pyrazines has been researched along with pyrimidinones in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 10 (50.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gudelsky, GA; Meltzer, HY; Nash, JF | 1 |
| Jasztold-Howorko, R; Machoń, Z | 1 |
| Avendaño, C; Corzo-Suárez, R; Espada, M; Gago, F; García-Granda, S; Martín-Santamaría, S; Rzepa, HS | 1 |
| Ghosh, KK; Harada, K; Katoh, A; Saito, R | 1 |
| Colburn, RW; Flores, CM; Liu, Y; Lubin, ML; Qin, N; Reitz, TL; Wang, Y | 1 |
| Anselmino, A; Atzori, C; Cargnel, A; Mazza, F; Piccinini, M; Rinaudo, MT; Tronconi, E; Valerio, A | 1 |
| Chawla, PS; Kochar, MS | 1 |
| Miura, S; Nishizawa, S; Ono, K; Teramae, N; Watanabe, M | 1 |
| O'Connor, OA | 1 |
| Belmonte, C; Morenilla-Palao, C; Valero, M; Viana, F | 1 |
| Beltrán, C; Darszon, A; De Blas, G; de la Vega-Beltrán, JL; Gibbs, GM; Martínez-López, P; Monroy, E; O'Bryan, MK; Orta, G; Treviño, CL | 1 |
| Ogura, M | 1 |
| Barbera, FA; Bozarth, JM; Glunz, PW; Jiang, W; Knabb, RM; Luettgen, JM; Newman, M; Rendina, AR; Rossi, KA; Schmitt, A; Scott Priestley, E; Wei, A; Wen, X; Wexler, RR; Wong, PC; Zhang, X | 1 |
| Dhandapani, P; Grötzinger, C; Huimann, P; Khajavi, N; Köhrle, J; Ljubojevic, N; Lucius, A; Mergler, S; Reinach, PS | 1 |
| Baillie, TA; Cyrus Khojasteh, S; Dalvie, D; Rietjens, IM | 1 |
| Hasvold, G; Hauge, S; Joel, M; Juzenas, P; Naucke, C; Rødland, GE; Stokke, T; Syljuåsen, RG | 1 |
| Fang, J; Hao, J; Li, Z; Lian, X; Qin, T; Wu, H; Wu, J; Wu, S; Zhang, W; Zhou, Q | 1 |
| Downward, J; Hancock, DC; Herbert, E; Horswell, S; Janes, MR; Li, LS; Molina-Arcas, M; Moore, C; Mugarza, E; Rana, S; Romero-Clavijo, P; van Maldegem, F | 1 |
| Albany, C; Chovanec, M; Cierna, Z; Kalavska, K; Konig, H; Kucerova, L; Liskova, V; Matuskova, M; Mego, M; Miklikova, S; Plava, J; Rogozea, A; Rojikova, L; Schmidtova, S | 1 |
| Bueno, R; Carrasco, RD; Case, AE; Frank, DA; Garg, S; Gokhale, PC; Griffin, JD; Hung, YP; Knott, A; Kulkarni, P; Lapidot, M; Meng, C; Ni, W; Podar, K; Pozhitkov, A; Saladi, SV; Salgia, R; Sattler, M; Sharma, S; Walker, SR; Weisberg, EL | 1 |
3 review(s) available for pyrazines and pyrimidinones
| Article | Year |
|---|---|
What's new in clinical pharmacology and therapeutics.
Topics: Abatacept; Acetanilides; Amides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antiparkinson Agents; Antirheumatic Agents; Antiviral Agents; Apomorphine; Benzazepines; Cardiovascular Agents; Fumarates; Hepatitis B; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; Humans; Hypoglycemic Agents; Immunoconjugates; Multiple Sclerosis; Natalizumab; Nucleosides; Papillomavirus Vaccines; Pharmacology, Clinical; Piperazines; Pyrazines; Pyrimidinones; Quinoxalines; Ranolazine; Sitagliptin Phosphate; Smoking Cessation; Telbivudine; Thymidine; Triazoles; Varenicline; Viral Vaccines | 2008 |
Novel agents in development for peripheral T-cell lymphoma.
Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Clinical Trials as Topic; Depsipeptides; Drug Design; Drugs, Investigational; Histone Deacetylase Inhibitors; Humans; Immunologic Factors; Lenalidomide; Lymphoma, T-Cell, Peripheral; Purine Nucleosides; Pyrazines; Pyrimidinones; Salvage Therapy; Thalidomide | 2010 |
Biotransformation and bioactivation reactions - 2015 literature highlights.
Topics: Acetaminophen; Allylbenzene Derivatives; Aniline Compounds; Animals; Anisoles; Benzbromarone; Biotransformation; Humans; Imidazoles; Niacinamide; Nitroimidazoles; Nitrosamines; Oxazoles; Oxazolidinones; Peroxides; Pyrazines; Pyrazoles; Pyridazines; Pyridines; Pyridones; Pyrimidinones; Thiophenes; Triazoles | 2016 |
1 trial(s) available for pyrazines and pyrimidinones
| Article | Year |
|---|---|
[Current development of new drugs in malignant lymphoma].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bendamustine Hydrochloride; Boronic Acids; Bortezomib; Brentuximab Vedotin; Diphtheria Toxin; Drug Discovery; Everolimus; Humans; Hydroxamic Acids; Immunoconjugates; Indoles; Inotuzumab Ozogamicin; Interleukin-2; Lenalidomide; Lymphoma; Lymphoma, B-Cell; Nitrogen Mustard Compounds; Purine Nucleosides; Pyrazines; Pyrimidinones; Recombinant Fusion Proteins; Sirolimus; Thalidomide; Vorinostat | 2012 |
16 other study(ies) available for pyrazines and pyrimidinones
| Article | Year |
|---|---|
Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Body Temperature; Butyrophenones; Chlorpromazine; Clozapine; Corticosterone; Haloperidol; Male; Neurosecretory Systems; Pyrazines; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1988 |
Synthesis of perhydropyrazino [1,2-c] pyrimidine derivatives.
