pyrazines has been researched along with interleukin-8 in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 17 (68.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brady, CS; FitzGerald, MX; Mackarel, AJ; O'Connor, CM; Russell, KJ | 1 |
| Abbruzzese, JL; Baker, C; Chiao, PJ; Dong, QG; Evans, DB; Frederick, WA; Fujioka, S; Schmidt, C; Sclabas, GM | 1 |
| Bar-Eli, M; Davis, DW; Dinney, CP; Kamat, AM; Karashima, T; Lashinger, L; McConkey, DJ; Millikan, R; Shen, Y | 1 |
| Broad, RM; Denlinger, CE; Jones, DR; Keller, MD; Mayo, MW | 1 |
| Chen, XL; Han, ZX; Wang, SY; Xu, QL; Zhang, Z; Zheng, H | 1 |
| Harada, K; Sato, M; Yoshida, H | 1 |
| Benedict, WF; Dinney, C; Kamat, A; McConkey, DJ; Papageorgiou, A | 1 |
| He, JL; Li, WM; Li, XY; Liu, HT; Yu, C | 1 |
| Bruserud, Ø; Ersvaer, E; Hatfield, KJ; Kittang, AO; Lassalle, P; Reikvam, H | 1 |
| Callander, NS; Hematti, P; Kim, J; Kim, K; Leith, CP; Markovina, S; Miyamoto, S; O'Connor, SL; Shi, Y; Trivedi, P; Xu, G | 1 |
| Du, Z; Fan, M; Gu, W; Jiao, Y; Kim, JG; Nosrat, CA; Pavicevic, Z; Pfeffer, LM; Rao, SK; Rosebush, M; Samant, S | 1 |
| Chen, WJ; He, JL; Li, WM; Liu, HT; Liu, HZ; Wang, YX; Yang, Z; Yin, J; Yu, C | 1 |
| Befani, CD; Daliani, DD; Hatzidaki, E; Liakos, P; Moutzouris, G; Papandreou, CN; Patrikidou, A; Tsapakidis, K; Vlachostergios, PJ; Voutsadakis, IA | 1 |
| Fujisawa, K; Hara, K; Kinouchi, M; Kuribayashi, N; Miyamoto, Y; Nagai, H; Ohe, G; Takamaru, N; Tamatani, T; Uchida, D | 1 |
| Chang, TP; Gatla, HR; Manna, S; Phyo, SA; Ramaswami, S; Sanacora, S; Singha, B; Vancurova, I | 1 |
| Jeong, J; Lee, KH; Yoo, CG | 1 |
| Chang, TP; Gatla, HR; Manna, S; Poltoratsky, V; Sanacora, S; Singha, B; Vancura, A; Vancurova, I | 1 |
| Fuchigami, M; Goda, T; Imai, C; Mochizuki, K; Osonoi, T; Saito, M | 1 |
| Burgstaller, G; Cei, D; Eickelberg, O; Lentner, B; Lenz, AG; Meiners, S; Schmid, O; Schmidmeir, M; Semren, N; Stoeger, T | 1 |
| Gatla, HR; Persaud, V; Singha, B; Vancurova, I | 1 |
| Gatla, HR; Phyo, SA; Singha, B; Vancurova, I | 1 |
| Teng, F; Tu, J; Zhang, C; Zhang, D | 1 |
| Chang, TP; Poltoratsky, V; Vancurova, I | 1 |
| Chang, TP; Sanacora, S; Urdinez, J; Vancurova, I | 1 |
| Chen, K; Chen, W; Jin, J; Li, D; Mao, W; Su, D; Wu, J; Ying, L; Yu, H; Zhang, F; Zhang, N | 1 |
1 trial(s) available for pyrazines and interleukin-8
| Article | Year |
|---|---|
Cotreatment with the α-glucosidase inhibitor miglitol and DPP-4 inhibitor sitagliptin improves glycemic control and reduces the expressions of CVD risk factors in type 2 diabetic Japanese patients.
Topics: 1-Deoxynojirimycin; Adult; Aged; Asian People; Biomarkers; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; E-Selectin; Female; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Incretins; Interleukin-8; Japan; Male; Middle Aged; Prospective Studies; Pyrazines; Risk Factors; Sitagliptin Phosphate; Triazoles; Vascular Cell Adhesion Molecule-1 | 2014 |
24 other study(ies) available for pyrazines and interleukin-8
| Article | Year |
|---|---|
Interleukin-8 and leukotriene-B(4), but not formylmethionyl leucylphenylalanine, stimulate CD18-independent migration of neutrophils across human pulmonary endothelial cells in vitro.
