Compounds > pyrazines
Page last updated: 2024-08-21

pyrazines and quinoxalines

pyrazines has been researched along with quinoxalines in 76 studies

Research

Studies (76)

TimeframeStudies, this research(%)All Research%
pre-19906 (7.89)18.7374
1990's4 (5.26)18.2507
2000's34 (44.74)29.6817
2010's25 (32.89)24.3611
2020's7 (9.21)2.80

Authors

AuthorsStudies
Donát, P; Rodgers, RJ; Shepherd, JK1
Cooper, SJ; Neill, JC1
Neurath, G1
Haddow, A; Ross, WC; Timmis, GM1
Mertes, MP1
Abou-Gharbia, M; Freed, ME; McCaully, RJ; Silver, PJ; Wendt, RL1
Hao, NJ; Lee, H; Lin, MY1
Adams, GE; Fielden, EM; Naylor, MA; Nolan, J; Stephens, MA; Stratford, IJ; Sutton, B; Tocher, JH1
Abd el-Samii, ZK; el-Feky, SA1
Bohme, GA; Boireau, A; Cheve, M; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M1
Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M1
Coupet, J; Dunlop, J; Graziano, D; Kagan, M; Mazandarani, H; Nelson, JA; Potoski, JR; Rosenzweig-Lipson, S; Sabalski, JE; Sabb, AL; Sukoff, S; Welmaker, GS; Zhang, Y1
Hiramoto, K; Kato, T; Kikugawa, K1
Benezech, V; Bonnet, P; Chapat, J; Deleuze-Masquefa, C; Elliott, K; Escale, R; Fabreguettes, J; Laurent, F; Michel, A; Parra, S; Pocock, T; Small, R; Subra, G; Vidal, J1
Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M1
Bouregeois, NM; Corbett, TH; Crantz, B; Hazeldine, ST; Horwitz, JP; Kushner, J; Palomino, E; Polin, L; White, K1
Cheng, JT; Huang, WC; Lai, TY; Liu, IM; Tsai, CC1
Reynolds, RC; Seitz, LE; Suling, WJ1
SHIHO, D; TAGAMI, S1
Katayev, E; Lynch, VM; Pantos, GD; Sessler, JL1
Akhila, V; Daga, P; Hegde, P; Rao, CS; Rao, YK; Ravikumar, V; Rudrawar, SV; Saibaba, V; Singh, SK1
Dallemagne, P; Déprez-Poulain, R; Forfar-Bares, I; Grellier, P; Guillon, J; Jarry, C; Labaied, M; Léger, JM; Lemaître, N; Péhourcq, F; Rochette, J; Sergheraert, C; Sonnet, P1
Fujiwara, E; Murai, S; Naraso, N; Nishida, J; Tada, H; Tomura, M; Yamashita, Y1
Barrish, JC; Behnia, K; Chen, P; Chong, S; Das, J; de Fex, H; Doweyko, AM; Gu, HH; Iwanowicz, EJ; Kanner, SB; Kocy, OR; Lin, J; McIntyre, KW; Moquin, RV; Norris, D; Pang, S; Pitt, S; Schieven, GL; Shen, DR; Shuster, DJ; Spergel, SH; Stanley, P; Thrall, S; Witmer, MR; Wityak, J1
Greenshaw, A; Hayes, D; Mosher, T1
Butini, S; Campiani, G; Chiasserini, L; Fattorusso, C; Gemma, S; Kukreja, G; Locatelli, GA; Maga, G; Nacci, V; Novellino, E; Persico, M; Romano, MP; Savini, L; Spadari, S1
Abraham, NG; Bolognesi, M; Di Pascoli, M; Rodella, L; Sacerdoti, D; Turkseven, S1
Durdaği, S; Karalti, O; Salzner, U1
Barrett, JE; Dunlop, J; Harrison, BL; Mazandarani, H; Rosenzweig-Lipson, S; Sabalski, J; Sabb, A; Stack, G; Welmaker, G; Zhang, J1
de Cian, A; Djukic, JP; Kyritsakas-Gruber, N; Michon, C; Pfeffer, M; Ratkovic, Z1
Greenshaw, AJ; Mosher, TM; Smith, JG1
Aparicio, D; Attanasi, OA; de Los Santos, JM; Filippone, P; Ignacio, R; Lillini, S; Mantellini, F; Palacios, F1
Boothman, L; Denk, F; Hirani, E; Raley, J; Sharp, T1
Chevallier, F; Mongin, F; Seggio, A; Vaultier, M1
Abboud, KA; Fox, ME; Jackson, M; Klosin, J; Lennon, IC1
