pyrazines has been researched along with adenosine in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.25) | 18.7374 |
| 1990's | 11 (34.38) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 12 (37.50) | 24.3611 |
| 2020's | 6 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Brink, A; Fuder, H; Meincke, M; Tauber, U | 1 |
| Barer, GR; Cai, YN; Emery, CJ; Russell, PC | 1 |
| Bonnafous, JC; Chapat, JP; Francoise, MA; Levallois, C; Mani, JC; Sablayrolles, C | 1 |
| Richardson, PJ; Sirinathsinghji, DJ; Vellucci, SV | 1 |
| Kirkpatrick, KA; Richardson, PJ | 1 |
| Bonnet, PA; Boucard, M; Chapat, JP; Laurent, F; Michel, A | 1 |
| Bonnet, PA; Chevillard, C; Gannoun-Zaki, L; Mathieu, MN; Michel, A; Zurbonsen, K | 1 |
| Marsh, JD; Vander Heide, RS | 1 |
| Funaya, H; Hori, M; Kitakaze, M; Minamino, T; Mori, H; Node, K; Shinozaki, Y | 1 |
| Anderson, DR; Chen, Q; Matsugi, T | 1 |
| Fong, M; Hori, M; Kambayashi, T; Kitakaze, M; Minamino, T; Node, K; Okuyama, Y; Terada, N; Yoshitake, M | 1 |
| O'Kane, EM; Stone, TW | 1 |
| Fredholm, BB; Lindström, K | 1 |
| Fujii, S; Ito, KL; Kaneko, K; Kato, H; Kuroda, Y; Sasaki, H; Yamazaki, Y; Yoshioka, M | 1 |
| Bakuradze, T; Baum, M; Eirich, M; Eisenbrand, G; Erk, T; Habermeyer, M; Montoya, GA; Richling, E | 1 |
| Cahu, J; DaCosta, L; Gaudichon, J; Martens, AC; Milano, F; Renoir, JM; Sola, B | 1 |
| Chang, NC; Chen, WT; Lee, TM; Lin, SZ; Yang, CC | 1 |
| Bavari, S; Cardile, AP; Mayers, DL | 1 |
| De Clercq, E | 2 |
| de Lamballerie, X; Guedj, J; Madelain, V; Mentré, F; Nguyen, TH; Olivo, A; Taburet, AM | 1 |
| Behera, I; Beigelman, L; Chaudhuri, S; Deval, J; Dyatkina, N; Jekle, A; Jin, Z; Kinkade, A; Rajwanshi, VK; Smith, DB; Symons, JA; Tucker, K; Wang, G | 1 |
| Chen, SS; Chiorazzi, N; Covey, T; Dadashian, EL; Herman, SEM; Izumi, R; Krantz, F; Lannutti, BJ; Mora-Jensen, HI; Niemann, CU; Ulrich, R; Wiestner, A | 1 |
| Jochmans, D; Neyts, J | 1 |
| Bernasconi, E; Bertoni, F; Cascione, L; Dirnhofer, S; Gaudio, E; Gerlach, MM; Mascia, M; Priebe, V; Spriano, F; Stathis, A; Tarantelli, C; Targa, A; Zucca, E | 1 |
| Marczak, A; Poczta, A; Rogalska, A; Łukawska, M | 1 |
| Lin, SX; Stephen, P; Thériault, JF; Wang, R; Zhang, WF | 1 |
| Carvalho Junior, RN; J C Neto, AM; Martins, AY; Reis, AF; S Costa, JF; Silva Arouche, TD | 1 |
| Brügel, M; Habler, K; Liebchen, U; Paal, M; Scharf, C; Schönermarck, U; Teupser, D; Vogeser, M | 1 |
| Celik, I; Duzgun, Z; Erol, M | 1 |
| Assis, LC; da Cunha, EFF; de Almeida La Porta, F; de Castro Ramalho, T; de Castro, AA; de Jesus, JPA; Kuca, K; Nepovimova, E | 1 |
| Barr, PM; Calvo, R; Melear, JM; O'Brien, SM; Patel, P; Roschewski, MJ; Sharman, JP; Smith, SD; Spurgeon, SE; Yang, H | 1 |
5 review(s) available for pyrazines and adenosine
| Article | Year |
|---|---|
Current status of chemically synthesized inhibitors of Ebola virus.
