pyrazines has been researched along with glyburide in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (22.22) | 18.7374 |
| 1990's | 7 (25.93) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gwilt, M; Henderson, CG; Orme, J; Rourke, JD | 2 |
| Abbiati, R; Artini, D; Bloch, K; Daturi, S; Mandelli, V; Orsini, G; Parenti, MA | 1 |
| Marco, J; Valverde, I | 1 |
| De Baere, H; De Leeuw, I; Decraene, P; Lemmens, P; Verhaegen, H | 1 |
| Hsu, PL; Luzzi, LA; Ma, JK | 1 |
| Isaia, GC; Rizzi, G | 1 |
| Bommartini, F; Pedrazzi, F | 1 |
| Bonnet, PA; Boucard, M; Chapat, JP; Laurent, F; Michel, A | 1 |
| MacKenzie, I; Saville, VL; Waterfall, JF | 1 |
| Henderson, C; Kane, K; Tweedie, D | 1 |
| A-Rahim, YI; Beyer, KH; Vesell, ES | 1 |
| Advenier, C; Bakdach, H; Bonnet, PA; Cui, YY; Michel, A; Naline, E | 1 |
| Cheng, JT; Huang, WC; Lai, TY; Liu, IM; Tsai, CC | 1 |
| Bergman, AJ; Gottesdiener, KM; Herman, GA; Hreniuk, D; Mistry, GC; Ruddy, M; Wagner, JA; Zheng, W; Zinny, MA | 1 |
| Arnold Chan, K; Dore, DD; Seeger, JD | 1 |
| Chen, B; Ernsberger, P; Escobedo, LV; Hou, D; Koletsky, MS; Koletsky, RJ; Moore, A | 1 |
| Inouye, S; Kanamori, T; Kondo, C; Suzuki, T | 1 |
| Berman, S; Efrati, S; Golik, A; Hamad, RA; Koren, S; Peleg, RK; Shemesh-Bar, L; Tirosh, A; Vinker, S | 1 |
| Chen, M; Guo, Z; Hao, J; Houze, J; Lin, DC; Lopez, E; Luo, J; Ma, Z; Nguyen, K; Rulifson, IC; Tian, B; Tian, L; Tran, T; Wang, Y; Zhang, Y | 1 |
| Carbone, A; Cicero, AF; D'Angelo, A; Derosa, G; Fogari, E; Franzetti, IG; Maffioli, P; Piccinni, MN; Querci, F | 2 |
| Schütt, M; Steinhoff, J; Süfke, S | 1 |
| Kimura, H; Masuda, S; Sato, D; Sato, Y | 1 |
| Bruce, SS; Connolly, ES; Heyer, EJ; Mergeche, JL | 1 |
| Aragonés, A; del Val, F; López, J; Luque, A; Sastre, J | 1 |
4 trial(s) available for pyrazines and glyburide
| Article | Year |
|---|---|
Sitagliptin, an dipeptidyl peptidase-4 inhibitor, does not alter the pharmacokinetics of the sulphonylurea, glyburide, in healthy subjects.
Topics: Adult; Cross-Over Studies; Drug Interactions; Enzyme Inhibitors; Female; Glyburide; Humans; Hypoglycemic Agents; Male; Pyrazines; Sitagliptin Phosphate; Triazoles | 2008 |
The effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients.
