Compounds > pyrazines
Page last updated: 2024-08-21

pyrazines and phenylalanine

pyrazines has been researched along with phenylalanine in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.53)18.2507
2000's12 (63.16)29.6817
2010's5 (26.32)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Epps, DE; Laborde, AL; Petzold, GL; Poorman, RA; Stuchly, CW; Van Drie, JH1
Hande, KR; Nelson, AR; Rothenberg, ML1
Brady, CS; FitzGerald, MX; Mackarel, AJ; O'Connor, CM; Russell, KJ1
Hwang, JJ; Ip, MM; Lee, PP; Murphy, G1
Eckhardt, SG; Hidalgo, M1
Hwang, JJ; Ip, MM; Lee, PP; Mead, L1
Christiansen, JS; Jørgensen, JO; Møller, N; Nielsen, S; Pedersen, SB1
Christiansen, JS; Hartmund, T; Jørgensen, JO; Møller, N; Nair, KS; Nielsen, S; Nørrelund, H1
Christiansen, JS; Frystyk, J; Ivarsen, P; Jørgensen, JO; Møller, N; Nair, KS; Nielsen, S; Nørrelund, H1
Arison, B; Birzin, E; Chen, KH; Cheng, FC; Feng, JJ; Hirschmann, R; Lin, A; Neelamkavil, S; Smith, AB; Taylor, L; Thornton, ER1
Berkers, CR; Groll, M; Ovaa, H; Ploegh, HL1
Christiansen, JS; Gjedde, S; Gjedsted, J; Gormsen, LC; Jørgensen, JO; Møller, N; Nørrelund, H; Schmitz, O1
Inouye, S; Kato, S; Oba, Y; Ojika, M1
Adams, A; De Kimpe, N; Van Lancker, F1
Chen, M; Guo, Z; Hao, J; Houze, J; Lin, DC; Lopez, E; Luo, J; Ma, Z; Nguyen, K; Rulifson, IC; Tian, B; Tian, L; Tran, T; Wang, Y; Zhang, Y1
Hu, Y; Li, J; Liu, T; Liu, Y; Ma, X; Shangguan, S; Si, M; Tang, L; Wu, H; Wu, P1
Hilgenfeld, R; Jochmans, D; Ma, Q; Nascimento, MS; Neyts, J; Rocha-Pereira, J1
Altmeyer, R; Gao, Q; Lan, K; Li, G; Wang, Y; Yuan, S; Zou, G1

Reviews

2 review(s) available for pyrazines and phenylalanine

ArticleYear
Development of matrix metalloproteinase inhibitors in cancer therapy.
    Journal of the National Cancer Institute, 2001, Feb-07, Volume: 93, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Biphenyl Compounds; Clinical Trials as Topic; Drugs, Investigational; Enzyme Inhibitors; Humans; Hydroxamic Acids; Imidazoles; Matrix Metalloproteinase Inhibitors; Neoplasms; Organic Chemicals; Phenylalanine; Phenylbutyrates; Protease Inhibitors; Pyrazines; Sulfonamides; Tetracycline; Tetracyclines; Thiophenes

2001
Drugs for type 2 diabetes.
    Treatment guidelines from the Medical Letter, 2008, Volume: 6, Issue:71

    Topics: alpha-Galactosidase; Biguanides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Combinations; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Nateglinide; Phenylalanine; Piperidines; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Thiazolidinediones; Triazoles

2008

Trials

3 trial(s) available for pyrazines and phenylalanine

ArticleYear
The effect of long-term pharmacological antilipolysis on substrate metabolism in growth hormone (GH)-substituted GH-deficient adults.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:7

    Topics: Adult; Body Composition; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Growth Hormone; Hormones; Human Growth Hormone; Humans; Hypolipidemic Agents; Lipoprotein Lipase; Lipoproteins; Male; Metabolism, Inborn Errors; Middle Aged; Phenylalanine; Pyrazines; Tyrosine

