pyrazines has been researched along with rolipram in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 18 (90.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beleta, J; Berga, P; Bou, J; Cardelús, I; Fernández, AG; Gristwood, RW; Llenas, J | 1 |
| Burns, F; Pyne, NJ | 1 |
| Lugnier, C; Muller, B; Stoclet, JC | 1 |
| Hall, IP; Hill, SJ | 1 |
| Diocee, BK; Martin, W; Moodie, SA; Souness, JE | 1 |
| Brown, AM; Hill, SJ; Stanley, C | 1 |
| England, PJ; Leigh, BK; Reeves, ML | 1 |
| Barnette, M; Grous, M | 1 |
| Dent, G; Liebig, S; Magnussen, H; Rabe, KF; Schudt, C; Tenor, H | 1 |
| Eckly, AE; Lugnier, C | 1 |
| Hellewell, PG; Rossi, AG; Teixeira, MM; Williams, TJ | 1 |
| Furman, BL; Pyne, NJ; Shafiee-Nick, R | 1 |
| Eckly, A; Lugnier, C; Okruhlicová, L; Slezák, J; Tribulová, N | 1 |
| Berto, L; Cortijo, J; Morcillo, EJ; Navarrete, C; Perpiñá, M; Sanz, C; Villagrasa, V | 1 |
| Berto, L; Bonnet, PA; Cortijo, J; Michel, A; Morcillo, EJ; Navarrete, C; Sanz, C; Villagrasa, V | 1 |
| Eckly-Michel, A; Lugnier, C; Martin, V | 1 |
| Nagai, H; Tanaka, H; Uno, T | 1 |
| Sawada, M; Suzumura, A; Takayanagi, T; Tamaru, T; Yoshikawa, M | 1 |
| Bergey, G; Bielekova, B; Clarence-Smith, K; Dhib-Jalbut, S; Jiang, H; Johnson, KP; Martin, R; Okazaki, H | 1 |
| Keravis, T; Le Bec, A; Lugnier, C; Pauvert, O; Proteau, S; Rousseau, E | 1 |
20 other study(ies) available for pyrazines and rolipram
| Article | Year |
|---|---|
Studies on the cardiac actions of flosequinan in vitro.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Action Potentials; Animals; Carbachol; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Pyrazines; Pyrrolidinones; Quinolines; Rolipram; Vasodilator Agents | 1992 |
Interaction of the catalytic subunit of protein kinase A with the lung type V cyclic GMP phosphodiesterase: modulation of non-catalytic binding sites.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaline Phosphatase; Animals; Cyclic GMP; Enzyme Activation; Guinea Pigs; Isoenzymes; Kinetics; Lung; Macromolecular Substances; Protein Kinases; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1992 |
Involvement of rolipram-sensitive cyclic AMP phosphodiesterase in the regulation of cardiac contraction.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Atenolol; Calcium Chloride; Colforsin; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Reserpine; Rolipram; Stereoisomerism; Xanthines | 1990 |
Effects of isozyme selective phosphodiesterase inhibitors on bovine tracheal smooth muscle tone.
Topics: Animals; Bronchodilator Agents; Cattle; Dose-Response Relationship, Drug; In Vitro Techniques; Isoenzymes; Methacholine Chloride; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Rolipram; Trachea | 1992 |
Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Calcium; Cells, Cultured; Chromatography, Ion Exchange; Colforsin; Cyclic AMP; Cyclic GMP; Dipyridamole; Endothelium, Vascular; Isoquinolines; Kinetics; Purinones; Pyrazines; Pyrrolidinones; Rolipram; Swine; Tetrahydroisoquinolines | 1990 |
Effect of isozyme-selective inhibitors of phosphodiesterase on histamine-stimulated cyclic AMP accumulation in guinea-pig hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cerebral Cortex; Cyclic AMP; Female; Guinea Pigs; Hippocampus; Histamine; Isoenzymes; Male; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1989 |
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Chromatography, Ion Exchange; Guinea Pigs; Heart Ventricles; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Molecular Weight; Myocardium; Pyrazines; Pyrrolidinones; Rolipram | 1987 |
Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antigens; Colon; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Immunization; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1994 |
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoenzymes; Lung; Lung Neoplasms; Male; Middle Aged; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitroprusside; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rolipram; Vital Capacity | 1993 |
Role of phosphodiesterases III and IV in the modulation of vascular cyclic AMP content by the NO/cyclic GMP pathway.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta, Thoracic; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Rats; Rats, Wistar; Rolipram | 1994 |
Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig.
Topics: Animals; Calmodulin; Cardiotonic Agents; Dermatitis; Edema; Eosinophils; Female; Guinea Pigs; In Vitro Techniques; Indium Radioisotopes; Isoenzymes; Male; Neutrophils; Passive Cutaneous Anaphylaxis; Phosphodiesterase Inhibitors; Purinones; Pyrazines; Pyrrolidinones; Rolipram; Skin | 1994 |
Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Thiophenes | 1995 |
Cytochemical distribution of cyclic AMP-dependent 3',5'-nucleotide phosphodiesterase in the rat myocardium.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiotonic Agents; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Histocytochemistry; Isoenzymes; Myocardium; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Rats; Rolipram | 1996 |
Inhibition of phosphodiesterase IV and intracellular calcium levels in human polymorphonuclear leukocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Calcium; Cardiotonic Agents; Cell Survival; Chemotaxis; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Fura-2; Humans; Imidazoles; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Parasympatholytics; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Rolipram; Thimerosal | 1996 |
Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: comparison with rolipram, SKF94120 and levcromakalim.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Bronchi; Bronchodilator Agents; Calcium; Cardiotonic Agents; Cromakalim; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Imidazoles; In Vitro Techniques; Leukocyte Elastase; Leukotriene B4; Muscle Relaxation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoric Diester Hydrolases; Pyrazines; Pyrroles; Pyrrolidinones; Rolipram; Superoxides | 1996 |
Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP-mediated vasorelaxation.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Aorta; Calcium; Cardiotonic Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Signal Transduction; Sulfonamides; Thionucleotides | 1997 |
Effects of isoenzyme selective phosphodiesterase inhibitors on bacterial lipopolysaccharide-induced bronchial hyperreactivity in guinea pigs.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cilostazol; Guinea Pigs; Isoenzymes; Lipopolysaccharides; Male; Neutrophils; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Quinolines; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha | 1998 |
Effects of phosphodiesterase inhibitors on cytokine production by microglia.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Anti-Ulcer Agents; Cilostazol; Colforsin; Dipyridamole; DNA Primers; Gene Expression Regulation, Enzymologic; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha; Vinca Alkaloids; Xanthines | 1999 |
The effect of vesnarinone on TNF alpha production in human peripheral blood mononuclear cells and microglia: a preclinical study for the treatment of multiple sclerosis.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Viral; Cell Division; Cell Line; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Influenza, Human; Interferon-gamma; Lipopolysaccharides; Microglia; Multiple Sclerosis; Pyrazines; Pyrrolidinones; Quinolines; Rolipram; T-Lymphocytes; Tumor Necrosis Factor-alpha | 1999 |
Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Nucleus; Chromatography, High Pressure Liquid; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Heart Ventricles; Intracellular Membranes; Isoenzymes; Myocardium; Pyrazines; Rolipram; Sheep | 1999 |