Compounds > pyrazines
Page last updated: 2024-08-21

pyrazines and leupeptins

pyrazines has been researched along with leupeptins in 69 studies

Research

Studies (69)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's34 (49.28)29.6817
2010's35 (50.72)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
An, WG; Blagosklonny, MV; Hwang, SG; Trepel, JB1
Bennink, JR; Chen, W; Crews, CM; Myung, J; Princiotta, MF; Schubert, U; Yewdell, JW1
McBride, WH; Pajonk, F; Pervan, M; Sun, JR; Withers, HR1
Schenkein, D1
Luker, GD; Luker, KE; Pica, CM; Piwnica-Worms, D; Song, J1
Anderson, KC; Chauhan, D; Hideshima, T; Li, G; Ohtake, Y; Podar, K; Shringarpure, R1
Dai, Y; Grant, S; Rahmani, M1
D'Anneo, A; De Blasio, A; Giuliano, M; Tesoriere, G; Vento, R1
Anderson, KC; Berkers, CR; Fiebiger, E; Galardy, PJ; Kessler, BM; Lichtman, E; Ovaa, H; Ploegh, HL; Verdoes, M1
Ballestrero, A; Belka, C; Boy, D; Brossart, P; Cirmena, G; Dal Bello, G; Nencioni, A; Patrone, F; Wesselborg, S; Wille, L1
Davis, JJ; Dong, F; Fang, B; Guo, W; Teraishi, F; Wu, S; Zhang, L; Zhu, H1
Bengston, AL; Denoyelle, C; Esteban, JA; Fernández, Y; Miller, TP; Soengas, MS; Tang, WH1
Chizzolini, C; Dayer, JM; Fineschi, S; Guerne, PA; Reith, W1
Anan, A; Baskin-Bey, ES; Bronk, SF; Gores, GJ; Shah, VH; Werneburg, NW1
Bazzaro, M; Lee, MK; Roden, RB; Santillan, A; Shih, IeM; Stirling, WL; Zoso, A1
Anderson, KC; Chakravarty, S; Dugar, S; Haghnazari, E; Henson, M; Hideshima, T; Higgins, LS; Kapoun, AM; Kerr, I; Luedtke, G; Ma, JY; Mavunkel, B; Medicherla, S; Navas, TA; Nguyen, AN; O'Young, G; Perumattam, J; Protter, AA; Reddy, M; Schreiner, GF; Stebbins, EG1
Gibson, SB; Hu, X; Johnston, JB; Kabore, AF; McCrea, K; Sun, J1
Aizu-Yokota, E; Hatake, K; Kasahara, T; Kuniyoshi, R; Mishima, Y; Rokudai, A; Sonoda, Y; Terui, Y1
Anderson, KC; Chauhan, D; Crawford, LJ; Irvine, AE; Morris, TC; Ovaa, H; Walker, B1
Barti-Juhász, H; Conte, P; Dominici, M; Douglas, L; Houghton, JA; Izeradjene, K; Kopper, L; Luca Cervo, G; Mihalik, R; Nagy, K; Peták, I; Spano, C; Székely-Szüts, K; Tillman, M1
Benedetti-Panici, P; Biffoni, M; Cognetti, F; Ferretti, G; Humphreys, R; Mariani, G; Pasquini, L; Peschle, C; Petronelli, A; Petrucci, E; Saulle, E; Scambia, G; Testa, U1
Birle, DC; Hedley, DW1
Chen, J; Pamarthy, D; Sun, Y; Tan, M; Wang, S; Wu, M; Yang, D; Zhang, H1
Chen, X; Ding, WX; Ni, HM; Yin, XM; Yu, J; Zhang, L1
Belloc, F; de Verneuil, H; Lacombe, F; Mahon, FX; Milpied, N; Moreau-Gaudry, F; Pigneux, A; Praloran, V; Reiffers, J; Uhalde, M1
Jarois, T; Ju, D; Xie, Y; Xu, H1
Jacquemont, C; Taniguchi, T1
Dolcet, X; Encinas, M; Eritja, N; Llobet, D; Llombart-Cussac, A; Marti, RM; Matias-Guiu, X; Schoenenberger, JA; Sorolla, A; Yeramian, A1
Banerjee, AK; Chumakov, KM; Dragunsky, EM; Gudkov, AV; Neznanov, N; Neznanova, L; Wek, RC1