2002
Effects of lowering circulating free fatty acid levels on protein metabolism in adult growth hormone deficient patients.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2002, Volume: 12, Issue:6

    Topics: Adult; Area Under Curve; Blood Glucose; Dwarfism, Pituitary; Fatty Acids, Nonesterified; Female; Forearm; Growth Hormone; Humans; Hypolipidemic Agents; Lipolysis; Male; Middle Aged; Phenylalanine; Proteins; Pyrazines; Tyrosine; Urea

2002
The decisive role of free fatty acids for protein conservation during fasting in humans with and without growth hormone.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:9

    Topics: Adult; Amino Acids; Fasting; Fatty Acids, Nonesterified; Growth Hormone; Heparin; Hormone Antagonists; Human Growth Hormone; Humans; Hypolipidemic Agents; Lipolysis; Male; Microdialysis; Muscle, Skeletal; Phenylalanine; Proteins; Pyrazines; Somatostatin; Triglycerides; Tyrosine; Urea

2003

Other Studies

14 other study(ies) available for pyrazines and phenylalanine

ArticleYear
The constituent tryptophans and bisANS as fluorescent probes of the active site and of a secondary binding site of stromelysin-1 (MMP-3).
    Journal of protein chemistry, 1998, Volume: 17, Issue:7

    Topics: Acrylamides; Anilino Naphthalenesulfonates; Binding Sites; Catalytic Domain; Fluorescence Polarization; Fluorescent Dyes; Hydroxamic Acids; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Models, Chemical; Phenylalanine; Protease Inhibitors; Protein Binding; Pyrazines; Spectrometry, Fluorescence; Sulfonamides; Thiophenes; Tryptophan

1998
New drugs on the horizon: matrix metalloproteinase inhibitors.
    Stem cells (Dayton, Ohio), 1999, Volume: 17, Issue:4

    Topics: Antineoplastic Agents; Azepines; Biphenyl Compounds; Humans; Hydroxamic Acids; Metalloendopeptidases; Organic Chemicals; Phenylalanine; Phenylbutyrates; Protease Inhibitors; Pyrazines; Sulfonamides; Thiophenes

1999
Interleukin-8 and leukotriene-B(4), but not formylmethionyl leucylphenylalanine, stimulate CD18-independent migration of neutrophils across human pulmonary endothelial cells in vitro.
    American journal of respiratory cell and molecular biology, 2000, Volume: 23, Issue:2

    Topics: CD11 Antigens; CD18 Antigens; Cell Line; Cell Movement; Chemotactic Factors; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Humans; Hydroxamic Acids; Interleukin-8; L-Selectin; Leukotriene B4; Lung; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Permeability; Phenylalanine; Protease Inhibitors; Pyrazines; Sulfonamides; Thiophenes

2000
Functional significance of MMP-9 in tumor necrosis factor-induced proliferation and branching morphogenesis of mammary epithelial cells.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Animals; Antibodies; Cell Division; Cells, Cultured; Enzyme Induction; Epithelial Cells; Female; Hydroxamic Acids; Mammary Glands, Animal; Matrix Metalloproteinase 9; Phenylalanine; Protease Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiophenes; Tumor Necrosis Factor-alpha

2000
Functional role of matrix metalloproteinases (MMPs) in mammary epithelial cell development.
    Journal of cellular physiology, 2001, Volume: 188, Issue:1

    Topics: Animals; Cell Size; Cells, Cultured; Culture Media, Conditioned; Culture Media, Serum-Free; Epidermal Growth Factor; Epithelial Cells; Extracellular Matrix; Female; Gelatinases; Humans; Hydroxamic Acids; Immunoblotting; Mammary Glands, Animal; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Organoids; Peptides; Phenylalanine; Phenylmercury Compounds; Protease Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiophenes; Transforming Growth Factor alpha

