Page last updated: 2024-08-21

pyrazines and cc-115

pyrazines has been researched along with cc-115 in 8 studies

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (37.50)	24.3611
2020's	5 (62.50)	2.80

Authors

Authors	Studies
Apuy, J; Bahmanyar, S; Bisonette, RR; Canan, SS; Cathers, BE; Correa, M; Elsner, J; Fultz, KE; Gamez, JC; Harris, R; Hickman, M; Khambatta, G; Lee, BG; Leisten, J; Moghaddam, MF; Mortensen, DS; Narla, RK; Packard, G; Papa, P; Parnes, JS; Peng, SX; Perrin-Ninkovic, SM; Raymon, HK; Richardson, SJ; Riggs, JR; Sankar, S; Sapienza, J; Shevlin, G; Tehrani, L; Whitefield, B; Worland, P; Zhao, J	1
Bendell, J; Brown, JR; Derks, IA; Eichhorst, B; Eldering, E; Fernandes, SM; Filvaroff, EH; Garrick, B; Hallek, M; Hege, K; Kater, AP; Kersten, MJ; Michot, JM; Reinhardt, HC; Rodríguez, MS; Ter Burg, J; Thijssen, R; Trowe, T; van Bochove, GG; van Kampen, RJ	1
Beebe, J; Zhang, JT	1
Distel, L; Dobler, C; Fietkau, R; Hecht, M; Jost, T	1
Chen, XF; Chen, Z; Gu, DH; Sun, X; Zheng, B; Zhu, H; Zhu, WL	1
Bürkel, F; Distel, L; Fietkau, R; Hecht, M; Heinzerling, L; Jost, T	1
Bürkel, F; Distel, LV; Faulhaber, EM; Fietkau, R; Hecht, M; Jost, T; Scheper, J; Symank, J	1
Castellano, GM; Garbuzenko, OB; Malhotra, J; Minko, T; Pine, SR; Sabaawy, HE; Zeeshan, S	1

Trials

1 trial(s) available for pyrazines and cc-115

Article	Year
Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia. Blood, 2016, 07-28, Volume: 128, Issue:4 Topics: Bridged Bicyclo Compounds, Heterocyclic; DNA-Activated Protein Kinase; Drug Resistance, Neoplasm; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Neoplasm Proteins; Nuclear Proteins; Purines; Pyrazines; Quinazolinones; Sulfonamides; TOR Serine-Threonine Kinases; Triazoles; Tumor Cells, Cultured; Vidarabine	2016

Article

Year

Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia.

Blood, 2016, 07-28, Volume: 128, Issue:4

Topics: Bridged Bicyclo Compounds, Heterocyclic; DNA-Activated Protein Kinase; Drug Resistance, Neoplasm; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Neoplasm Proteins; Nuclear Proteins; Purines; Pyrazines; Quinazolinones; Sulfonamides; TOR Serine-Threonine Kinases; Triazoles; Tumor Cells, Cultured; Vidarabine

2016

Other Studies

7 other study(ies) available for pyrazines and cc-115

Article	Year
Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. Journal of medicinal chemistry, 2015, Jul-23, Volume: 58, Issue:14 Topics: Animals; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Protein Conformation; Protein Kinase Inhibitors; Pyrazines; Rats; Signal Transduction; Structure-Activity Relationship; TOR Serine-Threonine Kinases; Triazoles; Xenograft Model Antitumor Assays	2015
CC-115, a Dual Mammalian Target of Rapamycin/DNA-Dependent Protein Kinase Inhibitor in Clinical Trial, Is a Substrate of ATP-Binding Cassette G2, a Risk Factor for CC-115 Resistance. The Journal of pharmacology and experimental therapeutics, 2019, Volume: 371, Issue:2 Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Survival; Clinical Trials as Topic; DNA; Dose-Response Relationship, Drug; Drug Resistance; HEK293 Cells; Humans; MCF-7 Cells; Neoplasm Proteins; Protein Kinase Inhibitors; Pyrazines; Risk Factors; Substrate Specificity; TOR Serine-Threonine Kinases; Triazoles	2019
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells. Cells, 2020, 09-01, Volume: 9, Issue:9 Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Line, Tumor; Cellular Senescence; DNA Damage; Fibroblasts; Head and Neck Neoplasms; Humans; Isoxazoles; Male; Protein Kinase Inhibitors; Pyrazines; Pyridines; Quinolines; Radiation, Ionizing; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Triazoles	2020
Dual inhibition of DNA-PKcs and mTOR by CC-115 potently inhibits human renal cell carcinoma cell growth. Aging, 2020, 10-27, Volume: 12, Issue:20 Topics: Animals; Carcinoma, Renal Cell; Cell Proliferation; DNA-Activated Protein Kinase; Female; Humans; Kidney Neoplasms; Mice; Pyrazines; TOR Serine-Threonine Kinases; Triazoles	2020
Dual mTOR/DNA-PK Inhibitor CC-115 Induces Cell Death in Melanoma Cells and Has Radiosensitizing Potential. International journal of molecular sciences, 2020, Dec-07, Volume: 21, Issue:23 Topics: Cell Death; Cell Line; Cell Line, Tumor; DNA-Activated Protein Kinase; Fibroblasts; Homologous Recombination; Humans; Melanoma; Protein Kinase Inhibitors; Pyrazines; Radiation Tolerance; TOR Serine-Threonine Kinases; Triazoles	2020
Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells. Genes, 2021, 06-17, Volume: 12, Issue:6 Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma, Squamous Cell; Cell Death; Cell Line, Tumor; Cells, Cultured; DNA Repair; DNA-Activated Protein Kinase; Head and Neck Neoplasms; Humans; Isoxazoles; Protein Kinase Inhibitors; Pyrazines; Pyridines; Quinolines; Triazoles; X-Rays	2021
Inhibition of Mtorc1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell Carcinoma. Molecular cancer therapeutics, 2022, 09-06, Volume: 21, Issue:9 Topics: Animals; Carboplatin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; DNA; Humans; Lung; Lung Neoplasms; Mechanistic Target of Rapamycin Complex 1; Mice; Paclitaxel; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrazines; TOR Serine-Threonine Kinases; Triazoles	2022