pyrazines has been researched along with endothelin-1 in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Jing, Z; Pu, Z; Zeng, Z; Zhu, W; Zuo, W | 1 |
| Chen, X; Demura, H; Jin, Z; Liu, H; Naruse, M; Pan, J; Shi, Y; Zeng, Z; Zhou, X; Zhu, W | 1 |
| Cao, W; Demura, H; Luo, W; Naruse, M; Shi, Y; Zeng, Z; Zhu, YJ | 1 |
| Bialecki, R; Heys, C; Hunt, SJ; James, R; Kelly, E; Mellor, S; Palmer, S; Tang, E; Wilson, C; Wright, N | 1 |
| Abbott, BM; Barthlow, HG; Bialecki, RA; Caccese, RG; Fisher, CS; Rumsey, J; Rumsey, W; Stow, RB | 1 |
| Adams, MA; Bennett, BM; Fraser, AB; Ratz, JD; Rees-Milton, KJ | 1 |
| Chen, S; Wang, L; Xu, Z | 1 |
| Li, Y; Shi, J; Sun, L; Wang, X | 1 |
| Lin, CL; Xu, YJ; Zhang, ZX | 1 |
| Bai, M; Jiang, AH; Ma, KL; Wang, QM; Wang, YJ | 1 |
| Bi, WF; Chang, NC; Chen, CH; Chen, JJ; Cheng, TH; Chiu, HC; Lian, WS; Lin, H; Liu, JC; Shih, CM; Wang, TC; Yang, HY | 1 |
| Chan, P; Chen, CH; Cheng, TH; Kao, PF; Lee, WS; Liu, JC; Yang, HY | 1 |
| Chen, DZ; Chen, SY; Gao, DF; Hao, GH; Niu, XL; Wang, WQ; Wei, J; Zhu, XL; Zhu, XX | 1 |
| Banu, E; Beuzeboc, P; Guyader, C; Medioni, J; Oudard, S; Scotte, F | 1 |
| Cheng, TH; Chou, YH; Hong, HJ; Wong, KL; Wu, KC; Wu, RS | 1 |
| Guo, RL; He, KW; Hu, YY | 1 |
| Cheng, Y; Sun, J; Wang, H; Yang, C; Zhang, S | 1 |
| Befani, CD; Daliani, DD; Hatzidaki, E; Liakos, P; Moutzouris, G; Papandreou, CN; Patrikidou, A; Tsapakidis, K; Vlachostergios, PJ; Voutsadakis, IA | 1 |
| Morrell, N; Sitbon, O | 1 |
| Feng, EZ; Huang, NX; Tian, ZX; Yang, SY; Yin, H; Zhang, Y | 1 |
| Fan, YX; Feng, GK; Jiang, J; Li, H; Ma, Z; Shi, W; Yang, X; Yin, YL | 1 |
| Araya, EI; Chichorro, JG; Dos Reis, RC; Kopruszinski, CM; Nones, CFM; Oliveira, LL; Rae, GA; Souza, RF | 1 |
| Deng, F; Fang, S; Zhang, B; Zhang, Y | 1 |
2 review(s) available for pyrazines and endothelin-1
| Article | Year |
|---|---|
[New targeted therapies in hormone-refractory prostate cancer].
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antineoplastic Agents; Boronic Acids; Bortezomib; Calcitriol; Cancer Vaccines; Diphosphonates; Docetaxel; Drug Resistance, Neoplasm; Endothelin-1; Epothilones; Humans; Male; Oligonucleotides, Antisense; Organoplatinum Compounds; Prostatic Neoplasms; Protease Inhibitors; Protein Kinase Inhibitors; Pyrazines; Taxoids | 2007 |
Pathways in pulmonary arterial hypertension: the future is here.