2001
Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanol.
    Journal of medicinal chemistry, 2005, Jun-16, Volume: 48, Issue:12

    Topics: Alanine; Binding Sites; Magnetic Resonance Spectroscopy; Membrane Proteins; Methanol; Models, Molecular; Peptides, Cyclic; Phenylalanine; Pyrazines; Receptors, Somatostatin; Solvents; Somatostatin; Stereoisomerism; Structure-Activity Relationship

2005
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.
    Structure (London, England : 1993), 2006, Volume: 14, Issue:3

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Catalytic Domain; Crystallization; Leucine; Mammals; Models, Molecular; Peptides; Phenylalanine; Proteasome Endopeptidase Complex; Protein Structure, Quaternary; Pyrazinamide; Pyrazines; Structure-Activity Relationship; Substrate Specificity; Yeasts

2006
Dose-response effects of free fatty acids on amino acid metabolism and ureagenesis.
    Acta physiologica (Oxford, England), 2008, Volume: 192, Issue:3

    Topics: Adult; Dose-Response Relationship, Drug; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Forearm; Glucose Clamp Technique; Heparin; Human Growth Hormone; Humans; Lipid Metabolism; Lipolysis; Male; Phenylalanine; Pyrazines; Somatostatin; Tyrosine; Urea

2008
Biosynthesis of coelenterazine in the deep-sea copepod, Metridia pacifica.
    Biochemical and biophysical research communications, 2009, Dec-18, Volume: 390, Issue:3

    Topics: Animals; Copepoda; Imidazoles; Luminescent Agents; Phenylalanine; Pyrazines; Tyrosine

2009
Formation of pyrazines in Maillard model systems of lysine-containing dipeptides.
    Journal of agricultural and food chemistry, 2010, Feb-24, Volume: 58, Issue:4

    Topics: Cystine; Dipeptides; Food Analysis; Gas Chromatography-Mass Spectrometry; Glucose; Leucine; Lysine; Maillard Reaction; Peptides; Phenylalanine; Pyrazines; Serine

2010
Evaluating insulin secretagogues in a humanized mouse model with functional human islets.
    Metabolism: clinical and experimental, 2013, Volume: 62, Issue:1

    Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glyburide; Humans; Incretins; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Nude; Nateglinide; Peptides; Phenylalanine; Pyrazines; Sitagliptin Phosphate; Specific Pathogen-Free Organisms; Triazoles; Venoms

2013
Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors.
    Bioorganic & medicinal chemistry, 2013, Sep-15, Volume: 21, Issue:18

    Topics: Animals; Binding Sites; Blood Glucose; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glucose Tolerance Test; Molecular Docking Simulation; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Pyrazines; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Structure-Activity Relationship; Triazoles

2013
The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8

    Topics: Amides; Antiviral Agents; Cell Line; Cysteine Endopeptidases; Cytidine; Drug Combinations; Drug Synergism; Hepatocytes; Humans; Isoxazoles; Molecular Docking Simulation; Norwalk virus; Papain; Phenylalanine; Pyrazines; Pyrrolidinones; Replicon; RNA-Dependent RNA Polymerase; Valine; Viral Proteins; Virus Replication

2014
In Vitro Assessment of Combinations of Enterovirus Inhibitors against Enterovirus 71.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:9

    Topics: Amides; Amino Acid Sequence; Animals; Antiviral Agents; Binding Sites; Cell Line, Tumor; Chlorocebus aethiops; Drug Combinations; Drug Resistance, Viral; Drug Synergism; Enterovirus A, Human; Humans; Indoles; Isoxazoles; Itraconazole; Molecular Docking Simulation; Mutation; Myoblasts; Phenols; Phenylalanine; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Pyrazines; Pyrrolidinones; Sequence Alignment; Sequence Homology, Amino Acid; Suramin; Valine; Vero Cells; Viral Nonstructural Proteins; Virus Replication

2016