pyrazines has been researched along with phenobarbital in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Radchenko, LU; Revazova, IuA; Sidirov, VP | 1 |
| Tian, YL | 1 |
| Legrum, W; Meyer, S | 1 |
| McCoubrie, M; Snaith, RP | 1 |
| Keyl, AC; Nishie, K; Waiss, AC | 1 |
| Fardel, O; Gilmore, KS; Guillouzo, A; Kensler, TW; Ketterer, B; Langouet, S; Meunier, B; Meyer, DJ; Morel, F; Tu, CP | 1 |
| Altuntas, TG; Gorrod, JW | 1 |
| Ellis, EM; Hayes, JD; Judah, DJ; Neal, GE; O'Connor, T | 1 |
| Corcos, L; Fardel, O; Guillouzo, A; Ketterer, B; Langouët, S; Meyer, DJ; Morel, F | 1 |
| de Sousa, G; Guillouzo, A; Langouët, S; Lorenzon, G; Nicolas, F; Placidi, M; Rahmani, R | 1 |
| Ha, TG; Jang, JJ; Kim, ND; Kim, SG | 1 |
| Bu, S; Kim, S; Kim, Y; Lee, M | 1 |
| Cherrington, NJ; Klaassen, CD; Maher, JM; Slitt, AL | 1 |
| Bae, SK; Kim, T; Kim, YH; Lee, MG; Lee, SJ | 1 |
| Boursier-Neyret, C; Fardel, O; Jigorel, E; Le Vee, M; Parmentier, Y | 1 |
| Beilke, LD; Besselsen, DG; Cheng, Q; Cherrington, NJ; Kulkarni, S; Slitt, AL | 1 |
| Aleksunes, LM; Beilke, LD; Besselsen, DG; Cherrington, NJ; Dvorak, K; Klaassen, CD; Olson, ER | 1 |
| Banerjee, A; Gartel, AL; Halasi, M; Kabirov, K; Landolfi, J; Lyubimov, AV; Wang, M | 1 |
| Droździk, A; Laszczyńska, M; Wajda, A; Łapczuk, J | 1 |
19 other study(ies) available for pyrazines and phenobarbital
| Article | Year |
|---|---|
[Mutagenic activity of luminal and pyrazidol].
Topics: Animals; Antidepressive Agents; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Chromosomes; Genes, Dominant; Genes, Lethal; Hybridization, Genetic; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mutagens; Phenobarbital; Pyrazines; Spermatozoa | 1977 |
[The beta-adrenoceptor and pathophysiological study on acute lung injury induced by oleic acid in rats].
Topics: Animals; Dexamethasone; Drugs, Chinese Herbal; Lung; Male; Oleic Acids; Phenobarbital; Plant Extracts; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Respiratory Distress Syndrome; Salvia miltiorrhiza | 1991 |
The combinations of inducers of the coumarin hydroxylase-locus help investigate their mode of action.
Topics: Amitrole; Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Enzyme Induction; Liver; Male; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Phenobarbital; Pyrazines; Pyrazoles | 1989 |
Antihypertensive drugs and depression.
Topics: Adult; Aged; Antihypertensive Agents; Bethanidine; Chlorthalidone; Depression; Diuretics; Drug Therapy, Combination; Fatigue; Furosemide; Guanethidine; Humans; Hydrochlorothiazide; Methyldopa; Middle Aged; Phenobarbital; Potassium; Pyrazines; Reserpine; Self-Assessment; Sodium Chloride Symporter Inhibitors; Theobromine | 1974 |
Pharmacology of alkyl and hydroxyalkylpyrazines.
Topics: Animals; Anticonvulsants; Central Nervous System; Glucose; Hypnotics and Sedatives; Imidazoles; Male; Mice; Pentylenetetrazole; Phenobarbital; Pyrazines; Reflex; Seizures | 1970 |
Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.
Topics: Cells, Cultured; Enzyme Induction; Gene Expression; Glutathione Transferase; Humans; Liver; Methylcholanthrene; Phenobarbital; Pyrazines; RNA, Messenger; Thiones; Thiophenes | 1993 |
Factors involved in the N-oxidation of isomeric aromatic diazines by microsomal preparations.
