pyrazines has been researched along with phenyl acetate in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (9.62) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (1.92) | 29.6817 |
| 2010's | 42 (80.77) | 24.3611 |
| 2020's | 4 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Goodman, DB; Lien, EL; Rasmussen, H | 1 |
| Johnson, FH; Shimomura, O | 1 |
| Cuthbert, AW; Wong, PY | 1 |
| Beuttenmüller, M; Eiden, F | 1 |
| Cragoe, EJ; Jones, JH | 1 |
| Hashino, A; Kosugi, K; Kuwabara, K; Kuwano, K; Noda, K | 1 |
| Barringer, SA; Huang, Y | 1 |
| Budunova, IV; Kirsanov, KI; Lesovaya, EA; Yakubovskaya, MG; Yemelyanov, AY | 1 |
| Bhalla, P; Budunova, I; Iwadate, K; Karseladze, A; Ugolkov, A; Yang, X; Yemelyanov, A | 1 |
| Arafat, T; Idkaidek, N | 1 |
| Clozel, M; Ernst, R; Haag, F; Kauser, K; Morrison, K; Studer, R | 1 |
| Denison, H; Eriksson, JW; Karlsson, C; Knutsson, M; Kujacic, M; Löfgren, L; Nilsson, C | 1 |
| Barlind, JG; Bauer, UA; Birch, AM; Birtles, S; Buckett, LK; Butlin, RJ; Davies, RD; Eriksson, JW; Hammond, CD; Hovland, R; Johannesson, P; Johansson, MJ; Kemmitt, PD; Lindmark, BT; Morentin Gutierrez, P; Noeske, TA; Nordin, A; O'Donnell, CJ; Petersson, AU; Redzic, A; Turnbull, AV; Vinblad, J | 1 |
| Arnaud, C; Blaise, S; Boutonnat, J; Cracowski, JL; Godin-Ribuot, D; Kotzki, S; Roustit, M | 1 |
| Benyahia, C; Boukais, K; Clapp, L; Danel, C; Fabre, A; Gomez, I; Leséche, G; Longrois, D; Norel, X; Silverstein, A | 1 |
| Clapp, LH; Ledwozyw, A; Orie, NN; Whittle, BJ; Williams, DJ | 1 |
| Hayashi, C; Hirano, T; Ishii, Y; Suzuki, Y | 1 |
| Al-Shurbaji, A; Denison, H; Eriksson, JW; Himmelmann, A; Knutsson, M; Löfgren, L; Mårtensson, G; Nilsson, C; Tornqvist, H | 1 |
| Minoura, H; Negoro, K; Shibasaki, M; Shimaya, A; Shimokawa, T; Tanaka, H; Yoshida, S | 1 |
| Lang, IM; Skoro-Sajer, N | 1 |
| Floettmann, E; Jones, HB; Lees, D; Seeliger, F | 1 |
| Bruderer, S; Dingemanse, J; Hurst, N; Kaufmann, P | 1 |
| Bruderer, S; Dingemanse, J; Kaufmann, P; Mant, T; Mukai, H; Okubo, K; Yamada, T | 1 |
| Äänismaa, P; Bruderer, S; Dingemanse, J; Halabi, A; Kaufmann, P; Niglis, S; Segrestaa, J | 1 |
| Asaki, T; Clozel, M; Gatfield, J; Hamamoto, T; Kuwano, K; Morrison, K | 1 |
| Srinivas, NR | 1 |
| Dingemanse, J; Kaufmann, P | 1 |
| Advani, A; Advani, SL; Azizi, PM; Batchu, SN; Bowskill, BB; Brijmohan, AS; Lee, WL; Liu, Y; Majumder, S; Thai, K; White, KE | 1 |
| Islam, MS; Jisaka, M; Khan, F; Nartey, MN; Nishimura, K; Rahman, MS; Shono, F; Syeda, PK; Yokota, K | 1 |
| Cruz, HG; Dingemanse, J; Halabi, A; Kaufmann, P; Krause, A; Ulč, I | 1 |
| Bruderer, S; Dingemanse, J; Mant, T; Mukai, H; Okubo, K | 1 |
| Jauhiainen, A; Taib, Z | 1 |
| Astruc, B; Dingemanse, J; Hurst, N; Kaufmann, P | 1 |