Argiroffo, CB; Bongiovanni, M; Chizzolini, C; Dayer, JM; Djaafar, S; Donati, Y; Ferrari-Lacraz, S; Fineschi, S; Goffin, L; Naso, F; Pache, JC1
Aguirre-Ghiso, JA; Schewe, DM1
Callahan, LA; Supinski, GS; Vanags, J1
Baumann, G; Fechner, M; Grimbo, N; Ludwig, A; Meiners, S; Stangl, K; Stangl, V; Wilck, N1
Dahlmann, B; Kloss, A; Ludwig, A; Meiners, S1
Bousquet-Dubouch, MP; Burlet-Schiltz, O; Gallay, N; Manenti, S; Matondo, M; Monsarrat, B; Payrastre, B; Recher, C; Uttenweiler-Joseph, S1
Baritaki, S; Berenson, J; Bonavida, B; Palladino, M; Yeung, K1
de Haan, CA; Drijfhout, JW; Kikkert, M; Posthuma, CC; Raaben, M; Rottier, PJ; Snijder, EJ; te Lintelo, EG; Verheije, MH1
Bui, TN; Efuet, ET; Keyomarsi, K1
Bartczak, A; Chen, L; Edwards, A; Khattar, R; Levy, G; Liu, MF; Ma, XZ; McGilvray, ID; Zhang, J1
Bendall, LJ; Bradstock, KF; Cisterne, A; Saunders, P; Weiss, J1
Ebert, B; Kisiela, M; Maser, E; Wsól, V1
Celiker, MY; Chang, TP; Ghosh, CC; Juvekar, A; Manna, S; Ramaswami, S; Vancurova, I; Vu, HY1
Baldisserotto, A; Destro, F; Gallerani, E; Gavioli, R; Marastoni, M; Marescotti, D; Sforza, F; Sicurella, M1
Brodie, C; Brodie, S; Cazacu, S; Finniss, S; Goldstein, RS; Kahana, S; Lee, HK; Mikkelsen, T; Roitman, V; Slavin, S; Xiang, C1
Anand, M; Armanious, H; Belch, A; Gelebart, P; Lai, R1
Gartel, AL; Pandit, B2
Eto, Y; Higuchi, T; Ida, H; Kobayashi, H; Nishida, H; Nishiyama, Y; Ohashi, T; Shimada, Y1
Seol, DW1
Bassell, GJ; Gross, C; Muddashetty, RS; Nalavadi, VC1
Filipczak, PT; Glowala-Kosinska, M; Krawczyk, Z; Piglowski, W; Scieglinska, D1
Ding, ZB; Fan, J; Gu, CY; Hui, B; Liu, WR; Peng, YF; Shi, GM; Shi, YH; Yang, H; Zhou, J1
Yerlikaya, A1
Bardag-Gorce, F; Bejaoui, M; Ben Abdennebi, H; Carbonell, T; Oliva, J; Pantazi, E; Rimola, A; Roselló-Catafau, J; Zaouali, MA1
Biskup, E; Gniadecki, R; Kamstrup, MR; Manfé, V1
Andreeff, M; Carter, BZ; Davis, RE; Ma, W; Mak, DH; Mak, PY; Wang, Z1
Ma, L; Shen, B; Sun, H; Sun, L; Sun, Y; Ye, Y; Yu, J; Zhang, D; Zhang, L; Zhu, C1
Brugge, JS; Coloff, JL; Ince, TA; Iwanicki, MP; Kim, M; Kroemer, G; Ofengeim, D; Pan, L; Vakifahmetoglu-Norberg, H; Xia, HG; Yuan, J1
Cho, NH; Choi, HK; Chun, YJ; Im, HJ; Kim, D; Kwon, Y; Park, N; Park, YS; Shin, S; Sung, CH; Ye, DJ1
Jeong, J; Lee, KH; Yoo, CG1
Beck, P; Cui, H; Dubiella, C; Groll, M; Krüger, A; Schmidt, B; Stein, ML; Voss, C1
Cebotaru, L; Cebotaru, V; Guggino, WB; Rapino, D1
Coombs, KM; Ezatti, P; Shahiduzzaman, M; Xin, G1
Goldberg, AL; Sha, Z1
Itoh, K; Liu, T; Maruyama, A; Mimura, J; Ohyama, C; Okada, T; Sato, H; Ye, P1
Chen, S; Dai, Y; Grant, S; Jones, R; Leng, Y; Lin, H; Orlowski, RZ; Pei, XY; Zhang, Y; Zhou, L1
Castro, LM; Dasgupta, S; Dulman, R; Ferro, ES; Fricker, LD; Schmidt, M; Yang, C1
Bachs, O; Coll, MJ; Gascón, P; Girós, M; Guerrero, M; Macías-Vidal, J; Serratosa, J1
Chao, A; Chen, GC; Chuang, WC; Huang, WP; Kao, C; Lai, CH; Lin, CY; Tsai, CL; Wang, HS; Wang, TH1