Topics: Adolescent; Adult; Aged; Blood Glucose; Blood Pressure; C-Reactive Protein; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipids; Male; Metformin; Middle Aged; Prospective Studies; Pyrazines; Sitagliptin Phosphate; Triazoles; Vascular Stiffness; Young Adult | 2012 |
A comparison between sitagliptin or glibenclamide in addition to metformin + pioglitazone on glycaemic control and β-cell function: the triple oral therapy.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fasting; Female; Glucose Clamp Technique; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin-Secreting Cells; Male; Metformin; Pioglitazone; Pyrazines; Sitagliptin Phosphate; Thiazolidinediones; Triazoles | 2013 |
A randomized, double-blind, comparative therapy evaluating sitagliptin versus glibenclamide in type 2 diabetes patients already treated with pioglitazone and metformin: a 3-year study.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fasting; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Obesity; Pioglitazone; Pyrazines; Sitagliptin Phosphate; Thiazolidinediones; Treatment Outcome; Triazoles | 2013 |
23 other study(ies) available for pyrazines and glyburide
| Article | Year |
|---|---|
Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Myocardial Ischemia; Piperidines; Potassium; Potassium Channels; Pyrazines; Pyridines; Sympatholytics; Thiazoles; Ventricular Fibrillation | 1992 |
Pharmacodynamic aspects of two sulphonylurea derivatives glipizide and glibenclamide.
Topics: Administration, Oral; Animals; Blood Glucose; Cyclohexanes; Dogs; Glucose; Glyburide; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Pancreas; Pyrazines; Rats; Sulfonylurea Compounds | 1973 |
Unaltered glucagon secretion after seven days of sulphonylurea administration in normal subjects.
Topics: Administration, Oral; Arginine; Blood Glucose; Cyclohexanes; Drug Evaluation; Female; Glucagon; Glyburide; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Male; Methods; Pancreas; Pyrazines; Sulfonylurea Compounds | 1973 |
An open comparative study of the efficacy and tolerance of a new antidiabetic agent: glipizide.
Topics: Blood Glucose; Chlorpropamide; Cyclohexanes; Diabetes Mellitus; Diet, Diabetic; Female; Glyburide; Glycosuria; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Nausea; Phenformin; Pyrazines; Sulfonylurea Compounds | 1973 |
Interactions of sulfonylureas with plasma proteins.
Topics: Acetohexamide; Acridines; Aniline Compounds; Animals; Binding Sites; Blood Proteins; Cattle; Chlorpropamide; Cyclohexanes; Glyburide; Humans; Hypoglycemic Agents; Naphthalenesulfonates; Protein Binding; Pyrazines; Serum Albumin; Serum Albumin, Bovine; Spectrometry, Fluorescence; Sulfonylurea Compounds; Tolbutamide; Warfarin | 1974 |
[Changes in blood glucose and insulin in 4 normal subjects after administration of a single dose of glipizide and glibenclamide].
Topics: Administration, Oral; Blood Glucose; Cyclohexanes; Glyburide; Humans; Hypoglycemic Agents; Insulin; Pyrazines; Sulfonylurea Compounds | 1974 |
[Clinical evaluation of glidiazinamide].
Topics: Blood Glucose; Cyclohexanes; Diabetes Mellitus; Evaluation Studies as Topic; Glucose Tolerance Test; Glyburide; Humans; Hypoglycemic Agents; Pyrazines; Sulfonylurea Compounds | 1972 |
Evaluation of the relaxant effects of SCA40, a novel charybdotoxin-sensitive potassium channel opener, in guinea-pig isolated trachealis.
Topics: Animals; Carbachol; Charybdotoxin; Glyburide; Guinea Pigs; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Potassium Channels; Potassium Chloride; Pyrazines; Scorpion Venoms; Trachea | 1993 |
K(+)-channel blockers and coronary vasoconstriction in guinea-pig perfused hearts in-vitro.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Coronary Vessels; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Perfusion; Phentolamine; Potassium Channels; Pyrazines; Pyridines; Vasoconstriction | 1993 |
Differential class III and glibenclamide effects on action potential duration in guinea-pig papillary muscle during normoxia and hypoxia/ischaemia.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Glyburide; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Microelectrodes; Myocardial Ischemia; Papillary Muscles; Piperidines; Potassium Channels; Pyrazines; Pyridines; Sotalol | 1993 |
Glibenclamide, but not class III drugs, prevents ischaemic shortening of the refractory period in guinea-pig hearts.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Electrocardiography; Glyburide; Guinea Pigs; Heart; Male; Myocardial Ischemia; Phenethylamines; Phentolamine; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sulfonamides; Temperature | 1993 |
Studies on pyrazinoylguanidine. 2. Comparative drug and dose effects on glucose and lipid metabolism in streptozotocin-induced diabetic rats.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glyburide; Guanidines; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Metabolism; Male; Metformin; Pyrazinamide; Pyrazines; Rats; Rats, Sprague-Dawley; Streptozocin | 1996 |
Effects of SCA40 on human bronchi and on guinea pig main bronchi in vitro. Comparison with cromakalim.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Capsaicin; Charybdotoxin; Cromakalim; Electric Stimulation; Female; Glyburide; Guinea Pigs; Humans; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Nitroprusside; Osmolar Concentration; Parasympatholytics; Potassium Channel Blockers; Potassium Channels; Pyrazines; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds | 1996 |
Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro.