| Fuchikami, C; Homan, J; Kosugi, K; Kuramoto, K; Kuwano, K; Murakami, K; Oka, M; Tajima, K | 1 |
| Clozel, M; Gatfield, J; Gnerre, C; Hess, P; Iglarz, M; Menyhart, K; Monnier, L; Morrison, K; Nayler, O; Wanner, D | 1 |
| Bruderer, S; Dingemanse, J; Hurst, N; Remenova, T | 1 |
| Honorato Pérez, J | 1 |
| Bruderer, S; Dingemanse, J; Hurst, N; Krause, A; Lott, D; Machacek, M | 1 |
| Alexander, JC; Candelario-Jalil, E; DeMars, KM; Febo, M; Yang, C | 1 |
| Boehler, M; Bruderer, S; Dingemanse, J; Ulč, I | 1 |
| Boehler, M; Bruderer, S; Dingemanse, J; Halabi, A; Petersen-Sylla, M; Remeňová, T | 1 |
| Äänismaa, P; de Kanter, R; Delahaye, S; Gnerre, C; Ichikawa, T; Pfeifer, T; Seeland, S; Segrestaa, J; Treiber, A; Yamada, T | 1 |
| Gnerre, C; Ichikawa, T; Nonaka, K; Seeland, S; Segrestaa, J; Treiber, A; Yamada, T | 1 |
| Brizzolara, R; Corallo, C; Cutolo, M; Giordano, N; Montagna, P; Paolino, S; Parodi, A; Pizzorni, C; Ruaro, B; Scabini, S; Smith, V; Soldano, S; Stratta, E; Sulli, A; Tavilla, PP; Trombetta, AC | 1 |
| Bauer, Y; Bolinger, M; Gatfield, J; Menyhart, K; Nayler, O; Renault, B; Schnoebelen, M; Studer, R; Zmajkovicova, K | 1 |
| Adlin Jenifer, JSC; Citarasu, T; Eswaramoorthy Thirumalaikumar, CL; Jeraldin Nisha, SR; Michaelbabu, M; Uma, G | 1 |
| Birtles, S; Morentin Gutierrez, P; Nilsson, C; Yates, J | 1 |
| Chen, H; He, J; Pu, D; Ren, F; Sun, B; Zhang, H; Zhang, Y | 1 |
| Huan, X; Wang, K; Wang, L; Wang, X; Zhang, Y; Zu, C | 1 |
| Chen, J; Shi, L; Xie, S; Xu, RA; Ye, X | 1 |
| Cheng, C; Duan, C; Lan, Y; Ling, M; Shi, Y; Wu, G; Zhou, Y | 1 |
| Chen, YA; Fan, C; Gu, EM; Luo, SB; Xu, RA; Zhou, SC | 1 |
3 review(s) available for pyrazines and phenyl acetate
| Article | Year |
|---|---|
Selexipag for the treatment of pulmonary arterial hypertension.
Topics: Acetamides; Acetates; Administration, Oral; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Prostaglandins I; Pyrazines; Receptors, Prostaglandin; Signal Transduction | 2014 |
Clinical pharmacology, efficacy, and safety of selexipag for the treatment of pulmonary arterial hypertension.
Topics: Acetamides; Acetates; Administration, Oral; Adult; Animals; Antihypertensive Agents; Drug Administration Schedule; Drug Therapy, Combination; Humans; Hypertension, Pulmonary; Pyrazines | 2017 |
Selexipag, a selective prostacyclin receptor agonist in pulmonary arterial hypertension: a pharmacology review.
Topics: Acetamides; Acetates; Administration, Oral; Animals; Antihypertensive Agents; Drug Design; Humans; Hypertension, Pulmonary; Pyrazines; Receptors, Epoprostenol | 2017 |
12 trial(s) available for pyrazines and phenyl acetate
| Article | Year |
|---|---|
Proof of mechanism for the DGAT1 inhibitor AZD7687: results from a first-time-in-human single-dose study.
