pyrazines has been researched along with spironolactone in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fraser, R; Hettiarachchi, J; Morton, JJ; Ramsay, LE; Shelton, J | 1 |
| Eisalo, A; Kohvakka, A; Manninen, V | 1 |
| Berg, KJ | 1 |
| Burkinshaw, L; Davidson, C; Morgan, DB | 1 |
| Benvenuti, C; Sanguigni, D | 1 |
| Corvol, P; Milliez, P; Thibonnier, M | 1 |
| Juhos, E; Radó, JP; Sawinsky, I | 1 |
| Juhos, E; Radó, JP | 1 |
| Albiez, G; Knauf, H; Lübcke, R; Wais, U | 1 |
| Cortright, RN; Groseclose, RG; Hopfer, U; Will, PC | 1 |
| Breckenridge, AM; Dollery, CT; George, CF | 1 |
| Beevers, DG; Brown, JJ; Davies, DL; Ferriss, JB; Fraser, R; Kremer, D; Lever, AF; Robertson, JI | 1 |
| Ilett, KF; Lockett, MF | 1 |
| Brummer, P | 1 |
| Sanna, GP | 1 |
| Brown, JJ; Davies, DL; Fraser, R; Kremer, D; Lever, AF; Robertson, JI | 1 |
| Riecker, G | 1 |
| Esch, I | 1 |
| Meyer, P; Milliez, P | 1 |
| Hillenbrand, P; Sherlock, S | 1 |
| Gitelman, HJ; Graham, JB; Welt, LG | 1 |
| Jelinek, J; Krajny, M; Selye, H | 1 |
| McNay, JL; Oran, E | 1 |
| Formanek, K; Hohenegger, M | 1 |
| Reynolds, TB; Yamada, S | 1 |
| Cragoe, EJ; Jones, JH | 1 |
| Glitzer, MS; Steelman, SL | 1 |
| Cumming, AM; Fraser, R; Leckie, B; Mason, P; Millar, JA; Robertson, JI | 1 |
| Drayer, JI; Hoefnagels, WH; Kloppenborg, PW; Smals, AG | 1 |
| McInnes, GT | 1 |
| Ceccarelli, S; Charney, AN; Costenbader, CL; Donowitz, M; Wallach, J | 1 |
| Fraser, R; Hettiarachchi, J; Morton, JJ; Ramsay, LE | 1 |
7 trial(s) available for pyrazines and spironolactone
| Article | Year |
|---|---|
The relative potency of amiloride and spironolactone in bendrofluazide-treated hypertensive patients [proceedings].
Topics: Amiloride; Bendroflumethiazide; Clinical Trials as Topic; Humans; Hypertension; Pyrazines; Spironolactone | 1978 |
Maintenance of potassium balance during diuretic therapy.
Topics: Adult; Aged; Amiloride; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle Aged; Placebos; Potassium; Potassium Chloride; Pyrazines; Spironolactone; Triamterene | 1979 |
The effects of potassium supplements, spironolactone of amiloride on the potassium status of patients with heart failure.
Topics: Adult; Aged; Amiloride; Female; Furosemide; Heart Failure; Humans; Male; Middle Aged; Potassium; Potassium Deficiency; Pyrazines; Spironolactone | 1978 |
Comparison of the potassium- retaining effects of amiloride and spironolactone in hypertensive patients with thiazide-induced hypokalaemia.
Topics: Adult; Aged; Amiloride; Blood Pressure; Body Weight; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle Aged; Pyrazines; Sodium; Spironolactone; Time Factors; Urea | 1973 |
Extrarenal effects of diuretic agents.
Topics: Acidosis, Renal Tubular; Adipose Tissue; Alkalosis; Animals; Antihypertensive Agents; Blood Volume; Clinical Trials as Topic; Diuretics; Erythrocytes; Ethacrynic Acid; Furosemide; Glucose; Glycogen; Humans; Hyperkalemia; Hypokalemia; Membrane Potentials; Potassium; Pyrazines; Sodium; Spironolactone; Triamterene | 1970 |
[Treatment of the hypertensive patient. Value of Amiloride during saldiuretic treatment].
Topics: Adult; Amiloride; Diuretics; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Kidney Function Tests; Male; Middle Aged; Natriuresis; Potassium; Pyrazines; Spironolactone; Water-Electrolyte Balance | 1972 |
Amiloride (MK-870), a new antikaluretic diuretic. Comparison to other antikaluretic diuretics in patients with liver disease and ascites.