Topics: Animals; Aorta; Apamin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Humans; In Vitro Techniques; Male; Oxadiazoles; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyrazines; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Vasodilator Agents | 2002 |
Sitagliptin: new drug. Type 2 diabetes: limited efficacy, too many unknown risks.
Topics: Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Europe; Glipizide; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Pyrazines; Triazoles | 2008 |
Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide.
Topics: Adolescent; Adult; Databases, Factual; Exenatide; Female; Glyburide; Humans; Hypoglycemic Agents; Insurance, Health; Male; Metformin; Middle Aged; Pancreatitis; Peptides; Pyrazines; Risk Assessment; Safety; Sitagliptin Phosphate; Triazoles; United States; Venoms; Young Adult | 2009 |
Sitagliptin lowers glucagon and improves glucose tolerance in prediabetic obese SHROB rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles | 2011 |
Video rate bioluminescence imaging of secretory proteins in living cells: localization, secretory frequency, and quantification.
Topics: Animals; Copepoda; Glucose; Glyburide; Imidazoles; Insulin; Insulin Secretion; Insulin-Secreting Cells; Luciferases; Luminescent Measurements; Mice; Protein Precursors; Pyrazines; Recombinant Fusion Proteins; Video Recording | 2011 |
Evaluating insulin secretagogues in a humanized mouse model with functional human islets.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glyburide; Humans; Incretins; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Nude; Nateglinide; Peptides; Phenylalanine; Pyrazines; Sitagliptin Phosphate; Specific Pathogen-Free Organisms; Triazoles; Venoms | 2013 |
[Diabetes treatment in patients with chronic kidney disease].
Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Substitution; Drug Therapy, Combination; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Kidney Failure, Chronic; Kidney Function Tests; Male; Metformin; Pyrazines; Sitagliptin Phosphate; Triazoles | 2013 |
Effects of a sitagliptin safety alert on prescription behaviour for oral antihyperglycaemic drugs: a propensity score-matched cohort study of prescription receipt data in Japan.
Topics: Aged; Cohort Studies; Female; Gliclazide; Glyburide; Humans; Hypoglycemic Agents; Japan; Logistic Models; Male; Middle Aged; Patient Safety; Practice Patterns, Physicians'; Propensity Score; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Triazoles | 2013 |
Inflammation and cognitive dysfunction in type 2 diabetic carotid endarterectomy patients.
Topics: Aged; Cognition Disorders; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Glyburide; Humans; Hypoglycemic Agents; Inflammation; Logistic Models; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Triazoles | 2013 |
Long-term efficacy of glibenclamide and sitagliptin therapy in adult patients with KCNJ11 permanent diabetes.
Topics: Adolescent; Adult; Diabetes Mellitus; DNA; DNA Mutational Analysis; Female; Follow-Up Studies; Glucagon-Like Peptide 1; Glyburide; Humans; Hypoglycemic Agents; Mutation; Potassium Channels, Inwardly Rectifying; Pyrazines; Sitagliptin Phosphate; Time Factors; Triazoles | 2014 |