pyrazines has been researched along with cyclic gmp in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.68) | 18.7374 |
| 1990's | 13 (41.94) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 9 (29.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burns, F; Pyne, NJ | 1 |
| Lugnier, C; Muller, B; Stoclet, JC | 1 |
| Barnette, MS; Barone, FC; Fowler, PJ; Grous, M; Ormsbee, HS; Price, WJ | 1 |
| Barnes, PJ; Rhoden, KJ | 1 |
| Diocee, BK; Martin, W; Moodie, SA; Souness, JE | 1 |
| Bryson, SE; Rodger, IW | 1 |
| Chiou, WF; Wu, CC; Yen, MH | 1 |
| Beavo, JA; Harrison, SA; Lathrop, DA; Rapundalo, ST; Schwartz, A | 1 |
| Li, YJ; Wu, JX; Yan, YF; Yu, XJ | 1 |
| Eckly, AE; Lugnier, C | 1 |
| Arnal, F; Hill, NS; Klinger, JR; Petit, RD; Warburton, RR; Wrenn, DS | 1 |
| Ito, M; Konishi, T; Kozeki, H; Masuoka, H; Nakano, T; Sugioka, M; Tanaka, T | 1 |
| Matsumori, A; Nose, Y; Ono, K; Sasayama, S; Sato, Y; Shioi, T | 1 |
| Bonnet, PA; Chevillard, C; Michel, A; Vittet, D; Zurbonsen, K | 1 |
| Eckly-Michel, A; Lugnier, C; Martin, V | 1 |
| Kang, KW; Kim, ND; Kim, SG; Schini-Kerth, VB | 1 |
| Hung, WC; Kan, YC; Lin, CH; Sheu, JR; Yen, MH | 1 |
| Adams, MA; Bennett, BM; Fraser, AB; Ratz, JD; Rees-Milton, KJ | 1 |
| Luo, R; Yan, F | 1 |
| Chen, J; Chen, Z; Fan, L; Liu, J; Wang, T; Xiao, H; Ye, Z; Yin, C | 1 |
| Huang, WC; Lai, TY; Liou, SS; Liu, IM; Tsai, CC | 1 |
| Acker, BA; Benson, AG; Blevis-Bal, RM; Bond, BR; Brown, DL; Cubbage, JW; Fobian, YM; Freskos, JN; Heasley, SE; Hughes, RO; Jacobsen, EJ; Macinnes, A; Maddux, TM; Mischke, BV; Molyneaux, JM; Moon, JB; Owen, DR; Rogier, DJ; Rumsey, JM; Stallings, WC; Tollefson, MB; Walker, JK; Williams, JM; Yu, Y; Zheng, Y | 1 |
| Gao, C; Li, J; Liu, X; Shao, Z; Sun, Z; Zhao, Z | 1 |
| Brandon, NJ; Brennan, J; Egerland, U; Erdei, J; Fan, KY; Graf, R; Grauer, S; Grunwald, C; Hage, T; Harrison, BL; Hoefgen, N; Kronbach, T; Langen, B; Lankau, HJ; Malamas, MS; Marquis, KL; Navarra, R; Ni, Y; Pangalos, MN; Parris, K; Robichaud, A; Schindler, R; Stange, H | 1 |
| Baerts, L; De Keulenaer, GW; De Meester, I; Demolder, M; Hamdani, N; Hervent, AS; Linke, WA; Matheeussen, V; Paulus, WJ; Vandekerckhove, L | 1 |
| Gui, C; Huang, K; Huang, Q; Huang, X; Wei, B; Yu, L | 1 |
| Duan, H; Li, N; Liu, H; Pu, F; Xiao, S; Zhang, A; Zhang, G; Zhao, L; Zhou, EM | 1 |
| Ashizawa, T; Hoffman, ID; Imada, H; Iwashita, H; Kamiguchi, N; Kawasaki, M; Kokubo, H; Mikami, S; Nakamura, S; Nakashima, K; Nomura, I; Oki, H; Sasaki, S; Suzuki, N; Taniguchi, T; Uchiyama, N; Zou, H | 1 |
| Ashigai, H; Ikeshima, E; Koizumi, K; Mizutani, M; Nakashima, K; Yajima, H | 1 |
| Deng, H; Luo, J; Shan, L; Wang, Y; Xu, B; Zhang, G; Zhang, X; Zhang, Z | 1 |
| Iwashita, H; Nakashima, M; Shiraishi, E; Suzuki, N | 1 |
1 review(s) available for pyrazines and cyclic gmp
| Article | Year |
|---|---|
[Effects of ligustrazine on blood vessels and blood components].