Arpin, C; Caignard, DH; Dallemagne, P; Guillon, J; Jarry, C; Lagardère, A; Larrouture, S; Moreau, S; Quentin, C; Vidaillac, C1
Egashira, N; Fujiwara, M; Iwasaki, K; Koushi, E; Mishima, K; Oishi, R1
Chawla, PS; Kochar, MS1
Booth, RG; Crump, EM; Nguyen, N; Robertson, K; Rowland, NE; Sun, Z1
Greenshaw, AJ; Hayes, DJ; Mosher, TM1
Cao, X; Garofalo, A; Grande, F; Louie, S; Neamati, N; Oshima, T; Yamada, R1
Fletcher, PJ; Higgins, GA; Isaac, M; Sinyard, J; Slassi, A; Tampakeras, M1
Peters, S; Quérée, P; Sharp, T1
Bruserud, O; Hatfield, KJ; Kalland, KH; Kittang, AO; Oyan, AM; Reikvam, H1
Alsina, M; Beg, AA; Boulware, D; Chen, DT; Dalton, WS; Hazlehurst, LA; Mathews, L; Oliveira, V; Shain, KH; Villagra, A; Wang, X; Yarde, DN1
Bruserud, Ø; Ersvaer, E; Hatfield, KJ; Kittang, AO; Lassalle, P; Reikvam, H1
Goettert, M; Jahns, H; Koch, P; Laufer, S; Schattel, V1
Lai, JJ; Salunke, DB; Sun, CM1
Mashimo, T; Nakae, A; Nakai, K; Oba, S; Ueda, K1
Greenshaw, AJ; Hayes, DJ; Hoang, J1
Gómez-Flores, NS; Morales-Castellanos, JJ; Peralta-Cruz, J; Ramírez-Hernández, K; Rodas-Suárez, OR1
Aldegunde, M; Mancebo, MJ; Pérez-Maceira, JJ1
Appleyard, SM; Cui, RJ; Roberts, BL; Zhao, H; Zhu, M1
Bosman, MC; Quax, WJ; Schuringa, JJ; Vellenga, E1
Banote, RK; Haldar, D; Kulkarni, P; Kumar, KL; Nakhi, A; Pal, M; Rahman, MS; Seerapu, GP1
Anderson, KC; Hide, M; Hideshima, H; Hideshima, T; Ikeda, H; Iwasaki, A; Yoshida, Y1
González, FV; Rodríguez, S; Vidal-Albalat, A1
Allanki, AD; Chandra Shekhar, A; Narsaiah, B; Shanthan Rao, P; Sijwali, PS1
Cui, S; Hu, Y; Hua, J; Li, X; Liu, JG; Long, Y; Tian, H; Wang, D; Wu, W; Zhou, H; Zhou, Y1
Bathula, SR; Kant, R; Prathap Reddy, M; Ravi, O; Sathyanarayana, P; Viswanadham, KK1
Aldegunde, M; Mancebo, MJ; Otero-Rodiño, C; Pérez-Maceira, JJ; Soengas, JL1
Breit, A; Glas, E; Gudermann, T; Lauffer, L1
Burke, LK; Davies, JR; Furby, HV; Garfield, AS; Heisler, LK; Isles, AR; Wilkinson, LS1
Bonnet, PA; Bou Karroum, N; Cuq, P; Deleuze-Masquefa, C; Diab-Assaf, M; Hadj-Kaddour, K; Kassab, I; Moarbess, G; Patinote, C1
Chen, ZZ; Ding, Y; Lei, J; Li, Y; McConnell, N; Song, GT; Xu, J; Xu, ZG; Zhu, J1
Cheng, Y; Dai, J; Fu, Y; Jiang, Q; Li, G; Li, Y; Qi, Q; Zhang, T; Zhu, B1
Bach, S; Baratte, B; Boullard, M; Caytan, E; Courtel, C; Curbet, I; Gédéon, C; Langlais, T; Lassagne, F; Lebreton, J; Limanton, E; Mongin, F; Paquin, L; Picot, L; Roisnel, T; Ruchaud, S; Souab, M; Thiéry, V1
Bonnet, PA; Bou Karroum, N; Bouharoun-Tayoun, H; Chamat, S; Cuq, P; Deleuze-Masquefa, C; Diab-Assaf, M; Guichou, JF; Kassab, I; Moarbess, G; Patinote, C1
Gao, D; Liu, D; Ma, X; Sun, M; Xu, D; Yu, H1
Sakai, M; Yoshimura, R1
Ospina-Villa, JD; Soto-Sánchez, J1
Ghosh, P; Ji, HK; Kim, IS; Kim, S; Ko, N; Mishra, NK; Moon, J; Oh, H; Park, MS1
Ávila-Ramos, F; Bivián-Castro, EY; Segoviano-Garfias, JJN; Zanor, GA1
Avila-Bonilla, RG; López-Sandoval, Á; Marchat, LA; Medina-Contreras, O; Ramírez-Moreno, E; Rivera, G; Soto-Sánchez, J1
Hoffman, GR; Schoffstall, AM1
Ghosh, S; Hajra, A; Mondal, K1