Topics: Animals; Biotransformation; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; In Vitro Techniques; Isomerism; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Pyrazines; Pyridazines; Pyrimidines; Rabbits | 1995 |
Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors.
Topics: Aldehyde Reductase; Animals; Antioxidants; Barbiturates; Butylated Hydroxyanisole; Carcinogens; Enzyme Induction; Ethoxyquin; Liver; Methylcholanthrene; Oxidation-Reduction; Phenobarbital; Pyrazines; Rats; Thiones; Thiophenes | 1996 |
A comparison of the effect of inducers on the expression of glutathione-S-transferases in the liver of the intact rat and in hepatocytes in primary culture.
Topics: Animals; Cells, Cultured; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Liver; Male; Methylcholanthrene; Phenobarbital; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiones; Thiophenes | 1996 |
Increase of cytochrome P-450 1A and glutathione transferase transcripts in cultured hepatocytes from dogs, monkeys, and humans after cryopreservation.
Topics: Animals; Cell Survival; Cells, Cultured; Cryopreservation; Cyclopentanes; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Dogs; Glutathione Transferase; Haplorhini; Humans; Liver; Phenobarbital; Pyrazines; RNA, Messenger; Thiones; Thiophenes | 1996 |
2-(Allylthio)pyrazine inhibition of aflatoxin B1-induced hepatocarcinogenesis in rats.
Topics: Aflatoxin B1; Animals; Carcinogenicity Tests; DNA Adducts; DNA, Neoplasm; Enzyme Inhibitors; Glutathione Transferase; Hepatectomy; Immunoenzyme Techniques; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Pyrazines; Rats; Rats, Sprague-Dawley; RNA | 1999 |
Effects of enzyme inducers and inhibitor on the pharmacokinetics of intravenous 2-(allylthio)pyrazine, a new chemoprotective agent, in rats.
Topics: Amines; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Isoniazid; Male; Phenobarbital; Proadifen; Pyrazines; Rats; Rats, Sprague-Dawley | 2000 |
Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites.
Topics: Acetaminophen; Allyl Compounds; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile; Blotting, Western; Branched DNA Signal Amplification Assay; Drug Resistance, Multiple; Kidney; Liver; Male; Mitochondrial Proteins; Phenobarbital; Pyrazines; Rats; Rats, Sprague-Dawley; Ribosomal Proteins; RNA, Messenger; Saccharomyces cerevisiae Proteins; Stilbenes; Sulfides; Thiones; Thiophenes; Time Factors | 2003 |
Effect of enzyme inducers and inhibitors on the pharmacokinetics of oltipraz in rats.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Isoniazid; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; Models, Animal; Phenobarbital; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 2005 |
Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Constitutive Androstane Receptor; Gene Expression Regulation; Hepatocytes; Humans; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; NF-E2-Related Factor 2; Phenobarbital; Polychlorinated Dibenzodioxins; Pregnane X Receptor; Pyrazines; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Receptors, Drug; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Symporters; Thiones; Thiophenes; Transcription Factors; Xenobiotics | 2006 |
Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.
Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis, Intrahepatic; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Phenobarbital; Protective Agents; Pyrazines; Pyridines; RNA, Messenger; Symporters; Thiones; Thiophenes; Time Factors; Up-Regulation | 2008 |
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Receptor; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiones; Thiophenes; Transcription Factors | 2009 |
Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Models, Animal; Liver; Liver Neoplasms; Mice; Phenobarbital; Pyrazines; Thiostrepton | 2012 |
Expression and functional regulation of the nuclear receptors AHR, PXR, and CAR, and the transcription factor Nrf2 in rat parotid gland.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Nucleus; Constitutive Androstane Receptor; Cytoplasm; Dexamethasone; Gene Expression Regulation; Male; NF-E2-Related Factor 2; Parotid Gland; Phenobarbital; Polychlorinated Dibenzodioxins; Pregnane X Receptor; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Salivary Ducts; Thiones; Thiophenes | 2014 |