Topics: Acetates; Adult; Area Under Curve; Cohort Studies; Diabetes Mellitus, Type 2; Diacylglycerol O-Acyltransferase; Diglycerides; Dose-Response Relationship, Drug; Humans; Insulin Resistance; Intestinal Absorption; Male; Mass Spectrometry; Postprandial Period; Pyrazines; Treatment Outcome; Triglycerides | 2013 |
Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial.
Topics: Acetates; Adult; Anti-Obesity Agents; Diabetes Mellitus, Type 2; Diacylglycerol O-Acyltransferase; Diarrhea; Dose-Response Relationship, Drug; Gastric Emptying; Glucagon-Like Peptide 1; Humans; Intestinal Absorption; Male; Middle Aged; Obesity; Peptide YY; Pyrazines; Treatment Outcome; Weight Loss | 2014 |
Multiple-dose up-titration study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of selexipag, an orally available selective prostacyclin receptor agonist, in healthy subjects.
Topics: Acetamides; Acetates; Administration, Oral; Adult; Double-Blind Method; Healthy Volunteers; Humans; Male; Maximum Tolerated Dose; Middle Aged; Platelet Aggregation; Pyrazines; Receptors, Epoprostenol | 2014 |
Pharmacokinetics and Tolerability of the Novel Oral Prostacyclin IP Receptor Agonist Selexipag.
Topics: Acetamides; Acetates; Administration, Oral; Adolescent; Adult; Antihypertensive Agents; Dose-Response Relationship, Drug; Double-Blind Method; Food-Drug Interactions; Half-Life; Humans; Male; Pyrazines; Receptors, Epoprostenol; Young Adult | 2015 |
Effect of lopinavir/ritonavir on the pharmacokinetics of selexipag an oral prostacyclin receptor agonist and its active metabolite in healthy subjects.
Topics: Acetamides; Acetates; Adult; Antihypertensive Agents; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Drug Combinations; Drug Interactions; Healthy Volunteers; Humans; Lopinavir; Male; Middle Aged; Pyrazines; Ritonavir; Young Adult | 2015 |
Pharmacokinetics of the novel oral prostacyclin receptor agonist selexipag in subjects with hepatic or renal impairment.
Topics: Acetamides; Acetates; Adult; Aged; Antihypertensive Agents; Area Under Curve; Case-Control Studies; Dose-Response Relationship, Drug; Female; Humans; Kidney Diseases; Liver Diseases; Male; Middle Aged; Prospective Studies; Pyrazines; Receptors, Epoprostenol; Severity of Illness Index | 2016 |
Investigation of Potential Pharmacodynamic and Pharmacokinetic Interactions Between Selexipag and Warfarin in Healthy Male Subjects.
Topics: Acetamides; Acetates; Adolescent; Adult; Anticoagulants; Cross-Over Studies; Double-Blind Method; Drug Interactions; Humans; International Normalized Ratio; Male; Middle Aged; Pyrazines; Warfarin; Young Adult | 2016 |
Absolute oral bioavailability of selexipag, a novel oral prostacyclin IP receptor agonist.
Topics: Acetamides; Acetates; Administration, Oral; Adult; Antihypertensive Agents; Biological Availability; Cross-Over Studies; Humans; Infusions, Intravenous; Male; Pyrazines; Receptors, Epoprostenol; Receptors, Prostaglandin; Young Adult | 2017 |
Population Modeling of Selexipag Pharmacokinetics and Clinical Response Parameters in Patients With Pulmonary Arterial Hypertension.
Topics: Acetamides; Acetates; Adult; Antihypertensive Agents; Bilirubin; Double-Blind Method; Exercise Tolerance; Female; Humans; Hypertension, Pulmonary; Leukocyte Count; Male; Models, Biological; Natriuretic Peptide, Brain; Peptide Fragments; Pyrazines; Treatment Outcome | 2017 |
Biocomparison Study of Adult and Paediatric Dose Strengths of the Prostacyclin Receptor Agonist Selexipag.