Topics: Adenine; Adenosine; Amides; Antiviral Agents; Cytosine; Drug Discovery; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Organophosphonates; Patents as Topic; Purine Nucleosides; Pyrazines; Pyrrolidines | 2014 |
Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential.
Topics: Adenosine; Amides; Antiviral Agents; Deoxyadenosines; Ebolavirus; Hepacivirus; HIV; Humans; Nucleosides; Pyrazines | 2015 |
Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials.
Topics: Adenine; Adenosine; Amides; Animals; Antiviral Agents; Disease Outbreaks; Ebolavirus; Healthy Volunteers; Hemorrhagic Fever, Ebola; Humans; Models, Animal; Purine Nucleosides; Pyrazines; Pyrrolidines | 2016 |
The path towards effective antivirals against rabies.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Drug Repositioning; Humans; Post-Exposure Prophylaxis; Pyrazines; Pyrrolidines; Rabies; Rabies virus | 2019 |
New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections.
Topics: Adenine; Adenosine; Alanine; Amides; Antiviral Agents; Base Pairing; Ebolavirus; Guanine; Hemorrhagic Fevers, Viral; Humans; Nucleotides; Phosphoric Acids; Pyrazines; Triazines | 2019 |
1 trial(s) available for pyrazines and adenosine
| Article | Year |
|---|---|
Phase 1/2 study of acalabrutinib and the PI3K delta inhibitor ACP-319 in relapsed/refractory B-cell Non-Hodgkin lymphoma.
Topics: Adenosine; Benzamides; Humans; Lymphoma, B-Cell; Phosphatidylinositol 3-Kinases; Pyrazines; Quinolines | 2022 |
26 other study(ies) available for pyrazines and adenosine
| Article | Year |
|---|---|
Purinoceptor-mediated modulation by endogenous and exogenous agonists of stimulation-evoked [3H]noradrenaline release on rat iris.
Topics: Adenosine; Animals; Electric Stimulation; In Vitro Techniques; Iris; Male; Norepinephrine; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Synaptic Transmission; Theophylline; Xanthines | 1992 |
Reactivity and site of vasomotion in pulmonary vessels of chronically hypoxic rats: relation to structural changes.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Almitrine; Angiotensin I; Animals; Bradykinin; Chronic Disease; Hypoxia; Male; Platelet Activating Factor; Pulmonary Circulation; Pyrazines; Rats; Rats, Inbred Strains; Reference Values; Respiration; Vasoconstriction; Vasodilator Agents; Vasomotor System | 1989 |
Theophylline-like properties of xanthine analogs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Adult; Animals; Female; Humans; In Vitro Techniques; Male; Mice; Pyrazines; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Thymidine; Xanthines | 1984 |
Adenosine A2 receptor regulation of apomorphine-induced turning in rats with unilateral striatal dopamine denervation.
Topics: Acetylcholine; Adenosine; Animals; Antihypertensive Agents; Apomorphine; Atropine; Brain; Dopamine; Female; Naloxone; Neostriatum; Oxidopamine; Phenethylamines; Purinergic Antagonists; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Sympathectomy, Chemical | 1993 |
Adenosine receptor-mediated modulation of acetylcholine release from rat striatal synaptosomes.
Topics: Acetylcholine; Adenosine; Animals; Cholinergic Fibers; Corpus Striatum; In Vitro Techniques; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Rats; Rats, Wistar; Receptors, Purinergic P1; Synaptosomes; Tritium; Veratridine; Xanthines | 1993 |
Pharmacological activities of imidazo[1,2-alpha]pyrazine derivatives.
