pyrazines has been researched along with nsc 361456 in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 8 (57.14) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Du, DL; Grieshaber, CK; Murphy, MJ; Volpe, DA | 1 |
| Berger, DP; Fiebig, HH; Plowman, J; Winterhalter, BR | 1 |
| Dykes, DJ; Griswold, DP; Harrison, SD; Plowman, J; Waud, WR | 1 |
| Brodfuehrer, JI; Moore, DJ; Powis, G; Wilke, TJ | 1 |
| Brodfüehrer, JI; Melder, DC; Moore, DJ; Powis, G; Wilke, TJ | 1 |
| Baker, DC; Hand, ES; Haugwitz, RD; Narayanan, VL; Plowman, J; Rampal, JB; Safavy, A | 1 |
| Kooistra, KL; Moore, DJ; Powis, G; Wilke, TJ | 1 |
| Ames, MM; Dhodapkar, MV; Reid, JM; Richardson, RL | 1 |
| Berezin, F; Janisch, L; Mick, R; Ratain, MJ; Schilsky, RL; Vogelzang, NJ | 1 |
| Balcerzak, SP; Kraut, EH; Supko, JG | 1 |
| Ansari, RH; Brockstein, BE; Garcia, JC; Mani, S; Meyer, SC; Mick, R; Ratain, MJ; Rhinehart, SN; Schilsky, RL; Stadler, WM; Taber, D; Vogelzang, NJ; Vokes, EE | 1 |
| Doroshow, J; Edelman, MJ; Grennan, T; Lauder, J; Meyers, FJ | 1 |
| Chapman, RA; Doolittle, GC; Flaherty, LE; Hammond, N; Klein, CE; Kraut, EH; Mills, GM; Sondak, VK; Unger, JM; Whitehead, RP | 1 |
| Brown, LC; Cummings, ME; Li, L; Patel, Y; Pegg, AE; Peterson, LA; Stram, DO; Urban, AM; Vu, CC; Warmka, JK; Wattenberg, EV | 1 |
6 trial(s) available for pyrazines and nsc 361456
| Article | Year |
|---|---|
Pyrazine diazohydroxide (NSC-361456). Phase I clinical and pharmacokinetic studies.
Topics: Adult; Aged; Antineoplastic Agents; Drug Tolerance; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Pyrazines | 1994 |
Phase I and pharmacokinetic study of a new antineoplastic agent: pyrazine diazohydroxide (NSC 361456).
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Administration Schedule; Female; Humans; Leukopenia; Male; Middle Aged; Pyrazines; Thrombocytopenia | 1994 |
Phase I evaluation and pharmacokinetic study of pyrazine-2-diazohydroxide administered as a single bolus intravenous injection in patients with advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Neoplasm Staging; Neoplasms; Pyrazines | 1993 |
Phase II and pharmacodynamic studies of pyrazine diazohydroxide (NSC 361456) in patients with advanced renal and colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cell Count; Colorectal Neoplasms; Female; Humans; Kidney Neoplasms; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Pyrazines; Survival Rate | 1998 |
Phase II trial of pyrazine diazohydroxide in androgen-independent prostate cancer.
Topics: Aged; Androgens; Antineoplastic Agents; Drug Resistance, Neoplasm; Humans; Male; Middle Aged; Prostatic Neoplasms; Pyrazines; Survival Rate | 1998 |
A phase II trial of pyrazine diazohydroxide in patients with disseminated malignant melanoma and no prior chemotherapy--Southwest Oncology Group study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; Injections, Intravenous; Male; Melanoma; Middle Aged; Pyrazines | 2002 |
8 other study(ies) available for pyrazines and nsc 361456
| Article | Year |
|---|---|
Comparative toxicity of fostriecin, hepsulfam and pyrazine diazohydroxide to human and murine hematopoietic progenitor cells in vitro.
Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Drugs, Investigational; Hematopoietic Stem Cells; Humans; Mice; Polyenes; Pyrazines; Pyrones; Sulfonic Acids | 1991 |
In vitro and in vivo evaluation of US-NCI compounds in human tumor xenografts.
Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Antineoplastic Agents; Drug Screening Assays, Antitumor; Female; Humans; Mice; Mice, Nude; National Institutes of Health (U.S.); Neoplasm Transplantation; Picolines; Polyenes; Pyrazines; Sirolimus; Sulfonic Acids; Terpenes; Tumor Stem Cell Assay; United States | 1990 |
Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo.
Topics: Animals; Antineoplastic Agents; Drug Administration Schedule; Drug Resistance; Drug Screening Assays, Antitumor; Female; Humans; Leukemia L1210; Leukemia P388; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazines | 1990 |
Disposition and metabolism of the antitumor agent pyrazine-2-diazohydroxide in mouse and beagle dog.
Topics: Animals; Antineoplastic Agents; Dogs; Half-Life; Metabolic Clearance Rate; Mice; Pyrazines; Tissue Distribution | 1988 |
In vitro cytotoxicity of pyrazine-2-diazohydroxide: specificity for hypoxic cells and effects of microsomal coincubation.
Topics: Animals; Antineoplastic Agents; Cell Survival; Half-Life; Humans; Hydrogen-Ion Concentration; Male; Microsomes, Liver; Pyrazines; Rats; Rats, Inbred F344; Rhabdomyosarcoma; Sulfhydryl Compounds; Tumor Cells, Cultured | 1988 |
Synthesis, chemical stability and pre-clinical anti-tumor activity of pyrazine diazohydroxide, sodium salt (NSC-361456).
Topics: Animals; Antineoplastic Agents; Azides; Drug Evaluation, Preclinical; Drug Stability; Female; Half-Life; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pyrazines; Pyrimethamine; Pyrimidines | 1987 |
Gas chromatographic assay for the new antitumor agent pyrazine-2-diazohydroxide (diazohydroxide) and its stability in buffer, blood and plasma.
Topics: Animals; Antineoplastic Agents; Buffers; Chromatography, Gas; Drug Stability; Half-Life; Humans; Mice; Plasma; Pyrazines | 1986 |
Role of aldehydes in the toxic and mutagenic effects of nitrosamines.
Topics: Aldehydes; Animals; CHO Cells; Cricetinae; Cricetulus; Dimethylnitrosamine; DNA Adducts; DNA Damage; DNA Methylation; Humans; Models, Chemical; Mutagenicity Tests; Nitrosamines; Nitrosomethylurethane; O(6)-Methylguanine-DNA Methyltransferase; Pyrazines | 2013 |