Topics: Animals; Anti-Inflammatory Agents; Central Nervous System; Pyrazines; Pyrimidinones; Structure-Activity Relationship | 1985 |
Diastereoselective reactions in glycine templates containing an ent-ardeemin fragment.
Topics: Alkylation; Chemistry, Organic; Crystallography, X-Ray; Glycine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Pyrazines; Pyrimidinones; Quinazolines; Stereoisomerism | 2002 |
Microbial growth-promotion activity of 3-hydroxymonoazine- and N-hydroxydiazine-type heterocycles.
Topics: Dose-Response Relationship, Drug; Gram-Positive Asporogenous Rods; Pyrazines; Pyridones; Pyrimidinones; Siderophores; Stimulation, Chemical; Structure-Activity Relationship | 2002 |
Molecular identification and functional characterization of a temperature-sensitive transient receptor potential channel (TRPM8) from canine.
Topics: Action Potentials; Amino Acid Sequence; Animals; Calcium; Cell Line; Cloning, Molecular; Cold Temperature; DNA, Complementary; Dogs; Dose-Response Relationship, Drug; Fluorometry; Ganglia, Spinal; Gene Library; Humans; Menthol; Mice; Molecular Sequence Data; Mustard Plant; Oocytes; Patch-Clamp Techniques; Plant Oils; Pyrazines; Pyridines; Pyrimidinones; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transfection; TRPM Cation Channels; Xenopus laevis | 2006 |
Detection of a proteasome in Pneumocystis carinii and its modulation by specific proteasome inhibitors.
Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Cell Line; Coumarins; Genes, Fungal; HIV Protease Inhibitors; Humans; Lopinavir; Models, Animal; Oligopeptides; Pneumocystis carinii; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrimidinones; Rats | 2006 |
A surface plasmon resonance sensor based on 3,5-diaminopyrazine with a high selectivity for thymine in AP site-containing DNA duplex.
Topics: DNA; DNA Probes; Ligands; Polymorphism, Single Nucleotide; Pyrazines; Pyrimidinones; Surface Plasmon Resonance; Thymine | 2008 |
Pharmacological and functional properties of TRPM8 channels in prostate tumor cells.
Topics: Arginine; Calcium; Cell Line; Cell Line, Tumor; Cell Membrane; Clotrimazole; Cold Temperature; Endoplasmic Reticulum; Glycine; Humans; Male; Menthol; Prostate; Prostatic Neoplasms; Pyrazines; Pyridines; Pyrimidinones; TRPM Cation Channels | 2011 |
TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction.
Topics: Acrosome Reaction; Animals; Capsaicin; Humans; Ion Channel Gating; Male; Menthol; Mice; Mice, Knockout; Pyrazines; Pyridines; Pyrimidinones; Spermatozoa; Temperature; Testis; TRPM Cation Channels | 2011 |
Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors.
Topics: Amides; Amidines; Binding Sites; Bridged Bicyclo Compounds; Catalytic Domain; Crystallography, X-Ray; Drug Design; Factor VIIa; Protein Binding; Pyrazines; Pyrimidinones; Serine Proteinase Inhibitors; Structure-Activity Relationship | 2013 |
3-Iodothyronamine increases transient receptor potential melastatin channel 8 (TRPM8) activity in immortalized human corneal epithelial cells.
Topics: Calcium; Capsaicin; Cell Line; Epithelial Cells; Humans; Interleukin-6; Membrane Potentials; Patch-Clamp Techniques; Pyrazines; Pyridines; Pyrimidinones; Thyronines; TRPM Cation Channels; TRPV Cation Channels | 2016 |
Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading.
Topics: A549 Cells; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinases; DNA Damage; DNA Replication; Drug Synergism; Flow Cytometry; Humans; Nuclear Proteins; Phenylurea Compounds; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazines; Pyrazoles; Pyrimidines; Pyrimidinones; S Phase; Thiophenes; Urea | 2017 |
Discovery and structure-activity relationship study of phthalimide-phenylpyridine conjugate as inhibitor of Wnt pathway.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Molecular Structure; Pyrazines; Pyridines; Pyrimidinones; Signal Transduction; Structure-Activity Relationship; Wnt Signaling Pathway | 2019 |
Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Survival; Imidazoles; Lung Neoplasms; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Pyrazines; Pyridones; Pyrimidinones; Receptor, IGF Type 1; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Targeting of Deregulated Wnt/β-Catenin Signaling by PRI-724 and LGK974 Inhibitors in Germ Cell Tumor Cell Lines.
Topics: Animals; Antineoplastic Agents; Apoptosis; beta Catenin; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Humans; Immunohistochemistry; Male; Mice; Mice, SCID; Neoplasms, Germ Cell and Embryonal; Pyrazines; Pyridines; Pyrimidinones; Testicular Neoplasms; Wnt Signaling Pathway | 2021 |
Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM).
Topics: Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Jumonji Domain-Containing Histone Demethylases; Mesothelioma, Malignant; Mice; Pyrazines; Pyrazoles; Pyrimidinones; Sulfonamides; Up-Regulation; Xenograft Model Antitumor Assays | 2021 |