Topics: Adenosine; Animals; Calcium; Cardiovascular Agents; Cattle; Diuresis; Guinea Pigs; Heart Atria; Heart Rate; Ileum; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myocardial Contraction; Parasympatholytics; Phosphodiesterase Inhibitors; Pyrazines; Rabbits; Rats; Rats, Wistar; Theophylline; Trachea | 1995 |
Apoptotic effects of imidazo[1,2-a]pyrazine derivatives in the human Dami cell line.
Topics: Adenosine; Apoptosis; Cell Division; Cyclic AMP; DNA; DNA Damage; Humans; Imidazoles; Isoenzymes; Leukemia, Megakaryoblastic, Acute; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Receptors, Purinergic P1; Receptors, Purinergic P2; Tumor Cells, Cultured | 1997 |
Through the looking glass: a positive inotropic drug and ischemic preconditioning.
Topics: 5'-Nucleotidase; Adenosine; Animals; Cardiotonic Agents; Dogs; Drug Approval; Enzyme Activation; Heart Failure; Humans; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardium; Neutropenia; Protein Kinase C; Pyrazines; Quinolines; Second Messenger Systems | 1997 |
Vesnarinone limits infarct size via adenosine-dependent mechanisms in the canine heart.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Diphosphate; Animals; Cardiotonic Agents; Dipyridamole; Dogs; Enzyme Activation; Enzyme Inhibitors; Infusions, Intra-Arterial; Ion Channel Gating; Myocardial Infarction; Myocardial Reperfusion Injury; Potassium Channels; Pyrazines; Quinolines; Receptors, Purinergic P1; Theophylline | 1997 |
Adenosine-induced relaxation of cultured bovine retinal pericytes.
Topics: Adenosine; Animals; Capillaries; Cattle; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Purinergic P1 Receptor Antagonists; Pyrazines; Receptors, Purinergic P1; Retinal Vessels; Theophylline; Vasodilator Agents; Xanthines | 1997 |
Vesnarinone inhibits adenosine uptake in endothelial cells, smooth muscle cells and myocytes, and mediates cytoprotection.
Topics: Adenosine; Animals; Cardiotonic Agents; Cattle; Cell Survival; Cells, Cultured; Endothelium, Vascular; Heart; Humans; Muscle, Smooth, Vascular; Myocardium; Pyrazines; Quinolines | 1997 |
Interaction between adenosine A1 and A2 receptor-mediated responses in the rat hippocampus in vitro.
Topics: Adenosine; Animals; Excitatory Postsynaptic Potentials; Hippocampus; Male; Organ Culture Techniques; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazines; Rats; Rats, Wistar; Receptors, Purinergic P1; Triazines; Triazoles | 1998 |
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors.
Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Caffeine; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Tritium; Xanthines | 1999 |
Endogenous adenosine regulates the effects of low-frequency stimulation on the induction of long-term potentiation in CA1 neurons of guinea pig hippocampal slices.
Topics: Adenosine; Afferent Pathways; Animals; Electric Stimulation; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Purinergic P1 Receptor Antagonists; Pyramidal Cells; Pyrazines; Receptors, Purinergic P1; Theophylline | 2000 |
Modulation of 3',5'-cyclic AMP homeostasis in human platelets by coffee and individual coffee constituents.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenosine Deaminase; Adult; Blood Platelets; Caffeine; Coffee; Cyclic AMP; Homeostasis; Humans; Phosphodiesterase Inhibitors; Pyrazines; Signal Transduction | 2014 |
Deazaneplanocin a is a promising drug to kill multiple myeloma cells in their niche.
Topics: Adenosine; Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Caspases; Cell Line, Tumor; Cell Proliferation; Drug Interactions; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Mice; Multiple Myeloma; Polycomb Repressive Complex 2; Pyrazines; Syndecan-1; Xenograft Model Antitumor Assays | 2014 |
Sitagliptin attenuates sympathetic innervation via modulating reactive oxygen species and interstitial adenosine in infarcted rat hearts.
Topics: Adenosine; Animals; Heart; Male; Myocardial Infarction; Pyrazines; Rats; Rats, Wistar; Reactive Oxygen Species; Sitagliptin Phosphate; Triazoles | 2015 |
Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs.
