Compounds > pyrazines
Page last updated: 2024-08-21

pyrazines and geldanamycin

pyrazines has been researched along with geldanamycin in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (77.78)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bisht, KS; Gius, D; Isaacs, JS; Mimnaugh, EG; Neckers, L; Vos, M; Xu, W; Yuan, X1
Bai, J; Callery, MP; Demirjian, A; Marasco, W; Sui, J; Vollmer, CM1
Magnuson, NS; McKenzie, IF; Shay, KP; Wang, Z; Xing, PX1
Mimnaugh, EG; Neckers, LM1
Mimnaugh, EG; Neckers, L; Vos, M; Xu, W; Yuan, X1
Charalambous, A; Dhodapkar, MV; Jagannath, S; Mazumder, A; Spisek, R; Vesole, DH1
Almasan, A; Banerjee, AK; Fairchild, RL; Gasparian, AV; Gorbachev, AV; Gudkov, AV; Gurova, KV; Komarov, AP; Neznanov, N; Neznanova, L1
Benz, CC; Gibson, BW; Held, JM; Marx, C1
Chan, CT; Chiosis, G; Gambhir, SS; Geller, R; Hoehne, A; Massoud, TF; Paulmurugan, R; Reeves, RE; Solow-Cordero, DE; Yaghoubi, SS1

Other Studies

9 other study(ies) available for pyrazines and geldanamycin

ArticleYear
Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:5

    Topics: Antineoplastic Agents; Benzoquinones; Boronic Acids; Bortezomib; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Viral; Cycloheximide; Detergents; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteins; Pyrazines; Quinones; Repressor Proteins; Rifabutin; Solubility; Ubiquitins; Vacuoles

2004
Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro.
    Cancer research, 2005, Mar-15, Volume: 65, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Benzoquinones; Boronic Acids; Bortezomib; Cell Line, Tumor; Doxorubicin; Drug Synergism; Gene Expression Regulation, Neoplastic; Gene Silencing; HSP90 Heat-Shock Proteins; Humans; Hydroxamic Acids; Lactams, Macrocyclic; Membrane Glycoproteins; Pancreatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Quinones; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha

2005
Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway.
    Molecular cancer research : MCR, 2005, Volume: 3, Issue:3

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Benzoquinones; Boronic Acids; Bortezomib; Cell Line, Tumor; Electroporation; Flow Cytometry; Heat-Shock Proteins; Hot Temperature; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Immunoblotting; Immunoprecipitation; K562 Cells; Lactams, Macrocyclic; Mice; Mice, Transgenic; Proteasome Endopeptidase Complex; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Pyrazines; Quinones; Time Factors; Ubiquitin

2005
Measuring ubiquitin conjugation in cells.
    Methods in molecular biology (Clifton, N.J.), 2005, Volume: 301

    Topics: Benzoquinones; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Humans; Lactams, Macrocyclic; Protein Processing, Post-Translational; Pyrazines; Quinones; Ubiquitin

2005
Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade.
    Molecular cancer research : MCR, 2006, Volume: 4, Issue:9

    Topics: Adenosine Triphosphatases; Animals; Benzoquinones; Boronic Acids; Bortezomib; Cell Cycle Proteins; Chlorocebus aethiops; COS Cells; Endoplasmic Reticulum; Genes, erbB-2; HSP90 Heat-Shock Proteins; Lactams, Macrocyclic; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Transport; Pyrazines; RNA, Small Interfering; Tunicamycin; Ubiquitins; Vacuoles; Valosin Containing Protein

2006
Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications.
    Blood, 2007, Jun-01, Volume: 109, Issue:11

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzoquinones; Boronic Acids; Bortezomib; Cell Line, Tumor; Dendritic Cells; Gamma Rays; HSP90 Heat-Shock Proteins; Humans; Interferon-gamma; Lactams, Macrocyclic; Leukocytes, Mononuclear; Multiple Myeloma; Neoplasms; Proteasome Endopeptidase Complex; Pyrazines

2007
Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.
    Cell cycle (Georgetown, Tex.), 2009, Volume: 8, Issue:23

    Topics: Antimalarials; Antineoplastic Agents; Apoptosis; Benzoquinones; Boronic Acids; Bortezomib; DNA-Binding Proteins; Heat Shock Transcription Factors; Heat-Shock Response; HeLa Cells; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Neoplasms; Pyrazines; Quinacrine; RNA, Small Interfering; Transcription Factors

2009
ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination.
    Cancer research, 2010, May-01, Volume: 70, Issue:9

    Topics: Benzoquinones; Boronic Acids; Bortezomib; Breast Neoplasms; Cell Line, Tumor; Clathrin; Down-Regulation; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Lysosomes; Mass Spectrometry; Microscopy, Fluorescence; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Receptor, ErbB-2; Ubiquitination

2010
Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Sep-11, Volume: 109, Issue:37

    Topics: Acetamides; Animals; Benzoquinones; Blotting, Western; Cell Line, Tumor; Drug Discovery; High-Throughput Screening Assays; HSP90 Heat-Shock Proteins; Humans; Imidazoles; Immunoprecipitation; Intramolecular Oxidoreductases; Lactams, Macrocyclic; Lead; Luciferases, Firefly; Luciferases, Renilla; Mice; Mice, Nude; Neoplasms; Positron-Emission Tomography; Prostaglandin-E Synthases; Protein Folding; Protein Isoforms; Pyrazines; Small Molecule Libraries; Thioacetamide; Thiophenes; Tomography, X-Ray Computed; Tritium

2012