Topics: Acetamides; Acetates; Administration, Oral; Adolescent; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Male; Middle Aged; Pyrazines; Therapeutic Equivalency; Young Adult | 2018 |
Effect of gemfibrozil and rifampicin on the pharmacokinetics of selexipag and its active metabolite in healthy subjects.
Topics: Acetamides; Acetates; Activation, Metabolic; Adolescent; Adult; Antihypertensive Agents; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inducers; Cytochrome P-450 CYP2C8 Inhibitors; Drug Interactions; Gemfibrozil; Germany; Half-Life; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Middle Aged; Prodrugs; Pyrazines; Rifampin; Risk Assessment; Young Adult | 2017 |
The metabolism and drug-drug interaction potential of the selective prostacyclin receptor agonist selexipag.
Topics: Acetamides; Acetates; Drug Interactions; Enzyme Inhibitors; Esterases; Hepatocytes; Humans; Membrane Transport Proteins; Metabolic Networks and Pathways; Metabolome; Metabolomics; Microsomes, Liver; NADP; Pyrazines; Receptors, Epoprostenol; Recombinant Proteins; RNA, Messenger | 2018 |
37 other study(ies) available for pyrazines and phenyl acetate
| Article | Year |
|---|---|
Effects of an acetyl-coenzyme A carboxylase inhibitor and a sodium-sparing diuretic on aldosterone-stimulated sodium transport, lipid synthesis, and phospholipid fatty acid composition in the toad urinary bladder.
Topics: Acetates; Acetyl-CoA Carboxylase; Aldosterone; Amiloride; Animals; Biological Transport, Active; Bufo marinus; Fatty Acids; Female; Leucine; Ligases; Lipids; Nafenopin; Phospholipids; Propionates; Protein Biosynthesis; Pyrazines; RNA; Sodium; Uridine; Urinary Bladder | 1975 |
Structure of the light-emitting moiety of aequorin.
Topics: Acetates; Acylation; Anhydrides; Animals; Benzyl Compounds; Chemical Phenomena; Chemistry; Cnidaria; Crustacea; Deuterium; Ferricyanides; Firefly Luciferin; Hydrogenation; Hydrolysis; Infrared Rays; Luminescent Measurements; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Oxidation-Reduction; Phenols; Potentiometry; Protein Binding; Proteins; Pyrazines; Spectrophotometry; Ultraviolet Rays | 1972 |
Amiloride, Ca 2+ and oxygen consumption of the urinary bladders of toads.
Topics: Acetates; Amiloride; Animals; Anura; Biological Transport; Calcium Chloride; Chelating Agents; Diuretics; Drug Synergism; Ethers; Europium; In Vitro Techniques; Lanthanum; Mathematics; Oxygen Consumption; Polarography; Pyrazines; Sodium; Sodium Chloride; Urinary Bladder | 1971 |
[Synthesis of substituted 8-methylene-pyrido(1,2-a)pyrazinones].
Topics: Acetates; Chemistry, Pharmaceutical; Infrared Rays; Magnetic Resonance Spectroscopy; Pyrazines; Pyridones; Spectrophotometry; Ultraviolet Rays | 1971 |
Pyrazine diuretics. 8. N-Amidino-3-aminopyrazinecarboxamide 4-oxides.
Topics: Acetates; Amides; Animals; Chemical Phenomena; Chemistry; Desoxycorticosterone; Diuretics; Oxides; Pyrazines; Rats | 1970 |
A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active fo
Topics: Acetamides; Acetates; Animals; Antihypertensive Agents; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; In Vitro Techniques; Male; Prodrugs; Pulmonary Artery; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Epoprostenol; Vasodilation | 2008 |
Monitoring of cocoa volatiles produced during roasting by selected ion flow tube-mass spectrometry (SIFT-MS).
Topics: Acetaldehyde; Acetates; Acetone; Aldehydes; Cacao; Food Handling; Hydrogen-Ion Concentration; Ketones; Mass Spectrometry; Pyrazines; Volatile Organic Compounds | 2011 |
Antitumor effect of non-steroid glucocorticoid receptor ligand CpdA on leukemia cell lines CEM and K562.
