Compounds > pyrazines
Page last updated: 2024-08-21

pyrazines and n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamide

pyrazines has been researched along with n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamide in 54 studies

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's21 (38.89)29.6817
2010's32 (59.26)24.3611
2020's1 (1.85)2.80

Authors

AuthorsStudies
Bristol, DR; Harrison, JE; Mark, L; Pomonis, JD; Valenzano, KJ; Walker, K1
Francis, J; Grant, ER; Hachicha, M; Hodges, D; Limberis, J; Malik, S; Rotshteyn, Y; Schmid, L; Sun, Q; Tafesse, L; Valenzano, KJ; Whittemore, ER; Wu, G1
Kyle, DJ; Rotshteyn, Y; Schmid, L; Su, X; Sun, Q; Tafesse, L; Valenzano, KJ1
Anthes, JC; Correll, CC; Phelps, PT1
Fujiuchi, A; Hara, T; Imai, A; Kanai, Y; Nakazato, E1
Gavva, NR; Klionsky, L; Louis, JC; Norman, MH; Tamir, R; Treanor, JJ; Wild, KD1
Colburn, RW; Flores, CM; Liu, Y; Lubin, ML; Qin, N; Reitz, TL; Wang, Y1
Christoph, T; Erdmann, VA; Frank, R; Gillen, C; Grünweller, A; Kurreck, J; Mika, J; Schäfer, MK; Wade, EJ; Weihe, E1
Acosta, MC; Belmonte, C; Donovan-Rodríguez, T; Madrid, R; Meseguer, V; Viana, F1
Belmonte, C; de la Peña, E; Madrid, R; Mälkiä, A; Meseguer, V; Valero, M; Viana, F1
Hara, T; Imai, A; Kanai, Y; Sakakibara, A1
De Man, JG; De Schepper, HU; De Winter, BY; Deiteren, A; Herman, AG; Martinet, W; Pelckmans, PA; Ruyssers, NE; Timmermans, JP; Van Nassauw, L1
Kita, Y; Nakazato-Imasato, E; Tanimoto-Mori, S; Toide, K1
Reilly, CA; Sabnis, AS; Shadid, M; Yost, GS1
Ishida, T; Kamei, C; Kanai, Y; Takeda, Y; Tanimoto-Mori, S; Toide, K; Tsutsui, R; Watanabe, S1
Bandell, M; Dhaka, A; Dubin, AE; Mathur, J; Patapoutian, A; Petrus, M; Uzzell, V1
Bredenoord, AJ; De Man, JG; De Schepper, HU; De Winter, BY; Pelckmans, PA; Timmermans, JP; Van Nassauw, L1
Kichko, TI; Reeh, PW1
Horie, S; Hosoya, T; Kurosawa, E; Matsumoto, K; Murayama, T; Priestley, JV; Tashima, K; Terui, H1
Beltrán, C; Castellano, LE; Chirinos, M; Darszon, A; De Blas, GA; Hernández-González, EO; Larrea, F; Ocampo, AY; Serrano, CJ; Treviño, CL1
Fernández-Ballester, G; Ferrer-Montiel, A; Malkia, A; Pertusa, M; Viana, F1
Brennan, FX; Bryant, RW; Devantier, HR; Long, DJ; Palmer, RK; Salemme, FR1
Fujihara, H; Hashimoto, H; Nagatomo, T; Ohbuchi, T; Otsubo, H; Saito, T; Suzuki, H; Ueta, Y; Yokoyama, T1
Bölcskei, K; Dézsi, L; Horváth, C; Kis-Varga, A; Petho, G; Szentirmay, E; Szolcsányi, J; Tékus, V; Visegrády, A1
Denda, M; Denda, S; Tsutsumi, M1
Belmonte, C; Morenilla-Palao, C; Valero, M; Viana, F1