Topics: Animals; Calcium Channel Blockers; Cell Division; Cyclic GMP; Endothelins; Fibrinolytic Agents; Humans; Microcirculation; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Platelet Aggregation Inhibitors; Pyrazines; Vasoconstriction; Vasodilator Agents | 2002 |
30 other study(ies) available for pyrazines and cyclic gmp
| Article | Year |
|---|---|
Interaction of the catalytic subunit of protein kinase A with the lung type V cyclic GMP phosphodiesterase: modulation of non-catalytic binding sites.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaline Phosphatase; Animals; Cyclic GMP; Enzyme Activation; Guinea Pigs; Isoenzymes; Kinetics; Lung; Macromolecular Substances; Protein Kinases; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1992 |
Implication of cyclic AMP in the positive inotropic effects of cyclic GMP-inhibited cyclic AMP phosphodiesterase inhibitors on guinea pig isolated left atria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Chloride; Cardiotonic Agents; Colforsin; Cyclic AMP; Cyclic GMP; Guinea Pigs; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Protoveratrines; Pyrazines; Pyridones; Sodium | 1990 |
Human lower oesophageal sphincter relaxation is associated with raised cyclic nucleotide content.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cyclic AMP; Cyclic GMP; Electric Stimulation; Esophagogastric Junction; Humans; In Vitro Techniques; Muscle Relaxation; Nitroprusside; Nucleotides, Cyclic; Purinones; Pyrazines; Tetrodotoxin | 1991 |
Potentiation of nonadrenergic neural relaxation in guinea pig airways by a cyclic cAMP phosphodiesterase inhibitor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Ethylmaleimide; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Nitroprusside; Potassium Chloride; Pyrazines; Tetrodotoxin; Trachea; Vasoactive Intestinal Peptide | 1990 |
Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Calcium; Cells, Cultured; Chromatography, Ion Exchange; Colforsin; Cyclic AMP; Cyclic GMP; Dipyridamole; Endothelium, Vascular; Isoquinolines; Kinetics; Purinones; Pyrazines; Pyrrolidinones; Rolipram; Swine; Tetrahydroisoquinolines | 1990 |
Effects of phosphodiesterase inhibitors on normal and chemically-skinned isolated airway smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Airway Resistance; Animals; Cyclic AMP; Cyclic GMP; Guinea Pigs; Histamine; Imidazoles; In Vitro Techniques; Male; Papaverine; Phosphodiesterase Inhibitors; Protein Kinases; Pyrazines | 1987 |
A possible mechanism of action of tetramethylpyrazine on vascular smooth muscle in rat aorta.
Topics: Animals; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenethylamines; Potassium; Pyrazines; Rats; Rats, Inbred Strains; Theophylline; Vasodilation | 1989 |
Cyclic AMP-dependent and cyclic AMP-independent actions of a novel cardiotonic agent, OPC-8212.
Topics: Action Potentials; Animals; Cardiotonic Agents; Cattle; Cyclic AMP; Cyclic GMP; Electrophysiology; In Vitro Techniques; Membrane Potentials; Phosphodiesterase Inhibitors; Purkinje Fibers; Pyrazines; Quinolines; Sodium; Solvents; Time Factors | 1988 |
Protective effect of tetramethylpyrazine against damages of aortic endothelial cells elicited by low-density lipoproteins.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Epoprostenol; Lipoproteins, LDL; Malondialdehyde; Pyrazines; Superoxide Dismutase | 1994 |
Role of phosphodiesterases III and IV in the modulation of vascular cyclic AMP content by the NO/cyclic GMP pathway.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta, Thoracic; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Rats; Rats, Wistar; Rolipram | 1994 |
Neutral endopeptidase inhibition attenuates development of hypoxic pulmonary hypertension in rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Chronic Disease; Cyclic GMP; Dioxolanes; Dipeptides; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Imidazoles; Male; Muscle, Smooth, Vascular; Myocardium; Neprilysin; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1993 |
Two isoforms of cGMP-inhibited cyclic nucleotide phosphodiesterases in human tissues distinguished by their responses to vesnarinone, a new cardiotonic agent.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aorta; Blood Platelets; Calcium; Calmodulin; Cardiotonic Agents; Cilostazol; Cyclic AMP; Cyclic GMP; Enoximone; Humans; Isoenzymes; Kidney; Myocardium; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Quinolines; Tetrazoles | 1993 |
Differential modulation of cytokine production by drugs: implications for therapy in heart failure.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Amrinone; Cells, Cultured; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Heart Failure; Humans; Interleukin-1; Interleukin-6; Kinetics; Leukocytes, Mononuclear; Lipopolysaccharides; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Pyrazines; Pyridazines; Quinazolines; Quinolines; Tumor Necrosis Factor-alpha | 1996 |
Modulation of the megakaryoblastic Dami cell line differentiation by phosphodiesterase inhibitors and imidazo[1,2-a]pyrazine derivatives.
Topics: Cell Differentiation; Cell Line; Cyclic GMP; Flow Cytometry; Glycoproteins; Humans; In Vitro Techniques; Leukemia, Megakaryoblastic, Acute; Phosphodiesterase Inhibitors; Pyrazines | 1997 |
Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP-mediated vasorelaxation.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Aorta; Calcium; Cardiotonic Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Signal Transduction; Sulfonamides; Thionucleotides | 1997 |
Inhibition of inducible nitric oxide synthase expression and stimulation of the endothelial formation of nitric oxide most likely accounts for the protective effect of 2-(allylthio)pyrazine in a murine model of endotoxemia.
