pyrazines has been researched along with simvastatin in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alberti, KG; Dyer, RG; Laker, MF; Stewart, MW | 1 |
| Cummings, MH; Watts, GF | 1 |
| Cramb, R; Head, A; Jakeman, PM; Kendall, MJ; Maxwell, S | 1 |
| Birkenhäger, JC; De Heide, L; Deckers, JW; Hoogerbrugge, N; Jansen, H; Zillikens, MC | 2 |
| Kleinjans, HA; Stalenhoef, AF; Stuyt, PM | 1 |
| Algra, A; Banga, JD; de Bruint, TW; Erkelens, DW; Kanters, SD | 1 |
| Baumann, P; Bumeder, I; Emmerich, B; Meinhardt, G; Schmidmaier, R; Straka, C | 1 |
| Eisendle, K; Fritsch, P; Linder, D; Philipp, W; Piza, H; Ratzinger, G; Schmuth, M; Zelger, B | 1 |
| Berges, C; Daniel, V; Fuchs, D; Naujokat, C; Opelz, G | 1 |
| Kao, DP; Kohrt, HE; Kugler, J | 1 |
| Bergman, AJ; Cote, J; Davies, MJ; De Smet, M; Herman, GA; Keymeulen, B; Laethem, T; Maes, A; Mathijs, Z; Roadcap, BA; Sun, L; Valesky, RJ; Wagner, JA; Yang, A; Zhao, JJ | 1 |
| Boucher, BJ | 1 |
| Burugula, L; Kandhagatla, R; Lodagala, DS; Makula, A; Mullangi, R; Pilli, NR | 1 |
| Anderson, MS; Cerra, M; Li, SX; Luo, WL; Matthews, C; O'Neill, EA; Stoch, SA; Wagner, JA | 1 |
| Anderson, MS; Engel, SS; Hanson, ME; Musliner, T; Steinberg, H | 1 |
| Kabbara, WK; Ramadan, WH | 1 |
| Droździk, M; Kurzawski, M; Machaliński, B; Niedzielski, A; Pius-Sadowska, E; Wajda, A; Łapczuk-Romańska, J | 1 |
2 review(s) available for pyrazines and simvastatin
| Article | Year |
|---|---|
Management of dyslipidemia and hyperglycemia with a fixed-dose combination of sitagliptin and simvastatin.
Topics: Biomarkers; Blood Glucose; Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Dyslipidemias; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Lipids; Pyrazines; Simvastatin; Sitagliptin Phosphate; Treatment Outcome; Triazoles | 2013 |
Sitagliptin/Simvastatin: a first combination tablet to treat type 2 diabetes and hypercholesterolemia--a review of its characteristics.
Topics: Biomarkers; Blood Glucose; Cardiovascular Diseases; Cholesterol; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Glycated Hemoglobin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypoglycemia; Polypharmacy; Pyrazines; Risk Factors; Simvastatin; Sitagliptin Phosphate; Treatment Outcome; Triazoles; Weight Gain | 2015 |
9 trial(s) available for pyrazines and simvastatin
| Article | Year |
|---|---|
The effects of lipid lowering drugs on metabolic control and lipoprotein composition in type 2 diabetic patients with mild hyperlipidaemia.
Topics: Apolipoproteins B; Bezafibrate; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Humans; Hyperlipidemias; Hypolipidemic Agents; Lovastatin; Middle Aged; Phospholipids; Placebos; Pyrazines; Simvastatin; Triglycerides | 1995 |
The impact of a short course of three lipid lowering drugs on fat oxidation during exercise in healthy volunteers.
Topics: Adult; Anticholesteremic Agents; Blood Pressure; Energy Metabolism; Exercise; Exercise Test; Exercise Tolerance; Fatty Acids, Nonesterified; Gemfibrozil; Heart Rate; Humans; Hydroxymethylglutaryl CoA Reductases; Hypolipidemic Agents; Lovastatin; Male; Oxidation-Reduction; Oxygen Consumption; Pyrazines; Random Allocation; Simvastatin; Single-Blind Method | 1993 |
The additional effects of acipimox to simvastatin in the treatment of combined hyperlipidaemia.