Acosta, MC; Belmonte, C; del Olmo, S; Dhaka, A; Echevarria, D; Gallar, J; Madrid, R; Morenilla-Palao, C; Parra, A; Viana, F1
Kiso, T; Kuramochi, T; Shibasaki, M; Shimaya, A; Shimokawa, T; Tanaka, H1
Beltrán, C; Darszon, A; De Blas, G; de la Vega-Beltrán, JL; Gibbs, GM; Martínez-López, P; Monroy, E; O'Bryan, MK; Orta, G; Treviño, CL1
Bartho, L; Benko, R; Illényi, L; Kelemen, D; Papp, A; Papp, R1
Hirata, H; Oshinsky, ML1
Bidaux, G; Fernández, JA; Magleby, KL; McGeown, JG; Prevarskaya, N; Scholfield, CN; Skryma, R; Zholos, AV1
Horie, S; Hosoya, T; Lo, MW; Matsumoto, K; Murayama, T; Takayama, H; Tashima, K1
Andersson, KE; Hosoda, T; Imamura, T; Ishizuka, O; Kurizaki, Y; Lei, Z; Nishizawa, O; Noguchi, W; Sudha, GS; Yamagishi, T; Yokoyama, H1
Beattie, RE; Beck, JP; Blanco, MJ; Broad, LM; Folly, EA; Mill, CE; Mogg, AJ1
Bult, H; De Man, JG; De Schepper, HU; De Winter, BY; Moreels, TG; Pelckmans, PA; Vermeulen, W1
Buckley, CL; Horton, JS; Stokes, AJ1
Mutoh, T; Taki, Y; Tsubone, H1
Brack, A; Hackel, D; Mousa, SA; Neumann, A; Partheil, A; Pflücke, D; Rittner, HL1
Baumann, K; Belmaáti, MS; Christensen, RE; Claesson, MH; Diemer, S; Hvarness, T; Pedersen, AE1
Alijevic, O; Boillat, A; Kellenberger, S1
Carlin, KP; Crumley, G; Ilyin, VI; Patel, A; Wu, G1
Asano, A; Dayanithi, G; Forostyak, O; Hosaka, YZ; Ichimura, M; Kayano, T; Kitamura, N; Moriya, T; Shibasaki, R; Shibuya, I; Takebuchi, N; Verkhratsky, A1
Bartho, L; Bencsik, T; Sandor, Z1
Fujita, T; Jiang, CY; Kumamoto, E; Wang, C; Xu, ZH1
Andrade, VA; Araujo, IG; Barbosa-Filho, JM; Braz, AL; Chaves, CG; Correia, Nde A; Cruz, Jdos S; de Albuquerque, JG; de Almeida, MM; de Medeiros, IA; Gomes, MA; Leite, Mde F; Nunes, XP; Pesquero, JL; Pinho-da-Silva, L; Silva, DF1
Dhandapani, P; Grötzinger, C; Huimann, P; Khajavi, N; Köhrle, J; Ljubojevic, N; Lucius, A; Mergler, S; Reinach, PS1
Ide, S; Kojima, S; Nakanishi, Y; Nishino, K; Tanamachi, K; Tanuma, S; Tsukimoto, M1
Aiso, S; Iizuka, S; Nakahara, J; Nishiyama, M; Suzuki, N; Suzuki, S; Yamamoto, M1
Fujita, T; Kumamoto, E; Piao, LH; Yu, T1
Fischer, MJM; Namer, B; Reeh, PW; Schwarz, MG1
Chen, HK; Chu, YH; Fan, HC; Lee, FP; Liu, SC; Lu, HH; Wang, HW; Yu, CJ1
Araya, EI; Chichorro, JG; Dos Reis, RC; Kopruszinski, CM; Nones, CFM; Oliveira, LL; Rae, GA; Souza, RF1
Gao, M; Hu, J; Li, Q; Nie, C; Qian, H; Qiao, Y; Qiao, Z; Wang, Q; Wang, Y; Yan, L1

Trials

1 trial(s) available for pyrazines and n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamide

ArticleYear
TRPA1 and TRPV1 Antagonists Do Not Inhibit Human Acidosis-Induced Pain.
    The journal of pain, 2017, Volume: 18, Issue:5

