated frog skin: evidence concerning site of action.
Topics: Animals; Anura; Biological Transport, Active; Cyclic AMP; Diuretics; Electric Conductivity; In Vitro Techniques; Membrane Potentials; Oxygen Consumption; Pyrazines; Skin; Sodium; Theophylline; Vasopressins | 1970 |
Sodium and water movement across the urinary bladder of a urodele amphibian (th mudpuppy Necturus maculosus): studies and vasotocin and aldosterone.
Topics: Aldosterone; Amphotericin B; Animals; Anura; Biological Transport; Caffeine; Cyclic AMP; Diuretics; In Vitro Techniques; Membrane Potentials; Ouabain; Peptides; Physiology, Comparative; Pituitary Hormones, Posterior; Pyrazines; Seasons; Sodium; Theophylline; Urinary Bladder; Urodela; Vasotocin; Water | 1971 |
Inhibition of cyclic 3',5'-adenosine monophosphate phosphodiesterase by substituted imidazopyrazines.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Bronchodilator Agents; Carbon Isotopes; Cattle; Cyclic AMP; Female; Glycerol; Heart; Imidazoles; In Vitro Techniques; Lung; Myocardium; Norepinephrine; Pancreas; Phosphoric Monoester Hydrolases; Pyrazines; Rabbits; Rats; Structure-Activity Relationship; Theophylline; Uterus; Vasodilator Agents | 1971 |
[Study of clinical and encephalographic action of 1035 MD in child neuropsychiatry. Apropos of 33 cases followed during a year].
Topics: Adolescent; Adult; Alpha Rhythm; Amino Alcohols; Child; Child Behavior Disorders; Cinnamates; Drug Combinations; Electroencephalography; Humans; Intellectual Disability; Piperazines; Psychometrics; Pyrazines; Theophylline; Vasodilator Agents | 1974 |
[Restructuring action of Sureptil in anxio-depressive components of involutive states].
Topics: Aged; Amino Alcohols; Bipolar Disorder; Cinnamates; Depressive Disorder, Major; Humans; Middle Aged; Psychological Tests; Psychoses, Alcoholic; Pyrazines; Theophylline; Vasodilator Agents | 1970 |
Theophylline-like properties of xanthine analogs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Adult; Animals; Female; Humans; In Vitro Techniques; Male; Mice; Pyrazines; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Thymidine; Xanthines | 1984 |
Effects of SCH 32651 on resting and stimulated acid secretion in guinea-pig isolated fundic mucosa.
Topics: Animals; Anti-Ulcer Agents; Bucladesine; Drug Interactions; Gastric Acid; Gastric Fundus; Gastric Mucosa; Guinea Pigs; Histamine; Imidazoles; In Vitro Techniques; Male; Methacholine Compounds; Potassium; Pyrazines; Theophylline; Time Factors | 1984 |
Pharmacological profile of a new anti-lipolytic agent: 5-methyl-pyrazine-2-carboxylic acid 4-oxide (acipimox) (1) I - Mechanism of action.
Topics: Adipose Tissue; Animals; Bucladesine; Fatty Acids, Nonesterified; Lipolysis; Male; Nicotinic Acids; Norepinephrine; Oxidative Phosphorylation; Pyrazines; Rats; Theophylline | 1981 |
In vitro and in vivo studies of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212), a novel positive inotropic drug, in various animals.
Topics: Aminopyridines; Amrinone; Animals; Blood Pressure; Cardiotonic Agents; Cardiovascular System; Cats; Dobutamine; Dogs; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Phentolamine; Pindolol; Pyrazines; Quinolines; Rabbits; Rats; Sodium-Potassium-Exchanging ATPase; Theophylline | 1984 |
Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40.
Topics: Animals; Cyclic AMP; Electric Stimulation; Electrophysiology; Female; Guinea Pigs; Imidazoles; Isoproterenol; Male; Nifedipine; Parasympatholytics; Pyrazines; Quinine; Theophylline; Trachea | 1995 |
The role of cyclic AMP and phosphodiesterase activity in the mechanism of action of tetramethylpyrazine on human and dog cardiac and dog coronary arterial tissues.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Action Potentials; Animals; Coronary Vessels; Cyclic AMP; Dogs; Epinephrine; Female; Heart; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardium; Purkinje Fibers; Pyrazines; Theophylline; Vasodilator Agents | 1993 |
Pharmacological activities of imidazo[1,2-alpha]pyrazine derivatives.
