Page last updated: 2024-08-21

pyrazines and endothelin-1

pyrazines has been researched along with endothelin-1 in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (21.74)18.2507
2000's10 (43.48)29.6817
2010's7 (30.43)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Jing, Z; Pu, Z; Zeng, Z; Zhu, W; Zuo, W1
Chen, X; Demura, H; Jin, Z; Liu, H; Naruse, M; Pan, J; Shi, Y; Zeng, Z; Zhou, X; Zhu, W1
Cao, W; Demura, H; Luo, W; Naruse, M; Shi, Y; Zeng, Z; Zhu, YJ1
Bialecki, R; Heys, C; Hunt, SJ; James, R; Kelly, E; Mellor, S; Palmer, S; Tang, E; Wilson, C; Wright, N1
Abbott, BM; Barthlow, HG; Bialecki, RA; Caccese, RG; Fisher, CS; Rumsey, J; Rumsey, W; Stow, RB1
Adams, MA; Bennett, BM; Fraser, AB; Ratz, JD; Rees-Milton, KJ1
Chen, S; Wang, L; Xu, Z1
Li, Y; Shi, J; Sun, L; Wang, X1
Lin, CL; Xu, YJ; Zhang, ZX1
Bai, M; Jiang, AH; Ma, KL; Wang, QM; Wang, YJ1
Bi, WF; Chang, NC; Chen, CH; Chen, JJ; Cheng, TH; Chiu, HC; Lian, WS; Lin, H; Liu, JC; Shih, CM; Wang, TC; Yang, HY1
Chan, P; Chen, CH; Cheng, TH; Kao, PF; Lee, WS; Liu, JC; Yang, HY1
Chen, DZ; Chen, SY; Gao, DF; Hao, GH; Niu, XL; Wang, WQ; Wei, J; Zhu, XL; Zhu, XX1
Banu, E; Beuzeboc, P; Guyader, C; Medioni, J; Oudard, S; Scotte, F1
Cheng, TH; Chou, YH; Hong, HJ; Wong, KL; Wu, KC; Wu, RS1
Guo, RL; He, KW; Hu, YY1
Cheng, Y; Sun, J; Wang, H; Yang, C; Zhang, S1
Befani, CD; Daliani, DD; Hatzidaki, E; Liakos, P; Moutzouris, G; Papandreou, CN; Patrikidou, A; Tsapakidis, K; Vlachostergios, PJ; Voutsadakis, IA1
Morrell, N; Sitbon, O1
Feng, EZ; Huang, NX; Tian, ZX; Yang, SY; Yin, H; Zhang, Y1
Fan, YX; Feng, GK; Jiang, J; Li, H; Ma, Z; Shi, W; Yang, X; Yin, YL1
Araya, EI; Chichorro, JG; Dos Reis, RC; Kopruszinski, CM; Nones, CFM; Oliveira, LL; Rae, GA; Souza, RF1
Deng, F; Fang, S; Zhang, B; Zhang, Y1

Reviews

2 review(s) available for pyrazines and endothelin-1

ArticleYear
[New targeted therapies in hormone-refractory prostate cancer].
    Bulletin du cancer, 2007, Volume: 94, Issue:7 Suppl

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antineoplastic Agents; Boronic Acids; Bortezomib; Calcitriol; Cancer Vaccines; Diphosphonates; Docetaxel; Drug Resistance, Neoplasm; Endothelin-1; Epothilones; Humans; Male; Oligonucleotides, Antisense; Organoplatinum Compounds; Prostatic Neoplasms; Protease Inhibitors; Protein Kinase Inhibitors; Pyrazines; Taxoids

2007
Pathways in pulmonary arterial hypertension: the future is here.
    European respiratory review : an official journal of the European Respiratory Society, 2012, Dec-01, Volume: 21, Issue:126

    Topics: Acetamides; Animals; Antihypertensive Agents; Benzamides; Clinical Trials as Topic; Drugs, Investigational; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Epoprostenol; Guanylate Cyclase; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Lisuride; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Piperazines; Protein Kinase Inhibitors; Pyrazines; Pyrazoles; Pyrimidines; Serotonin Antagonists; Sulfonamides