    Topics: Acid Sensing Ion Channel Blockers; Acidosis; Adult; Amiloride; Analgesics; Analysis of Variance; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Oximes; Pain; Pain Measurement; Pyrazines; Pyridines; TRPA1 Cation Channel; TRPV Cation Channels

2017

Other Studies

53 other study(ies) available for pyrazines and n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamide

ArticleYear
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:1

    Topics: Analgesics; Animals; Ataxia; Capsaicin; Hyperalgesia; Inflammation; Male; Nerve Tissue; Pain; Pain Threshold; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug

2003
N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:1

    Topics: Analgesics; Animals; Calcium; Dose-Response Relationship, Drug; Electrophysiology; Humans; Hydrogen-Ion Concentration; Pyrazines; Pyridines; Rats; Receptors, Drug; Skin; Transfection

2003
Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists.
    Bioorganic & medicinal chemistry letters, 2004, Nov-15, Volume: 14, Issue:22

    Topics: Animals; Cell Line; Drug Evaluation, Preclinical; Humans; Molecular Structure; Piperazines; Pyrazines; Pyridazines; Pyridines; Receptors, Drug; Time Factors; TRPV Cation Channels

2004
Cloning and functional characterization of dog transient receptor potential vanilloid receptor-1 (TRPV1).
    European journal of pharmacology, 2005, Apr-18, Volume: 513, Issue:1-2

    Topics: Amino Acid Sequence; Animals; Biological Transport; Calcium; Capsaicin; Cell Line; Cloning, Molecular; Diterpenes; DNA, Complementary; Dogs; Dopamine; Dose-Response Relationship, Drug; Fluorometry; Genetic Vectors; Genotype; Humans; Molecular Sequence Data; Mutation, Missense; Phorbol Esters; Phylogeny; Pyrazines; Pyridines; Receptors, Drug; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transfection

2005
Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats.
    Neuropharmacology, 2005, Volume: 49, Issue:7

    Topics: Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; In Vitro Techniques; Injections, Spinal; Male; Nerve Tissue Proteins; Neuropeptides; Pain; Pain Measurement; Physical Stimulation; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Substance P; TRPV Cation Channels; Up-Regulation

2005
Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1.
    Molecular pharmacology, 2005, Volume: 68, Issue:6

    Topics: Animals; Binding Sites; Capsaicin; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Protein Binding; Protein Conformation; Protons; Pyrazines; Pyridines; Rabbits; Rats; TRPV Cation Channels

2005
Molecular identification and functional characterization of a temperature-sensitive transient receptor potential channel (TRPM8) from canine.
    European journal of pharmacology, 2006, Jan-13, Volume: 530, Issue:1-2

    Topics: Action Potentials; Amino Acid Sequence; Animals; Calcium; Cell Line; Cloning, Molecular; Cold Temperature; DNA, Complementary; Dogs; Dose-Response Relationship, Drug; Fluorometry; Ganglia, Spinal; Gene Library; Humans; Menthol; Mice; Molecular Sequence Data; Mustard Plant; Oocytes; Patch-Clamp Techniques; Plant Oils; Pyrazines; Pyridines; Pyrimidinones; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transfection; TRPM Cation Channels; Xenopus laevis

2006
Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo.
    Biochemical and biophysical research communications, 2006, Nov-10, Volume: 350, Issue:1

    Topics: Animals; Base Sequence; Capsaicin; Chlorocebus aethiops; Colitis; COS Cells; Disease Models, Animal; Humans; Male; Mice; Molecular Sequence Data; Nervous System Diseases; Pain; Pyrazines; Pyridines; Rats; RNA Interference; Sequence Alignment; Sequence Homology, Amino Acid; TRPV Cation Channels

2006
Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Nov-29, Volume: 26, Issue:48

    Topics: Animals; Cell Line; Cold Temperature; Guinea Pigs; Humans; In Vitro Techniques; Mice; Neurons, Afferent; Peripheral Nerves; Presynaptic Terminals; Pyrazines; Pyridines; Rats; Thermoreceptors; Thermosensing; Trigeminal Ganglion; TRPM Cation Channels