Topics: Animals; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Enzyme Inhibitors; Lipopolysaccharides; Male; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Organ Culture Techniques; Phenylephrine; Pyrazines; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 1997 |
The antiplatelet activity of tetramethylpyrazine is mediated through activation of NO synthase.
Topics: Blood Platelets; Calcium; Cyclic GMP; Enzyme Activation; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Platelet Aggregation Inhibitors; Pyrazines | 2000 |
Endothelin receptor antagonism does not prevent the development of in vivo glyceryl trinitrate tolerance in the rat.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Biotransformation; Blood Pressure; Cyclic GMP; Drug Tolerance; Endothelin Receptor Antagonists; Endothelin-1; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Nitroglycerin; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Sulfonamides; Vasodilator Agents | 2000 |
[Effect of chuanxiongzine on the relaxation of isolated rabbit corpus cavernosum tissues].
Topics: Animals; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Penis; Pyrazines; Rabbits | 2004 |
Role of cGMP signals in tetramethylpyrazine induced relaxation of the isolated rat aortic strip.
Topics: Animals; Aorta; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Guanylate Cyclase; In Vitro Techniques; Male; Pyrazines; Rats; Rats, Wistar; Vasodilation | 2005 |
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Topics: Administration, Oral; Aminopyridines; Animals; Chemistry, Pharmaceutical; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Humans; Hydrogen-Ion Concentration; Hypertension; Microsomes; Models, Chemical; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Solubility | 2009 |
Effects of tetramethylpyrazine on nitric oxide/cGMP signaling after cerebral vasospasm in rabbits.
Topics: Animals; Basilar Artery; Blotting, Western; Calcium Signaling; Cerebral Angiography; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Endothelial Cells; Male; Microscopy, Confocal; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrazines; Rabbits; Signal Transduction; Subarachnoid Hemorrhage; Tomography, X-Ray Computed; Ultrasonography, Doppler, Transcranial; Vasodilator Agents; Vasospasm, Intracranial | 2010 |
Highly potent, selective, and orally active phosphodiesterase 10A inhibitors.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Avoidance Learning; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Dogs; Female; Humans; Hydrolysis; Hyperkinesis; In Vitro Techniques; Isoenzymes; Ligands; Male; Mice; Microsomes; Models, Molecular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Conformation; Pyrazines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Recombinant Proteins; Stereoisomerism; Stereotyped Behavior; Structure-Activity Relationship | 2011 |
Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4.
Topics: Animals; Atrial Natriuretic Factor; Compliance; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Diastole; Dipeptidyl-Peptidase IV Inhibitors; Drug Evaluation, Preclinical; Heart; Heart Ventricles; Male; Mice; Myocytes, Cardiac; Pyrazines; Random Allocation; Sitagliptin Phosphate; Triazoles; Ventricular Dysfunction, Left | 2014 |
Ligustrazine attenuates the platelet-derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways.
Topics: Arteriosclerosis; Becaplermin; Cell Movement; Cell Proliferation; Cyclic GMP; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-sis; Pyrazines; Signal Transduction | 2015 |
Carbon Monoxide Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by the Cyclic GMP/Protein Kinase G and NF-κB Signaling Pathway.
Topics: Animals; Antiviral Agents; Carbon Monoxide; Cell Line; Chlorocebus aethiops; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytokines; Epithelial Cells; Gene Expression Regulation; Heme Oxygenase-1; Host-Pathogen Interactions; Macrophages, Alveolar; NF-kappa B; Organometallic Compounds; Porcine respiratory and reproductive syndrome virus; Pyrazines; Pyrroles; RNA, Messenger; Signal Transduction; Swine; Virus Internalization; Virus Replication | 2017 |
Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor
Topics: Animals; Brain; Cognition; Cognition Disorders; Crystallography, X-Ray; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Drug Design; Halogenation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Phosphodiesterase Inhibitors; Pyrazines; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley | 2017 |
2-Ethylpyrazine Induces Vasodilatation by Releasing Nitric Oxide in the Endothelium.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Endothelium, Vascular; Flavoring Agents; Male; Models, Animal; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrazines; Rats; Rats, Wistar; Regional Blood Flow; Vasoconstriction; Vasodilation | 2017 |
A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs.
Topics: Animals; Arterial Pressure; Calcium; Cardiotonic Agents; Coronary Circulation; Cyclic GMP; Dogs; Extracellular Matrix; Intracellular Space; Lactates; Male; Myocardial Infarction; Nitric Oxide; Potassium Channels; Pyrazines; Rats; Receptors, Adrenergic, beta; Vasodilation; Vasodilator Agents | 2018 |
TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models.
Topics: Aging; Animals; Brain; Cognition; Cognition Disorders; Cognitive Dysfunction; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Male; Memory Disorders; Memory, Episodic; Phosphodiesterase Inhibitors; Pyrazines; Pyridines; Rats; Rats, Inbred F344; Rats, Long-Evans; Rats, Sprague-Dawley | 2019 |