Page last updated: 2024-08-21

pyrazines and malondialdehyde

pyrazines has been researched along with malondialdehyde in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.33)18.7374
1990's6 (13.95)18.2507
2000's13 (30.23)29.6817
2010's22 (51.16)24.3611
2020's1 (2.33)2.80

Authors

AuthorsStudies
Lawson, TW; Murray, WJ; Stohs, SJ; Wahba, ZZ1
Li, YJ; Wu, JX; Yan, YF; Yu, XJ1
Shi, YT; Shi, ZX; Zhang, JL1
Chen, ZH; She, WD1
Higuchi, C; Nakano, Y; Nihei, H; Nishimura, H; Omata, M; Sanaka, T; Shinobe, M; Sugino, N1
Lin, LN; Wang, WT; Xu, ZJ1
Wang, D; Wei, M; Zhang, H; Zhao, S1
Lin, CC; Lin, SC; Liu, CF; Ng, LT1
Li, Y; Shi, J; Sun, L; Wang, X1
Lee, LM; Liu, CF; Yang, PP1
Cheng, F; Feng, L; Li, S; Li, Y; Xiong, Y; Zhang, L1
Gan, WJ; Lin, R; Liu, JT; Wang, WR1
Chen, CF; Huang, TC; Lin, CH; Lin, SC; Liu, CF1
Cheng, B; Dang, XQ; Fan, LH; Wang, CS; Wang, KZ1
Fu, H; Li, J; Li, QX; Shao, L; Xia, L1
Chen, HP; He, M; Huang, QR; Liu, D; Zeng, GH1
Ju, Y; Liu, WK; Ma, L; Zhang, YK1
Hu, X; Tian, M; Wan, H; Yang, J; Zhang, H; Zhao, C; Zhu, H1
Cheng, F; Feng, L; Guo, Y; Ke, N; Li, Q; Li, S; Li, Y1
Cheng, YN; Guo, XL; Liu, XY; Ou, Y; Zhai, L1
Fang, ZX; Hao, ML; Ni, SR; Song, ZJ; Wang, FY; Wang, WT; Xie, KJ1
Li, D; Lin, LN; Wang, WT; Xu, ZJ1
Deng, X; Gao, Y; He, M; Li, N; Zhu, Y1
Gao, C; Peng, H; Wang, S; Zhang, X1
Li, J; Lu, J; Wan, H; Yang, J; Zhang, Y; Zhu, Z1
Cheng, Y; Sun, J; Wang, H; Yang, C; Zhang, S1
Gao, C; Liu, Y; Ma, L; Wang, S; Zhang, X1
Luo, G; Shi, J; Wang, Y1
Guo, L; Sun, Y; Wang, A; Xu, C1
Cheng, Y; Gong, J; Jiang, S; Lv, L; Meng, Q; Xu, J1
Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Pintana, H1
Chang, G; Duan, Q; Lu, K; Qin, S; Wang, Y; Ye, L; Zhang, D; Zhang, P; Zheng, A1
Nader, MA1
Chen, Y; Cui, Q; Shan, L; Sun, Y; Wang, D; Wang, Y; Xu, B; Xu, Q; Yu, P; Zhang, G; Zhang, M; Zhao, Z1
Jin, D; Sakonjo, H; Takai, S1
Ban, N; Kawana, H; Murano, T; Nagayama, D; Nagumo, A; Ohira, M; Saiki, A; Shirai, K; Tatsuno, I; Yamaguchi, T1
Chen, L; Dai, L; Ding, Y; Gong, Y; Hou, X; Zheng, Y; Zhou, H1
Hu, DH; Lu, CY; Peng, XM; Xi, L; Zheng, ZX1
Gao, Q; Huang, W; Su, M; Yang, Y; Zeng, Z; Zhu, B1
Kuang, W; Lan, Z; Zhang, X; Zhu, W1
Jing, G; Jinmin, Z; Li, Z; Min, L; Xinyong, L; Yaqing, J; Yulei, J1
Lv, X; Su, Q; Ye, Z1
Acar, E; Altunrende, F; Can, O; Canat, L; Eraldemir, FC; Otunctemur, A; Sonmez, K; Yildirim, F1