2006
Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors.
    The Journal of physiology, 2007, May-15, Volume: 581, Issue:Pt 1

    Topics: Animals; Calcium Channel Blockers; Cell Line; Cold Temperature; Evoked Potentials; Humans; Imidazoles; Ion Channel Gating; Membrane Potentials; Methanol; Mice; Phenanthrolines; Protease Inhibitors; Pyrazines; Pyridines; Rats; Thermoreceptors; Transfection; TRPM Cation Channels

2007
Differential involvement of TRPV1 receptors at the central and peripheral nerves in CFA-induced mechanical and thermal hyperalgesia.
    The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:5

    Topics: Analgesics; Anilides; Animals; Cinnamates; Dose-Response Relationship, Drug; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Injections; Injections, Spinal; Male; Nerve Endings; Neurons, Afferent; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Regression Analysis; TRPV Cation Channels

2007
TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats.
    American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 294, Issue:1

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Gastric Emptying; Gastrointestinal Motility; Gastroparesis; Intestinal Mucosa; Intestines; Male; Muscle Relaxation; Neurons, Afferent; Peptide Fragments; Pyrazines; Pyridines; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; RNA, Messenger; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels

2008
Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
    Behavioural pharmacology, 2008, Volume: 19, Issue:1

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Chronic Disease; Cold Temperature; Constriction, Pathologic; Disease Models, Animal; Diterpenes; gamma-Aminobutyric Acid; Male; Mexiletine; Morphine; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pregabalin; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve; Sodium Channel Blockers; TRPV Cation Channels

2008
Human lung epithelial cells express a functional cold-sensing TRPM8 variant.
    American journal of respiratory cell and molecular biology, 2008, Volume: 39, Issue:4

    Topics: Amino Acid Sequence; Animals; Bronchi; Capsaicin; Cell Line; Cold Temperature; Cytokines; Endoplasmic Reticulum; Epithelial Cells; Humans; Lung; Menthol; Molecular Sequence Data; Pyrazines; Pyridines; Thapsigargin; Thermoreceptors; Thermosensing; TRPM Cation Channels

2008
Studies on somnolence in the daytime caused by drugs used for neuropathic pain.
    Journal of pharmacological sciences, 2008, Volume: 107, Issue:3

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Male; Mexiletine; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Sleep; TRPV Cation Channels

2008
TRPV1 is activated by both acidic and basic pH.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jan-07, Volume: 29, Issue:1

    Topics: Acids; Ammonium Chloride; Animals; Calcium; Capsaicin; Cell Line, Transformed; Ganglia, Spinal; Humans; Hydrogen-Ion Concentration; Luminescent Proteins; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pyrazines; Pyridines; Sensory Receptor Cells; Sensory System Agents; Transfection; TRPV Cation Channels

2009
Involvement of afferent neurons in the pathogenesis of endotoxin-induced ileus in mice: role of CGRP and TRPV1 receptors.
    European journal of pharmacology, 2009, Aug-01, Volume: 615, Issue:1-3

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Gastric Emptying; Gastrointestinal Transit; Hexamethonium; Ileus; Lipopolysaccharides; Male; Mice; Neurons, Afferent; Peptide Fragments; Pyrazines; Pyridines; Receptors, Calcitonin Gene-Related Peptide; Sepsis; TRPV Cation Channels

2009
TRPV1 controls acid- and heat-induced calcitonin gene-related peptide release and sensitization by bradykinin in the isolated mouse trachea.
    The European journal of neuroscience, 2009, Volume: 29, Issue:9

    Topics: Amiloride; Animals; Boron Compounds; Bradykinin; Calcitonin Gene-Related Peptide; Calcium; Extracellular Space; Hot Temperature; Hydrogen-Ion Concentration; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Protons; Pyrazines; Pyridines; Ruthenium Red; Sensory System Agents; Sodium Channel Blockers; Trachea; TRPV Cation Channels