Topics: Acetamides; Animals; Antihypertensive Agents; Benzamides; Clinical Trials as Topic; Drugs, Investigational; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Epoprostenol; Guanylate Cyclase; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Lisuride; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Piperazines; Protein Kinase Inhibitors; Pyrazines; Pyrazoles; Pyrimidines; Serotonin Antagonists; Sulfonamides | 2012 |
1 trial(s) available for pyrazines and endothelin-1
| Article | Year |
|---|---|
Plasma endothelin-1 and nitric oxide correlate with ligustrazine alleviation of pulmonary artery hypertension in patients of chronic cor pulmonale from high altitude plateau during acute exacerbation.
Topics: Altitude; Blood Gas Analysis; Chronic Disease; Endothelin-1; Humans; Hypertension, Pulmonary; Nitric Oxide; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pyrazines; Respiration | 2014 |
20 other study(ies) available for pyrazines and endothelin-1
| Article | Year |
|---|---|
[Effect of tetramethyl pyrazine on coronary vasoconstriction induced by endothelin-1 in dogs].
Topics: Animals; Coronary Angiography; Coronary Vessels; Dogs; Endothelin-1; Heart Rate; Male; Myocardial Ischemia; Pyrazines; Vasoconstriction; Vasodilator Agents | 1996 |
Tetramethylpyrazine, a Chinese drug, blocks coronary vasoconstriction by endothelin-1 and decreases plasma endothelin-1 levels in experimental animals.
Topics: 6-Ketoprostaglandin F1 alpha; Angiography; Animals; Coronary Vessels; Dogs; Drugs, Chinese Herbal; Electrocardiography; Endothelin-1; Male; Pyrazines; Rabbits; Vasoconstriction; Vasodilator Agents | 1998 |
Effects of tetramethylpyrazine, a Chinese medicine, on plasma endothelin-1 levels during acute pulmonary hypoxia in anesthetized dogs.
Topics: Anesthesia, General; Animals; Blood Pressure; Dogs; Drugs, Chinese Herbal; Endothelin-1; Hemodynamics; Hypoxia; Lung Diseases; Pulmonary Alveoli; Pulmonary Circulation; Pyrazines; Vascular Resistance; Vasodilator Agents | 1998 |
Pharmacological profile of ZD1611, a novel, orally active endothelin ETA receptor antagonist.
Topics: Administration, Oral; Animals; Aorta; Binding, Competitive; Dogs; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Female; Humans; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Male; Mice; Peptide Fragments; Pyrazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides | 1999 |
ZD1611, an orally active endothelin-A receptor antagonist, prevents chronic hypoxia-induced pulmonary hypertension in the rat.
Topics: Anesthesia; Animals; Blood Gas Analysis; Blood Pressure; Endothelin Receptor Antagonists; Endothelin-1; Hematocrit; Hypertension, Pulmonary; Hypoxia; Isometric Contraction; Male; Muscle, Smooth, Vascular; Organ Size; Pulmonary Artery; Pulmonary Circulation; Pyrazines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sulfonamides; Ventricular Function, Right | 1999 |
Endothelin receptor antagonism does not prevent the development of in vivo glyceryl trinitrate tolerance in the rat.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Biotransformation; Blood Pressure; Cyclic GMP; Drug Tolerance; Endothelin Receptor Antagonists; Endothelin-1; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Nitroglycerin; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Sulfonamides; Vasodilator Agents | 2000 |
[Effect of hypoxic hypercapnia on expression of endothelin-1 mRNA of pulmonary arterioles in rats].
Topics: Animals; Arterioles; Endothelin-1; Hypercapnia; Hypoxia; Male; Pulmonary Artery; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2000 |
Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.
Topics: Animals; Disease Models, Animal; Endothelin-1; Free Radical Scavengers; Kidney; Kidney Diseases; Malondialdehyde; Pyrazines; Random Allocation; Rats; Rats, Wistar; Renal Artery; Reperfusion Injury; Superoxide Dismutase | 2002 |
[Therapeutic mechanism of combination therapy of ligustrazine and nitrendipine in treating patients with chronic obstructive pulmonary disease].
