pyrazines has been researched along with imidazole in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T | 1 |
| Fotsch, C; St Jean, DJ | 1 |
| Bonacin, JA; Rechenberg, HR; Souza, VR; Toma, HE | 1 |
| Baures, PW; DiCesare, JC; Solinas, R | 1 |
| Bouskela, E; Cordi, A; De Wael, F; Jeanjot, P; Marchand-Brynaert, J; Moens, C; Rees, JF; Verbeuren, T | 1 |
| Bittner, MA; Cooke, A; Dong, H; Foreman, K; Gokhale, PC; Ji, Q; Jin, M; Kleinberg, A; Landfair, D; Mak, G; Mulvihill, KM; Mulvihill, MJ; O'Connor, M; Pachter, JA; Rosenfeld-Franklin, M; Siu, KW; Wild, R; Yao, Y | 1 |
| Abbott, MP; Amaral, AT; Caramori, GF; Cavicchioli, M; de Rezende, L; Ferreira, AM; Fonseca, DE; Gonçalves, MB; Petrilli, HM; Silveira, VC | 1 |
| Drzewiecka-Matuszek, A; Mazur, G; Orzeł, Ł; Rutkowska-Zbik, D; Stochel, G | 1 |
| Deeb, O; Goodarzi, M; Pieters, S; Saeys, W; Vander Heyden, Y | 1 |
| Ferreira, PJO; Min, CG; Pinto da Silva, L | 1 |
| Alvarez-Ginarte, YM; Badel, YP; Bencomo-Martínez, A; Giorgetti, A; Guaitoli, V; Montero-Cabrera, LA; Suku, E | 1 |
| Aubé, J; Crawford, DM; Li, B; Li, K; Morgan, GL | 1 |
1 review(s) available for pyrazines and imidazole
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
11 other study(ies) available for pyrazines and imidazole
| Article | Year |
|---|---|
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase | 1981 |
Spectroscopic and electrochemical properties of iron(II) complexes of polydentate Schiff bases containing pyrazine, pyridine and imidazole groups.
Topics: Electrochemistry; Histidine; Imidazoles; Iron; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Conformation; Pyrazines; Pyridines; Schiff Bases; Solvents; Spectrophotometry; Spectrophotometry, Infrared; Spectroscopy, Mossbauer | 2008 |
Parallel synthesis of an imidazole-4,5-dicarboxamide library bearing amino acid esters and alkanamines.
Topics: Amines; Amino Acids; Aminoimidazole Carboxamide; Esters; Imidazoles; Pyrazines; Small Molecule Libraries | 2008 |
In vitro and in vivo studies of 6,8-(diaryl)imidazo[1,2-a]pyrazin-3(7H)-ones as new antioxidants.
Topics: Amines; Animals; Antioxidants; Capillary Permeability; Chromatography, High Pressure Liquid; Cricetinae; Imidazoles; Ischemia; Male; Oxidation-Reduction; Pyrazines; Reperfusion Injury | 2009 |
Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Imidazoles; Mice; Neoplasms; Protein Kinase Inhibitors; Pyrazines; Receptor, IGF Type 1; Structure-Activity Relationship; Transplantation, Heterologous | 2011 |
Peculiar reactivity of a di-imine copper(II) complex regarding its binding to albumin protein.
Topics: Animals; Cattle; Copper; Humans; Imidazoles; Imines; Ligands; Models, Molecular; Molecular Conformation; Organometallic Compounds; Protein Binding; Pyrazines; Pyridines; Reactive Oxygen Species; Serum Albumin | 2013 |
Exploring novel modified vitamin B12 as a drug carrier: forecast from density functional theory modeling.
Topics: Cisplatin; Cobalt; Coordination Complexes; Drug Carriers; Ethylenediamines; Imidazoles; Ligands; Models, Theoretical; Pyrazines; Vitamin B 12 | 2013 |
Particle swarm optimization and genetic algorithm as feature selection techniques for the QSAR modeling of imidazo[1,5-a]pyrido[3,2-e]pyrazines, inhibitors of phosphodiesterase 10A.
Topics: Algorithms; Humans; Imidazoles; Models, Molecular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Pyrazines; Pyridines; Quantitative Structure-Activity Relationship | 2013 |
Theoretically obtained insight into the mechanism and dioxetanone species responsible for the singlet chemiexcitation of Coelenterazine.
Topics: Amides; Electron Transport; Heterocyclic Compounds, 1-Ring; Imidazoles; Luminescence; Models, Chemical; Models, Molecular; Molecular Conformation; Pyrazines | 2017 |
A computational strategy to understand structure-activity relationship of 1,3-disubstituted imidazole [1,5-α] pyrazine derivatives described as ATP competitive inhibitors of the IGF-1 receptor related to Ewing sarcoma.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Binding Sites; Binding, Competitive; Cell Line; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Ligands; Mice; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Pyrazines; Quantitative Structure-Activity Relationship; Receptor, IGF Type 1; Reproducibility of Results | 2020 |
Enzymatic Synthesis of Diverse Heterocycles by a Noncanonical Nonribosomal Peptide Synthetase.
Topics: Aldehydes; Amino Acids; Biological Products; Carboxylic Acids; Cyclic N-Oxides; Dipeptides; Imidazoles; Peptide Synthases; Pseudomonas; Pyrazines; Virulence Factors | 2021 |