Topics: Adenosine; Animals; Calcium; Cardiovascular Agents; Cattle; Diuresis; Guinea Pigs; Heart Atria; Heart Rate; Ileum; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myocardial Contraction; Parasympatholytics; Phosphodiesterase Inhibitors; Pyrazines; Rabbits; Rats; Rats, Wistar; Theophylline; Trachea | 1995 |
Studies on pyrazinoylguanidine. 4. Upregulation of phosphodiesterase activity in rat adipose tissue and downregulation of gluconeogenesis and adenosine 3',5'-monophosphate concentrations in perfused rat liver.
Topics: Adipocytes; Adipose Tissue; Animals; Cell Membrane; Cyclic AMP; Down-Regulation; Gluconeogenesis; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Liver; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Rats; Rats, Sprague-Dawley; Theophylline; Up-Regulation | 1996 |
Vesnarinone limits infarct size via adenosine-dependent mechanisms in the canine heart.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Diphosphate; Animals; Cardiotonic Agents; Dipyridamole; Dogs; Enzyme Activation; Enzyme Inhibitors; Infusions, Intra-Arterial; Ion Channel Gating; Myocardial Infarction; Myocardial Reperfusion Injury; Potassium Channels; Pyrazines; Quinolines; Receptors, Purinergic P1; Theophylline | 1997 |
Adenosine-induced relaxation of cultured bovine retinal pericytes.
Topics: Adenosine; Animals; Capillaries; Cattle; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Purinergic P1 Receptor Antagonists; Pyrazines; Receptors, Purinergic P1; Retinal Vessels; Theophylline; Vasodilator Agents; Xanthines | 1997 |
Effects of isoenzyme selective phosphodiesterase inhibitors on bacterial lipopolysaccharide-induced bronchial hyperreactivity in guinea pigs.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cilostazol; Guinea Pigs; Isoenzymes; Lipopolysaccharides; Male; Neutrophils; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Quinolines; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha | 1998 |
Effects of phosphodiesterase inhibitors on cytokine production by microglia.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Anti-Ulcer Agents; Cilostazol; Colforsin; Dipyridamole; DNA Primers; Gene Expression Regulation, Enzymologic; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha; Vinca Alkaloids; Xanthines | 1999 |
Effect of a new chemoprotective agent, 2-(allylthio)pyrazine, on the pharmacokinetics of intravenous theophylline in rats.
Topics: Animals; Area Under Curve; Biotransformation; Bronchodilator Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Infusions, Intravenous; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Theophylline | 1999 |
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors.
Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Caffeine; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Tritium; Xanthines | 1999 |
Effects of adenosine receptors on the synaptic and EPSP-spike components of long-term potentiation and depotentiation in the guinea-pig hippocampus.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Excitatory Postsynaptic Potentials; Guinea Pigs; Hippocampus; Long-Term Potentiation; Male; Neuronal Plasticity; Organ Culture Techniques; Pyrazines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Synaptic Transmission; Theophylline | 1999 |
Endogenous adenosine regulates the effects of low-frequency stimulation on the induction of long-term potentiation in CA1 neurons of guinea pig hippocampal slices.
Topics: Adenosine; Afferent Pathways; Animals; Electric Stimulation; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Purinergic P1 Receptor Antagonists; Pyramidal Cells; Pyrazines; Receptors, Purinergic P1; Theophylline | 2000 |
Effects of A1 and A2 adenosine receptor antagonists on the induction and reversal of long-term potentiation in guinea pig hippocampal slices of CA1 neurons.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Dendrites; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Guinea Pigs; Hippocampus; Long-Term Potentiation; Neuronal Plasticity; Organ Culture Techniques; Pyramidal Cells; Pyrazines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Theophylline | 2000 |
In vivo inhibition of human CYP1A2 activity by oltipraz.
Topics: Adult; Antineoplastic Agents; Caffeine; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Female; Humans; Male; Methylation; Pyrazines; Theophylline; Thiones; Thiophenes | 2001 |
PHARMACOLOGICAL OR TOXICOLOGICAL COMPOUNDS AS PROTECTIVE OR THERAPEUTIC AGENTS AGAINST RADIATION INJURY IN EXPERIMENTAL ANIMALS. II. THE INFLUENCE OF VARIOUS CHEMICAL COMPOUNDS ON RADIATION LETHALITY IN MICE. REP NO. 51.
Topics: Animals; Animals, Laboratory; Cresols; Cyanides; Indoles; Pharmacology; Pyrazines; Radiation Injuries; Radiation-Protective Agents; Research; Statistics as Topic; Theophylline; Thiourea | 1964 |
Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation?
Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dihydralazine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Models, Biological; NADP; Paroxetine; Pyrazines; Resveratrol; Stilbenes; Theophylline; Thiones; Thiophenes | 2007 |