Topics: CD11 Antigens; CD18 Antigens; Cell Line; Cell Movement; Chemotactic Factors; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Humans; Hydroxamic Acids; Interleukin-8; L-Selectin; Leukotriene B4; Lung; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Permeability; Phenylalanine; Protease Inhibitors; Pyrazines; Sulfonamides; Thiophenes | 2000 |
Function of nuclear factor kappaB in pancreatic cancer metastasis.
Topics: Animals; Blotting, Northern; Blotting, Western; Boronic Acids; Bortezomib; Enzyme Inhibitors; Genes, Reporter; Humans; Immunohistochemistry; Interleukin-8; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; NF-kappa B; Pancreatic Neoplasms; Phenotype; Pyrazines; Retroviridae; Time Factors; Tumor Cells, Cultured | 2003 |
The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; CDC2-CDC28 Kinases; Cell Death; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Deoxycytidine; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Gemcitabine; Humans; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-8; Male; Matrix Metalloproteinase 9; Mice; Mice, Nude; Multienzyme Complexes; Neoplasm Transplantation; Neovascularization, Pathologic; Proteasome Endopeptidase Complex; Pyrazines; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms; Vascular Endothelial Growth Factor A | 2004 |
Combined proteasome and histone deacetylase inhibition in non-small cell lung cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Butyrates; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Survival; Cysteine Endopeptidases; Histone Deacetylases; Humans; Interleukin-8; Lung Neoplasms; Multienzyme Complexes; NF-kappa B; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Transcription, Genetic; Transcriptional Activation; Treatment Outcome; Tumor Cells, Cultured | 2004 |
Ligustrazine attenuates acute lung injury after burn trauma.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Capillary Permeability; Interleukin-8; Lung; Male; Models, Animal; Peroxidase; Pyrazines; Random Allocation; Rats; Rats, Wistar; Respiratory Distress Syndrome | 2005 |
Vesnarinone inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing the expression of vascular endothelial growth factor and interleukin-8.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Interleukin-8; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Neovascularization, Pathologic; NF-kappa B; Protein Binding; Pyrazines; Quinolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2005 |
Combination therapy with IFN-alpha plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Growth Processes; Fibroblast Growth Factor 2; Humans; Interferon-alpha; Interleukin-8; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Pyrazines; TNF-Related Apoptosis-Inducing Ligand; Urinary Bladder Neoplasms; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2006 |
Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-kappaB signaling pathways.
Topics: Base Sequence; Cell Adhesion; Cells, Cultured; Culture Media; DNA Primers; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Humans; Interleukin-8; Lipopolysaccharides; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; U937 Cells; Umbilical Veins | 2009 |
Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release.
Topics: Adult; Aged; Aged, 80 and over; Angiopoietin-1; Angiopoietin-2; Antibodies; Boronic Acids; Bortezomib; Cell Proliferation; Cells, Cultured; Coculture Techniques; Endothelial Cells; Female; Fibroblasts; Hepatocyte Growth Factor; Humans; Imidazoles; Interleukin-8; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplasm Proteins; Osteoblasts; Proteoglycans; Pyrazines; Quinoxalines; Receptor Cross-Talk; Receptor, TIE-2; Signal Transduction | 2010 |
Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-kappaB activity in myeloma cells.
Topics: Antineoplastic Agents; Bone Marrow Cells; Boronic Acids; Bortezomib; Humans; Interleukin-8; Multiple Myeloma; NF-kappa B; Pyrazines; Stromal Cells | 2010 |
Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Biomarkers; Boronic Acids; Bortezomib; Carcinoma, Squamous Cell; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression Profiling; Humans; Inflammation; Interleukin-8; Microarray Analysis; Mouth Neoplasms; NF-kappa B; Pyrazines; RNA, Small Interfering | 2010 |
Tetramethylpyrazine inhibits migration of SKOV3 human ovarian carcinoma cells and decreases the expression of interleukin-8 via the ERK1/2, p38 and AP-1 signaling pathways.