Topics: Acetates; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cytostatic Agents; Fluocinolone Acetonide; Humans; K562 Cells; Leukemia; Ligands; NF-kappa B; Pyrazines; Receptors, Glucocorticoid; Tacrolimus Binding Proteins; Transcription Factor AP-1; Tyramine | 2011 |
Differential targeting of androgen and glucocorticoid receptors induces ER stress and apoptosis in prostate cancer cells: a novel therapeutic modality.
Topics: Acetates; Adult; Aged; Aged, 80 and over; Androgen Receptor Antagonists; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Carcinoma; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Pyrazines; Receptors, Androgen; Receptors, Glucocorticoid; Transcription Factor CHOP; Transcriptional Activation; Tyramine | 2012 |
Saliva versus plasma pharmacokinetics: theory and application of a salivary excretion classification system.
Topics: Acetates; Anthraquinones; Azithromycin; Benzhydryl Compounds; Cinacalcet; Cloxacillin; Cresols; Cyclopropanes; Female; Fluorobenzenes; Humans; Hydrochlorothiazide; Losartan; Male; Metformin; Naphthalenes; Phenylpropanolamine; Piroxicam; Pyrazines; Pyrimidines; Quinolines; Rosuvastatin Calcium; Saliva; Sitagliptin Phosphate; Sulfides; Sulfonamides; Tamsulosin; Tolterodine Tartrate; Triazoles | 2012 |
Differential effects of Selexipag [corrected] and prostacyclin analogs in rat pulmonary artery.
Topics: Acetamides; Acetates; Alprostadil; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Epoprostenol; Hypertension, Pulmonary; In Vitro Techniques; Male; Pulmonary Artery; Pyrazines; Rats; Rats, Wistar; Receptors, Epoprostenol; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2012 |
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).
Topics: Acetates; Animals; Diacylglycerol O-Acyltransferase; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; Pyrazines; Rats; Solubility | 2012 |
Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats.
Topics: Acetates; Acrylamides; Animals; Data Interpretation, Statistical; Electric Stimulation; Electrodes; Guanylate Cyclase; In Vitro Techniques; Iontophoresis; Male; Nitrosamines; Oxazoles; Platelet Aggregation Inhibitors; Pyrazines; Pyrazoles; Rats; Rats, Wistar; Receptors, Epoprostenol; Regional Blood Flow; Skin | 2013 |
A comparative study of PGI2 mimetics used clinically on the vasorelaxation of human pulmonary arteries and veins, role of the DP-receptor.
Topics: Acetates; Aged; Drug Evaluation, Preclinical; Epoprostenol; Female; Humans; Iloprost; In Vitro Techniques; Inhibitory Concentration 50; Male; Middle Aged; Molecular Mimicry; Pulmonary Artery; Pulmonary Veins; Pyrazines; Receptors, Epoprostenol; Receptors, Immunologic; Receptors, Prostaglandin; Receptors, Prostaglandin E, EP4 Subtype; Vasodilation; Vasodilator Agents | 2013 |
Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins.
Topics: Acetamides; Acetates; Animals; Benzofurans; Benzyl Compounds; Epoprostenol; Female; Iloprost; Imidazoles; Male; Propionates; Pulmonary Artery; Pulmonary Veins; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Epoprostenol; Vasodilation | 2013 |
Chemiluminescent 2,6-diphenylimidazo[1,2-a]pyrazin-3(7H)-ones: a new entry to Cypridina luciferin analogues.
Topics: Acetates; Animals; Buffers; Cyprinidae; Dimethyl Sulfoxide; Ethylene Glycols; Luminescent Agents; Luminescent Measurements; Methyl Ethers; Models, Molecular; Molecular Conformation; Pyrazines; Sodium Hydroxide | 2014 |
Novel GPR40 agonist AS2575959 exhibits glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion.
Topics: Acetates; Animals; Blood Glucose; Dipeptidyl-Peptidase IV Inhibitors; Drug Synergism; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Glycated Hemoglobin; Hypoglycemic Agents; Incretins; Insulin; Insulin Secretion; Male; Mice; Mice, Inbred ICR; Mice, Obese; Pyrazines; Receptors, G-Protein-Coupled; Sitagliptin Phosphate; Spiro Compounds; Triazoles | 2014 |
Pharmacological inhibition of DGAT1 induces sebaceous gland atrophy in mouse and dog skin while overt alopecia is restricted to the mouse.
