pyrazines has been researched along with ck-2017357 in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 14 (82.35) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Albertus, DL; Browne, WF; Chen, MM; Claflin, DR; Clarke, D; Collibee, SE; Driscoll, L; Garard, M; Godinez, G; Hansen, R; Hartman, JJ; Hinken, AC; Jia, Z; Kawas, R; Lee, KH; Lu, PP; Malik, FI; Marquez, D; Morgan, BP; Morgans, DJ; Muci, AR; Rodriguez, H; Russell, AJ; Saikali, KG; Schaletzky, J; Vijayakumar, V | 1 |
| Cedarbaum, JM; Chen, M; Cudkowicz, ME; Hansen, RL; Jones, D; Lee, J; Mahoney, K; Malik, F; Mao, J; Maragakis, N; Russell, AJ; Saikali, K; Shefner, J; Watson, ML; Wolff, AA | 1 |
| Bromberg, MB; Gibson, SB | 1 |
| Jampel, SB; Jasper, JR; Malik, FI; Miciak, JJ; Tankersley, C; Tibbs, ME; Wagner, KR; Warsing, LC | 1 |
| Meng, L; Shefner, JM; Wolff, AA | 1 |
| Meng, L; Shefner, JM; Watson, ML; Wolff, AA | 1 |
| Baudry, S; Chen, MM; Chou, W; Enoka, RM; Hansen, R; Malik, FI; Morgans, DJ; Russell, AJ; Saikali, KG; Stoltz, RR; Vijayakumar, V; Wolff, AA | 1 |
| Hinken, AC; Hwee, DT; Jasper, JR; Jia, Z; Kennedy, A; Malik, FI; Morgans, DJ; Russell, AJ; Ryans, J | 1 |
| Dimachkie, MM; Malik, FI; Meng, L; Rosenfeld, J; Sanders, DB | 1 |
| Scott, A | 1 |
| Andrews, JA; Bian, A; Cudkowicz, ME; Hardiman, O; Lee, J; Malik, FI; Meng, L; Shefner, JM; Wolff, AA | 1 |
| Carey, KA; Farrar, MA; Jones, KJ; Kariyawasam, D | 1 |
| Andrews, JA; Cockcroft, BM; Cudkowicz, ME; Hardiman, O; Lee, JH; Malik, FI; Meng, L; Rudnicki, SA; Shefner, JM; Wolff, AA | 1 |
| Granzier, HL; Hwee, DT; Kolb, J; Lee, EJ; Malik, FI | 1 |
| Hartman, JJ; Li, MX; Mercier, P; Sykes, BD | 1 |
| Beggs, AH; Bendahan, D; Bernard, M; Borsboom, T; Bottinelli, R; Brocca, L; de Winter, JM; Gineste, C; Gondin, J; Hwee, DT; Malik, FI; Minardi, E; Ottenheijm, CAC; Pellegrino, MA; Rossi, M | 1 |
| Accart, N; Alave Reyes-Furrer, A; Bachmann, D; Bono, E; De Andrade, S; Dunbar, A; Jeker, H; Keller, H; Rausch, M; Rimann, M; Steinmann, M | 1 |
2 review(s) available for pyrazines and ck-2017357
| Article | Year |
|---|---|
Amyotrophic lateral sclerosis: drug therapy from the bench to the bedside.
Topics: Amyotrophic Lateral Sclerosis; Antioxidants; Excitatory Amino Acid Antagonists; Genetic Therapy; Humans; Imidazoles; Immunosuppressive Agents; Pyrazines; Stem Cell Transplantation; Superoxide Dismutase; Superoxide Dismutase-1 | 2012 |
New and developing therapies in spinal muscular atrophy.
Topics: Cholestenones; Genetic Therapy; Humans; Imidazoles; Neuroprotective Agents; Oligonucleotides; Physical Therapy Modalities; Pyrazines; Respiration, Artificial; Spinal Muscular Atrophies of Childhood; Survival of Motor Neuron 1 Protein; Survival of Motor Neuron 2 Protein | 2018 |
7 trial(s) available for pyrazines and ck-2017357
| Article | Year |
|---|---|
Safety, tolerability and pharmacodynamics of a skeletal muscle activator in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Female; Hand Strength; Humans; Imidazoles; Male; Middle Aged; Muscle, Skeletal; Neuroprotective Agents; Pyrazines; Riluzole; Treatment Outcome | 2012 |
The relationship between tirasemtiv serum concentration and functional outcomes in patients with ALS.
