pyrazines has been researched along with rottlerin in 4 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Durrant, D; Lee, RM; Liu, J; Yang, HS | 1 |
| Kagechika, H; Kurosu, T; Miura, O; Ohki, M; Wu, N | 1 |
| Khan, S; Li, WH; Sun, SR; Tang, Z; Wan, JN; Wang, CH; Yao, F; Zhang, YM; Zhu, S | 1 |
| Chernoff, J; Prudnikova, TY | 1 |
4 other study(ies) available for pyrazines and rottlerin
| Article | Year |
|---|---|
The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta.
Topics: Acetophenones; Antineoplastic Agents; Apoptosis; Benzopyrans; Boronic Acids; Bortezomib; Enzyme Inhibitors; Humans; Mitochondria; Peptide Fragments; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Kinase C-delta; Pyrazines; U937 Cells | 2004 |
Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.
Topics: Acetophenones; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Benzenesulfonates; Benzopyrans; Biphenyl Compounds; Boronic Acids; Bortezomib; Caspases; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Interleukin-3; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitochondria; Mutation; Niacinamide; Nitrophenols; Phenylurea Compounds; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazines; Pyridines; Pyrimidines; Sorafenib; Sulfonamides | 2009 |
PKC?-dependent activation of the ubiquitin proteasome system is responsible for high glucose-induced human breast cancer MCF-7 cell proliferation, migration and invasion.
Topics: Acetophenones; Apoptosis; Benzopyrans; Boronic Acids; Bortezomib; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Glucose; Humans; MCF-7 Cells; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase C-delta; Pyrazines; Ubiquitin | 2013 |
The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin.
Topics: Acetophenones; Benzopyrans; Cell Line, Tumor; Chromosomes, Human, Pair 11; Drug Synergism; Female; Humans; Ovarian Neoplasms; p21-Activated Kinases; Piperidines; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Signal Transduction | 2017 |