Reviews

5 review(s) available for pyrazines and quinoxalines

ArticleYear
[Nitrogen compounds of tobacco smoke].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:7

    Topics: Acridines; Alkaloids; Alkanes; Amines; Amino Acids; Aniline Compounds; Carbazoles; Cyanates; Indoles; Isoquinolines; Ketones; Niacinamide; Nicotiana; Nicotine; Nicotinic Acids; Nitriles; Nitrites; Nitrosamines; Piperidines; Plants, Toxic; Pyrazines; Pyridines; Pyrroles; Pyrrolidines; Quinolines; Quinoxalines; Smoking

1969
What's new in clinical pharmacology and therapeutics.
    WMJ : official publication of the State Medical Society of Wisconsin, 2008, Volume: 107, Issue:2

    Topics: Abatacept; Acetanilides; Amides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antiparkinson Agents; Antirheumatic Agents; Antiviral Agents; Apomorphine; Benzazepines; Cardiovascular Agents; Fumarates; Hepatitis B; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; Humans; Hypoglycemic Agents; Immunoconjugates; Multiple Sclerosis; Natalizumab; Nucleosides; Papillomavirus Vaccines; Pharmacology, Clinical; Piperazines; Pyrazines; Pyrimidinones; Quinoxalines; Ranolazine; Sitagliptin Phosphate; Smoking Cessation; Telbivudine; Thymidine; Triazoles; Varenicline; Viral Vaccines

2008
Current status of quinoxaline and quinoxaline 1,4-di-N-oxides derivatives as potential antiparasitic agents.
    Chemical biology & drug design, 2021, Volume: 98, Issue:4

    Topics: Animals; Antiparasitic Agents; Benzene; Chagas Disease; Humans; Leishmaniasis; Malaria; Oxidation-Reduction; Oxides; Pyrazines; Quinoxalines; Structure-Activity Relationship

2021
Syntheses and Applications of 1,2,3-Triazole-Fused Pyrazines and Pyridazines.
    Molecules (Basel, Switzerland), 2022, Jul-22, Volume: 27, Issue:15

    Topics: Pyrazines; Pyridazines; Quinoxalines; Triazoles

2022
Transition-metal-catalyzed
    Organic & biomolecular chemistry, 2022, 09-28, Volume: 20, Issue:37

    Topics: Benzene; Catalysis; Pyrazines; Quinoxalines; Transition Elements

2022

Other Studies

71 other study(ies) available for pyrazines and quinoxalines

ArticleYear
Differential effects of novel ligands for 5-HT receptor subtypes on nonopioid defensive analgesia in male mice.
    Neuroscience and biobehavioral reviews, 1991,Winter, Volume: 15, Issue:4

    Topics: Aggression; Analgesia; Animals; Dioxins; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred DBA; Pyrazines; Quinolines; Quinoxalines; Reaction Time; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Spiro Compounds

1991
Selective reduction by serotonergic agents of hypertonic saline consumption in rats: evidence for possible 5-HT1C receptor mediation.
    Psychopharmacology, 1989, Volume: 99, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Drinking Behavior; Fenfluramine; Fluoxetine; Hypertonic Solutions; Indoles; Male; Piperazines; Pyrazines; Quinoxalines; Quipazine; Rats; Receptors, Serotonin; Serotonin

1989
The chain of unexpected discovery: xanthopterin-stimulated renal mitosis.
    Perspectives in biology and medicine, 1972,Winter, Volume: 15, Issue:2

    Topics: Animals; Biochemistry; Creativity; History, 20th Century; Hyperplasia; Hypertrophy; Hypoxanthines; Kidney; Kidney Diseases; Mitosis; Pteridines; Purines; Pyrazines; Pyrimidines; Quinoxalines; Rats; Stimulation, Chemical; Structure-Activity Relationship; United Kingdom; Xanthine Oxidase; Xanthopterin

1972
Cofactor inhibition of thymidylate synthetase. Tetrahydrofolic acid analogs.
    Journal of medicinal chemistry, 1970, Volume: 13, Issue:1

    Topics: Bacillus; Binding Sites; Escherichia coli; Folic Acid; Folic Acid Antagonists; Methods; Pyrazines; Quinoxalines; Staphylococcus; Transferases

1970
Tetrahydropyrrolo[1,2-a]quinoxalines and tetrahydropyrrolo[1,2-a]pyrido[3,2-a]pyrazines: vascular smooth muscle relaxants and antihypertensive agents.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Chemical Phenomena; Chemistry; Female; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscle Relaxation; Muscle, Smooth, Vascular; Neuromuscular Depolarizing Agents; Optical Rotation; Pyrazines; Pyrroles; Quinoxalines; Rabbits; Spectrophotometry, Infrared; Structure-Activity Relationship

1984
Effects of Maillard reaction products on mutagen formation in boiled pork juice.
    Mutagenesis, 1995, Volume: 10, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Maillard Reaction; Meat; Mutagens; Picolines; Pyrazines; Quinolines; Quinoxalines; Swine; Thiophenes

1995
Heterocyclic mono-N-oxides with potential applications as bioreductive anti-tumour drugs: Part 1. 8-Alkylamino-substituted phenylimidazo [1,2-a] quinoxalines.
    Anti-cancer drug design, 1993, Volume: 8, Issue:6

    Topics: Antineoplastic Agents; Cell Division; Cell Hypoxia; Drug Design; Imidazoles; Oxidation-Reduction; Pyrazines; Quinoxalines; Structure-Activity Relationship; Tumor Cells, Cultured

1993
Synthesis and antifungal activity of some imidazo, pyrazino and v-triazoloquinoxalines.
    Die Pharmazie, 1997, Volume: 52, Issue:8