Topics: Adenosine; Amides; Antiviral Agents; Cell Line; Cytidine; DNA-Directed RNA Polymerases; Guanosine Monophosphate; Humans; Inhibitory Concentration 50; Mitochondria; Mitochondrial Proteins; Nucleosides; Prodrugs; Protein Biosynthesis; Pyrazines; Ribonucleosides; RNA; RNA, Mitochondrial; Sofosbuvir; Structure-Activity Relationship; Transcription Initiation Site; Transcription, Genetic | 2017 |
Combined BTK and PI3Kδ Inhibition with Acalabrutinib and ACP-319 Improves Survival and Tumor Control in CLL Mouse Model.
Topics: Adenosine; Agammaglobulinaemia Tyrosine Kinase; Animals; Apoptosis; B-Lymphocytes; Benzamides; Cell Line, Tumor; Cell Proliferation; Class Ia Phosphatidylinositol 3-Kinase; Disease Models, Animal; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazines; Quinolines; Tumor Microenvironment | 2017 |
Single and combined BTK and PI3Kδ inhibition with acalabrutinib and ACP-319 in pre-clinical models of aggressive lymphomas.
Topics: Adenosine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Drug Synergism; Humans; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Mice, SCID; Protein Kinase Inhibitors; Pyrazines; Quinolines; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Antileukemic activity of novel adenosine derivatives.
Topics: Adenosine; Amidines; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Caspases; Cell Line; Cell Line, Tumor; Cladribine; DNA Fragmentation; HL-60 Cells; Humans; Leukemia, Monocytic, Acute; Pyrazines; S Phase; Sulfones; THP-1 Cells | 2019 |
Novel Coronavirus Polymerase and Nucleotidyl-Transferase Structures: Potential to Target New Outbreaks.
Topics: Adenine; Adenosine; Amides; Antiviral Agents; Betacoronavirus; Binding Sites; Coronavirus Infections; COVID-19; Humans; Molecular Docking Simulation; Nucleotidyltransferases; Pandemics; Pneumonia, Viral; Protein Structure, Tertiary; Pyrazines; Pyrrolidines; RNA-Dependent RNA Polymerase; SARS-CoV-2 | 2020 |
Interactions Between Remdesivir, Ribavirin, Favipiravir, Galidesivir, Hydroxychloroquine and Chloroquine with Fragment Molecular of the COVID-19 Main Protease with Inhibitor N3 Complex (PDB ID:6LU7) Using Molecular Docking.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; Binding Sites; Chloroquine; Coronavirus 3C Proteases; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cysteine Endopeptidases; Drug Interactions; Humans; Hydrogen Bonding; Hydroxychloroquine; Ligands; Molecular Docking Simulation; Nanotechnology; Pandemics; Pneumonia, Viral; Protease Inhibitors; Pyrazines; Pyrrolidines; Ribavirin; SARS-CoV-2; Static Electricity; Viral Nonstructural Proteins | 2020 |
Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC-MS/MS method in human serum
Topics: Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Azithromycin; Chloroquine; Chromatography, Liquid; COVID-19; COVID-19 Drug Treatment; Furans; Humans; Hydroxychloroquine; Isotopes; Lopinavir; Pandemics; Pyrazines; Pyrroles; Ritonavir; SARS-CoV-2; Tandem Mass Spectrometry; Triazines | 2021 |
In silico evaluation of potential inhibitory activity of remdesivir, favipiravir, ribavirin and galidesivir active forms on SARS-CoV-2 RNA polymerase.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Drug Repositioning; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Pyrazines; Pyrrolidines; Ribavirin; RNA, Viral; SARS-CoV-2 | 2022 |
Effect of drug metabolism in the treatment of SARS-CoV-2 from an entirely computational perspective.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; Drug Design; Drug Discovery; Humans; Metabolic Networks and Pathways; Molecular Docking Simulation; Nitro Compounds; Pyrazines; Pyrrolidines; Ribavirin; SARS-CoV-2; Thiazoles | 2021 |