Reviews

2 review(s) available for pyrazines and leupeptins

ArticleYear
Proteasome inhibitors in the treatment of B-cell malignancies.
    Clinical lymphoma, 2002, Volume: 3, Issue:1

    Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Cell Cycle Proteins; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Enzymes; Gene Expression Regulation; Hodgkin Disease; Humans; Leukemia, B-Cell; Leupeptins; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Mice; Multiple Myeloma; Neoplasm Proteins; NF-kappa B; Oncogene Proteins; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Substrate Specificity; Transcription Factors; Treatment Outcome

2002
Apoptosis meets proteasome, an invaluable therapeutic target of anticancer drugs.
    The Italian journal of biochemistry, 2003, Volume: 52, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Clinical Trials as Topic; Cysteine Endopeptidases; Humans; Leupeptins; Models, Biological; Multienzyme Complexes; Neoplasms; Peptide Hydrolases; Phenotype; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines

2003

Other Studies

67 other study(ies) available for pyrazines and leupeptins

ArticleYear
Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition.
    Leukemia, 2000, Volume: 14, Issue:7

    Topics: Acetylcysteine; Acrylates; Amino Acid Chloromethyl Ketones; Apoptosis; Boronic Acids; Bortezomib; Calpain; Cathepsins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Drug Synergism; Genes, p53; Humans; Jurkat Cells; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Neoplasms; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; U937 Cells

2000
Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Jan-16, Volume: 98, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Aminopeptidases; Animals; Antigen Presentation; Antigens; Boronic Acids; Bortezomib; CD8-Positive T-Lymphocytes; Cell Survival; Cysteine Endopeptidases; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Drug Resistance; Endopeptidases; Enzyme Activation; H-2 Antigens; Leupeptins; Lymphoma, T-Cell; Mice; Multienzyme Complexes; Neoplasm Proteins; Oligopeptides; Peptide Fragments; Phenols; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Pyrazines; Selection, Genetic; Serine Endopeptidases; Sulfones; Thymus Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tyramine; Ubiquitins

2001
Molecular pathways that modify tumor radiation response.
    American journal of clinical oncology, 2001, Volume: 24, Issue:5

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cysteine Endopeptidases; Drug Synergism; Humans; Leupeptins; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Radiation Tolerance; Signal Transduction; Tumor Cells, Cultured; Ubiquitins

2001
Imaging 26S proteasome activity and inhibition in living mice.
    Nature medicine, 2003, Volume: 9, Issue:7

    Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Coleoptera; Cysteine Proteinase Inhibitors; Genes, Reporter; HeLa Cells; Humans; Kinetics; Leupeptins; Luciferases; Luminescent Measurements; Male; Mice; Mice, Nude; Molecular Biology; Peptide Hydrolases; Proteasome Endopeptidase Complex; Pyrazines; Transfection; Ubiquitin; Xenograft Model Antitumor Assays

2003
Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells.
    Cancer research, 2003, Oct-01, Volume: 63, Issue:19

    Topics: Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Survival; Cysteine Endopeptidases; Drug Resistance, Neoplasm; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Leupeptins; Lymphoma; Molecular Chaperones; Multienzyme Complexes; Neoplasm Proteins; Proteasome Endopeptidase Complex; Pyrazines; RNA, Messenger; Transfection

2003
Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process.
    Oncogene, 2003, Oct-16, Volume: 22, Issue:46

    Topics: Anisomycin; Antineoplastic Agents; Apoptosis; Blast Crisis; Boronic Acids; Bortezomib; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia, Myeloid, Acute; Leupeptins; Mitogen-Activated Protein Kinases; Multienzyme Complexes; NF-kappa B; Piperidines; Proteasome Endopeptidase Complex; Pyrazines; Tumor Cells, Cultured; U937 Cells

2003
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib.
    Nature methods, 2005, Volume: 2, Issue:5

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Humans; Leupeptins; Mice; Multiple Myeloma; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines

2005
Cooperative cytotoxicity of proteasome inhibitors and tumor necrosis factor-related apoptosis-inducing ligand in chemoresistant Bcl-2-overexpressing cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jun-01, Volume: 11, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Boronic Acids; Bortezomib; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Etoposide; Flow Cytometry; Humans; Immunoblotting; Jurkat Cells; Leupeptins; Membrane Glycoproteins; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; NF-kappa B; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha

2005
Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation.
    Cancer biology & therapy, 2005, Volume: 4, Issue:7

    Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein; Boronic Acids; Bortezomib; Caspases; Cell Proliferation; Colonic Neoplasms; Cysteine Proteinase Inhibitors; Cytochromes c; Drug Resistance, Neoplasm; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Membrane Glycoproteins; Membrane Proteins; Mitochondrial Proteins; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2005
Chemical blockage of the proteasome inhibitory function of bortezomib: impact on tumor cell death.
    The Journal of biological chemistry, 2006, Jan-13, Volume: 281, Issue:2

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Antineoplastic Agents; Antioxidants; Binding, Competitive; Boronic Acids; Bortezomib; Breast Neoplasms; Cell Death; Cell Line; Cell Line, Tumor; Cell Survival; Drug Antagonism; Fibroblasts; Free Radicals; Humans; Immunoblotting; Kinetics; Leupeptins; Melanocytes; Melanoma; Membrane Potentials; Models, Biological; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Reactive Oxygen Species; Skin; Time Factors

2006
Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:3

    Topics: Acetylcysteine; Anthracenes; Boronic Acids; Bortezomib; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; Fibroblasts; Fibrosis; Genes, jun; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Matrix Metalloproteinase 1; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Pyrazines; RNA Polymerase II; RNA, Messenger; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Up-Regulation

2006
Proteasome inhibition induces hepatic stellate cell apoptosis.
    Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:2

    Topics: Animals; Apoptosis; Bile Ducts; Boronic Acids; Bortezomib; Cell Line; Humans; Leupeptins; Ligation; Liver; Liver Cirrhosis; Mice; NF-kappa B; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rats; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor

2006
Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis.
    Cancer research, 2006, Apr-01, Volume: 66, Issue:7

