pyrazines has been researched along with epalrestat in 4 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kashima, K; Mori, M; Sato, K; Sato, N; Shimizu, H | 1 |
| Hotta, N | 1 |
| Kakehashi, A; Kinoshita, N; Matsumoto, T; Ota, A; Shimmura, M; Takano, H; Tanaka, Y; Toyoda, F; Tsuji, J | 1 |
| Ishibashi, Y; Kato, H; Matsui, T; Matsumoto, T; Yamagishi, S | 1 |
1 review(s) available for pyrazines and epalrestat
| Article | Year |
|---|---|
[Progress on the drug therapy for diabetic microangiopathies: aldose reductase inhibitor].
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetic Angiopathies; Drug Design; Humans; Imidazolidines; Polymers; Polymorphism, Genetic; Pyrazines; Rhodanine; Spiro Compounds; Thiazolidines | 2005 |
3 other study(ies) available for pyrazines and epalrestat
| Article | Year |
|---|---|
Effect of epalrestat, an aldose reductase inhibitor, on the generation of oxygen-derived free radicals in neutrophils from streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Luminescent Measurements; Luminol; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pyrazines; Rats; Rats, Wistar; Reactive Oxygen Species; Rhodanine; Superoxides; Thiazolidines | 1998 |
Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetic Retinopathy; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Glycated Hemoglobin; Male; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Retina; Rhodanine; Spiro Compounds; Thiazolidines; Time Factors | 2014 |
Ranirestat has a stronger inhibitory activity on aldose reductase and suppresses inflammatory reactions in high glucose-exposed endothelial cells.
Topics: Aldehyde Reductase; Anti-Inflammatory Agents; Cell Line, Tumor; Chromatography, Liquid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Inflammation Mediators; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Rhodanine; Sorbitol; Spiro Compounds; Superoxides; Tandem Mass Spectrometry; Thiazolidines; Vascular Cell Adhesion Molecule-1 | 2016 |