Page last updated: 2024-08-21

pyrazines and rb 90740

pyrazines has been researched along with rb 90740 in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Adams, GE; Cole, S; Haigh, A; Jenner, T; Naylor, MA; Robertson, N; Siemann, D; Stephens, MA; Stratford, IJ1
Adams, GE; Fielden, EM; Naylor, MA; Nolan, J; O'Neill, P; Stratford, IJ; Sutton, BM1
Adams, GE; Cole, S; Fielden, EM; Naylor, MA; Reeves, NJ; Stratford, IJ; Sutton, BM1
Barham, HM; Stratford, IJ1
Hall, EJ; Hei, TK; Liu, SX1
Dennis, MF; Everett, SA; Naylor, MA; Patel, KB; Priyadarsini, KI; Stratford, IJ; Stratford, MR; Tracy, M; Wardman, P1
Barham, HM; Chinje, EC; Inglis, R; Stratford, IJ1
Adams, GE; Hall, EJ; Hei, TK; Laderoute, KR; Langmuir, VK; Liu, SX; Mendonca, HL; Naylor, MA; Sutherland, RM1

Other Studies

8 other study(ies) available for pyrazines and rb 90740

ArticleYear
Fused pyrazine mono-N-oxides as bioreductive drugs. III. Characterization of RB 90740 in vitro and in vivo.
    Anti-cancer drugs, 1995, Volume: 6, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Survival; Cricetinae; DNA Damage; Female; Male; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Pyrazines; Tumor Cells, Cultured

1995
Radiolytic and photochemical reduction of the hypoxic cytotoxin 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-a] pyrido [3,2-e] pyrazine 5-oxide (RB90740) and a potential mechanism for hypoxia-selective toxicity.
    International journal of radiation oncology, biology, physics, 1994, May-15, Volume: 29, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Humans; Hydrogen-Ion Concentration; Mice; Oxidation-Reduction; Photochemistry; Pyrazines; Tumor Cells, Cultured

1994
Pharmacokinetics, metabolism and distribution of 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-A] pyrido [3,2-E] pyrazine-5-oxide in C3H mice.
    International journal of radiation oncology, biology, physics, 1994, May-15, Volume: 29, Issue:2

    Topics: Animals; Antineoplastic Agents; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Pyrazines; Tissue Distribution

1994
Enzymology of the reduction of the novel fused pyrazine mono-n-oxide bioreductive drug, RB90740 roles for P450 reductase and cytochrome b5 reductase.
    Biochemical pharmacology, 1996, Mar-22, Volume: 51, Issue:6

    Topics: Animals; Antineoplastic Agents; Biotransformation; Cytochrome Reductases; Cytochrome-B(5) Reductase; Female; Mice; Mice, Inbred C3H; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Pyrazines

1996
Oncogenic potential of bifunctional bioreductive drugs.
    The British journal of cancer. Supplement, 1996, Volume: 27

    Topics: Animals; Antineoplastic Agents; Aziridines; Cell Survival; Cell Transformation, Neoplastic; Indolequinones; Indoles; Mice; Mice, Inbred C3H; Mitomycin; Oxidation-Reduction; Pyrazines; Structure-Activity Relationship

1996
Chemical properties which control selectivity and efficacy of aromatic N-oxide bioreductive drugs.
    The British journal of cancer. Supplement, 1996, Volume: 27

    Topics: Antineoplastic Agents; Free Radicals; Hydrogen-Ion Concentration; Oxidation-Reduction; Oxides; Pulse Radiolysis; Pyrazines; Tirapazamine; Triazines

1996
Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells.
    British journal of cancer, 1996, Volume: 74, Issue:8

    Topics: Animals; Antineoplastic Agents; Biotransformation; Cytochrome Reductases; Cytochrome-B(5) Reductase; Female; Humans; Hydroxymercuribenzoates; Mice; Mice, Inbred C3H; Neoplasm Proteins; Neoplasms; Protease Inhibitors; Pyrazines; Reproducibility of Results; Spectrophotometry; Tumor Cells, Cultured

1996
Fused pyrazine mono-n-oxides as bioreductive drugs. II Cytotoxicity in human cells and oncogenicity in a rodent transformation assay.
    International journal of radiation oncology, biology, physics, 1996, Jan-01, Volume: 34, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Mice; Mice, Inbred C3H; Pyrazines; Radiobiology; Structure-Activity Relationship; Tumor Cells, Cultured

1996