    Topics: Animals; Apoptosis; Boronic Acids; Bortezomib; Caspases; Cell Division; Cell Line, Tumor; Female; G2 Phase; Humans; Leupeptins; Mice; Mice, Nude; Oligopeptides; Ovarian Neoplasms; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Ubiquitin; Xenograft Model Antitumor Assays

2006
Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo.
    Leukemia, 2006, Volume: 20, Issue:6

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; In Vitro Techniques; Indoles; Injections, Intravenous; Leupeptins; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 14; Molecular Chaperones; Multiple Myeloma; Neoplasm Proteins; Protease Inhibitors; Pyrazines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2006
The TRAIL apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary chronic lymphocytic leukemia cells.
    Apoptosis : an international journal on programmed cell death, 2006, Volume: 11, Issue:7

    Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; B-Lymphocytes; Boronic Acids; Bortezomib; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Cell Survival; Cysteine Proteinase Inhibitors; Drug Synergism; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Leupeptins; Membrane Glycoproteins; Middle Aged; Proteasome Inhibitors; Pyrazines; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2006
Differential regulation of eotaxin-1/CCL11 and eotaxin-3/CCL26 production by the TNF-alpha and IL-4 stimulated human lung fibroblast.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:6

    Topics: Asthma; Boronic Acids; Bortezomib; Cell Line; Chemokine CCL11; Chemokine CCL26; Chemokines, CC; Drug Synergism; Enzyme Inhibitors; Fibroblasts; Humans; Hypersensitivity; Immunoblotting; Interleukin-4; Leupeptins; Lung; Mitogen-Activated Protein Kinases; NF-kappa B; Pyrazines; Recombinant Proteins; STAT6 Transcription Factor; Tumor Necrosis Factor-alpha

2006
Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132.
    Cancer research, 2006, Jun-15, Volume: 66, Issue:12

    Topics: Apoptosis; Boronic Acids; Bortezomib; Catalysis; Cell Line, Tumor; Glyoxal; HeLa Cells; Humans; Leucine; Leupeptins; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Substrate Specificity

2006
Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria.
    Pathology oncology research : POR, 2006, Volume: 12, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Boronic Acids; Bortezomib; Caspase 3; Caspase 8; Colonic Neoplasms; Drug Synergism; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Mitochondria; Mitochondrial Proteins; Oligopeptides; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; TNF-Related Apoptosis-Inducing Ligand

2006
Proteasome inhibitors sensitize ovarian cancer cells to TRAIL induced apoptosis.
    Apoptosis : an international journal on programmed cell death, 2007, Volume: 12, Issue:4

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Boronic Acids; Bortezomib; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspases; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Female; Humans; Leupeptins; Membrane Proteins; Mitochondria; Ovarian Neoplasms; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand

2007
Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors.
    Cancer research, 2007, Feb-15, Volume: 67, Issue:4

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Boronic Acids; Bortezomib; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Caspase 3; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Colonic Neoplasms; E1A-Associated p300 Protein; Enzyme Activation; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leupeptins; Male; Prostatic Neoplasms; Protease Inhibitors; Protein Binding; Pyrazines; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2007
p27 degradation by an ellipticinium series of compound via ubiquitin-proteasome pathway.
    Cancer biology & therapy, 2007, Volume: 6, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Boronic Acids; Bortezomib; Brain Neoplasms; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Cysteine Proteinase Inhibitors; Ellipticines; Glioblastoma; Humans; Leupeptins; Mice; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Radiation-Sensitizing Agents; S-Phase Kinase-Associated Proteins; Transcription, Genetic; Tumor Cells, Cultured; Ubiquitin; Ubiquitin-Protein Ligases

2007
A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:3

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Boronic Acids; Bortezomib; Caspase Inhibitors; Caspases; Cell Nucleus; Colonic Neoplasms; Cysteine Proteinase Inhibitors; Cytochromes c; Humans; Leupeptins; Mice; Mitochondria; Proteasome Inhibitors; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Reactive Oxygen Species; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2007
Proteasome inhibition specifically sensitizes leukemic cells to anthracyclin-induced apoptosis through the accumulation of Bim and Bax pro-apoptotic proteins.
    Cancer biology & therapy, 2007, Volume: 6, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anthracyclines; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Boronic Acids; Bortezomib; Cell Line, Tumor; Female; Humans; Idarubicin; Leukemia, Myeloid, Acute; Leupeptins; Male; Membrane Proteins; Middle Aged; Protease Inhibitors; Proteasome Inhibitors; Proto-Oncogene Proteins; Pyrazines; Tumor Cells, Cultured

2007
Diminished feedback regulation of proteasome expression and resistance to proteasome inhibitors in breast cancer cells.
    Breast cancer research and treatment, 2008, Volume: 107, Issue:2

    Topics: Apoptosis; Boronic Acids; Bortezomib; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Feedback, Physiological; Humans; Leupeptins; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Temperature; Tetrazolium Salts; Thiazoles

2008
Proteasome function is required for DNA damage response and fanconi anemia pathway activation.
    Cancer research, 2007, Aug-01, Volume: 67, Issue:15