2012

Trials

1 trial(s) available for pyrazines and endothelin-1

ArticleYear
Plasma endothelin-1 and nitric oxide correlate with ligustrazine alleviation of pulmonary artery hypertension in patients of chronic cor pulmonale from high altitude plateau during acute exacerbation.
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2014, Volume: 30, Issue:6

    Topics: Altitude; Blood Gas Analysis; Chronic Disease; Endothelin-1; Humans; Hypertension, Pulmonary; Nitric Oxide; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pyrazines; Respiration

2014

Other Studies

20 other study(ies) available for pyrazines and endothelin-1

ArticleYear
[Effect of tetramethyl pyrazine on coronary vasoconstriction induced by endothelin-1 in dogs].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1996, Volume: 18, Issue:2

    Topics: Animals; Coronary Angiography; Coronary Vessels; Dogs; Endothelin-1; Heart Rate; Male; Myocardial Ischemia; Pyrazines; Vasoconstriction; Vasodilator Agents

1996
Tetramethylpyrazine, a Chinese drug, blocks coronary vasoconstriction by endothelin-1 and decreases plasma endothelin-1 levels in experimental animals.
    Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1

    Topics: 6-Ketoprostaglandin F1 alpha; Angiography; Animals; Coronary Vessels; Dogs; Drugs, Chinese Herbal; Electrocardiography; Endothelin-1; Male; Pyrazines; Rabbits; Vasoconstriction; Vasodilator Agents

1998
Effects of tetramethylpyrazine, a Chinese medicine, on plasma endothelin-1 levels during acute pulmonary hypoxia in anesthetized dogs.
    Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1

    Topics: Anesthesia, General; Animals; Blood Pressure; Dogs; Drugs, Chinese Herbal; Endothelin-1; Hemodynamics; Hypoxia; Lung Diseases; Pulmonary Alveoli; Pulmonary Circulation; Pyrazines; Vascular Resistance; Vasodilator Agents

1998
Pharmacological profile of ZD1611, a novel, orally active endothelin ETA receptor antagonist.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3

    Topics: Administration, Oral; Animals; Aorta; Binding, Competitive; Dogs; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Female; Humans; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Male; Mice; Peptide Fragments; Pyrazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides

1999
ZD1611, an orally active endothelin-A receptor antagonist, prevents chronic hypoxia-induced pulmonary hypertension in the rat.
    Pulmonary pharmacology & therapeutics, 1999, Volume: 12, Issue:5

    Topics: Anesthesia; Animals; Blood Gas Analysis; Blood Pressure; Endothelin Receptor Antagonists; Endothelin-1; Hematocrit; Hypertension, Pulmonary; Hypoxia; Isometric Contraction; Male; Muscle, Smooth, Vascular; Organ Size; Pulmonary Artery; Pulmonary Circulation; Pyrazines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sulfonamides; Ventricular Function, Right

1999
Endothelin receptor antagonism does not prevent the development of in vivo glyceryl trinitrate tolerance in the rat.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2

    Topics: Animals; Aorta, Thoracic; Binding, Competitive; Biotransformation; Blood Pressure; Cyclic GMP; Drug Tolerance; Endothelin Receptor Antagonists; Endothelin-1; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Nitroglycerin; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Sulfonamides; Vasodilator Agents

2000
[Effect of hypoxic hypercapnia on expression of endothelin-1 mRNA of pulmonary arterioles in rats].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2000, Volume: 23, Issue:10

    Topics: Animals; Arterioles; Endothelin-1; Hypercapnia; Hypoxia; Male; Pulmonary Artery; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger

2000
Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.
    Microsurgery, 2002, Volume: 22, Issue:8

    Topics: Animals; Disease Models, Animal; Endothelin-1; Free Radical Scavengers; Kidney; Kidney Diseases; Malondialdehyde; Pyrazines; Random Allocation; Rats; Rats, Wistar; Renal Artery; Reperfusion Injury; Superoxide Dismutase

2002
[Therapeutic mechanism of combination therapy of ligustrazine and nitrendipine in treating patients with chronic obstructive pulmonary disease].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2001, Volume: 21, Issue:1

    Topics: Aged; Drug Therapy, Combination; Endothelin-1; Female; Humans; Male; Middle Aged; Nitrendipine; P-Selectin; Pulmonary Disease, Chronic Obstructive; Pyrazines; Thromboxane B2; Vasodilator Agents

2001
[Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2003, Volume: 28, Issue:12

