Page last updated: 2024-08-21

pyrazines and ketoconazole

pyrazines has been researched along with ketoconazole in 3 studies

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (66.67)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Kuang, XD; Li, XH; Xiong, YQ	1
Chatta, G; Chen, E; Cooper, M; Egorin, M; Karol, M; Neuwirth, R; Rader, M; Ramalingam, S; Ramanathan, RK; Riordan, W; Trepicchio, W; Venkatakrishnan, K; von Moltke, L	1
Atsriku, C; Li, Y; Liu, H; Narayanan, R; Nissel, J; Surapaneni, S; Tong, Z; Wang, X	1

Trials

1 trial(s) available for pyrazines and ketoconazole

Article	Year
Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: a prospective, multicenter, open-label, randomized, two-way crossover drug-drug interaction study. Clinical therapeutics, 2009, Volume: 31 Pt 2 Topics: Antifungal Agents; Antineoplastic Agents; Area Under Curve; Boronic Acids; Bortezomib; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Humans; Ketoconazole; Male; Middle Aged; Neoplasms; Prospective Studies; Pyrazines	2009

Article

Year

Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: a prospective, multicenter, open-label, randomized, two-way crossover drug-drug interaction study.

Clinical therapeutics, 2009, Volume: 31 Pt 2

Topics: Antifungal Agents; Antineoplastic Agents; Area Under Curve; Boronic Acids; Bortezomib; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Humans; Ketoconazole; Male; Middle Aged; Neoplasms; Prospective Studies; Pyrazines

2009

Other Studies

2 other study(ies) available for pyrazines and ketoconazole

Article	Year
[Study on metabolism of tetramethylpyrazine in system of rat liver microsomes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2006, Volume: 31, Issue:23 Topics: Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dexamethasone; Ketoconazole; Male; Metabolic Clearance Rate; Microsomes, Liver; Pyrazines; Random Allocation; Rats; Rats, Wistar; Vasodilator Agents	2006
Assessment of drug-drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of rapamycin kinase. Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:1 Topics: Animals; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Ketoconazole; Membrane Transport Proteins; Microsomes, Liver; Prospective Studies; Pyrazines; Sirolimus; TOR Serine-Threonine Kinases	2019

Article

Year

[Study on metabolism of tetramethylpyrazine in system of rat liver microsomes].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2006, Volume: 31, Issue:23

Topics: Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dexamethasone; Ketoconazole; Male; Metabolic Clearance Rate; Microsomes, Liver; Pyrazines; Random Allocation; Rats; Rats, Wistar; Vasodilator Agents

2006

Assessment of drug-drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of rapamycin kinase.

Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:1

Topics: Animals; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Ketoconazole; Membrane Transport Proteins; Microsomes, Liver; Prospective Studies; Pyrazines; Sirolimus; TOR Serine-Threonine Kinases

2019