Trials

3 trial(s) available for pyrazines and malondialdehyde

ArticleYear
[Clinical study of naoxin sutong in the treatment of acute cerebral infarction].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1994, Volume: 14, Issue:8

    Topics: Acute Disease; Aged; Cerebral Infarction; Disulfides; Female; Humans; Hypolipidemic Agents; Male; Malondialdehyde; Middle Aged; Pyrazines; Sulfinic Acids

1994
[Clinical study on ligustrazine in treating myocardial ischemia and reperfusion injury].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1997, Volume: 17, Issue:5

    Topics: Adolescent; Adult; Female; Free Radical Scavengers; Glutathione Peroxidase; Heart Septal Defects; Heart Valve Diseases; Humans; Male; Malondialdehyde; Myocardial Reperfusion Injury; Pyrazines; Rheumatic Heart Disease; Superoxide Dismutase

1997
Metformin reduces circulating malondialdehyde-modified low-density lipoprotein in type 2 diabetes mellitus.
    Clinical and investigative medicine. Medecine clinique et experimentale, 2014, Aug-01, Volume: 37, Issue:4

    Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lipoproteins, LDL; Male; Malondialdehyde; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Triazoles

2014

Other Studies

40 other study(ies) available for pyrazines and malondialdehyde

ArticleYear
Factors influencing the induction of DNA single strand breaks in rats by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
    Toxicology, 1989, Volume: 58, Issue:1

    Topics: Animals; Cell Nucleus; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Drug; Female; Iron; Lipid Peroxides; Liver; Malondialdehyde; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Aryl Hydrocarbon; Receptors, Drug; Subcellular Fractions; Thiones; Thiophenes; Time Factors

1989
Protective effect of tetramethylpyrazine against damages of aortic endothelial cells elicited by low-density lipoproteins.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1994, Volume: 15, Issue:5

    Topics: Animals; Aorta; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Epoprostenol; Lipoproteins, LDL; Malondialdehyde; Pyrazines; Superoxide Dismutase

1994
[Effect of ligustrazine on kanamycin ototoxicity].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1995, Volume: 15, Issue:10

    Topics: Animals; Auditory Threshold; Cochlea; Female; Free Radical Scavengers; Guinea Pigs; Hearing Loss; Kanamycin; Male; Malondialdehyde; Pyrazines; Superoxide Dismutase

1995
Therapeutic effect of a newly developed antioxidative agent (OPC-15161) on experimental immune complex nephritis.
    Nephron, 1997, Volume: 76, Issue:3

    Topics: Animals; Antioxidants; Dipyridamole; Free Radical Scavengers; Immune Complex Diseases; Kidney; Kidney Cortex; Lipid Peroxidation; Male; Malondialdehyde; Nephritis; Phosphatidylcholines; Prednisolone; Proteinuria; Pyrazines; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides

1997
[Prophylactic effects of magnesium sulfate and ligustrazin on the hypoxic-ischemic brain damage in neonatal rats].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1997, Volume: 19, Issue:4

    Topics: Animals; Animals, Newborn; Brain Ischemia; Calcium Channel Blockers; Cerebral Cortex; Female; Hypoxia; Magnesium Sulfate; Male; Malondialdehyde; Neurons; Pyrazines; Rats; Rats, Wistar; Superoxide Dismutase

1997
Hepatoprotective and therapeutic effects of tetramethylpyrazine on acute econazole-induced liver injury.
    Planta medica, 2002, Volume: 68, Issue:6

    Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cytochrome c Group; Dose-Response Relationship, Drug; Econazole; Ferrous Compounds; Free Radical Scavengers; Lipid Peroxidation; Liver; Liver Diseases; Male; Malondialdehyde; Pyrazines; Rats; Rats, Wistar; Silymarin; Superoxides; Vitamin E