    Topics: Animals; Brain Ischemia; Endothelin-1; Female; Infarction, Middle Cerebral Artery; Insulin; Insulin Resistance; Male; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2003
Inhibition of cyclic strain-induced endothelin-1 secretion by tetramethylpyrazine.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:7

    Topics: Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelin-1; Endothelium, Vascular; Humans; Ligusticum; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Pyrazines; Reactive Oxygen Species; Transcription Factor AP-1

2005
Tetramethylpyrazine downregulates angiotensin II-induced endothelin-1 gene expression in vascular endothelial cells.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:10

    Topics: Angiotensin II; Antioxidants; Blotting, Northern; Blotting, Western; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Down-Regulation; Endothelial Cells; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Phosphorylation; Promoter Regions, Genetic; Pyrazines; Reactive Oxygen Species; Recombinant Fusion Proteins; RNA, Messenger; Superoxides; Transfection

2005
[Relationship between cardiomyocyte protein synthesis and cell viability].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2007, Volume: 27, Issue:6

    Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Endothelin-1; Myocytes, Cardiac; Protein Biosynthesis; Pyrazines; Rats; Rats, Sprague-Dawley

2007
Tetramethylpyrazine inhibits angiotensin II-increased NAD(P)H oxidase activity and subsequent proliferation in rat aortic smooth muscle cells.
    The American journal of Chinese medicine, 2007, Volume: 35, Issue:6

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Cell Proliferation; Cells, Cultured; DNA; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Male; Muscle, Smooth, Vascular; NADPH Oxidases; Pyrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Vasodilator Agents

2007
Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.
    Immunological investigations, 2012, Volume: 41, Issue:3

    Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Benzylisoquinolines; Cells, Cultured; Down-Regulation; Drugs, Chinese Herbal; E-Selectin; Endothelin-1; Endothelium, Vascular; Evodia; Humans; Interleukin-1alpha; Lipopolysaccharides; Morphinans; Proline; Pyrazines; Quinazolines; Quinolizines; Swine; Thromboxane B2

2012
Neuroprotective effects of NKN on focal cerebral ischemia in rats.
    Turkish neurosurgery, 2012, Volume: 22, Issue:1

    Topics: Abietanes; Acetophenones; Animals; Benzoates; Brain Ischemia; Bridged-Ring Compounds; Drug Combinations; Endothelin-1; Glucosides; Immunohistochemistry; In Situ Hybridization; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Neurologic Examination; Neurons; Neuroprotective Agents; Pyrazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stroke; Superoxide Dismutase

2012
Bortezomib reverses the proliferative and antiapoptotic effect of neuropeptides on prostate cancer cells.
    International journal of urology : official journal of the Japanese Urological Association, 2012, Volume: 19, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; bcl-Associated Death Protein; Bombesin; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Endothelin-1; Humans; Interleukin-8; Male; Mitogen-Activated Protein Kinases; NF-kappa B; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Pyrazines; RNA, Messenger; Signal Transduction; Translocation, Genetic; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A

2012
Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy.
    Biomedical and environmental sciences : BES, 2015, Volume: 28, Issue:9

    Topics: Alcohol-Induced Disorders, Nervous System; Animals; Cerebrovascular Circulation; Disease Models, Animal; Endothelin-1; Learning; Male; Memory; Pyrazines; Random Allocation; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A; Vasodilator Agents

2015
Mechanisms involved in facial heat hyperalgesia induced by endothelin-1 in female rats.
    Archives of oral biology, 2017, Volume: 83

    Topics: Animals; Carbazoles; Diterpenes; Endothelin-1; Face; Female; Hot Temperature; Hyperalgesia; Indole Alkaloids; Nerve Growth Factor; Oligopeptides; Peptides, Cyclic; Piperidines; Pyrazines; Pyridines; Rats; Rats, Wistar; Trigeminal Ganglion

2017
Ligustrazine prevents basilar artery remodeling in two-kidney-two-clip renovascular hypertension rats via suppressing PI3K/Akt signaling.
    Microvascular research, 2020, Volume: 128

    Topics: Angiotensin II; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelin-1; Hypertension, Renovascular; Ligation; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pyrazines; Rats, Sprague-Dawley; Renal Artery; Signal Transduction; Temporal Arteries; Vascular Remodeling

2020