2009
Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:2

    Topics: Animals; Atropine; Capsaicin; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Immunohistochemistry; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin A; Pyrazines; Pyridines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Rectum; Substance P; Tetrodotoxin; Time Factors; TRPV Cation Channels; Ubiquitin Thiolesterase

2009
TRPM8, a versatile channel in human sperm.
    PloS one, 2009, Jun-30, Volume: 4, Issue:6

    Topics: Acrosome Reaction; Calcium; Capsaicin; Chemotaxis; Fluorescent Antibody Technique, Indirect; Humans; Male; Models, Biological; Progesterone; Pyrazines; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sperm Motility; Spermatozoa; TRPM Cation Channels

2009
Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.
    Molecular pain, 2009, Nov-03, Volume: 5

    Topics: Animals; Capsaicin; Clotrimazole; Cold Temperature; Humans; Imidazoles; Ion Channel Gating; Menthol; Mice; Models, Molecular; Molecular Dynamics Simulation; Mutant Proteins; Mutation; Phenotype; Pyrazines; Pyridines; Structure-Activity Relationship; TRPM Cation Channels; Tyrosine

2009
Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:2

    Topics: Acrylamides; Administration, Oral; Alkaloids; Anilides; Animals; Avoidance Learning; Benzodioxoles; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cinnamates; Diterpenes; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazines; Pyridines; Taste; TRPM Cation Channels; TRPV Cation Channels

2010
TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jan-20, Volume: 30, Issue:3

    Topics: Analysis of Variance; Angiotensin II; Anilides; Animals; Capsaicin; Chelating Agents; Cinnamates; Diuretics, Osmotic; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; In Vitro Techniques; Male; Mannitol; Mice; Mice, Inbred C57BL; Mice, Knockout; Miniature Postsynaptic Potentials; Neurons; Piperidines; Pyrazines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Signal Transduction; Supraoptic Nucleus; TRPV Cation Channels; Vasoconstrictor Agents

2010
Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.
    European journal of pharmacology, 2010, Sep-01, Volume: 641, Issue:2-3

    Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Pain; Pyrazines; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea

2010
Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold-sensitive TRP receptors in epidermal permeability barrier homoeostasis.
    Experimental dermatology, 2010, Volume: 19, Issue:9

    Topics: Administration, Cutaneous; Anilides; Animals; Cells, Cultured; Epidermis; Homeostasis; Humans; Hyperplasia; Keratinocytes; Male; Menthol; Mice; Mice, Hairless; Permeability; Pyrazines; Pyridines; Ruthenium Red; Skin Diseases; TRPM Cation Channels

2010
Pharmacological and functional properties of TRPM8 channels in prostate tumor cells.
    Pflugers Archiv : European journal of physiology, 2011, Volume: 461, Issue:1

    Topics: Arginine; Calcium; Cell Line; Cell Line, Tumor; Cell Membrane; Clotrimazole; Cold Temperature; Endoplasmic Reticulum; Glycine; Humans; Male; Menthol; Prostate; Prostatic Neoplasms; Pyrazines; Pyridines; Pyrimidinones; TRPM Cation Channels

2011
Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea.
    Nature medicine, 2010, Volume: 16, Issue:12

    Topics: 4-Aminopyridine; Animals; Cold Temperature; Cornea; Dry Eye Syndromes; Menthol; Mice; Mice, Transgenic; Ocular Physiological Phenomena; Pyrazines; Pyridines; Shaker Superfamily of Potassium Channels; Tears; Thermoreceptors; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels

2010
Enhanced insulin secretion and sensitization in diabetic mice on chronic treatment with a transient receptor potential vanilloid 1 antagonist.
    Life sciences, 2011, Mar-14, Volume: 88, Issue:11-12

    Topics: Animals; Blood Glucose; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Insulin; Insulin Secretion; Lipid Metabolism; Male; Mice; Mice, Inbred ICR; Mice, Obese; Pancreas; Pyrazines; Pyridines; TRPV Cation Channels