    Topics: Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Boronic Acids; Bortezomib; BRCA1 Protein; Cell Cycle Proteins; Cells, Cultured; DNA Damage; DNA Repair; DNA-Binding Proteins; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Female; Flow Cytometry; Gamma Rays; HeLa Cells; Humans; Leupeptins; Microscopy, Fluorescence; Nuclear Proteins; Ovarian Neoplasms; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Serine-Threonine Kinases; Pyrazines; Rad51 Recombinase; RNA-Binding Proteins; RNA, Small Interfering; Signal Transduction; Tumor Suppressor Proteins; Ubiquitin

2007
Antioxidants block proteasome inhibitor function in endometrial carcinoma cells.
    Anti-cancer drugs, 2008, Volume: 19, Issue:2

    Topics: Antioxidants; Antipyrine; Apoptosis; Ascorbic Acid; Blotting, Western; Boronic Acids; Bortezomib; Butylated Hydroxyanisole; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Line, Tumor; Cell Survival; Coumarins; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Edaravone; Endometrial Neoplasms; Ergothioneine; Female; Humans; Leupeptins; Oligopeptides; Proteasome Inhibitors; Pyrazines; Ubiquitin; Vitamin E; Vitamins

2008
Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication.
    PloS one, 2008, Apr-02, Volume: 3, Issue:4

    Topics: Boronic Acids; Bortezomib; DNA; DNA Replication; Eukaryotic Initiation Factor-2; HeLa Cells; Humans; Leupeptins; Models, Biological; Poliovirus; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Transfection; Vesiculovirus; Viral Proteins; Virus Replication

2008
In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis.
    American journal of respiratory cell and molecular biology, 2008, Volume: 39, Issue:4

    Topics: Animals; Bleomycin; Boronic Acids; Bortezomib; Cells, Cultured; Collagen Type I; Fibrosis; Hydroxyproline; Leupeptins; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proteasome Inhibitors; Protein Serine-Threonine Kinases; Pulmonary Fibrosis; Pyrazines; Scleroderma, Systemic; Signal Transduction; Skin; Transforming Growth Factor beta

2008
Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy.
    Cancer research, 2009, Feb-15, Volume: 69, Issue:4

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Cycle; Cell Death; Cell Survival; Endoplasmic Reticulum Chaperone BiP; Eukaryotic Initiation Factor-2; G1 Phase; Humans; Leupeptins; Multiple Myeloma; Phosphorylation; Pyrazines; Resting Phase, Cell Cycle

2009
Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction.
    American journal of physiology. Lung cellular and molecular physiology, 2009, Volume: 296, Issue:6

    Topics: Animals; Atrophy; Boronic Acids; Bortezomib; Caspase 3; Cysteine Proteinase Inhibitors; Diaphragm; Endotoxemia; Enzyme Activation; Leupeptins; Male; Muscle Contraction; Muscle Weakness; Oligopeptides; Organ Size; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Sepsis; Tyrosine

2009
Potent anti-inflammatory effects of low-dose proteasome inhibition in the vascular system.
    Journal of molecular medicine (Berlin, Germany), 2009, Volume: 87, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Boronic Acids; Bortezomib; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation; Humans; Leupeptins; Male; Monocytes; NF-kappa B; Oxidative Stress; Proteasome Inhibitors; Pyrazines; Rats; Rats, Inbred Dahl; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2009
Multiple cardiac proteasome subtypes differ in their susceptibility to proteasome inhibitors.
    Cardiovascular research, 2010, Jan-15, Volume: 85, Issue:2

    Topics: Animals; Boronic Acids; Bortezomib; Leupeptins; Male; Myocardium; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Rats, Wistar

2010
Proteasome inhibitor-induced apoptosis in acute myeloid leukemia: a correlation with the proteasome status.
    Leukemia research, 2010, Volume: 34, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Daunorubicin; Drug Resistance, Neoplasm; Female; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Leupeptins; Male; Middle Aged; Prognosis; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Tumor Cells, Cultured; U937 Cells

2010
Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization.
    Cancer research, 2009, Nov-01, Volume: 69, Issue:21

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cisplatin; Humans; Lactones; Leupeptins; Male; Melanoma; Membrane Potential, Mitochondrial; NF-kappa B; Phosphatidylethanolamine Binding Protein; Prostatic Neoplasms; Proteasome Inhibitors; Proto-Oncogene Proteins c-raf; Pyrazines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Snail Family Transcription Factors; TNF-Related Apoptosis-Inducing Ligand; Transcription Factors; Transfection; Tumor Cells, Cultured

2009
The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle.
    Journal of virology, 2010, Volume: 84, Issue:15

    Topics: Animals; Boronic Acids; Bortezomib; Cats; Cell Line; Chlorocebus aethiops; Coronavirus Infections; Coronavirus, Feline; Leupeptins; Mice; Murine hepatitis virus; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Severe acute respiratory syndrome-related coronavirus; Ubiquitin; Virus Internalization; Virus Release; Virus Replication

2010
Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells.
    Cell biology and toxicology, 2011, Volume: 27, Issue:2

    Topics: Acetylcysteine; Animals; Biological Assay; Boronic Acids; Bortezomib; Cell Extracts; Cells, Cultured; Chymotrypsin; High-Throughput Screening Assays; Inhibitory Concentration 50; Leupeptins; Mice; Models, Biological; Oligopeptides; Ornithine Decarboxylase; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Recombinant Fusion Proteins; Time Factors