Topics: Adult; Aged; Cholesterol, LDL; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hyperlipidemias; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Pyrazines; Simvastatin; Treatment Outcome; Triglycerides | 1997 |
The additional effects of acipimox to simvastatin in the treatment of combined hyperlipidaemia.
Topics: Adult; Aged; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Pyrazines; Simvastatin; Treatment Outcome | 1998 |
Tolerability and effects of high doses acipimox as additional lipid-lowering therapy in familial hypercholesterolemia.
Topics: Adult; Aged; Cholesterol, VLDL; Dose-Response Relationship, Drug; Drug Hypersensitivity; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Lipoproteins, LDL; Male; Middle Aged; Pyrazines; Safety; Simvastatin | 1998 |
Intensive lipid-lowering strategy in patients with diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diet; Female; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Pyrazines; Simvastatin; Triglycerides | 1999 |
First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma.
Topics: Bendamustine Hydrochloride; Boronic Acids; Bortezomib; Cell Adhesion; Drug Resistance, Neoplasm; Feasibility Studies; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Multiple Myeloma; Nitrogen Mustard Compounds; Pyrazines; Salvage Therapy; Simvastatin | 2007 |
Effect of sitagliptin on the pharmacokinetics of simvastatin.
Topics: Adult; Cross-Over Studies; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Pyrazines; Simvastatin; Sitagliptin Phosphate; Time Factors; Triazoles | 2009 |
The effects of simvastatin on the pharmacokinectics of sitagliptin.
Topics: Adult; Area Under Curve; Cross-Over Studies; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pyrazines; Simvastatin; Sitagliptin Phosphate; Triazoles; Young Adult | 2012 |
8 other study(ies) available for pyrazines and simvastatin
| Article | Year |
|---|---|
Drug treatment of hypercholesterolaemia in a patient with Gilbert's syndrome.
Topics: Administration, Oral; Bezafibrate; Bilirubin; Colestipol; Gilbert Disease; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Liver; Liver Function Tests; Lovastatin; Male; Middle Aged; Pravastatin; Pyrazines; Simvastatin | 1994 |
Inflammation and lipid accumulation in xanthoma disseminatum: Therapeutic considerations.
Topics: Adult; Histiocytosis, Non-Langerhans-Cell; Humans; Inflammation; Lipid Metabolism; Male; Pyrazines; Rosiglitazone; Simvastatin; Thiazolidinediones | 2008 |
HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway.
Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Burkitt Lymphoma; Cell Division; Cell Line; Cell Membrane; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Drug Resistance, Neoplasm; G2 Phase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myeloid Cell Leukemia Sequence 1 Protein; Polyisoprenyl Phosphates; Proto-Oncogene Proteins c-bcl-2; Pyrazines; rhoA GTP-Binding Protein; Simvastatin | 2008 |
Renal failure and rhabdomyolysis associated with sitagliptin and simvastatin use.
Topics: Acute Kidney Injury; Aged; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pyrazines; Rhabdomyolysis; Simvastatin; Sitagliptin Phosphate; Triazoles | 2008 |
Renal failure and rhabdomyolysis associated with sitagliptin and simvastatin use. But what about the amiodarone?
Topics: Amiodarone; Contraindications; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters; Pyrazines; Renal Insufficiency; Rhabdomyolysis; Simvastatin; Sitagliptin Phosphate; Triazoles; United Kingdom; United States | 2009 |
Sitagliptin and simvastatin (juvisync).
Topics: Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Drug Costs; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrazines; Simvastatin; Sitagliptin Phosphate; Triazoles | 2011 |
Simultaneous determination of sitagliptin and simvastatin in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.
Topics: Administration, Oral; Chromatography, Liquid; Dipeptidyl-Peptidase IV Inhibitors; Drug Stability; Humans; Least-Squares Analysis; Liquid-Liquid Extraction; Male; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Simvastatin; Sitagliptin Phosphate; Tandem Mass Spectrometry; Triazoles | 2013 |
Effects of simvastatin on nuclear receptors, drug metabolizing enzymes and transporters expression in Human Umbilical Vein Endothelial Cells.
Topics: ATP Binding Cassette Transporter, Subfamily B; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Peroxisome-Targeting Signal 1 Receptor; Polychlorinated Dibenzodioxins; Pyrazines; Receptors, Aryl Hydrocarbon; Simvastatin; Thiones; Thiophenes | 2018 |