    Topics: Antifungal Agents; Aspergillus flavus; Aspergillus niger; Candida albicans; Chemical Phenomena; Chemistry, Physical; Cyclization; Fungi; Imidazoles; Microbial Sensitivity Tests; Pyrazines; Quinoxalines; Triazoles

1997
8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazines: highly potent in vivo AMPA antagonists.
    Bioorganic & medicinal chemistry letters, 2000, Mar-20, Volume: 10, Issue:6

    Topics: Animals; Anticonvulsants; Excitatory Amino Acid Antagonists; Isoquinolines; Mice; Oocytes; Pyrazines; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Tetrazoles; Xenopus laevis

2000
4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity.
    Bioorganic & medicinal chemistry letters, 2000, May-15, Volume: 10, Issue:10

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Isoquinolines; Mice; Mice, Inbred DBA; Pyrazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles; Urea

2000
Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines.
    Bioorganic & medicinal chemistry letters, 2000, Sep-04, Volume: 10, Issue:17

    Topics: Animals; Appetite Depressants; Eating; Male; Pyrazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship

2000
Prevention of the formation of mutagenic and/or carcinogenic heterocyclic amines by food factors.
    BioFactors (Oxford, England), 2000, Volume: 12, Issue:1-4

    Topics: Amines; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Antioxidants; Ascorbic Acid; Cattle; Food; Free Radical Scavengers; Free Radicals; Glucose; Heterocyclic Compounds; Hot Temperature; Imidazoles; Meat; Mutagens; Pyrazines; Quinoxalines

2000
Imidazo[1,2-a]quinoxalines: synthesis and cyclic nucleotide phosphodiesterase inhibitory activity.
    European journal of medicinal chemistry, 2001, Volume: 36, Issue:3

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cardiotonic Agents; Cattle; Enzyme Inhibitors; Guinea Pigs; Inhibitory Concentration 50; Isoenzymes; Magnetic Resonance Spectroscopy; Male; Muscle Relaxation; Muscle, Smooth; Nitriles; Pyrazines; Quinoxalines; Structure-Activity Relationship

2001
Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz.
    Bioorganic & medicinal chemistry letters, 2001, May-07, Volume: 11, Issue:9

    Topics: Animals; Anticonvulsants; Carboxylic Acids; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Injections, Intravenous; Isoquinolines; Mice; Pyrazines; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Tetrazoles; Xenopus

2001
II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469).
    Journal of medicinal chemistry, 2002, Jul-04, Volume: 45, Issue:14

    Topics: Animals; Antineoplastic Agents; Benzoxazoles; Drug Screening Assays, Antitumor; Mice; Neoplasm Transplantation; Propionates; Pyrazines; Pyridines; Quinazolines; Quinolines; Quinoxalines; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazines; Tumor Cells, Cultured

2002
Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro.
    Life sciences, 2002, Aug-02, Volume: 71, Issue:11

    Topics: Animals; Aorta; Apamin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Humans; In Vitro Techniques; Male; Oxadiazoles; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyrazines; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Vasodilator Agents

2002
Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives.
    Journal of medicinal chemistry, 2002, Dec-05, Volume: 45, Issue:25

    Topics: Anti-Bacterial Agents; Microbial Sensitivity Tests; Mycobacterium avium; Mycobacterium tuberculosis; Pyrazinamide; Pyrazines; Quinoxalines; Structure-Activity Relationship

2002
Studies on compounds related to pyrazine. I. Synthesis of 2-substituted oxazolo(b)quinoxaline.
    Pharmaceutical bulletin, 1957, Volume: 5, Issue:1

    Topics: Heterocyclic Compounds; Pyrazines; Quinoxalines

1957
Pyrazine analogues of dipyrrolylquinoxalines.
    Organic letters, 2003, Oct-30, Volume: 5, Issue:22

    Topics: Crystallography, X-Ray; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Molecular Conformation; Molecular Structure; Pyrazines; Pyrroles; Quinoxalines

2003
Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors.
    Bioorganic & medicinal chemistry, 2004, Apr-15, Volume: 12, Issue:8

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Edema; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Pyrazines; Quinoxalines; Rats; Rats, Wistar

2004
Synthesis, antimalarial activity, and molecular modeling of new pyrrolo[1,2-a]quinoxalines, bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines.
    Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8

    Topics: Animals; Antimalarials; Cell Line; Crystallography, X-Ray; Drug Resistance; Erythrocytes; Hemeproteins; Humans; In Vitro Techniques; Models, Molecular; Plasmodium falciparum; Protein Binding; Pyrazines; Pyridines; Pyrroles; Quinoxalines; Rats; Structure-Activity Relationship

2004
Preparation, characterization, and FET properties of novel dicyanopyrazinoquinoxaline derivatives.
    Organic letters, 2004, Jun-10, Volume: 6, Issue:12

    Topics: Models, Chemical; Molecular Structure; Nitriles; Pyrazines; Quinoxalines

2004
Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excell
    Journal of medicinal chemistry, 2004, Aug-26, Volume: 47, Issue:18

