Page last updated: 2024-08-21

pyrazines and pyrimidine

pyrazines has been researched along with pyrimidine in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's2 (10.00)18.2507
2000's5 (25.00)29.6817
2010's9 (45.00)24.3611
2020's3 (15.00)2.80

Authors

AuthorsStudies
Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T1
Fotsch, C; St Jean, DJ1
Walker, MA1
Buxeraud, J; Comby, F; Lagorce, JF; Raby, C; Rousseau, A1
Cho, MK; Kim, SG1
Gallagher, T; Karig, G; Millar, NS; Sharples, CG; Simpson, GL; Spencer, JA; Wonnacott, S; Wright, E1
Deepak, HS; Joy, A; Suryaprakash, N1
Li, Y; Wan, J; Xu, X1
Chevallier, F; Mongin, F; Seggio, A; Vaultier, M1
Agren, H; Alvarez Ruiz, J; Coreno, M; de Simone, M; Gao, B; Kivimäki, A; Rachlew, E; Vall-llosera, G1
Dahal, UP; Jones, JP; Joswig-Jones, C1
Foote, DB; Scarborough, TD; Uiterwaal, CJ1
Cai, ZL; Reimers, JR1
Gorfinkiel, JD; Mašín, Z1
Batista, ER; Birnbaum, ER; John, KD; Martin, RL; Wilson, JJ1
Baek, B; Hyun, SY; Kim, B; Kim, Y; Lee, HJ; Lee, HY; Lee, J; Min, HY; Pham, PC1
Berteina-Raboin, S; Campos, JF; Loubidi, M; Scherrmann, MC1
Cherukupalli, S; Du, X; Jia, H; Liu, X; Yu, J; Zhan, P1
Balamurali, MM; Chanda, K; Maiti, B; Rao, RN; Saikia, AA1
Abu-Zaied, MA; Elgemeie, GH; Mahmoud, NM1

Reviews

2 review(s) available for pyrazines and pyrimidine

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012
Improvement in aqueous solubility achieved via small molecular changes.
    Bioorganic & medicinal chemistry letters, 2017, 12-01, Volume: 27, Issue:23

    Topics: Carbon; Drug Discovery; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Water

2017

Other Studies

18 other study(ies) available for pyrazines and pyrimidine

ArticleYear
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:10

    Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase

1981
Synthesis and antithyroid activity of pyridine, pyrimidine and pyrazine derivatives of thiazole-2-thiol and 2-thiazoline-2-thiol.
    Chemical & pharmaceutical bulletin, 1993, Volume: 41, Issue:7

    Topics: Animals; Antithyroid Agents; Male; Pyrazines; Pyridines; Pyrimidines; Rats; Rats, Wistar; Thiazoles; Thyrotropin; Thyroxine

1993
Differential induction of rat hepatic microsomal epoxide hydrolase and rGSTA2 by diazines: the role of cytochrome P450 2E1-mediated metabolic activation.
    Chemico-biological interactions, 1998, Nov-27, Volume: 116, Issue:3

    Topics: Acetone; Animals; beta-Naphthoflavone; Biotransformation; Blotting, Northern; Cytochrome P-450 CYP2E1; Enzyme Induction; Enzyme Inhibitors; Epoxide Hydrolases; Glutathione Transferase; Isoenzymes; Male; Microsomes, Liver; Pyrazines; Pyridazines; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Starvation

1998
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
    Journal of medicinal chemistry, 2002, Jul-18, Volume: 45, Issue:15

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Brain; Bridged-Ring Compounds; Cell Line; Ligands; Molecular Conformation; Monte Carlo Method; Neurons; Nicotinic Agonists; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship

2002
Determination of natural abundance 15N-1H and 13C-1H dipolar couplings of molecules in a strongly orienting media using two-dimensional inverse experiments.
    Magnetic resonance in chemistry : MRC, 2006, Volume: 44, Issue:5

    Topics: Carbon Isotopes; Deuterium; Liquid Crystals; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Pyrazines; Pyridazines; Pyrimidines

2006
Theoretical study of the vertical excited states of benzene, pyrimidine, and pyrazine by the symmetry adapted cluster--configuration interaction method.
    Journal of computational chemistry, 2007, Jul-30, Volume: 28, Issue:10

    Topics: Benzene; Computer Simulation; Models, Chemical; Pyrazines; Pyrimidines; Spectrum Analysis

2007
Lithium-mediated zincation of pyrazine, pyridazine, pyrimidine, and quinoxaline.
    The Journal of organic chemistry, 2007, Aug-17, Volume: 72, Issue:17

    Topics: Lithium; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pyrazines; Pyridazines; Pyrimidines; Quinoxalines; Zinc