Topics: Aged; Drug Therapy, Combination; Endothelin-1; Female; Humans; Male; Middle Aged; Nitrendipine; P-Selectin; Pulmonary Disease, Chronic Obstructive; Pyrazines; Thromboxane B2; Vasodilator Agents | 2001 |
[Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat].
Topics: Animals; Brain Ischemia; Endothelin-1; Female; Infarction, Middle Cerebral Artery; Insulin; Insulin Resistance; Male; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2003 |
Inhibition of cyclic strain-induced endothelin-1 secretion by tetramethylpyrazine.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelin-1; Endothelium, Vascular; Humans; Ligusticum; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Pyrazines; Reactive Oxygen Species; Transcription Factor AP-1 | 2005 |
Tetramethylpyrazine downregulates angiotensin II-induced endothelin-1 gene expression in vascular endothelial cells.
Topics: Angiotensin II; Antioxidants; Blotting, Northern; Blotting, Western; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Down-Regulation; Endothelial Cells; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Phosphorylation; Promoter Regions, Genetic; Pyrazines; Reactive Oxygen Species; Recombinant Fusion Proteins; RNA, Messenger; Superoxides; Transfection | 2005 |
[Relationship between cardiomyocyte protein synthesis and cell viability].
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Endothelin-1; Myocytes, Cardiac; Protein Biosynthesis; Pyrazines; Rats; Rats, Sprague-Dawley | 2007 |
Tetramethylpyrazine inhibits angiotensin II-increased NAD(P)H oxidase activity and subsequent proliferation in rat aortic smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Cell Proliferation; Cells, Cultured; DNA; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Male; Muscle, Smooth, Vascular; NADPH Oxidases; Pyrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Vasodilator Agents | 2007 |
Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Benzylisoquinolines; Cells, Cultured; Down-Regulation; Drugs, Chinese Herbal; E-Selectin; Endothelin-1; Endothelium, Vascular; Evodia; Humans; Interleukin-1alpha; Lipopolysaccharides; Morphinans; Proline; Pyrazines; Quinazolines; Quinolizines; Swine; Thromboxane B2 | 2012 |
Neuroprotective effects of NKN on focal cerebral ischemia in rats.
Topics: Abietanes; Acetophenones; Animals; Benzoates; Brain Ischemia; Bridged-Ring Compounds; Drug Combinations; Endothelin-1; Glucosides; Immunohistochemistry; In Situ Hybridization; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Neurologic Examination; Neurons; Neuroprotective Agents; Pyrazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stroke; Superoxide Dismutase | 2012 |
Bortezomib reverses the proliferative and antiapoptotic effect of neuropeptides on prostate cancer cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-Associated Death Protein; Bombesin; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Endothelin-1; Humans; Interleukin-8; Male; Mitogen-Activated Protein Kinases; NF-kappa B; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Pyrazines; RNA, Messenger; Signal Transduction; Translocation, Genetic; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A | 2012 |
Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Cerebrovascular Circulation; Disease Models, Animal; Endothelin-1; Learning; Male; Memory; Pyrazines; Random Allocation; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A; Vasodilator Agents | 2015 |
Mechanisms involved in facial heat hyperalgesia induced by endothelin-1 in female rats.
Topics: Animals; Carbazoles; Diterpenes; Endothelin-1; Face; Female; Hot Temperature; Hyperalgesia; Indole Alkaloids; Nerve Growth Factor; Oligopeptides; Peptides, Cyclic; Piperidines; Pyrazines; Pyridines; Rats; Rats, Wistar; Trigeminal Ganglion | 2017 |
Ligustrazine prevents basilar artery remodeling in two-kidney-two-clip renovascular hypertension rats via suppressing PI3K/Akt signaling.
Topics: Angiotensin II; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelin-1; Hypertension, Renovascular; Ligation; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pyrazines; Rats, Sprague-Dawley; Renal Artery; Signal Transduction; Temporal Arteries; Vascular Remodeling | 2020 |