    Topics: Animals; Anti-Inflammatory Agents; Biological Availability; Cytokines; Enzyme Inhibitors; Female; Hydrogen Bonding; Inhibitory Concentration 50; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Mice, Inbred C57BL; Models, Molecular; Pyrazines; Quantitative Structure-Activity Relationship; Quinoxalines; src-Family Kinases

2004
Differential effects of 5-HT2C receptor ligands on place conditioning and locomotor activity in rats.
    European journal of pharmacology, 2005, May-16, Volume: 515, Issue:1-3

    Topics: Aminopyridines; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Indoles; Ligands; Male; Motor Activity; Oxadiazoles; Piperazines; Pyrazines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Time Factors

2005
Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.
    Biochemistry, 2005, Jul-19, Volume: 44, Issue:28

    Topics: Adenosine Triphosphate; Antiviral Agents; Binding Sites; Binding, Competitive; DNA, Viral; Enzyme Inhibitors; Hepacivirus; Hydrazines; Hydrolysis; Molecular Mimicry; Pyrazines; Quinolines; Quinoxalines; RNA Helicases; Substrate Specificity; Viral Nonstructural Proteins

2005
Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes.
    Biochemical and biophysical research communications, 2006, Feb-17, Volume: 340, Issue:3

    Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitometry; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase; Heme; Immunohistochemistry; Male; Mesoporphyrins; Muscle Contraction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Oxadiazoles; Oxidative Stress; Protoporphyrins; Pyrazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Time Factors

2006
Does the donor-acceptor concept work for designing synthetic metals? III. Theoretical investigation of copolymers between quinoid acceptors and aromatic donors.
    Journal of molecular modeling, 2006, Volume: 12, Issue:5

    Topics: Metals; Models, Chemical; Models, Molecular; Molecular Conformation; Polymers; Pyrazines; Pyrroles; Quinoxalines; Thiadiazoles; Thiophenes

2006
Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503.
    Brain research, 2006, Feb-16, Volume: 1073-1074

    Topics: Animals; Anti-Obesity Agents; Arachidonic Acid; Behavior, Animal; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Eating; Humans; Male; Mice; Mice, Inbred C57BL; Obesity; Phosphoric Monoester Hydrolases; Pyrazines; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists; Tritium

2006
New manganese-scaffolded organic triple-deckers based on quinoxaline, pyrazine and pyrimidine cores.
    Dalton transactions (Cambridge, England : 2003), 2006, Mar-28, Issue:12

    Topics: Electrochemistry; Magnetic Resonance Spectroscopy; Manganese; Organometallic Compounds; Pyrazines; Pyrimidines; Quinoxalines; Spectroscopy, Fourier Transform Infrared

2006
Aversive stimulus properties of the 5-HT2C receptor agonist WAY 161503 in rats.
    Neuropharmacology, 2006, Volume: 51, Issue:3

    Topics: Amphetamine; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Food Preferences; Male; Pyrazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Retention, Psychology; Saccharin; Serotonin 5-HT2 Receptor Agonists; Sweetening Agents; Time Factors

2006
Straightforward access to pyrazines, piperazinones, and quinoxalines by reactions of 1,2-diaza-1,3-butadienes with 1,2-diamines under solution, solvent-free, or solid-phase conditions.
    The Journal of organic chemistry, 2006, Aug-04, Volume: 71, Issue:16

    Topics: Amines; Aza Compounds; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Piperazine; Piperazines; Pyrazines; Quinoxalines; Solutions; Solvents

2006
In vivo evidence that 5-HT(2C) receptors inhibit 5-HT neuronal activity via a GABAergic mechanism.
    British journal of pharmacology, 2006, Volume: 149, Issue:7

    Topics: Action Potentials; Aminopyridines; Animals; Brain Chemistry; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunohistochemistry; Indoles; Male; Neural Inhibition; Neurons; Picrotoxin; Piperazines; Positron-Emission Tomography; Proto-Oncogene Proteins c-fos; Pyrazines; Pyridines; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Ritanserin; Serotonin

2006
Lithium-mediated zincation of pyrazine, pyridazine, pyrimidine, and quinoxaline.
    The Journal of organic chemistry, 2007, Aug-17, Volume: 72, Issue:17

    Topics: Lithium; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pyrazines; Pyridazines; Pyrimidines; Quinoxalines; Zinc

2007
Bis-(2,5-diphenylphospholanes) with sp2 carbon linkers: synthesis and application in asymmetric hydrogenation.
    The Journal of organic chemistry, 2008, Feb-01, Volume: 73, Issue:3

    Topics: Carbon; Catalysis; Cinnamates; Cross-Linking Reagents; Hydrogenation; Ligands; Magnetic Resonance Spectroscopy; Maleic Anhydrides; Models, Molecular; Molecular Structure; Phenol; Phosphorus; Pyrazines; Quinoxalines; Rhodium; Stereoisomerism; Succinates

2008
Synthesis of new 4-[2-(alkylamino) ethylthio]pyrrolo[1,2-a]quinoxaline and 5-[2-(alkylamino) ethylthio]pyrrolo[1,2-a]thieno[3,2-e]pyrazine derivatives, as potential bacterial multidrug resistance pump inhibitors.
    Journal of enzyme inhibition and medicinal chemistry, 2007, Volume: 22, Issue:5

