pyrazines has been researched along with oxadiazoles in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.69) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 6 (20.69) | 24.3611 |
| 2020's | 7 (24.14) | 2.80 |
| Authors | Studies |
|---|---|
| Foks, H; Janowiec, M; Landowska, E; Pancechowska-Ksepko, D; Zwolska-Kwiek, Z | 1 |
| Foks, H; Janowiec, M; Pancechowska-Ksepko, D; Zwolska-Kwiek, Z | 3 |
| Benos, DJ; Watthey, JW | 1 |
| Desai, M; Dotson, R; Rutledge, R; Watthey, JW | 1 |
| Dawson, GR; Iversen, SD | 1 |
| Franzblau, SG; Gezginci, MH; Martin, AR | 1 |
| Choi, J; Colucci, J; Giroux, A; Han, BH; Han, Y; Holtzman, DM; Nicholson, DW; Robertson, GS; Roy, S; Siman, R; Tam, J; Vaillancourt, J; Xanthoudakis, S; Xu, D; Zamboni, R | 1 |
| Cheng, JT; Huang, WC; Lai, TY; Liu, IM; Tsai, CC | 1 |
| Beebe, X; Beutel, BA; Bui, MH; Merta, PJ; Nilius, AM; Soni, NB; Wagner, R | 1 |
| Colucci, J; Coulombe, N; Han, Y; Huang, J; Méthot, N; Nicholson, DW; Rasper, D; Roy, S; Tam, J; Toulmond, S; Vaillancourt, JP; Xanthoudakis, S; Zamboni, R | 1 |
| Ashdown, H; Boucher, M; Bureau, Y; Colucci, J; Degen, S; Flückiger, JP; Giroux, A; Han, Y; Ng, GY; Nicholson, DW; O'Donnell, R; Pikounis, B; Rigby, M; Robertson, GS; Roy, S; Tam, J; Tang, K; Toulmond, S; Xanthoudakis, S; Zamboni, R; Zhu, Y | 1 |
| Greenshaw, A; Hayes, D; Mosher, T | 1 |
| Abraham, NG; Bolognesi, M; Di Pascoli, M; Rodella, L; Sacerdoti, D; Turkseven, S | 1 |
| Kim, KW; Lu, B; Moretti, L | 1 |
| DeRuyter, B; Guo, Z; Holstein, M; Lu, Y; Rabinovitch, A | 1 |
| Kazi, A; Lawrence, HR; Ozcan, S; Sebti, SM; Sun, Y; Tecleab, A | 1 |
| Apseloff, G; Atiee, G; Bush, MA; Collins, DA; Corsino, L; Feldman, PL; Gillmor, D; McMullen, SL; Morrow, L; Nunez, DJ | 1 |
| Cortese, D; Fruttero, R; Gasco, A; Guglielmo, S; Kommer, VP; Rolando, B; Vottero, F; Williams, DL | 1 |
| Al-Barazanji, K; Benson, W; Binz, J; Chen, L; Generaux, C; McNulty, J; Young, A | 1 |
| Ge, J; Hu, D; Li, K; Luo, Z; Rong, H; Tang, M; Wu, Y; Xian, B; Zhuang, J | 1 |
| Honkimaa, A; Hyöty, H; Sioofy-Khojine, AB | 1 |
| Alexopoulos, SJ; Chen, SY; Childress, ES; Dai, Y; Garcia, CJ; Hargett, SR; Hoehn, KL; Salamoun, JM; Santiago-Rivera, J; Santos, WL; Shah, DP; Tucker, SP | 1 |
| Alexopoulos, SJ; Beretta, M; Brandon, AE; Byrne, FL; Carrive, P; Chen, SY; Cooney, GJ; Garcia, CJ; Hargett, SR; Hoehn, KL; Lackner, C; Lawrence, RT; Lee, B; Olzomer, EM; Philp, A; Philp, AM; Salamoun, JM; Santos, WL; Shah, DP; Sligar, J; Tucker, SP; Turner, N | 1 |
| Cao, M; Chen, JH; Chen, XY; Dong, DL; Fu, Y; Hu, N; Li, FF; Li, WF; Sun, ZJ; Yang, XR; Zhao, H | 1 |
| Gizawy, MA; Shamsel-Din, HA | 1 |
| Chen, CY; Cui, ZL; Fu, Y; Gao, ZX; Liu, F; Ma, S; Zhang, L; Zhou, MR | 1 |
| Dai, Y; Hargett, S; Hoehn, KL; Salamoun, JM; Santiago-Rivera, JA; Santos, WL | 1 |
1 trial(s) available for pyrazines and oxadiazoles
| Article | Year |
|---|---|
Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263), metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies.