2007
The C 1s and N 1s near edge x-ray absorption fine structure spectra of five azabenzenes in the gas phase.
    The Journal of chemical physics, 2008, Jan-28, Volume: 128, Issue:4

    Topics: Absorption; Aza Compounds; Benzene Derivatives; Carbon; Electrons; Energy Transfer; Gases; Nitrogen; Photons; Pyrazines; Pyridines; Pyrimidines; Spectrum Analysis; Triazines; X-Rays

2008
Comparative study of the affinity and metabolism of type I and type II binding quinoline carboxamide analogues by cytochrome P450 3A4.
    Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1

    Topics: Amides; Catalytic Domain; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dealkylation; Hydroxylation; Protein Binding; Pyrazines; Pyridines; Pyrimidines; Quinolines; Small Molecule Libraries; Structure-Activity Relationship; Substrate Specificity

2012
Ultrafast resonance-enhanced multiphoton ionization in the azabenzenes: pyridine, pyridazine, pyrimidine, and pyrazine.
    The Journal of chemical physics, 2012, Feb-07, Volume: 136, Issue:5

    Topics: Ions; Light; Models, Molecular; Pyrazines; Pyridazines; Pyridines; Pyrimidines

2012
Hydrogen bonding and reactivity of water to azines in their S1 (n,π*) electronic excited states in the gas phase and in solution.
    Physical chemistry chemical physics : PCCP, 2012, Jul-07, Volume: 14, Issue:25

    Topics: Computer Simulation; Dimerization; Hydrogen Bonding; Models, Chemical; Photochemical Processes; Protons; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Quantum Theory; Water

2012
Shape and core excited resonances in electron collisions with diazines.
    The Journal of chemical physics, 2012, Nov-28, Volume: 137, Issue:20

    Topics: Electrons; Models, Molecular; Pyrazines; Pyridazines; Pyrimidines; Quantum Theory

2012
Synthesis and characterization of nitrogen-rich macrocyclic ligands and an investigation of their coordination chemistry with lanthanum(III).
    Inorganic chemistry, 2015, Jan-05, Volume: 54, Issue:1

    Topics: Coordination Complexes; Crystallography, X-Ray; Cyclams; Heterocyclic Compounds; Kinetics; Lanthanoid Series Elements; Macrocyclic Compounds; Mesylates; Molecular Conformation; Nitrogen; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Quantum Theory; Stereoisomerism; Thermodynamics

2015
Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.
    Molecular cancer, 2018, 02-19, Volume: 17, Issue:1

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Dasatinib; Humans; Imidazoles; Immunohistochemistry; MCF-7 Cells; Pyrazines; Pyrimidines; Receptor, IGF Type 1; Receptors, Somatomedin; src-Family Kinases; Xenograft Model Antitumor Assays

2018
A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles.
    Molecules (Basel, Switzerland), 2018, Mar-18, Volume: 23, Issue:3

    Topics: Green Chemistry Technology; Heterocyclic Compounds, Fused-Ring; Nitriles; Nitrogen; Pyrazines; Pyrimidines

2018
Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors.
    European journal of medicinal chemistry, 2020, Sep-15, Volume: 202

    Topics: Antiviral Agents; Capsid Proteins; Dose-Response Relationship, Drug; Drug Design; Hepatitis B e Antigens; Hepatitis B virus; Microbial Sensitivity Tests; Molecular Structure; Pyrazines; Pyrazoles; Pyridines; Pyrimidines; Structure-Activity Relationship; Thiazoles; Virus Replication

2020
Diversity-Oriented Synthesis of Thiazolidine-2-imines via Microwave-Assisted One-Pot, Telescopic Approach and Its Interaction with Biomacromolecules.
    ACS combinatorial science, 2020, 11-09, Volume: 22, Issue:11

    Topics: Acetylcholinesterase; Aminopyridines; Anticonvulsants; Antineoplastic Agents; Antitubercular Agents; Catalysis; Cholinesterase Inhibitors; Ethylene Dibromide; Humans; Imines; Isothiocyanates; Microwaves; Pyrazines; Pyrimidines; Small Molecule Libraries; Structure-Activity Relationship; Thiazolidines; Thiourea

2020
Synthesis of novel pyrimidine thioglycosides as structural analogs of favipiravir (avigan) and their antibird flu virus activity.
    Nucleosides, nucleotides & nucleic acids, 2021, Volume: 40, Issue:3

    Topics: Amides; Antiviral Agents; Chemistry Techniques, Synthetic; Influenza A Virus, H5N1 Subtype; Pyrazines; Pyrimidines; Thioglycosides

2021