Compounds > pyrazines
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pyrazines and pyrazinoic acid

pyrazines has been researched along with pyrazinoic acid in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19905 (41.67)18.7374
1990's4 (33.33)18.2507
2000's2 (16.67)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bohn, DL; Fanelli, GM; Zacchei, AG1
Roboz, J; Suzuki, R; Yü, TF1
Foks, H; Manowska, W; Sienicka, J1
Ellard, GA; Haslam, RM1
Beyer, KH; Gelarden, RT; Jeszenka, EV; Passananti, GT; Vesell, ES1
Kobayashi, M; Nagasawa, T; Yamada, H; Yanaka, N1
A-Rahim, YI; Beyer, KH; Vesell, ES1
Beyer, KH; Vesell, ES1
Bohme, GA; Boireau, A; Bouquerel, J; Damour, D; Debono, MW; Genevois-Borella, A; Hardy, JC; Hubert, P; Jimonet, P; Manfré, F; Mignani, S; Nemecek, P; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M1
FOKS, H; SAWLEWICZ, J1
Berkers, CR; Groll, M; Ovaa, H; Ploegh, HL1
Bakuradze, T; Buckel, L; Eisenbrand, G; Glaß-Theis, A; Kremer, JI; Pickard, S; Richling, E; Stadlmair, LF1

Trials

1 trial(s) available for pyrazines and pyrazinoic acid

ArticleYear
Studies on pyrazinoylguanidine. 7. Effects of single oral doses in normal human subjects.
    Pharmacology, 1999, Volume: 58, Issue:3

    Topics: Adult; Blood Glucose; Cross-Over Studies; Fatty Acids, Nonesterified; Guanidines; Hormones; Humans; Hypolipidemic Agents; Lipids; Male; Pyrazinamide; Pyrazines; Single-Blind Method

1999

Other Studies

11 other study(ies) available for pyrazines and pyrazinoic acid

ArticleYear
Renal excretion of a slauretic-uricosuric agent (MK-196) and interaction with a urate-retaining drug, pyrazinoate, in the chimpanzee.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 200, Issue:2

    Topics: Acetazolamide; Animals; Diuresis; Drug Interactions; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Indans; Indenes; Kidney; Male; p-Aminohippuric Acid; Pan troglodytes; Probenecid; Pyrazinamide; Pyrazines; Sodium Chloride; Time Factors; Uric Acid; Uricosuric Agents

1977
Mass fragmentographic determination of pyrazinamide and its metabolites in serum and urine.
    Journal of chromatography, 1978, Jan-11, Volume: 147

    Topics: Gas Chromatography-Mass Spectrometry; Humans; Methods; Pyrazinamide; Pyrazines

1978
[Synthesis and tuberculostatic activity of some derivatives of pyrazine-2-carboxylic acid].
    Acta poloniae pharmaceutica, 1976, Volume: 33, Issue:6

    Topics: Antitubercular Agents; Chemical Phenomena; Chemistry; Mycobacterium tuberculosis; Pyrazinamide; Pyrazines

1976
Observations on the reduction of the renal elimination of urate in man caused by the administration of pyrazinamide.
    Tubercle, 1976, Volume: 57, Issue:2

    Topics: Humans; Male; Pyrazinamide; Pyrazines; Time Factors; Uric Acid

1976
Pharmacokinetics of pyrazinoyl-guanidine, 3-aminopyrazinoyl-guanidine and their corresponding pyrazinoic acid metabolites in humans and dogs.
    Pharmacology, 1992, Volume: 45, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Drug Stability; Guanidines; Half-Life; Humans; Hydrolysis; Molecular Structure; Pyrazinamide; Pyrazines; Uremia

1992
Nitrilase-catalyzed production of pyrazinoic acid, an antimycobacterial agent, from cyanopyrazine by resting cells of Rhodococcus rhodochrous J1.
    The Journal of antibiotics, 1990, Volume: 43, Issue:10

    Topics: Aminohydrolases; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pyrazinamide; Pyrazines; Rhodococcus; Spectrophotometry, Infrared; Temperature

1990
Studies on pyrazinoylguanidine. 2. Comparative drug and dose effects on glucose and lipid metabolism in streptozotocin-induced diabetic rats.
    Pharmacology, 1996, Volume: 52, Issue:3

    Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glyburide; Guanidines; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Metabolism; Male; Metformin; Pyrazinamide; Pyrazines; Rats; Rats, Sprague-Dawley; Streptozocin

1996
Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action.
    Bioorganic & medicinal chemistry letters, 2001, Jan-22, Volume: 11, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Combinatorial Chemistry Techniques; Disease Models, Animal; Excitatory Amino Acid Antagonists; Imidazoles; Inhibitory Concentration 50; Male; Mice; Oocytes; Pyrazinamide; Pyrazines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship

2001
[N-OXIDES OF 2-PYRAZINECARBOXYLIC ACID].
    Acta poloniae pharmaceutica, 1964, Volume: 21

    Topics: Chemistry, Pharmaceutical; Oxides; Pyrazinamide; Pyrazines; Research

1964
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.
    Structure (London, England : 1993), 2006, Volume: 14, Issue:3

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Catalytic Domain; Crystallization; Leucine; Mammals; Models, Molecular; Peptides; Phenylalanine; Proteasome Endopeptidase Complex; Protein Structure, Quaternary; Pyrazinamide; Pyrazines; Structure-Activity Relationship; Substrate Specificity; Yeasts

2006
Alkylpyrazines from Coffee are Extensively Metabolized to Pyrazine Carboxylic Acids in the Human Body.
    Molecular nutrition & food research, 2019, Volume: 63, Issue:14

    Topics: Adult; Carboxylic Acids; Chromatography, High Pressure Liquid; Coffee; Female; Healthy Volunteers; Humans; Male; Pyrazinamide; Pyrazines; Spectrometry, Mass, Electrospray Ionization

2019