2011
Proteasome inhibition in vivo promotes survival in a lethal murine model of severe acute respiratory syndrome.
    Journal of virology, 2010, Volume: 84, Issue:23

    Topics: Animals; Blotting, Northern; Blotting, Western; Boronic Acids; Bortezomib; Coronavirus Infections; Cytokines; DNA Primers; Gene Expression Regulation; Histological Techniques; Leupeptins; Lung; Mice; Murine hepatitis virus; Phosphorylation; Pneumonia; Proline; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; STAT Transcription Factors; Survival Analysis; Thiocarbamates; Ubiquitination; Virus Replication

2010
The mammalian target of rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre-B acute lymphocytic leukemia.
    Haematologica, 2011, Volume: 96, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cell Line, Tumor; Combined Modality Therapy; Everolimus; Humans; Immunosuppressive Agents; Leupeptins; Mice; Mice, Inbred NOD; Mice, SCID; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Protease Inhibitors; Pyrazines; Radiation, Ionizing; Sirolimus; Survival Rate; TOR Serine-Threonine Kinases; Whole-Body Irradiation

2011
Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29.
    Chemico-biological interactions, 2011, May-30, Volume: 191, Issue:1-3

    Topics: 20-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductase Family 1 Member C3; Aldo-Keto Reductases; Boronic Acids; Bortezomib; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Hydroxyprostaglandin Dehydrogenases; Isothiocyanates; Leupeptins; Maleates; Multidrug Resistance-Associated Protein 2; NF-E2-Related Factor 2; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; RNA, Messenger; Sulfoxides; Thiocyanates; Time Factors

2011
Bortezomib induces nuclear translocation of IκBα resulting in gene-specific suppression of NF-κB--dependent transcription and induction of apoptosis in CTCL.
    Molecular cancer research : MCR, 2011, Volume: 9, Issue:2

    Topics: Apoptosis; Base Sequence; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Nucleus; DNA, Neoplasm; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Humans; I-kappa B Proteins; Leupeptins; Lymphoma, T-Cell, Cutaneous; Molecular Sequence Data; NF-kappa B; NF-kappa B p50 Subunit; NF-KappaB Inhibitor alpha; Protein Binding; Protein Subunits; Protein Transport; Pyrazines; Transcription Factor RelA; Transcription, Genetic

2011
Proteasome inhibitors induce the presentation of an Epstein-Barr virus nuclear antigen 1-derived cytotoxic T lymphocyte epitope in Burkitt's lymphoma cells.
    Immunology, 2011, Volume: 133, Issue:1

    Topics: Antigen Presentation; Blotting, Western; Boronic Acids; Bortezomib; Burkitt Lymphoma; Cell Line; Epitopes, T-Lymphocyte; Epstein-Barr Virus Nuclear Antigens; Fluorescent Antibody Technique; Humans; Leupeptins; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; T-Lymphocytes, Cytotoxic

2011
Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions.
    Cellular signalling, 2011, Volume: 23, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Astrocytes; Boronic Acids; Bortezomib; Cell Line, Tumor; Down-Regulation; Glioma; Humans; Leupeptins; Mutagenesis, Site-Directed; Neoplastic Stem Cells; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-akt; Pyrazines; TNF-Related Apoptosis-Inducing Ligand; X-Linked Inhibitor of Apoptosis Protein

2011
Constitutive activation of metalloproteinase ADAM10 in mantle cell lymphoma promotes cell growth and activates the TNFα/NFκB pathway.
    Blood, 2011, Jun-09, Volume: 117, Issue:23

    Topics: ADAM Proteins; ADAM10 Protein; Amyloid Precursor Protein Secretases; Boronic Acids; Bortezomib; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cysteine Proteinase Inhibitors; Enzyme Activation; Female; Humans; Leupeptins; Lymphoma, Mantle-Cell; Male; Membrane Proteins; Palatine Tonsil; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Signal Transduction; Tonsillar Neoplasms; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2011
FoxM1 knockdown sensitizes human cancer cells to proteasome inhibitor-induced apoptosis but not to autophagy.
    Cell cycle (Georgetown, Tex.), 2011, Oct-01, Volume: 10, Issue:19

    Topics: Apoptosis; Autophagy; Boronic Acids; Bortezomib; Caspase 3; Cell Line, Tumor; Forkhead Box Protein M1; Forkhead Transcription Factors; Humans; Leupeptins; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; RNA Interference; RNA, Small Interfering; Thiostrepton

2011
Proteasome inhibitors improve the function of mutant lysosomal α-glucosidase in fibroblasts from Pompe disease patient carrying c.546G>T mutation.
    Biochemical and biophysical research communications, 2011, Nov-18, Volume: 415, Issue:2

    Topics: alpha-Glucosidases; Boronic Acids; Bortezomib; Cysteine Proteinase Inhibitors; Enzyme Stability; Fibroblasts; Glycogen Storage Disease Type II; Humans; Leupeptins; Mutation; Proteasome Inhibitors; Protein Transport; Pyrazines

2011
Proteasome inhibitors suppress expression of NPM and ARF proteins.
    Cell cycle (Georgetown, Tex.), 2011, Nov-15, Volume: 10, Issue:22