Topics: Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Male; Mesylates; Metformin; Middle Aged; Oxadiazoles; Peptide YY; Prognosis; Pyrazines; Receptors, G-Protein-Coupled; Sitagliptin Phosphate; Triazoles | 2014 |
28 other study(ies) available for pyrazines and oxadiazoles
| Article | Year |
|---|---|
[Studies of pyrazine derivatives. XVII. Synthesis and the tuberculostatic activity of pyrazinyl-1,3,4-oxadiazole derivatives].
Topics: Antitubercular Agents; Mycobacterium tuberculosis; Oxadiazoles; Pyrazines | 1986 |
[Studies of pyrazine derivatives. XX. Synthesis and tuberculostatic activity of 3-pyrazinol-1,2,4-oxadiazole derivatives].
Topics: Antitubercular Agents; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Mycobacterium tuberculosis; Oxadiazoles; Pyrazines | 1986 |
[Studies on pyrazine derivatives. XXII. Synthesis and tuberculostatic activity of the products of reactions of pyrazinyl-1,3,4-oxadiazol-2-thione with amines].
Topics: Amines; Animals; Antitubercular Agents; Chemical Phenomena; Chemistry; In Vitro Techniques; Mice; Mycobacterium tuberculosis; Oxadiazoles; Pyrazines; Tuberculosis | 1988 |
[Studies of pyrazine derivatives. XXV. Synthesis and the tuberculostatic activity of the products of reaction of 5-(6-methoxy- and 5-(6 morpholinopyrazinyl)-1,3,4-oxadiazol-2-thione with amines].
Topics: Chemical Phenomena; Chemistry; Culture Media; Cyclohexylamines; In Vitro Techniques; Morpholines; Mycobacterium tuberculosis; Oxadiazoles; Piperidines; Propylamines; Pyrazines; Thiones | 1988 |
Inferences on the nature of the apical sodium entry site in frog skin epithelium.
Topics: Amiloride; Animals; Benzimidazoles; Biological Transport; Epithelium; In Vitro Techniques; Oxadiazoles; Pyrazines; Rana catesbeiana; Skin; Sodium; Structure-Activity Relationship | 1981 |
Synthesis and diuretic profile of 3-(3-amino-1,2,4-oxadiazol-5-yl)-5-chloro-2,6-pyrazinediamine, an amiloride-type diuretic.
Topics: Animals; Diuretics; Dogs; Hydrochlorothiazide; Natriuresis; Oxadiazoles; Pyrazines; Rats; Structure-Activity Relationship | 1980 |
The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory.
Topics: Animals; Avoidance Learning; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Conditioning, Classical; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Indans; Learning; Memory; Mice; Oxadiazoles; Pain Threshold; Parasympathomimetics; Physostigmine; Piperidines; Pyrazines; Quinuclidines; Rats; Receptors, Muscarinic; Thiophenes | 1993 |
Antimycobacterial activity of substituted isosteres of pyridine- and pyrazinecarboxylic acids. 2.
Topics: Antitubercular Agents; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxadiazoles; Pyrazines; Pyridines; Structure-Activity Relationship | 2001 |
Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury.
Topics: Animals; Animals, Newborn; Apoptosis; Caspase 3; Caspase Inhibitors; Cysteine Proteinase Inhibitors; Hydrolysis; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Oxadiazoles; Pyrazines; Rats; Rats, Sprague-Dawley | 2002 |
Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro.
Topics: Animals; Aorta; Apamin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Humans; In Vitro Techniques; Male; Oxadiazoles; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyrazines; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Vasodilator Agents | 2002 |
Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents.
Topics: Anti-Bacterial Agents; Drug Evaluation, Preclinical; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Oxadiazoles; Pyrazines; Structure-Activity Relationship | 2003 |
Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics.
Topics: Animals; Apoptosis; Biomarkers; Caspase 3; Caspase Inhibitors; Cysteine Proteinase Inhibitors; DNA Fragmentation; Female; Genes, bcl-2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxadiazoles; Pyrazines; Rats; Rats, Sprague-Dawley; Sepsis; Spectrin; T-Lymphocytes | 2004 |
Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease.
Topics: Animals; Autoradiography; Caspase 3; Caspase Inhibitors; Cell Count; Cell Death; Diffusion; Dizocilpine Maleate; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Half-Life; Huntington Disease; Male; Malonates; Neostriatum; Neurons; Neuroprotective Agents; Oxadiazoles; Pyrazines; Rats; Rats, Sprague-Dawley | 2004 |
Differential effects of 5-HT2C receptor ligands on place conditioning and locomotor activity in rats.
Topics: Aminopyridines; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Indoles; Ligands; Male; Motor Activity; Oxadiazoles; Piperazines; Pyrazines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Time Factors | 2005 |
Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes.
Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitometry; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase; Heme; Immunohistochemistry; Male; Mesoporphyrins; Muscle Contraction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Oxadiazoles; Oxidative Stress; Protoporphyrins; Pyrazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Time Factors | 2006 |
M867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models.
Topics: Animals; Apoptosis; Autophagy; Base Sequence; Caspase Inhibitors; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Humans; Lung Neoplasms; Mice; Mice, Knockout; Oxadiazoles; Pyrazines; Radiation Tolerance; RNA, Small Interfering; Transplantation, Heterologous | 2008 |
Stimulating β-cell regeneration by combining a GPR119 agonist with a DPP-IV inhibitor.
Topics: Acids, Heterocyclic; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Humans; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Oxadiazoles; Pyrazines; Receptors, G-Protein-Coupled; Regeneration; Sitagliptin Phosphate; Triazoles | 2013 |
Discovery of PI-1840, a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity.
Topics: Acetamides; Animals; Antineoplastic Agents; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Humans; Mice; Oxadiazoles; Proteasome Inhibitors; Pyrazines | 2014 |
New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoquinolines; Molecular Structure; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Praziquantel; Pyrazines; Schistosoma mansoni; Structure-Activity Relationship | 2014 |
Synergistic Effects of a GPR119 Agonist with Metformin on Weight Loss in Diet-Induced Obese Mice.
Topics: Animals; Body Weight; Diet, High-Fat; Dose-Response Relationship, Drug; Drug Synergism; Eating; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Hypoglycemic Agents; Insulin; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Oxadiazoles; Proto-Oncogene Proteins c-fos; Pyrazines; Receptors, G-Protein-Coupled; Weight Loss | 2015 |
BAM15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.
Topics: Amacrine Cells; Animals; Apoptosis; Caspase 3; Cell Differentiation; Diamines; Disease Models, Animal; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Ki-67 Antigen; Neurofilament Proteins; Neurons; Oxadiazoles; Photoreceptor Cells; Protective Agents; Pyrazines; Retina; Retinal Ganglion Cells; Specimen Handling; Transportation; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2019 |
A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses.
Topics: A549 Cells; Amides; Antiviral Agents; Azithromycin; Benzimidazoles; Coxsackievirus Infections; Diabetes Mellitus, Type 1; Drug Repositioning; Enterovirus B, Human; Fluoxetine; Guanidine; Humans; Immunoglobulin G; Lovastatin; Oxadiazoles; Oxazoles; Oximes; Pyrazines; Ribavirin; Sulfonamides | 2020 |
[1,2,5]Oxadiazolo[3,4-
Topics: Animals; Diamines; Liver; Male; Mice, Inbred C57BL; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxadiazoles; Oxygen Consumption; Pyrazines; Uncoupling Agents | 2020 |
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice.
Topics: Adipose Tissue; Administration, Oral; Animals; Blood Glucose; Body Temperature; Body Weight; Diamines; Diet, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose Clamp Technique; Humans; Insulin Resistance; Liver; Male; Membrane Potential, Mitochondrial; Mice; Mitochondria; Obesity; Oxadiazoles; Oxidative Stress; Pyrazines | 2020 |
Chemical mitochondrial uncouplers share common inhibitory effect on NLRP3 inflammasome activation through inhibiting NFκB nuclear translocation.
Topics: Active Transport, Cell Nucleus; AMP-Activated Protein Kinases; Animals; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cytokines; Diamines; Humans; Inflammasomes; Macrophages; Mice; Mitochondria; NF-kappa B; NF-KappaB Inhibitor alpha; Niclosamide; NLR Family, Pyrin Domain-Containing 3 Protein; Oxadiazoles; Phosphorylation; Pyrazines; RAW 264.7 Cells; THP-1 Cells; Uncoupling Agents | 2021 |
A novel dipeptide coupled with pyrazine-oxadiazole derivative as a potential antitubercular agent: Synthesis, radioiodination and bioevaluation.
Topics: Animals; Antitubercular Agents; Dipeptides; Iodine Radioisotopes; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxadiazoles; Pyrazines | 2021 |
The new mitochondrial uncoupler BAM15 induces ROS production for treatment of acute myeloid leukemia.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cytarabine; Diamines; Leukemia, Myeloid, Acute; Mice; Oxadiazoles; Pyrazines; Reactive Oxygen Species | 2022 |
Conversion of oxadiazolo[3,4-b]pyrazines to imidazo[4,5-b]pyrazines via a tandem reduction-cyclization sequence generates new mitochondrial uncouplers.
Topics: Cyclization; Mitochondria; Oxadiazoles; Pyrazines | 2022 |