Topics: Acid-Base Equilibrium; Amidines; Ascites; Autopsy; Carcinoma; Diuretics; Ethacrynic Acid; Humans; Hydrochlorothiazide; Hydrogen-Ion Concentration; Hyperkalemia; Liver Cirrhosis; Liver Neoplasms; Pyrazines; Spironolactone; Triamterene; Water-Electrolyte Balance | 1970 |
25 other study(ies) available for pyrazines and spironolactone
| Article | Year |
|---|---|
[Use and abuse of potassium-saving diuretics].
Topics: Amiloride; Humans; Hypertension; Pyrazines; Spironolactone; Substance-Related Disorders | 1979 |
[Comparison of spironolactone and amiloride combined with hydrochlorothiazide in the treatment of slight or moderate hypertension].
Topics: Amiloride; Blood Glucose; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Spironolactone; Uric Acid | 1978 |
[Spirolactones and potassium-sparing diuretics].
Topics: Amiloride; Edema; Humans; Hyperaldosteronism; Hypertension; Pyrazines; Spironolactone; Triamterene | 1978 |
Paradoxical reversal of the suppressed potassium secretion during treatment with combinations of antikaluretic agents (spironolactone, canrenone, triamterene, amiloride); a possible site of action in Henle's loop.
Topics: Amiloride; Canrenone; Humans; Kidney Tubules; Liver Cirrhosis; Loop of Henle; Male; Middle Aged; Potassium; Pregnadienes; Pyrazines; Sodium; Spironolactone; Triamterene | 1976 |
Opposite effects of spironolactone and amiloride on potassium excretion in a patient with ascites due to liver cirrhosis.
Topics: Amiloride; Ascites; Drug Interactions; Female; Humans; Liver Cirrhosis; Middle Aged; Potassium; Pyrazines; Spironolactone | 1976 |
[Potassium-saving effects of amiloride, triamterene and spironolactone].
Topics: Amiloride; Animals; Potassium; Pyrazines; Rats; Spironolactone; Triamterene | 1976 |
Amiloride-sensitive salt and fluid absorption in small intestine of sodium-depleted rats.
Topics: Adrenalectomy; Amiloride; Animals; Body Water; Colon; Diet, Sodium-Restricted; Electric Conductivity; Hyperaldosteronism; Intestinal Absorption; Intestine, Small; Intestines; Male; Membrane Potentials; Pyrazines; Rats; Rats, Inbred Strains; Sodium Chloride; Spironolactone | 1985 |
Spironolactone and amiloride in the treatment of low renin hyperaldosteronism and related syndromes.
Topics: Adrenocortical Hyperfunction; Amiloride; Angiotensin II; Body Water; Corticosterone; Diuretics; Extracellular Space; Humans; Hyperaldosteronism; Hypertension; Plasma Volume; Potassium; Pyrazines; Renin; Secretory Rate; Sodium; Spironolactone; Urea | 1973 |
Adaptation to the natriuretic actions of hydrochlorothiazide, frusemide and amiloride, by rats.
Topics: Adaptation, Physiological; Adrenal Glands; Adrenalectomy; Aldosterone; Amiloride; Animals; Corticosterone; Diuresis; Diuretics; Female; Furosemide; Hydrochlorothiazide; Juxtaglomerular Apparatus; Natriuresis; Potassium; Pyrazines; Rats; Renin; Sodium; Sodium Chloride; Spironolactone; Time Factors | 1972 |
[Letter: Potassium retaining diuretics].
Topics: Amiloride; Humans; Potassium; Pyrazines; Spironolactone; Stimulation, Chemical; Triamterene | 1974 |
Antikaluretic action of amiloride.
Topics: Amiloride; Animals; Calcium; Diuretics; Furosemide; Hydrochlorothiazide; Kidney; Potassium; Pyrazines; Rats; Spironolactone | 1973 |
Amiloride in primary hyperaldosteronism with chronic peptic ulceration.
Topics: Aged; Amiloride; Bicarbonates; Blood Pressure; Body Water; Chlorides; Chronic Disease; Diuretics; Female; Humans; Hyperaldosteronism; Hypertension; Peptic Ulcer; Potassium; Pyrazines; Sodium; Spironolactone; Urea | 1973 |
[Antikaliuretic agents].
Topics: Adult; Aged; Aldosterone; Chemistry; Diuretics; Female; History, 20th Century; Humans; Hyperaldosteronism; Male; Mineralocorticoid Receptor Antagonists; Potassium; Pyrazines; Spironolactone; Triamterene | 1971 |
Use of metolazone in the treatment of ascites due to liver disease.
