Page last updated: 2024-08-21

pyrazines and nsc 361456

pyrazines has been researched along with nsc 361456 in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19904 (28.57)18.7374
1990's8 (57.14)18.2507
2000's1 (7.14)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Du, DL; Grieshaber, CK; Murphy, MJ; Volpe, DA1
Berger, DP; Fiebig, HH; Plowman, J; Winterhalter, BR1
Dykes, DJ; Griswold, DP; Harrison, SD; Plowman, J; Waud, WR1
Brodfuehrer, JI; Moore, DJ; Powis, G; Wilke, TJ1
Brodfüehrer, JI; Melder, DC; Moore, DJ; Powis, G; Wilke, TJ1
Baker, DC; Hand, ES; Haugwitz, RD; Narayanan, VL; Plowman, J; Rampal, JB; Safavy, A1
Kooistra, KL; Moore, DJ; Powis, G; Wilke, TJ1
Ames, MM; Dhodapkar, MV; Reid, JM; Richardson, RL1
Berezin, F; Janisch, L; Mick, R; Ratain, MJ; Schilsky, RL; Vogelzang, NJ1
Balcerzak, SP; Kraut, EH; Supko, JG1
Ansari, RH; Brockstein, BE; Garcia, JC; Mani, S; Meyer, SC; Mick, R; Ratain, MJ; Rhinehart, SN; Schilsky, RL; Stadler, WM; Taber, D; Vogelzang, NJ; Vokes, EE1
Doroshow, J; Edelman, MJ; Grennan, T; Lauder, J; Meyers, FJ1
Chapman, RA; Doolittle, GC; Flaherty, LE; Hammond, N; Klein, CE; Kraut, EH; Mills, GM; Sondak, VK; Unger, JM; Whitehead, RP1
Brown, LC; Cummings, ME; Li, L; Patel, Y; Pegg, AE; Peterson, LA; Stram, DO; Urban, AM; Vu, CC; Warmka, JK; Wattenberg, EV1

Trials

6 trial(s) available for pyrazines and nsc 361456

ArticleYear
Pyrazine diazohydroxide (NSC-361456). Phase I clinical and pharmacokinetic studies.
    Investigational new drugs, 1994, Volume: 12, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Drug Tolerance; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Pyrazines

1994
Phase I and pharmacokinetic study of a new antineoplastic agent: pyrazine diazohydroxide (NSC 361456).
    Cancer research, 1994, Jan-01, Volume: 54, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Administration Schedule; Female; Humans; Leukopenia; Male; Middle Aged; Pyrazines; Thrombocytopenia

1994
Phase I evaluation and pharmacokinetic study of pyrazine-2-diazohydroxide administered as a single bolus intravenous injection in patients with advanced solid tumors.
    Cancer research, 1993, Oct-15, Volume: 53, Issue:20

    Topics: Adult; Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Neoplasm Staging; Neoplasms; Pyrazines

1993
Phase II and pharmacodynamic studies of pyrazine diazohydroxide (NSC 361456) in patients with advanced renal and colorectal cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cell Count; Colorectal Neoplasms; Female; Humans; Kidney Neoplasms; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Pyrazines; Survival Rate

1998
Phase II trial of pyrazine diazohydroxide in androgen-independent prostate cancer.
    Investigational new drugs, 1998, Volume: 16, Issue:2

    Topics: Aged; Androgens; Antineoplastic Agents; Drug Resistance, Neoplasm; Humans; Male; Middle Aged; Prostatic Neoplasms; Pyrazines; Survival Rate

1998
A phase II trial of pyrazine diazohydroxide in patients with disseminated malignant melanoma and no prior chemotherapy--Southwest Oncology Group study.
    Investigational new drugs, 2002, Volume: 20, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; Injections, Intravenous; Male; Melanoma; Middle Aged; Pyrazines

2002

Other Studies

8 other study(ies) available for pyrazines and nsc 361456

ArticleYear
Comparative toxicity of fostriecin, hepsulfam and pyrazine diazohydroxide to human and murine hematopoietic progenitor cells in vitro.
    Investigational new drugs, 1991, Volume: 9, Issue:2

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Drugs, Investigational; Hematopoietic Stem Cells; Humans; Mice; Polyenes; Pyrazines; Pyrones; Sulfonic Acids

1991
In vitro and in vivo evaluation of US-NCI compounds in human tumor xenografts.
    Cancer treatment reviews, 1990, Volume: 17, Issue:2-3

    Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Antineoplastic Agents; Drug Screening Assays, Antitumor; Female; Humans; Mice; Mice, Nude; National Institutes of Health (U.S.); Neoplasm Transplantation; Picolines; Polyenes; Pyrazines; Sirolimus; Sulfonic Acids; Terpenes; Tumor Stem Cell Assay; United States

1990
Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo.
    Cancer chemotherapy and pharmacology, 1990, Volume: 25, Issue:6

    Topics: Animals; Antineoplastic Agents; Drug Administration Schedule; Drug Resistance; Drug Screening Assays, Antitumor; Female; Humans; Leukemia L1210; Leukemia P388; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazines

1990
Disposition and metabolism of the antitumor agent pyrazine-2-diazohydroxide in mouse and beagle dog.
    Cancer chemotherapy and pharmacology, 1988, Volume: 21, Issue:4

    Topics: Animals; Antineoplastic Agents; Dogs; Half-Life; Metabolic Clearance Rate; Mice; Pyrazines; Tissue Distribution

1988
In vitro cytotoxicity of pyrazine-2-diazohydroxide: specificity for hypoxic cells and effects of microsomal coincubation.
    Investigational new drugs, 1988, Volume: 6, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Survival; Half-Life; Humans; Hydrogen-Ion Concentration; Male; Microsomes, Liver; Pyrazines; Rats; Rats, Inbred F344; Rhabdomyosarcoma; Sulfhydryl Compounds; Tumor Cells, Cultured

1988
Synthesis, chemical stability and pre-clinical anti-tumor activity of pyrazine diazohydroxide, sodium salt (NSC-361456).
    Anti-cancer drug design, 1987, Volume: 2, Issue:3

    Topics: Animals; Antineoplastic Agents; Azides; Drug Evaluation, Preclinical; Drug Stability; Female; Half-Life; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pyrazines; Pyrimethamine; Pyrimidines

1987
Gas chromatographic assay for the new antitumor agent pyrazine-2-diazohydroxide (diazohydroxide) and its stability in buffer, blood and plasma.
    Journal of chromatography, 1986, Nov-28, Volume: 383, Issue:1

    Topics: Animals; Antineoplastic Agents; Buffers; Chromatography, Gas; Drug Stability; Half-Life; Humans; Mice; Plasma; Pyrazines

1986
Role of aldehydes in the toxic and mutagenic effects of nitrosamines.
    Chemical research in toxicology, 2013, Oct-21, Volume: 26, Issue:10

    Topics: Aldehydes; Animals; CHO Cells; Cricetinae; Cricetulus; Dimethylnitrosamine; DNA Adducts; DNA Damage; DNA Methylation; Humans; Models, Chemical; Mutagenicity Tests; Nitrosamines; Nitrosomethylurethane; O(6)-Methylguanine-DNA Methyltransferase; Pyrazines

2013