2002
Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.
    Microsurgery, 2002, Volume: 22, Issue:8

    Topics: Animals; Disease Models, Animal; Endothelin-1; Free Radical Scavengers; Kidney; Kidney Diseases; Malondialdehyde; Pyrazines; Random Allocation; Rats; Rats, Wistar; Renal Artery; Reperfusion Injury; Superoxide Dismutase

2002
Effect of tetramethylpyrazine on lipid peroxidation in streptozotocin-induced diabetic mice.
    The American journal of Chinese medicine, 2002, Volume: 30, Issue:4

    Topics: Animals; Blood Glucose; Blood Urea Nitrogen; Body Weight; Diabetes Mellitus, Experimental; Free Radical Scavengers; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Pyrazines; Thiobarbituric Acid Reactive Substances

2002
Effect of ligustrazine on ischemia-reperfusion injury in murine kidney.
    Transplantation proceedings, 2004, Volume: 36, Issue:7

    Topics: Animals; Blood Urea Nitrogen; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Nephrectomy; Pyrazines; Renal Circulation; Reperfusion Injury; Superoxide Dismutase; Vasodilator Agents

2004
[Effect of ligustrazine on injury of vascular endothelial cells ECV-304 induced by hypoxia and lack of glucose].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2004, Volume: 29, Issue:5

    Topics: Cell Hypoxia; Cell Line; Cell Membrane; Endothelial Cells; Humans; Hypoglycemia; L-Lactate Dehydrogenase; Ligusticum; Malondialdehyde; Membrane Fluidity; Nitric Oxide; Plants, Medicinal; Protective Agents; Pyrazines

2004
Antioxidative effects of tetramethylpyrazine on acute ethanol-induced lipid peroxidation.
    The American journal of Chinese medicine, 2005, Volume: 33, Issue:6

    Topics: Animals; Antioxidants; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Myocardium; Pyrazines

2005
Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits.
    BMC neuroscience, 2006, Jun-14, Volume: 7

    Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Male; Malondialdehyde; Microscopy, Electron, Transmission; Motor Neurons; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rabbits; Spinal Cord; Spinal Cord Ischemia; Superoxide Dismutase; Treatment Outcome; Up-Regulation

2006
Protective effect of ligustrazine on accelerated anti-glomerular basement membrane antibody nephritis in rats is based on its antioxidant properties.
    European journal of pharmacology, 2007, Jun-01, Volume: 563, Issue:1-3

    Topics: Animals; Anti-Glomerular Basement Membrane Disease; Antibodies; Antioxidants; Autoantibodies; Blood Urea Nitrogen; Catalase; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Kidney; Male; Malondialdehyde; Proteinuria; Pyrazines; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase

2007
Delayed protection of tetramethylpyrazine on neonatal rat cardiomyocytes subjected to anoxia-reoxygenation injury.
    Basic & clinical pharmacology & toxicology, 2007, Volume: 100, Issue:6

    Topics: Alkaloids; Animals; Benzophenanthridines; Cell Survival; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutathione Peroxidase; HSP70 Heat-Shock Proteins; In Vitro Techniques; L-Lactate Dehydrogenase; Malondialdehyde; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protein Kinase C; Pyrazines; Rats; Superoxide Dismutase; Vasodilator Agents

2007
[Impacts of tetramethylpyrazine on BDNF, bFGF expression and neuron-protection in severe brain injury tissue of rat].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2008, Volume: 39, Issue:2

    Topics: Animals; Brain Injuries; Brain-Derived Neurotrophic Factor; Female; Fibroblast Growth Factor 2; Immunohistochemistry; Male; Malondialdehyde; Neurons; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase

2008
Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia.
    Nuclear medicine communications, 2008, Volume: 29, Issue:12

    Topics: Animals; Antioxidants; Brain; Gene Expression Regulation; Glucose; Infarction, Middle Cerebral Artery; Interleukin-1; Ischemic Attack, Transient; Isoflavones; Male; Malondialdehyde; Nervous System Diseases; Neuroprotective Agents; Nitric Oxide; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Synaptophysin; Tetrazolium Salts