Topics: Antineoplastic Agents; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Coculture Techniques; Female; Genes, Reporter; Humans; Interleukin-8; Luciferases; Mitogen-Activated Protein Kinases; Monocytes; Ovarian Neoplasms; Phosphorylation; Pyrazines; Signal Transduction; Transcription Factor AP-1; Transcription, Genetic | 2011 |
Bortezomib reverses the proliferative and antiapoptotic effect of neuropeptides on prostate cancer cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-Associated Death Protein; Bombesin; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Endothelin-1; Humans; Interleukin-8; Male; Mitogen-Activated Protein Kinases; NF-kappa B; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Pyrazines; RNA, Messenger; Signal Transduction; Translocation, Genetic; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A | 2012 |
Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor-κB activity in human oral cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Female; Humans; I-kappa B Proteins; Interleukin-6; Interleukin-8; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Neoplasm Transplantation; Neovascularization, Pathologic; NF-kappa B; NF-KappaB Inhibitor alpha; Poly(ADP-ribose) Polymerases; Pyrazines; Radiation-Sensitizing Agents; Transcription Factor RelA; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2013 |
Proteasome inhibition by bortezomib increases IL-8 expression in androgen-independent prostate cancer cells: the role of IKKα.
Topics: Antineoplastic Agents; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Chromatin Immunoprecipitation; Enzyme-Linked Immunosorbent Assay; Humans; I-kappa B Kinase; Interleukin-8; Male; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Pyrazines; Real-Time Polymerase Chain Reaction; RNA, Small Interfering; Transfection | 2013 |
Long-term incubation with proteasome inhibitors (PIs) induces IκBα degradation via the lysosomal pathway in an IκB kinase (IKK)-dependent and IKK-independent manner.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Dipeptides; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; I-kappa B Kinase; I-kappa B Proteins; Interleukin-8; Ketones; Leupeptins; Lysosomes; Microtubule-Associated Proteins; Mutation, Missense; NF-kappa B; NF-KappaB Inhibitor alpha; Proteasome Inhibitors; Proteolysis; Pyrazines; Thiophenes; Time Factors | 2013 |
Proteasome inhibition increases recruitment of IκB kinase β (IKKβ), S536P-p65, and transcription factor EGR1 to interleukin-8 (IL-8) promoter, resulting in increased IL-8 production in ovarian cancer cells.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Nucleus; Chemokine CCL2; Chemokine CXCL5; Early Growth Response Protein 1; Female; Gene Expression Regulation, Leukemic; Humans; I-kappa B Kinase; Interleukin-8; Multiple Myeloma; Ovarian Neoplasms; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Transcription Factor RelA | 2014 |
Efficient bioactive delivery of aerosolized drugs to human pulmonary epithelial cells cultured in air-liquid interface conditions.
Topics: Administration, Inhalation; Aerosols; Anti-Inflammatory Agents; Blood-Air Barrier; Boronic Acids; Bortezomib; Cell Culture Techniques; Cell Line, Tumor; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Interleukin-8; Kinetics; Promoter Regions, Genetic; Proteasome Inhibitors; Pyrazines; Reproducibility of Results; Respiratory Mucosa; Transcriptional Activation; Tumor Necrosis Factor-alpha; Up-Regulation | 2014 |
Evaluating cytoplasmic and nuclear levels of inflammatory cytokines in cancer cells by western blotting.
Topics: Antineoplastic Agents; Blotting, Western; Boronic Acids; Bortezomib; Cell Fractionation; Cell Line, Tumor; Cell Nucleus; Complex Mixtures; Cytoplasm; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression; HMGB1 Protein; Humans; Interleukin-8; Male; Pyrazines | 2014 |
Quantitative analysis of bortezomib-induced IL-8 gene expression in ovarian cancer cells.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Female; Gene Expression; Humans; Interleukin-6; Interleukin-8; NF-kappa B; Pyrazines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2014 |
Ultrasound-enhanced protective effect of tetramethylpyrazine against cerebral ischemia/reperfusion injury.
Topics: Animals; bcl-2-Associated X Protein; Brain Ischemia; Glutamic Acid; High-Energy Shock Waves; Interleukin-8; Ligusticum; Medicine, Chinese Traditional; Microscopy, Electron, Scanning; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2014 |
Bortezomib inhibits expression of TGF-β1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells.
Topics: Antineoplastic Agents; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Movement; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Proteins; Interleukin-10; Interleukin-17; Interleukin-8; Lymphoma, T-Cell, Cutaneous; Models, Genetic; NF-kappa B; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Protein Binding; Pyrazines; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Skin Neoplasms; Transforming Growth Factor beta1 | 2015 |
Anticancer drug bortezomib increases interleukin-8 expression in human monocytes.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Humans; Interleukin-8; Macrophages; p38 Mitogen-Activated Protein Kinases; Pyrazines; Real-Time Polymerase Chain Reaction; U937 Cells | 2015 |
Overcoming Linsitinib intrinsic resistance through inhibition of nuclear factor-κB signaling in esophageal squamous cell carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Interleukin-6; Interleukin-8; NF-kappa B; Phenylenediamines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyrazines; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2017 |