Topics: Aged; Amyotrophic Lateral Sclerosis; Drug Administration Schedule; Female; Humans; Imidazoles; Male; Middle Aged; Muscle Strength; Pyrazines; Recovery of Function; Treatment Outcome | 2013 |
A study to evaluate safety and tolerability of repeated doses of tirasemtiv in patients with amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Cohort Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Imidazoles; Male; Middle Aged; Muscle Strength; Pyrazines; Treatment Outcome | 2013 |
Tirasemtiv amplifies skeletal muscle response to nerve activation in humans.
Topics: Administration, Oral; Adolescent; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electric Stimulation; Humans; Imidazoles; Male; Middle Aged; Muscle, Skeletal; Neuromuscular Agents; Pyrazines; Troponin T; Young Adult | 2014 |
A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Imidazoles; Male; Middle Aged; Muscle, Skeletal; Myasthenia Gravis; Outcome Assessment, Health Care; Protein Binding; Pyrazines; Receptors, Cholinergic; Young Adult | 2015 |
VITALITY-ALS, a phase III trial of tirasemtiv, a selective fast skeletal muscle troponin activator, as a potential treatment for patients with amyotrophic lateral sclerosis: study design and baseline characteristics.
Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Female; Follow-Up Studies; Humans; Imidazoles; Male; Pyrazines; Severity of Illness Index; Troponin | 2018 |
A phase III trial of
Topics: Adult; Amyotrophic Lateral Sclerosis; Disease Progression; Double-Blind Method; Female; Humans; Imidazoles; Male; Middle Aged; Muscle Strength; Muscle, Skeletal; Pyrazines; Treatment Outcome | 2019 |
8 other study(ies) available for pyrazines and ck-2017357
| Article | Year |
|---|---|
Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases.
Topics: Adenosine Triphosphatases; Animals; Calcium; Cattle; Humans; Imidazoles; Molecular Targeted Therapy; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Myasthenia Gravis; Myosins; Neuromuscular Diseases; Pyrazines; Rabbits; Rats; Troponin; Troponin C | 2012 |
Fast skeletal muscle troponin activator in the dy2J muscular dystrophy model.
Topics: Analysis of Variance; Animals; Creatine Kinase; Disease Models, Animal; Female; Imidazoles; Laminin; Longitudinal Studies; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle Fibers, Skeletal; Muscle Strength; Muscular Dystrophies; Mutation; Physical Endurance; Pyrazines; Respiratory Physiological Phenomena; Troponin | 2013 |
Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Female; Humans; Imidazoles; Mice; Mice, Transgenic; Motor Neurons; Muscle Strength; Muscle, Skeletal; Pyrazines; Troponin | 2014 |
Drug therapy: On the treatment trail for ALS.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Benzamides; C9orf72 Protein; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Edaravone; Genetic Therapy; Humans; Imidazoles; Mesenchymal Stem Cells; Motor Neurons; Neuroglia; Off-Label Use; Oligoribonucleotides, Antisense; Piperidines; Precision Medicine; Pyrazines; Pyridines; Riluzole; RNAi Therapeutics; Stem Cell Transplantation; Superoxide Dismutase; Thiazoles; United States; United States Food and Drug Administration | 2017 |
Functional Characterization of the Intact Diaphragm in a Nebulin-Based Nemaline Myopathy (NM) Model-Effects of the Fast Skeletal Muscle Troponin Activator
Topics: Animals; Copper Transporter 1; Diaphragm; Disease Models, Animal; Imidazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle Proteins; Muscle, Skeletal; Myopathies, Nemaline; Pyrazines; Troponin | 2019 |
Structural Basis of
Topics: Binding Sites; Crystallography, X-Ray; Humans; Imidazoles; Molecular Docking Simulation; Muscle, Skeletal; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Pyrazines; Troponin C; Troponin I | 2021 |
Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice.
Topics: Actins; Animals; Humans; Imidazoles; Mice; Muscle, Skeletal; Mutation; Myopathies, Nemaline; Pyrazines | 2021 |
Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses.
Topics: Bioprinting; Caffeine; Collagen; Drug Combinations; Electric Stimulation; Exercise; Humans; Imidazoles; Laminin; Muscle Contraction; Muscle, Skeletal; Printing, Three-Dimensional; Proteoglycans; Pyrazines | 2021 |