Topics: Acetates; Alopecia; Animals; Diacylglycerol O-Acyltransferase; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Insulin Resistance; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Pyrazines; Sebaceous Glands; Skin | 2015 |
Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
Topics: Acetamides; Acetates; Administration, Oral; Animals; CHO Cells; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cricetulus; Dogs; Double-Blind Method; Haplorhini; Humans; Hypertension, Pulmonary; Myocytes, Smooth Muscle; Platelet Aggregation Inhibitors; Pulmonary Artery; Pyrazines; Randomized Controlled Trials as Topic; Rats; Receptors, Epoprostenol; Structure-Activity Relationship | 2015 |
Comment on: "pharmacokinetics and tolerability of the novel oral prostacyclin IP receptor agonist selexipag".
Topics: Acetamides; Acetates; Food-Drug Interactions; Humans; Male; Pyrazines; Receptors, Epoprostenol | 2015 |
Authors' reply to Srinivas: "pharmacokinetics and tolerability of the novel oral prostacyclin IP receptor agonist selexipag".
Topics: Acetamides; Acetates; Food-Drug Interactions; Humans; Male; Pyrazines; Receptors, Epoprostenol | 2015 |
Prostaglandin I2 Receptor Agonism Preserves β-Cell Function and Attenuates Albuminuria Through Nephrin-Dependent Mechanisms.
Topics: Acetamides; Acetates; Animals; Cell Line; Cell Survival; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phosphorylation; Podocytes; Prodrugs; Protein Processing, Post-Translational; Pyrazines; Receptors, Epoprostenol; Renal Insufficiency; RNA Interference | 2016 |
Pretreatment of cultured preadipocytes with arachidonic acid during the differentiation phase without a cAMP-elevating agent enhances fat storage after the maturation phase.
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; 6-Ketoprostaglandin F1 alpha; Acetates; Adipocytes; Adipogenesis; Animals; Arachidonic Acid; Cell Differentiation; Cells, Cultured; Cyclic AMP; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Gene Expression Regulation; Humans; Hydroxyprostaglandin Dehydrogenases; Membrane Proteins; Mesenchymal Stem Cells; Mice; Prostaglandin-E Synthases; Pyrazines; Receptors, Prostaglandin; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Triglycerides | 2016 |
COPD biomarkers as tools for decision making in early clinical drug development.
Topics: Acetates; Biomarkers; Clinical Trials as Topic; Cluster Analysis; Endpoint Determination; Humans; Interleukin-6; Lung; Prognosis; Pulmonary Disease, Chronic Obstructive; Pyrazines | 2016 |
A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcine and human pulmonar
Topics: Acetamides; Acetates; Animals; Cyclic AMP; Endothelium, Vascular; Humans; Male; Nitric Oxide; Pulmonary Artery; Pyrazines; Rats; Receptors, Epoprostenol; Swine; Vasodilation; Vasodilator Agents | 2017 |
Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low
Topics: Acetamides; Acetates; Animals; beta-Arrestins; Cell Proliferation; CHO Cells; Contractile Proteins; Cricetinae; Cricetulus; Cyclic AMP; Epoprostenol; Extracellular Matrix; Humans; Hypertension, Pulmonary; Iloprost; Male; Muscle Contraction; Muscle Relaxation; Pyrazines; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Epoprostenol | 2017 |
Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog.
Topics: Acetates; Age Factors; Animals; Brain Ischemia; Epoprostenol; Infarction, Middle Cerebral Artery; Male; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Stroke | 2017 |
Cross-species comparison of the metabolism and excretion of selexipag.
Topics: Acetamides; Acetates; Animals; Bile; Body Fluids; Chromatography, High Pressure Liquid; Dogs; Hepatocytes; Macaca fascicularis; Metabolome; Microsomes, Liver; Pyrazines; Rats; Rats, Sprague-Dawley; Species Specificity | 2019 |
Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts.