2008
The protective mechanism of ligustrazine against renal ischemia/reperfusion injury.
    The Journal of surgical research, 2011, Volume: 166, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Disease Models, Animal; Gene Expression; Intercellular Adhesion Molecule-1; Kidney; Kidney Diseases; Kidney Transplantation; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Neutrophils; Oxidative Stress; Peroxidase; Pyrazines; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2011
TMPDP, a tetramethylpyrazine derivative, protects vascular endothelial cells from oxidation damage by hydrogen peroxide.
    Die Pharmazie, 2010, Volume: 65, Issue:10

    Topics: Antioxidants; Biphenyl Compounds; Calcium; Cell Survival; Endothelium, Vascular; Free Radical Scavengers; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Lipid Peroxidation; Malondialdehyde; Myocytes, Smooth Muscle; Oxidants; Picrates; Pyrazines; Reactive Oxygen Species; Superoxide Dismutase

2010
[Effect of ligustrazine and L-arginine on function of mitochondria in myocardium after ischemia/reperfusion injury of myocardium in rabbits].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2007, Volume: 23, Issue:2

    Topics: Animals; Arginine; Calcium; Malondialdehyde; Mitochondria, Heart; Myocardial Reperfusion Injury; Pyrazines; Rabbits; Superoxide Dismutase

2007
[Effects of ligustrazin on lipid peroxidation during hepatic ischemia reperfusion injury].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2002, Volume: 18, Issue:2

    Topics: Alanine Transaminase; Animals; Female; Lipid Peroxidation; Liver; Male; Malondialdehyde; Pyrazines; Rabbits; Reperfusion Injury; Superoxide Dismutase; Xanthine Oxidase

2002
Protective effects and mechanism of tetramethylpyrazine against lens opacification induced by sodium selenite in rats.
    Experimental eye research, 2011, Volume: 93, Issue:1

    Topics: Administration, Topical; Animals; Calcium; Calcium Channel Blockers; Catalase; Cataract; Disease Models, Animal; Drugs, Chinese Herbal; Glutathione Peroxidase; Lens, Crystalline; Ligusticum; Malondialdehyde; Photometry; Pyrazines; Rats; Rats, Sprague-Dawley; Sodium Selenite; Superoxide Dismutase

2011
Effects of Ligustrazine on pancreatic and renal damage after scald injury.
    Burns : journal of the International Society for Burn Injuries, 2012, Volume: 38, Issue:1

    Topics: Amylases; Analysis of Variance; Animals; Blood Urea Nitrogen; Burns; Creatinine; Histocompatibility Antigens Class I; Immunohistochemistry; Kidney; Male; Malondialdehyde; Models, Animal; Pancreas; Pyrazines; Rats; Rats, Inbred Lew; Superoxide Dismutase; Time Factors; Vasodilator Agents

2012
Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia.
    Journal of ethnopharmacology, 2012, Mar-06, Volume: 140, Issue:1

    Topics: Animals; Astragalus Plant; Cardiovascular Agents; Caspase 3; Disease Models, Animal; Drug Synergism; Glucose; Hippocampus; Ischemic Attack, Transient; Male; Malondialdehyde; Neuroprotective Agents; Nimodipine; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Positron-Emission Tomography; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Saponins; Superoxide Dismutase; Triterpenes

2012
Neuroprotective effects of NKN on focal cerebral ischemia in rats.
    Turkish neurosurgery, 2012, Volume: 22, Issue:1

    Topics: Abietanes; Acetophenones; Animals; Benzoates; Brain Ischemia; Bridged-Ring Compounds; Drug Combinations; Endothelin-1; Glucosides; Immunohistochemistry; In Situ Hybridization; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Neurologic Examination; Neurons; Neuroprotective Agents; Pyrazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stroke; Superoxide Dismutase