    Topics: Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Microbial Sensitivity Tests; Molecular Structure; Multidrug Resistance-Associated Proteins; Pyrazines; Quinoxalines; Staphylococcus aureus

2007
2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice.
    Journal of pharmacological sciences, 2007, Volume: 105, Issue:4

    Topics: Aminopyridines; Amphetamines; Analysis of Variance; Animals; Animals, Outbred Strains; Behavior, Animal; Dose-Response Relationship, Drug; Dronabinol; Freezing Reaction, Cataleptic; Indoles; Injections, Intraperitoneal; Ketanserin; Male; Mice; Pyrazines; Quinoxalines; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists; Time Factors

2007
Effect of (-)-trans-PAT, a novel 5-HT2C receptor agonist, on intake of palatable food in mice.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 91, Issue:1

    Topics: Amphetamine; Animals; Appetite Depressants; Catecholamines; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Eating; Female; Food Preferences; Mice; Mice, Inbred C57BL; Pyrazines; Quinoxalines; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists; Tetrahydronaphthalenes

2008
Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats.
    Behavioural brain research, 2009, Feb-11, Volume: 197, Issue:2

    Topics: Aminopyridines; Amphetamine; Animals; Conditioning, Operant; Dopamine Agents; Dose-Response Relationship, Drug; Indoles; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Motor Activity; Nicotine; Nicotinic Agonists; Pyrazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists

2009
Combination effects of SC144 and cytotoxic anticancer agents.
    Anti-cancer drugs, 2009, Volume: 20, Issue:5

    Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Cytotoxins; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Inhibitory Concentration 50; Injections, Intraperitoneal; Mice; Mice, Nude; Organoplatinum Compounds; Paclitaxel; Pyrazines; Quinoxalines; Xenograft Model Antitumor Assays

2009
Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice.
    Neuropharmacology, 2009, Volume: 57, Issue:3

    Topics: Aminopyridines; Animals; Benzazepines; Dexfenfluramine; Eating; Ethylamines; Feeding Behavior; Indoles; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naphthyridines; Piperazines; Pyrazines; Quinoxalines; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists

2009
Further pharmacological characterization of 5-HT(2C) receptor agonist-induced inhibition of 5-HT neuronal activity in the dorsal raphe nucleus in vivo.
    British journal of pharmacology, 2009, Volume: 158, Issue:6

    Topics: Animals; Glutamate Decarboxylase; Immunohistochemistry; Male; Neurons; Proto-Oncogene Proteins c-fos; Pyrazines; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists

2009
Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
    European journal of haematology, 2010, Volume: 84, Issue:3

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Angiopoietin-2; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cells, Cultured; Chemokines; Coculture Techniques; Culture Media, Serum-Free; Cytarabine; Diterpenes; Endothelial Cells; Female; Humans; Imidazoles; Leukemia, Myeloid; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Middle Aged; Neoplasm Proteins; NF-kappa B; Protease Inhibitors; Pyrazines; Quinoxalines; Receptor, TIE-2; Recombinant Proteins; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured

2010
Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma.
    Cancer research, 2009, Dec-15, Volume: 69, Issue:24

    Topics: Boronic Acids; Bortezomib; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Gene Expression; Humans; Imidazoles; Melphalan; Multiple Myeloma; NF-kappa B; Pyrazines; Quinoxalines; Transcription Factor RelB

2009
Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release.
    Expert opinion on investigational drugs, 2010, Volume: 19, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Angiopoietin-1; Angiopoietin-2; Antibodies; Boronic Acids; Bortezomib; Cell Proliferation; Cells, Cultured; Coculture Techniques; Endothelial Cells; Female; Fibroblasts; Hepatocyte Growth Factor; Humans; Imidazoles; Interleukin-8; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplasm Proteins; Osteoblasts; Proteoglycans; Pyrazines; Quinoxalines; Receptor Cross-Talk; Receptor, TIE-2; Signal Transduction

2010
Pyridinylquinoxalines and pyridinylpyridopyrazines as lead compounds for novel p38 alpha mitogen-activated protein kinase inhibitors.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Humans; Models, Chemical; Molecular Structure; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyrazines; Pyridines; Quinoxalines; Structure-Activity Relationship

2010
Multistep microwave-assisted divergent synthesis of indolo-fused pyrazino-/diazepinoquinoxalinones on PEG support.
    Organic letters, 2010, May-21, Volume: 12, Issue:10

    Topics: Amino Acids; Indoles; Microwaves; Molecular Structure; Polyethylene Glycols; Pyrazines; Quinoxalines; Solubility; Stereoisomerism

2010
5-HT2C receptor agonists attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain.
    European journal of pain (London, England), 2010, Volume: 14, Issue:10

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Ethylamines; Indoles; Injections, Spinal; Male; Neuralgia; Pain Measurement; Pain Threshold; Physical Stimulation; Pyrazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides; Trigeminal Neuralgia

2010
The role of nucleus accumbens shell GABA receptors on ventral tegmental area intracranial self-stimulation and a potential role for the 5-HT(2C) receptor.
    Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:12