2011
TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction.
    Journal of cellular physiology, 2011, Volume: 226, Issue:6

    Topics: Acrosome Reaction; Animals; Capsaicin; Humans; Ion Channel Gating; Male; Menthol; Mice; Mice, Knockout; Pyrazines; Pyridines; Pyrimidinones; Spermatozoa; Temperature; Testis; TRPM Cation Channels

2011
Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC.
    European journal of pharmacology, 2012, Jan-05, Volume: 674, Issue:1

    Topics: Animals; Capsaicin; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Kidney Pelvis; Male; Mice; Muscle Contraction; Muscle, Smooth; Organ Specificity; Pyrazines; Pyridines; Rats; Trachea; TRPV Cation Channels; Urinary Bladder

2012
Ocular dryness excites two classes of corneal afferent neurons implicated in basal tearing in rats: involvement of transient receptor potential channels.
    Journal of neurophysiology, 2012, Volume: 107, Issue:4

    Topics: Acetanilides; Action Potentials; Analysis of Variance; Animals; Cornea; Disease Models, Animal; Dose-Response Relationship, Drug; Dry Eye Syndromes; Eye; Male; Mannitol; Neurons, Afferent; Osmolar Concentration; Purines; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Stimulation, Chemical; Tears; Temperature; Transient Receptor Potential Channels; Vision, Ocular

2012
Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors.
    The Journal of biological chemistry, 2012, Jan-27, Volume: 287, Issue:5

    Topics: Antifungal Agents; Clotrimazole; HEK293 Cells; Hot Temperature; Humans; Ion Channel Gating; Protein Isoforms; Pyrazines; Pyridines; Thermoreceptors; TRPM Cation Channels

2012
Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice.
    Laboratory investigation; a journal of technical methods and pathology, 2012, Volume: 92, Issue:5

    Topics: Animals; Carbolines; Dextran Sulfate; Disease Models, Animal; Electromyography; Hyperalgesia; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nociception; Pyrazines; Pyridines; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Time Factors; TRPV Cation Channels; Tryptophan Hydroxylase; Visceral Afferents

2012
Functional roles of transient receptor potential melastatin 8 (TRPM8) channels in the cold stress-induced detrusor overactivity pathways in conscious rats.
    Neurourology and urodynamics, 2013, Volume: 32, Issue:5

    Topics: Administration, Intravenous; Animals; Cold Temperature; Consciousness; Disease Models, Animal; Female; Methanol; Pressure; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; TRPM Cation Channels; Urinary Bladder; Urinary Bladder, Overactive; Urination; Urodynamics

2013
Altered pharmacology of native rodent spinal cord TRPV1 after phosphorylation.
    British journal of pharmacology, 2013, Volume: 168, Issue:4

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Protein Kinase C; Pyrazines; Pyridines; Rats; Rats, Inbred Strains; Spinal Cord; TRPV Cation Channels

2013
Role of TRPV1 and TRPA1 in visceral hypersensitivity to colorectal distension during experimental colitis in rats.
    European journal of pharmacology, 2013, Jan-05, Volume: 698, Issue:1-3

    Topics: Acetanilides; Animals; Colitis; Colon; Drug Synergism; Female; Purines; Pyrazines; Pyridines; Rats; Rats, Wistar; Rectum; Reflex; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels

2013
Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice.
    Channels (Austin, Tex.), 2013, Jan-01, Volume: 7, Issue:1

    Topics: Animals; Apoptosis; Cardiomegaly; Disease Models, Animal; Heart Failure; Humans; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Natriuretic Peptide, Brain; Pyrazines; Pyridines; TRPV Cation Channels

2013
Desflurane but not sevoflurane augments laryngeal C-fiber inputs to nucleus tractus solitarii neurons by activating transient receptor potential-A1.
    Life sciences, 2013, May-02, Volume: 92, Issue:14-16