Topics: Adult; Ascites; Chlorides; Chronic Disease; Diuretics; Female; Hepatic Encephalopathy; Humans; Hypokalemia; Hyponatremia; Ketones; Liver Diseases; Male; Middle Aged; Nitrogen; Pyrazines; Quinazolines; Spironolactone; Sulfonamides; Uremia | 1971 |
A familial disorder characterized by hypokalemia and hypomagnesemia.
Topics: Calcium; Diuretics; Female; Humans; Kidney; Magnesium; Magnesium Deficiency; Pedigree; Potassium; Potassium Deficiency; Pyrazines; Sodium Chloride; Spironolactone; Triamterene | 1969 |
Prevention of digitoxin poisoning by various steroids.
Topics: Anabolic Agents; Androstanes; Animals; Body Weight; Desoxycorticosterone; Digitoxin; Diuretics; Estradiol; Ethisterone; Ethylestrenol; Female; Fluoxymesterone; Hydrocortisone; Ketones; Methyltestosterone; Nandrolone; Norethandrolone; Norethynodrel; Organ Size; Oxandrolone; Oxymetholone; Poisoning; Pregnanes; Pregnenolone; Progesterone; Pyrazines; Rats; Spironolactone; Testosterone; Triamterene | 1969 |
Possible predisposition of diabetic patients to hyperkalemia following administration of potassium-retaining diuretic, amiloride (MK 870).
Topics: Adult; Aged; Bicarbonates; Blood Pressure; Body Weight; Chemical Phenomena; Chemistry; Chlorides; Creatinine; Diabetes Mellitus; Diuretics; Electrocardiography; Female; Humans; Hyperkalemia; Male; Middle Aged; Potassium; Pyrazines; Sodium; Spironolactone; Triamterene; Water-Electrolyte Balance | 1970 |
[Influence of triamterene, aldactone and amilorid on the electrolyte excretion following oral potassium loading test in rats].
Topics: Administration, Oral; Animals; Diuresis; Diuretics; Male; Natriuresis; Potassium; Pyrazines; Rats; Spironolactone; Triamterene; Urine | 1970 |
Pyrazine diuretics. V. N-Amidino-3-aminopyrazinecarboxamidines and analogous 2,4-diaminopteridines.
Topics: Adrenal Glands; Adrenalectomy; Animals; Chemical Phenomena; Chemistry, Physical; Diuretics; Dogs; Pteridines; Pyrazines; Rats; Spironolactone; Triamterene | 1968 |
N-Amidino-3,5-diamino-6-chloropyrazine-carboxamide: an active diuretic in the carboxamide series.
Topics: Adrenalectomy; Aldosterone; Amides; Amidines; Animals; Desoxycorticosterone; Diuretics; Hydrochlorothiazide; Hydrocortisone; Male; Potassium; Pyrazines; Rats; Sodium; Spironolactone; Sulfhydryl Compounds | 1966 |
Metabolic effects of high dose amiloride and spironolactone: a comparative study in normal subjects.
Topics: Adult; Aldosterone; Amiloride; Angiotensin II; Dose-Response Relationship, Drug; Endocrine Glands; Humans; Male; Metabolism; Mineralocorticoids; Potassium; Pyrazines; Renin; Sodium; Spironolactone; Time Factors | 1984 |
Spironolactone and amiloride in hypertensive patients with and without aldosterone excess.
Topics: Adult; Amiloride; Blood Pressure; Body Weight; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Renin; Spironolactone; Urea | 1980 |
Relative potency of amiloride and spironolactone in healthy man.
Topics: Adult; Amiloride; Dose-Response Relationship, Drug; Humans; Male; Potassium; Pyrazines; Sodium; Spironolactone | 1982 |
Effects of spironolactone and amiloride on corticosteroid-induced changes in colonic function.
Topics: Adrenal Cortex Hormones; Amiloride; Animals; Biological Transport, Active; Colon; In Vitro Techniques; Jejunum; Male; Perfusion; Pyrazines; Rats; Sodium; Spironolactone; Water | 1981 |
Amiloride, spironolactone, and potassium chloride in thiazide-treated hypertensive patients.
Topics: Adult; Aldosterone; Amiloride; Angiotensin II; Bendroflumethiazide; Bicarbonates; Blood Pressure; Diuretics; Female; Humans; Hypertension; Hypokalemia; Male; Middle Aged; Placebos; Potassium; Potassium Chloride; Pyrazines; Sodium; Sodium Chloride Symporter Inhibitors; Spironolactone | 1980 |