    Topics: Animals; Baclofen; Eating; Male; Motor Activity; Muscimol; Nucleus Accumbens; Pyrazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, GABA; Self Stimulation; Ventral Tegmental Area

2011
Microwave-assisted solvent-free synthesis and in vitro antibacterial screening of quinoxalines and pyrido[2, 3b]pyrazines.
    Molecules (Basel, Switzerland), 2012, May-04, Volume: 17, Issue:5

    Topics: Anti-Bacterial Agents; Bacteria; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Microwaves; Pyrazines; Quinoxalines; Solvents

2012
Serotonin-induced brain glycogenolysis in rainbow trout (Oncorhynchus mykiss).
    The Journal of experimental biology, 2012, Sep-01, Volume: 215, Issue:Pt 17

    Topics: Animals; Benzopyrans; Brain; Glycogen; Glycogen Phosphorylase, Brain Form; Glycogenolysis; Indoles; Injections, Intraperitoneal; Injections, Intraventricular; Morpholines; Oncorhynchus mykiss; Piperazines; Pyrazines; Pyridines; Quinoxalines; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Thiophenes; Time Factors

2012
Serotonin activates catecholamine neurons in the solitary tract nucleus by increasing spontaneous glutamate inputs.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Nov-14, Volume: 32, Issue:46

    Topics: Action Potentials; Animals; Catecholamines; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Male; Mice; Neurons; Patch-Clamp Techniques; Piperazines; Pyrazines; Quinoxalines; Receptors, Presynaptic; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Receptor Agonists; Solitary Nucleus; Tyrosine 3-Monooxygenase

2012
Bortezomib sensitivity of acute myeloid leukemia CD34(+) cells can be enhanced by targeting the persisting activity of NF-κB and the accumulation of MCL-1.
    Experimental hematology, 2013, Volume: 41, Issue:6

    Topics: Antigens, CD34; Boronic Acids; Bortezomib; Coculture Techniques; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Humans; I-kappa B Kinase; Imidazoles; Leukemia, Myeloid, Acute; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Neoplastic Stem Cells; NF-kappa B; Primary Cell Culture; Protease Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Quinoxalines; Recombinant Proteins; RNA, Small Interfering; Stromal Cells; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured

2013
Transition metal free hydrolysis/cyclization strategy in a single pot: synthesis of fused furo N-heterocycles of pharmacological interest.
    Organic & biomolecular chemistry, 2013, Aug-14, Volume: 11, Issue:30

    Topics: Animals; Cyclization; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Enzyme Inhibitors; Heterocyclic Compounds; Hydrolysis; Models, Molecular; Molecular Structure; Pyrazines; Quinoxalines; Sirtuins; Structure-Activity Relationship; Zebrafish

2013
IKKβ inhibitor in combination with bortezomib induces cytotoxicity in breast cancer cells.
    International journal of oncology, 2014, Volume: 44, Issue:4

    Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Boronic Acids; Bortezomib; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; I-kappa B Kinase; I-kappa B Proteins; Imidazoles; MCF-7 Cells; NF-KappaB Inhibitor alpha; Phosphorylation; Pyrazines; Quinoxalines; Transcription Factor RelA

2014
Nitroepoxides as versatile precursors to 1,4-diamino heterocycles.
    Organic letters, 2014, Mar-21, Volume: 16, Issue:6

    Topics: Catalysis; Diamines; Epoxy Compounds; Molecular Structure; Nitro Compounds; Piperazines; Pyrazines; Quinoxalines; Stereoisomerism

2014
Emergence of pyrido quinoxalines as new family of antimalarial agents.
    European journal of medicinal chemistry, 2014, Apr-22, Volume: 77

    Topics: Antimalarials; Dose-Response Relationship, Drug; Erythrocytes; Humans; Molecular Structure; Plasmodium falciparum; Pyrazines; Quinoxalines; Structure-Activity Relationship

2014
New organic donor-acceptor-π-acceptor sensitizers for efficient dye-sensitized solar cells and photocatalytic hydrogen evolution under visible-light irradiation.
    ChemSusChem, 2014, Volume: 7, Issue:10

    Topics: Electric Power Supplies; Hydrogen; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Photochemistry; Pyrazines; Quinoxalines; Solar Energy; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet

2014
Iodine-mediated oxidative annulation for one-pot synthesis of pyrazines and quinoxalines using a multipathway coupled domino strategy.
    Chemical communications (Cambridge, England), 2014, Nov-14, Volume: 50, Issue:88

    Topics: Cyclization; Diamines; Ethylenes; Iodine; Oxidation-Reduction; Pyrazines; Quinoxalines; Stereoisomerism

2014
Food intake inhibition in rainbow trout induced by activation of serotonin 5-HT2C receptors is associated with increases in POMC, CART and CRF mRNA abundance in hypothalamus.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2016, Volume: 186, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Agouti-Related Protein; Animals; Corticotropin-Releasing Hormone; Eating; Fish Proteins; Gene Expression; Hypothalamus; Nerve Tissue Proteins; Oncorhynchus mykiss; Pro-Opiomelanocortin; Pyrazines; Quinoxalines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; RNA, Messenger; Serotonin Receptor Agonists