    Topics: Acetanilides; Anesthetics, Inhalation; Animals; Capsaicin; Desflurane; Guinea Pigs; Isoflurane; Isothiocyanates; Laryngeal Nerves; Larynx; Male; Methyl Ethers; Nerve Fibers; Neurons; Purines; Pyrazines; Pyridines; Sevoflurane; Solitary Nucleus; Time Factors; Transient Receptor Potential Channels

2013
The molecular link between C-C-chemokine ligand 2-induced leukocyte recruitment and hyperalgesia.
    The journal of pain, 2013, Volume: 14, Issue:9

    Topics: Aldehydes; Animals; Chemokine CCL2; Ciguatoxins; Cyclophosphamide; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Immunosuppressive Agents; Leukocytes; Macrophages; Male; Pain Threshold; Physical Stimulation; Pyrazines; Pyridines; Rats; Rats, Wistar; Reaction Time; Reactive Oxygen Species; Receptors, CCR2; Time Factors

2013
Antiproliferative effects of TRPV1 ligands on nonspecific and enteroantigen-specific T cells from wild-type and Trpv1 KO mice.
    Inflammatory bowel diseases, 2014, Volume: 20, Issue:6

    Topics: Animals; Antigens; Antipruritics; beta 2-Microglobulin; Capsaicin; CD4-Positive T-Lymphocytes; Cell Proliferation; Colitis; Cytokines; Disease Models, Animal; Ligands; Lymphoid Tissue; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, SCID; Pyrazines; Pyridines; Signal Transduction; TRPV Cation Channels

2014
Calcium entry via TRPV1 but not ASICs induces neuropeptide release from sensory neurons.
    Molecular and cellular neurosciences, 2014, Volume: 61

    Topics: Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Acids; Amiloride; Animals; Calcitonin Gene-Related Peptide; Calcium; Calcium Channel Blockers; Cell Count; Cells, Cultured; GABA Antagonists; Ganglia, Spinal; Hydrogen-Ion Concentration; Phosphopyruvate Hydratase; Picrotoxin; Pyrazines; Pyridines; Rats; Sensory Receptor Cells; Substance P; TRPV Cation Channels

2014
Phenylarsine oxide as a redox modulator of transient receptor potential vanilloid type 1 channel function.
    Journal of neuroscience research, 2015, Volume: 93, Issue:2

    Topics: Adult; Animals; Arsenicals; Calcium; Capsaicin; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Humans; Membrane Potentials; Neurons; Oxidation-Reduction; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels

2015
Full-length transient receptor potential vanilloid 1 channels mediate calcium signals and possibly contribute to osmoreception in vasopressin neurones in the rat supraoptic nucleus.
    Cell calcium, 2015, Volume: 57, Issue:1

    Topics: Action Potentials; Animals; Calcium Signaling; Capsaicin; Cells, Cultured; HEK293 Cells; Humans; Male; Mannitol; Neurons; Osmolar Concentration; Oxytocin; Pyrazines; Pyridines; Rats; Rats, Transgenic; Rats, Wistar; Supraoptic Nucleus; Temperature; TRPV Cation Channels

2015
High-Concentration Piperine: Capsaicin-Sensitive and -Insensitive Effects on Isolated Organs.
    Pharmacology, 2015, Volume: 96, Issue:1-2

    Topics: Acetanilides; Alkaloids; Animals; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Nifedipine; Piperidines; Polyunsaturated Alkamides; Purines; Pyrazines; Pyridines; Trachea; TRPV Cation Channels; Urinary Bladder

2015
Action of thymol on spontaneous excitatory transmission in adult rat spinal substantia gelatinosa neurons.
    Neuroscience letters, 2015, Oct-08, Volume: 606

    Topics: Acetanilides; Animals; Capsaicin; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Neurons; Purines; Pyrazines; Pyridines; Rats, Sprague-Dawley; Sodium Channel Blockers; Substantia Gelatinosa; Synaptic Transmission; Tetrodotoxin; Thymol; TRPA1 Cation Channel; TRPC Cation Channels; TRPM Cation Channels