Topics: Acetamides; Acetates; Actins; Aged; Cells, Cultured; Female; Fibroblasts; Gene Expression; Humans; Middle Aged; Muscle, Smooth; Myofibroblasts; Pyrazines; S100 Calcium-Binding Protein A4; Scleroderma, Systemic; Skin | 2018 |
The Antifibrotic Activity of Prostacyclin Receptor Agonism Is Mediated through Inhibition of YAP/TAZ.
Topics: Acetates; Acyltransferases; Adaptor Proteins, Signal Transducing; Case-Control Studies; Cell Differentiation; Cell Proliferation; Cyclic AMP; Extracellular Matrix; Fibroblasts; Gene Expression Regulation; Humans; Idiopathic Pulmonary Fibrosis; Interleukin-6; Lung; Male; Myofibroblasts; Plasminogen Activator Inhibitor 1; Pyrazines; Receptors, Epoprostenol; Signal Transduction; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta1; YAP-Signaling Proteins | 2019 |
Antimicrobial potential of haloalkaliphilic Nocardiopsis sp. AJ1 isolated from solar salterns in India.
Topics: Acetates; Anti-Infective Agents; Bacteria; Bacterial Proteins; Dactinomycin; Fungi; Microbial Sensitivity Tests; Models, Molecular; Nocardia; Peptide Synthases; Phylogeny; Pyrazines; Pyrroles; RNA, Ribosomal, 16S; Salinity; Soil Microbiology; Viruses | 2019 |
Evolving data analysis of an Oral Lipid Tolerance Test toward the standard for the Oral Glucose Tolerance Test: Cross species modeling effects of AZD7687 on plasma triacylglycerol.
Topics: Acetates; Animals; Biomarkers; Body Mass Index; Cohort Studies; Data Analysis; Diacylglycerol O-Acyltransferase; Dietary Fats; Glucose Tolerance Test; Healthy Volunteers; Humans; Lipid Metabolism; Male; Meals; Mice; Mice, Inbred ICR; Models, Biological; Pyrazines; Rats; Rats, Wistar; Species Specificity; Time Factors; Triglycerides | 2019 |
Characterization of the aroma release and perception of white bread during oral processing by gas chromatography-ion mobility spectrometry and temporal dominance of sensations analysis.
Topics: Acetates; Adult; Aldehydes; Bread; Butylene Glycols; Consumer Behavior; Female; Fermentation; Flour; Gas Chromatography-Mass Spectrometry; Humans; Ion Mobility Spectrometry; Male; Mastication; Odorants; Pyrazines; Taste; Triticum; Volatile Organic Compounds; Young Adult | 2019 |
Blocking TG2 attenuates bleomycin-induced pulmonary fibrosis in mice through inhibiting EMT.
Topics: Acetates; Actins; Animals; Antibiotics, Antineoplastic; Benzopyrans; Bleomycin; Cadherins; Cell Line; Epithelial Cells; Epithelial-Mesenchymal Transition; Gene Knockdown Techniques; GTP-Binding Proteins; In Vitro Techniques; Mice; Protein Glutamine gamma Glutamyltransferase 2; Pulmonary Fibrosis; Pyrazines; Respiratory Mucosa; Transglutaminases; Vimentin | 2020 |
Simultaneous quantification and pharmacokinetic investigation of selexipag and its main metabolite ACT-333679 in rat plasma by UPLC-MS/MS method.
Topics: Acetamides; Acetates; Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Pyrazines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry | 2020 |
Modification of Sensory Expression of 3-Isobutyl-2-methoxypyrazine in Wines through Blending Technique.
Topics: Acetates; Adult; Female; Food Analysis; Fruit; Gas Chromatography-Mass Spectrometry; Humans; Male; Odorants; Principal Component Analysis; Pyrazines; Reproducibility of Results; Vitis; Volatile Organic Compounds; Volatilization; Wine; Young Adult | 2021 |
Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles.
Topics: Acetamides; Acetates; Animals; Antihypertensive Agents; Area Under Curve; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C8 Inhibitors; Dogs; Female; Herb-Drug Interactions; Male; Pyrazines; Quercetin; Tandem Mass Spectrometry | 2022 |