pyrazines has been researched along with pyrazolanthrone in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dent, P; Grant, S; Rahmani, M; Yu, C | 1 |
| Chizzolini, C; Dayer, JM; Fineschi, S; Guerne, PA; Reith, W | 1 |
| Bagain, L; Chen, Z; Lee, TL; Malhotra, PS; Nottingham, L; Ricker, JL; Van Waes, C; Yeh, NT | 1 |
| Jiao, BM; Li, ZL; Qian, HJ; Su, L; Zheng, JS | 1 |
| Bai, QX; Zhang, XY | 1 |
| Gu, Y; Hu, Y; Shen, Y; Shu, Y; Sun, Y; Wang, L; Wu, X; Xu, Q | 1 |
| Gao, X; Ma, W; Wang, Y; Zhang, X; Zhong, M | 1 |
7 other study(ies) available for pyrazines and pyrazolanthrone
| Article | Year |
|---|---|
The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Caspases; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia; MAP Kinase Signaling System; Membrane Potentials; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Protease Inhibitors; Pyrazines; Pyridines; Reactive Oxygen Species; Signal Transduction; U937 Cells | 2004 |
Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.
Topics: Acetylcysteine; Anthracenes; Boronic Acids; Bortezomib; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; Fibroblasts; Fibrosis; Genes, jun; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Matrix Metalloproteinase 1; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Pyrazines; RNA Polymerase II; RNA, Messenger; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Up-Regulation | 2006 |
Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-kappaB and activator protein-1 related mechanisms.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle; Cell Line, Tumor; Drug Synergism; Genes, Reporter; Head and Neck Neoplasms; Humans; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Signal Transduction; Transcription Factor AP-1; Ubiquitination; Xenograft Model Antitumor Assays | 2008 |
[The influence of JNK inhibitor on hemodynamics after ischemia/reperfusion injury to the heart in rats].
Topics: Animals; Anthracenes; Disease Models, Animal; Hemodynamics; JNK Mitogen-Activated Protein Kinases; Male; Myocardial Reperfusion Injury; Protein Kinase Inhibitors; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley | 2008 |
Curcumin enhances cytotoxic effects of bortezomib in human multiple myeloma H929 cells: potential roles of NF-κB/JNK.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Curcumin; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Multiple Myeloma; p38 Mitogen-Activated Protein Kinases; Pyrazines; Transcription Factor RelA | 2012 |
Preferential cytotoxicity of bortezomib toward highly malignant human liposarcoma cells via suppression of MDR1 expression and function.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Survival; Cycloheximide; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Liposarcoma; MAP Kinase Kinase 4; Mice, Nude; Protein Kinase Inhibitors; Pyrazines; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Tetramethyl Pyrazine Protects Hippocampal Neurons Against Anoxia/Reoxygenation Injury Through Inhibiting Apoptosis Mediated by JNK/MARK Signal Pathway.
Topics: Animals; Anthracenes; Apoptosis; Cells, Cultured; Hippocampus; Hypoxia; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Neurons; Neuroprotective Agents; Oxygen; Phosphorylation; Pyrazines; Rats, Sprague-Dawley; RNA, Messenger | 2016 |