2015
TRPM8 Channel Activation Induced by Monoterpenoid Rotundifolone Underlies Mesenteric Artery Relaxation.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Animals; Blotting, Western; Calcium; Calcium Signaling; Capsaicin; Cold Temperature; Cytosol; In Vitro Techniques; Ion Channel Gating; Male; Menthol; Mesenteric Arteries; Monoterpenes; Pyrazines; Pyridines; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Ruthenium Red; TRPM Cation Channels; TRPV Cation Channels; Vasodilation

2015
3-Iodothyronamine increases transient receptor potential melastatin channel 8 (TRPM8) activity in immortalized human corneal epithelial cells.
    Cellular signalling, 2016, Volume: 28, Issue:3

    Topics: Calcium; Capsaicin; Cell Line; Epithelial Cells; Humans; Interleukin-6; Membrane Potentials; Patch-Clamp Techniques; Pyrazines; Pyridines; Pyrimidinones; Thyronines; TRPM Cation Channels; TRPV Cation Channels

2016
Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells.
    Biological & pharmaceutical bulletin, 2016, Jul-01, Volume: 39, Issue:7

    Topics: Acrylamides; Anilides; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line, Tumor; Cell Survival; Cinnamates; DNA Damage; Gamma Rays; Humans; Mice; Necrosis; Neoplasms; Pyrazines; Pyridines; Radiation-Sensitizing Agents; TRPV Cation Channels

2016
Transient receptor potential vanilloid 1-immunoreactive signals in murine enteric glial cells.
    World journal of gastroenterology, 2016, Nov-28, Volume: 22, Issue:44

    Topics: Animals; Animals, Newborn; Cells, Cultured; Coculture Techniques; Enteric Nervous System; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Smooth Muscle; Neuroglia; Pyrazines; Pyridines; S100 Calcium Binding Protein beta Subunit; Time Factors; TRPV Cation Channels

2016
Presynaptic facilitation by tetracaine of glutamatergic spontaneous excitatory transmission in the rat spinal substantia gelatinosa - Involvement of TRPA1 channels.
    Brain research, 2017, 02-15, Volume: 1657

    Topics: Acetanilides; Amides; Anesthetics, Local; Animals; Bupivacaine; Capsaicin; Excitatory Postsynaptic Potentials; Glutamic Acid; Levobupivacaine; Male; Neurotransmitter Agents; Pain; Patch-Clamp Techniques; Presynaptic Terminals; Prilocaine; Purines; Pyrazines; Pyridines; Rats, Sprague-Dawley; Ropivacaine; Ruthenium Red; Substantia Gelatinosa; Tetracaine; Tetrodotoxin; Tissue Culture Techniques; TRPA1 Cation Channel; TRPC Cation Channels

2017
The identification of the TRPM8 channel on primary culture of human nasal epithelial cells and its response to cooling.
    Medicine, 2017, Volume: 96, Issue:31

    Topics: Blotting, Western; Cells, Cultured; Cold Temperature; Epithelial Cells; Female; Fibroblasts; Humans; Immunohistochemistry; Keratin-14; Keratin-18; Male; Menthol; Mucin 5AC; Nasal Mucosa; Pyrazines; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sensory System Agents; TRPM Cation Channels

2017
Mechanisms involved in facial heat hyperalgesia induced by endothelin-1 in female rats.
    Archives of oral biology, 2017, Volume: 83

    Topics: Animals; Carbazoles; Diterpenes; Endothelin-1; Face; Female; Hot Temperature; Hyperalgesia; Indole Alkaloids; Nerve Growth Factor; Oligopeptides; Peptides, Cyclic; Piperidines; Pyrazines; Pyridines; Rats; Rats, Wistar; Trigeminal Ganglion

2017
Study on chemical modification and analgesic activity of N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl) piperazine-1-carboxamide.
    European journal of medicinal chemistry, 2020, May-15, Volume: 194

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Fever; Humans; Models, Molecular; Molecular Structure; Pyrazines; Pyridines; Rats; Structure-Activity Relationship; TRPV Cation Channels

2020