2012
Effects of Ligustrazine on pulmonary damage in rats following scald injury.
    Burns : journal of the International Society for Burn Injuries, 2012, Volume: 38, Issue:5

    Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Histocompatibility Antigens Class I; Immunohistochemistry; Lung; Male; Malondialdehyde; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Random Allocation; Rats; Rats, Inbred Lew; Spleen; Superoxide Dismutase; Vasodilator Agents

2012
Ligustrazine phosphate ethosomes for treatment of Alzheimer's disease, in vitro and in animal model studies.
    AAPS PharmSciTech, 2012, Volume: 13, Issue:2

    Topics: Acrylic Resins; Administration, Cutaneous; Alzheimer Disease; Amnesia; Animals; Antioxidants; Behavior, Animal; Brain; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Escape Reaction; Ethanol; Glutathione Peroxidase; Lipid Peroxidation; Male; Malondialdehyde; Memory; Mice; Mice, Inbred ICR; Mice, Nude; Microscopy, Confocal; Permeability; Phosphatidylcholines; Pyrazines; Rats; Rats, Sprague-Dawley; Reaction Time; Scopolamine; Skin; Skin Absorption; Superoxide Dismutase; Technology, Pharmaceutical; Time Factors

2012
Evaluation of antioxidant and immunity function of tetramethylpyrazine phosphate tablets in vivo.
    Molecules (Basel, Switzerland), 2012, May-08, Volume: 17, Issue:5

    Topics: Animals; Antioxidants; Blood Pressure; Body Weight; Cardiotonic Agents; Catalase; Glutathione Peroxidase; Heart; Heart Failure; Interleukin-6; Isoproterenol; Malondialdehyde; Organ Size; Organophosphates; Oxidative Stress; Pyrazines; Rats; Rats, Wistar; Superoxide Dismutase; Tablets; Tumor Necrosis Factor-alpha; Ventricular Function, Left

2012
Ligustrazine attenuates myocardial ischemia reperfusion injury in rats by activating the phosphatidylinositol 3-kinase/Akt pathway.
    Annals of clinical and laboratory science, 2012,Spring, Volume: 42, Issue:2

    Topics: Animals; Creatine Kinase, MB Form; Enzyme Activation; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxide Dismutase

2012
Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin-resistant rats.
    British journal of pharmacology, 2013, Volume: 169, Issue:5

    Topics: Adamantane; Animals; Blood Glucose; Blood Pressure; Body Weight; Cardiotonic Agents; Cholesterol; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Heart; Heart Rate; Insulin; Insulin Resistance; Male; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria, Heart; Nitriles; Obesity; Oxidative Stress; Pyrazines; Pyrrolidines; Rats, Wistar; Reactive Oxygen Species; Sitagliptin Phosphate; Triazoles; Vildagliptin

2013
Protective effects of sitagliptin on myocardial injury and cardiac function in an ischemia/reperfusion rat model.
    European journal of pharmacology, 2013, Oct-15, Volume: 718, Issue:1-3

    Topics: Animals; Apoptosis; Body Weight; Cardiotonic Agents; Creatine Kinase, MB Form; Disease Models, Animal; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glutathione Peroxidase; Heart; Heart Ventricles; L-Lactate Dehydrogenase; Male; Malondialdehyde; Myocytes, Cardiac; Organ Size; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Reperfusion Injury; Sitagliptin Phosphate; Superoxide Dismutase; Triazoles

2013
Sitagliptin ameliorates lipid profile changes and endothelium dysfunction induced by atherogenic diet in rabbits.
    Naunyn-Schmiedeberg's archives of pharmacology, 2014, Volume: 387, Issue:5

    Topics: Animals; Diet, Atherogenic; Dipeptidyl-Peptidase IV Inhibitors; Endothelium, Vascular; L-Lactate Dehydrogenase; Lipids; Male; Malondialdehyde; NF-kappa B; Nitric Oxide; Pyrazines; Rabbits; Sitagliptin Phosphate; Triazoles