    Topics: ADP-Ribosylation Factors; Boronic Acids; Bortezomib; Cysteine Proteinase Inhibitors; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression; HeLa Cells; Humans; Leupeptins; Nuclear Proteins; Nucleophosmin; Proteasome Inhibitors; Pyrazines; RNA, Messenger; Thiostrepton

2011
p53-Independent up-regulation of a TRAIL receptor DR5 by proteasome inhibitors: a mechanism for proteasome inhibitor-enhanced TRAIL-induced apoptosis.
    Biochemical and biophysical research communications, 2011, Dec-09, Volume: 416, Issue:1-2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Brain Neoplasms; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Glioma; Humans; Leupeptins; Proteasome Inhibitors; Pyrazines; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53; Up-Regulation

2011
Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Feb-22, Volume: 32, Issue:8

    Topics: Analysis of Variance; Animals; Boronic Acids; Bortezomib; Cells, Cultured; Dendrites; Disks Large Homolog 4 Protein; Drosophila Proteins; Embryo, Mammalian; Enzyme Inhibitors; Female; Fragile X Mental Retardation Protein; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Leupeptins; Male; Membrane Proteins; Methoxyhydroxyphenylglycol; Mutation; Neurons; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Biosynthesis; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; RNA, Messenger; Serine; Signal Transduction; Synapses; Transfection; Ubiquitination

2012
HSPA2 overexpression protects V79 fibroblasts against bortezomib-induced apoptosis.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2012, Volume: 90, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle; Cell Line; Cell Survival; Cold-Shock Response; Cricetinae; Cysteine Proteinase Inhibitors; Fibroblasts; Gene Expression; HSP70 Heat-Shock Proteins; Humans; Leupeptins; Pyrazines; Recombinant Proteins; Stress, Physiological

2012
Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma.
    Cancer, 2012, Nov-15, Volume: 118, Issue:22

    Topics: Adenine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Boronic Acids; Bortezomib; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Membrane Proteins; Microtubule-Associated Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines

2012
Expression of heme oxygenase-1 in response to proteasomal inhibition.
    Protein and peptide letters, 2012, Volume: 19, Issue:12

    Topics: Animals; Base Sequence; Blotting, Western; Boronic Acids; Bortezomib; Breast Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Induction; Female; Genes, p53; Heme Oxygenase-1; Humans; Leupeptins; Melanoma, Experimental; Mice; Molecular Sequence Data; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Regulatory Sequences, Nucleic Acid

2012
Proteasome inhibitors protect the steatotic and non-steatotic liver graft against cold ischemia reperfusion injury.
    Experimental and molecular pathology, 2013, Volume: 94, Issue:2

    Topics: Adiponectin; Animals; Boronic Acids; Bortezomib; Cold Ischemia; Cysteine Proteinase Inhibitors; Cytoprotection; Fatty Liver; Interleukin-1; Leupeptins; Liver Transplantation; Mitochondria, Liver; Organ Preservation; Organ Preservation Solutions; Oxidative Stress; Proteasome Inhibitors; Pyrazines; Rats; Rats, Zucker; Reperfusion Injury; Tumor Necrosis Factor-alpha

2013
Proteasome inhibition as a novel mechanism of the proapoptotic activity of γ-secretase inhibitor I in cutaneous T-cell lymphoma.
    The British journal of dermatology, 2013, Volume: 168, Issue:3

    Topics: Amyloid Precursor Protein Secretases; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Enzyme Inhibitors; Humans; Leupeptins; Lymphoma, T-Cell, Cutaneous; NF-kappa B; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Receptor, Notch1; Skin Neoplasms; Tumor Suppressor Protein p53

2013
XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells.
    Leukemia research, 2013, Volume: 37, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Caspases; Cell Line, Tumor; Cell Survival; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Leukemic; HL-60 Cells; HSP72 Heat-Shock Proteins; Humans; I-kappa B Proteins; Leukemia, Myeloid, Acute; Leupeptins; Myeloid Cell Leukemia Sequence 1 Protein; NF-KappaB Inhibitor alpha; Oligonucleotides, Antisense; Oligopeptides; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; X-Linked Inhibitor of Apoptosis Protein

2013
Identification of proteasome subunit beta type 6 (PSMB6) associated with deltamethrin resistance in mosquitoes by proteomic and bioassay analyses.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Proliferation; Cells, Cultured; Cloning, Molecular; Culicidae; Cysteine Proteinase Inhibitors; Drug Resistance; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Insect Proteins; Insecticides; Larva; Leupeptins; Nitriles; Phylogeny; Proteasome Endopeptidase Complex; Proteomics; Pyrazines; Pyrethrins; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2013
Chaperone-mediated autophagy degrades mutant p53.
    Genes & development, 2013, Aug-01, Volume: 27, Issue:15

    Topics: Antineoplastic Agents; Autophagy; Boronic Acids; Bortezomib; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Leupeptins; Lysosomes; Molecular Chaperones; Mutation; Proteasome Endopeptidase Complex; Proteolysis; Pyrazines; Tumor Suppressor Protein p53; Ubiquitination