2016
Endogenous 5-HT2C Receptors Phosphorylate the cAMP Response Element Binding Protein via Protein Kinase C-Promoted Activation of Extracellular-Regulated Kinases-1/2 in Hypothalamic mHypoA-2/10 Cells.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 358, Issue:1

    Topics: Animals; Cell Culture Techniques; Cell Line; Cyclic AMP; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neurons; Paraventricular Hypothalamic Nucleus; Phosphorylation; Protein Kinase C; Pyrazines; Pyridines; Quinoxalines; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT2 Receptor Agonists

2016
Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT
    Molecular brain, 2016, 12-08, Volume: 9, Issue:1

    Topics: Alternative Splicing; Animals; Anorexia; Appetite; Arcuate Nucleus of Hypothalamus; Base Sequence; Disease Models, Animal; Feeding Behavior; Mice; Mutant Proteins; Neurons; Prader-Willi Syndrome; Pro-Opiomelanocortin; Proto-Oncogene Proteins c-fos; Pyrazines; Quinoxalines; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists

2016
Imidazo[1,2-a]pyrazine, Imidazo[1,5-a]quinoxaline and Pyrazolo[1,5-a]quinoxaline derivatives as IKK1 and IKK2 inhibitors.
    European journal of medicinal chemistry, 2017, Sep-29, Volume: 138

    Topics: Dose-Response Relationship, Drug; Humans; I-kappa B Kinase; Imidazoles; Molecular Structure; Protein Kinase Inhibitors; Pyrazines; Pyrazoles; Quinoxalines; Structure-Activity Relationship

2017
Microwave-assisted facile construction of quinoxalinone and benzimidazopyrazinone derivatives via two paths of post-Ugi cascade reaction.
    Molecular diversity, 2019, Volume: 23, Issue:1

    Topics: Combinatorial Chemistry Techniques; Microwaves; Pyrazines; Quinoxalines

2019
Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's models.
    Chemical communications (Cambridge, England), 2018, Oct-11, Volume: 54, Issue:82

    Topics: Aged; Alzheimer Disease; Animals; Brain; Cell Line, Tumor; Fluorescent Dyes; Humans; Male; Mice, Transgenic; Optical Imaging; Pyrazines; Quinoxalines; tau Proteins

2018
From Quinoxaline, Pyrido[2,3-
    Molecules (Basel, Switzerland), 2018, Nov-13, Volume: 23, Issue:11

    Topics: Carbazoles; Carbolines; Molecular Structure; Oxidative Coupling; Palladium; Pyrazines; Quinoxalines

2018
Novel and Selective TLR7 Antagonists among the Imidazo[1,2-
    Journal of medicinal chemistry, 2019, 08-08, Volume: 62, Issue:15

    Topics: Cell Line; Dose-Response Relationship, Drug; Humans; Imidazoles; Protein Structure, Secondary; Pyrazines; Quinoxalines; Toll-Like Receptor 7

2019
Inhibition of TRPA1 and IL-6 signal alleviates neuropathic pain following chemotherapeutic bortezomib.
    Physiological research, 2019, 10-25, Volume: 68, Issue:5

    Topics: Acetanilides; Analgesics; Animals; Bortezomib; Disease Models, Animal; Ganglia, Spinal; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Male; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Phosphorylation; Proteasome Inhibitors; Purines; Pyrazines; Quinoxalines; Rats, Sprague-Dawley; Receptors, Interleukin-6; Sensory Receptor Cells; Signal Transduction; TRPA1 Cation Channel

2019
Mechanotransduction-Targeting Drugs Attenuate Stiffness-Induced Hepatic Stellate Cell Activation in Vitro.
    Biological & pharmaceutical bulletin, 2021, Mar-01, Volume: 44, Issue:3

    Topics: Actins; Adenosine Triphosphate; Animals; Benzamides; Cells, Cultured; Colchicine; Collagen Type I; Hepatic Stellate Cells; Imidazoles; Integrins; Male; Mechanotransduction, Cellular; Paclitaxel; Piperazines; Pyrazines; Quinoxalines; Rats, Sprague-Dawley; Roscovitine; Sulfonamides; Transforming Growth Factor beta; Tubulin Modulators

2021
Site-selective and metal-free C-H nitration of biologically relevant N-heterocycles.
    Archives of pharmacal research, 2021, Volume: 44, Issue:11

    Topics: Aniline Compounds; Chemistry Techniques, Synthetic; Nitrites; Pyrazines; Quinoxalines

2021
Equilibrium Studies of Iron (III) Complexes with Either Pyrazine, Quinoxaline, or Phenazine and Their Catecholase Activity in Methanol.
    Molecules (Basel, Switzerland), 2022, May-19, Volume: 27, Issue:10

    Topics: Catechol Oxidase; Iron; Methanol; Phenazines; Pyrazines; Quinoxalines

2022
Proteomic and Functional Analysis of the Effects of Quinoxaline Derivatives on
    Frontiers in cellular and infection microbiology, 2022, Volume: 12

    Topics: Animals; Entamoeba histolytica; Humans; Proteomics; Pyrazines; Quinoxalines; Reactive Oxygen Species; Thioredoxin-Disulfide Reductase; Trophozoites

2022