2014
Design, synthesis, and preliminary cardioprotective effect evaluation of danshensu derivatives.
    Chemical biology & drug design, 2014, Volume: 84, Issue:3

    Topics: Animals; Cardiotonic Agents; Cell Line, Tumor; Creatine Kinase; Disease Models, Animal; Drug Design; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heme Oxygenase-1; Ischemia; L-Lactate Dehydrogenase; Lactates; Malondialdehyde; NF-E2-Related Factor 2; Phenylpropionates; Phosphatidylinositol 3-Kinases; Protein Binding; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Signal Transduction; Stereoisomerism

2014
Significance of vascular dipeptidyl peptidase-4 inhibition on vascular protection in Zucker diabetic fatty rats.
    Journal of pharmacological sciences, 2014, Volume: 125, Issue:4

    Topics: Animals; Atherosclerosis; Blood Glucose; Carotid Arteries; Chemokine CCL2; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Gene Expression; Glucose Tolerance Test; In Vitro Techniques; Insulin; Linagliptin; Malondialdehyde; NADPH Oxidases; Purines; Pyrazines; Quinazolines; Rats, Zucker; Sitagliptin Phosphate; Triazoles; Vasodilation

2014
Heme oxygenase-1 dependant pathway contributes to protection by tetramethylpyrazine against chronic hypoxic injury on medulla oblongata in rats.
    Journal of the neurological sciences, 2016, Feb-15, Volume: 361

    Topics: Animals; Heme Oxygenase-1; Hypoxia, Brain; Male; Malondialdehyde; Medulla Oblongata; Neurons; Neuroprotective Agents; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Superoxide Dismutase

2016
[Protective effects of perfluorocarbon combined with ligustrazine against lung ischemia-reperfusion injury in rats].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2016, Volume: 36, Issue:2

    Topics: Animals; Cytokines; Fluorocarbons; Lung Injury; Malondialdehyde; Peroxidase; Protective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2016
Effect of Salvia miltiorrhiza and ligustrazine injection on myocardial ischemia/reperfusion and hypoxia/reoxygenation injury.
    Molecular medicine reports, 2016, Volume: 14, Issue:5

    Topics: Animals; bcl-2-Associated X Protein; Caspase 3; Coronary Occlusion; Coronary Vessels; Creatine Kinase; Gene Expression Regulation; Humans; L-Lactate Dehydrogenase; Male; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Oncogene Protein v-akt; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rats; Reperfusion Injury; Salvia miltiorrhiza; Signal Transduction

2016
Ligustrazine modulates renal cysteine biosynthesis in rats exposed to cadmium.
    Environmental toxicology and pharmacology, 2017, Volume: 54

    Topics: Aldehydes; Animals; Cadmium; Cystathionine beta-Synthase; Cysteine; Environmental Pollutants; Glutathione; Glutathione Disulfide; Kidney; Kidney Diseases; Male; Malondialdehyde; Methionine Adenosyltransferase; Protective Agents; Pyrazines; Rats, Sprague-Dawley

2017
Protective effects of tetramethylpyrazine analogue Z-11 on cerebral ischemia reperfusion injury.
    European journal of pharmacology, 2019, Feb-05, Volume: 844

    Topics: Animals; Brain; Glutathione; Heme Oxygenase (Decyclizing); Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Neuroprotective Agents; NF-E2-Related Factor 2; Pyrazines; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase

2019
Ligustrazine Attenuates Myocardial Injury Induced by Coronary Microembolization in Rats by Activating the PI3K/Akt Pathway.
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Animals; Heart Injuries; Malondialdehyde; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2019
Protective effect of oltipraz in testicular ischaemia/reperfusion injury: An experimental study.
    Andrologia, 2022, Volume: 54, Issue:1

    Topics: Humans; Ischemia; Male; Malondialdehyde; Pyrazines; Rats; Reperfusion Injury; Spermatic Cord Torsion; Testis; Thiones; Thiophenes

2022