2013
Induction of steroid sulfatase expression in PC-3 human prostate cancer cells by insulin-like growth factor II.
    Toxicology letters, 2013, Nov-25, Volume: 223, Issue:2

    Topics: 17-Hydroxysteroid Dehydrogenases; Androstadienes; Boronic Acids; Bortezomib; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Insulin-Like Growth Factor II; Leupeptins; Male; Morpholines; NF-kappa B; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polymerase Chain Reaction; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyrazines; Sequence Analysis, DNA; Signal Transduction; Steryl-Sulfatase; Sulfones; Sulfotransferases; Wortmannin

2013
Long-term incubation with proteasome inhibitors (PIs) induces IκBα degradation via the lysosomal pathway in an IκB kinase (IKK)-dependent and IKK-independent manner.
    The Journal of biological chemistry, 2013, Nov-08, Volume: 288, Issue:45

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Dipeptides; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; I-kappa B Kinase; I-kappa B Proteins; Interleukin-8; Ketones; Leupeptins; Lysosomes; Microtubule-Associated Proteins; Mutation, Missense; NF-kappa B; NF-KappaB Inhibitor alpha; Proteasome Inhibitors; Proteolysis; Pyrazines; Thiophenes; Time Factors

2013
Systematic comparison of peptidic proteasome inhibitors highlights the α-ketoamide electrophile as an auspicious reversible lead motif.
    Angewandte Chemie (International ed. in English), 2014, Feb-03, Volume: 53, Issue:6

    Topics: Binding Sites; Boronic Acids; Bortezomib; Catalytic Domain; Crystallography, X-Ray; HeLa Cells; Humans; Leupeptins; Molecular Dynamics Simulation; Oligopeptides; Peptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Pyrazines

2014
Correcting the cystic fibrosis disease mutant, A455E CFTR.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Anilides; Animals; Boronic Acids; Bortezomib; Chlorocebus aethiops; COS Cells; Cycloheximide; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Expression; Genetic Complementation Test; Half-Life; Humans; Hydroxamic Acids; Leupeptins; Mutation; Plasmids; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Pyrazines; Small Molecule Libraries; Transfection

2014
Proteasomal serine hydrolases are up-regulated by and required for influenza virus infection.
    Journal of proteome research, 2014, May-02, Volume: 13, Issue:5

    Topics: Animals; Aprotinin; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Dogs; Host-Pathogen Interactions; Humans; Influenza A Virus, H1N1 Subtype; Leupeptins; Madin Darby Canine Kidney Cells; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteome; Proteomics; Pyrazines; RNA Interference; Serine Proteases; Sulfones; Up-Regulation; Virus Replication

2014
Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97.
    Current biology : CB, 2014, Jul-21, Volume: 24, Issue:14

    Topics: Boronic Acids; Bortezomib; Cell Line; Endoplasmic Reticulum; HEK293 Cells; Humans; Leupeptins; Nuclear Proteins; Nuclear Respiratory Factor 1; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Pyrazines; RNA Interference; RNA, Small Interfering; Ubiquitin Thiolesterase; Ubiquitination; Unfolded Protein Response

2014
Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition.
    Molecular and cellular biology, 2014, Sep-15, Volume: 34, Issue:18

    Topics: Activating Transcription Factor 4; Amino Acid Transport System y+; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cysteine; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glutathione; Glycine; HEK293 Cells; HeLa Cells; Humans; Leupeptins; NF-E2-Related Factor 2; Oligopeptides; Proteasome Endopeptidase Complex; Pyrazines; RNA, Small Interfering; Sulfasalazine; Urinary Bladder Neoplasms

2014
Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
    Molecular and cellular biology, 2014, Sep-15, Volume: 34, Issue:18

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Boronic Acids; Bortezomib; Cell Line, Tumor; Cells, Cultured; Cyclin T; Cyclin-Dependent Kinase 9; Cycloheximide; Flavonoids; Gene Expression Regulation; Heat-Shock Proteins; Humans; Indoles; Leupeptins; Membrane Proteins; Mice; Mice, Knockout; Mitochondrial Proteins; Piperidines; Protein Transport; Pyrazines; Pyrroles; RNA, Small Interfering; Sequestosome-1 Protein

2014
Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; HEK293 Cells; Humans; Inhibitory Concentration 50; Intracellular Space; Leupeptins; Oligopeptides; Peptides; Proteasome Inhibitors; Pyrazines

2014
The proteasome inhibitor bortezomib reduced cholesterol accumulation in fibroblasts from Niemann-Pick type C patients carrying missense mutations.
    The FEBS journal, 2014, Volume: 281, Issue:19

    Topics: Boronic Acids; Bortezomib; Carrier Proteins; Cells, Cultured; Cholesterol; Endosomes; Fibroblasts; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Membrane Glycoproteins; Mutation, Missense; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Protein Transport; Proteolysis; Pyrazines

2014
Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation.
    Cell death & disease, 2014, Nov-06, Volume: 5

    Topics: Antineoplastic Agents; Autophagy; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Survival; Cisplatin; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Leupeptins; MAP Kinase Kinase 4; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phagosomes; Phosphorylation; Proteasome Inhibitors; Pyrazines; Signal Transduction

2014