Compounds > pyrazines
Page last updated: 2024-08-21

pyrazines and nadp

pyrazines has been researched along with nadp in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's5 (55.56)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tampo, Y; Tsukamoto, M; Yonaha, M1
Crause, P; Gloe, T; Keller, M; Pohl, U; Sohn, HY1
Anastacio, VM; Augusto, O; da Luz, PL; Junqueira, ML; Krieger, JE; Laurindo, FR; Pereira, AC; Souza, HP; Souza, LC1
Arison, BH; Baillie, TA; Burgey, CS; Lin, JH; Pearson, PG; Silva Elipe, MV; Singh, R; White, R; Wong, BK; Yu, X1
Begleiter, A; Bird, RP; Curphey, TJ; Sivananthan, K1
Chapple, S; Collins, C; Fairman, DA1
Gao, Y; Li, H; Shen, GL; Tan, Y; Zhuang, XM1
Äänismaa, P; de Kanter, R; Delahaye, S; Gnerre, C; Ichikawa, T; Pfeifer, T; Seeland, S; Segrestaa, J; Treiber, A; Yamada, T1
Kharechkina, ES; Kruglov, AG; Nikiforova, AB1

Trials

1 trial(s) available for pyrazines and nadp

ArticleYear
The metabolism and drug-drug interaction potential of the selective prostacyclin receptor agonist selexipag.
    Xenobiotica; the fate of foreign compounds in biological systems, 2018, Volume: 48, Issue:7

    Topics: Acetamides; Acetates; Drug Interactions; Enzyme Inhibitors; Esterases; Hepatocytes; Humans; Membrane Transport Proteins; Metabolic Networks and Pathways; Metabolome; Metabolomics; Microsomes, Liver; NADP; Pyrazines; Receptors, Epoprostenol; Recombinant Proteins; RNA, Messenger

2018

Other Studies

8 other study(ies) available for pyrazines and nadp

ArticleYear
Superoxide production from paraquat evoked by exogenous NADPH in pulmonary endothelial cells.
    Free radical biology & medicine, 1999, Volume: 27, Issue:5-6

    Topics: Animals; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Flavoproteins; Imidazoles; Interleukin-1; Luminescent Measurements; Lung; NAD; NADP; Oxidoreductases; Paraquat; Pyrazines; Spectrophotometry; Succinic Acid; Superoxide Dismutase; Superoxides; Swine; Xanthine

1999
Pitfalls of using lucigenin in endothelial cells: implications for NAD(P)H dependent superoxide formation.
    Free radical research, 2000, Volume: 32, Issue:3

    Topics: Acridines; Arsenicals; Cells, Cultured; Cytochrome c Group; Imidazoles; Luminescent Measurements; NAD; NADH, NADPH Oxidoreductases; NADP; NADPH Oxidases; Neutrophils; Onium Compounds; Pyrazines; Superoxides; Umbilical Veins; Xanthine; Xanthine Oxidase

2000
Vascular oxidant stress early after balloon injury: evidence for increased NAD(P)H oxidoreductase activity.
    Free radical biology & medicine, 2000, Apr-15, Volume: 28, Issue:8

    Topics: Acridines; Animals; Biphenyl Compounds; Catheterization; Cyclic N-Oxides; Cyclooxygenase Inhibitors; Electron Spin Resonance Spectroscopy; Electron Transport; Endothelium, Vascular; Free Radicals; Glutathione; Imidazoles; Lipoxygenase Inhibitors; Luminescent Measurements; Male; Metalloporphyrins; NAD; NADH, NADPH Oxidoreductases; NADP; NADPH Oxidases; NF-kappa B; Nitric Oxide Synthase; Onium Compounds; Oxidation-Reduction; Oxidative Stress; Oxygen Consumption; Pyrazines; Rabbits; Reactive Oxygen Species; Recombinant Fusion Proteins; Spin Labels; Superoxide Dismutase; Superoxides; Transcription, Genetic; Wound Healing; Xanthine Oxidase

2000
Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.
    Chemical research in toxicology, 2003, Volume: 16, Issue:2

    Topics: Administration, Oral; Animals; Binding, Competitive; Biotransformation; Carbon Radioisotopes; Epoxy Compounds; Glutathione; Humans; Imines; Microsomes, Liver; NADP; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Protease Inhibitors; Protein Binding; Pyrazines; Rats; Spectrometry, Mass, Electrospray Ionization; Thrombin

2003
Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2003, Volume: 12, Issue:6

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colonic Neoplasms; Dimethyl Fumarate; Disease Models, Animal; Enzyme Induction; Fumarates; Glucuronosyltransferase; Glutathione Transferase; Inactivation, Metabolic; Intestinal Mucosa; Liver; Male; NAD(P)H Dehydrogenase (Quinone); NADP; Pyrazines; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes

2003
Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation?
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:12

    Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dihydralazine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Models, Biological; NADP; Paroxetine; Pyrazines; Resveratrol; Stilbenes; Theophylline; Thiones; Thiophenes

2007
[Investigation of metabolic kinetics and reaction phenotyping of ligustrazin by using liver microsomes and recombinant human enzymes].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:3

    Topics: Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Glucuronosyltransferase; Humans; Ligusticum; Microsomes, Liver; NADP; Pyrazines; Rats; Uridine Diphosphate Glucuronic Acid

2014
Pyridine nucleotides regulate the superoxide anion flash upon permeabilization of mitochondrial membranes: An MCLA-based study.
    Free radical biology & medicine, 2018, 08-20, Volume: 124

    Topics: Animals; Imidazoles; Male; Mitochondrial Membranes; NADP; Permeability; Pyrazines; Pyridines; Rats; Rats, Wistar; Superoxides

2018