Page last updated: 2024-08-21

pyrazines and acetaminophen

pyrazines has been researched along with acetaminophen in 9 studies

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (33.33)	18.2507
2000's	2 (22.22)	29.6817
2010's	3 (33.33)	24.3611
2020's	1 (11.11)	2.80

Authors

Authors	Studies
Davies, MH; Schamber, GJ; Schnell, RC	1
Davies, MH; Schnell, RC	1
Kim, ND; Kwak, MK; Lee, MG; Lee, WI	1
Auyeung, DJ; Kessler, FK; Kessler, MR; Ritter, JK	1
Cherrington, NJ; Klaassen, CD; Maher, JM; Slitt, AL	1
Court, MH; Epstein, CR; Giesing, D; Greenblatt, DJ; Harmatz, JS; Kadota, T; Kurosaki, C; Nakagawa, Y; Nakamura, T; Zhao, Y	1
Baillie, TA; Cyrus Khojasteh, S; Dalvie, D; Rietjens, IM	1
Chang, Y; Hao, B; Li, C; Li, R; Li, Y; Liu, F; Ma, X; Muhammad, I; Shi, C; Wang, F; Yang, Y; Zhang, Y	1
Chen, XP; Du, YX	1

Reviews

2 review(s) available for pyrazines and acetaminophen

Article	Year
Biotransformation and bioactivation reactions - 2015 literature highlights. Drug metabolism reviews, 2016, Volume: 48, Issue:2 Topics: Acetaminophen; Allylbenzene Derivatives; Aniline Compounds; Animals; Anisoles; Benzbromarone; Biotransformation; Humans; Imidazoles; Niacinamide; Nitroimidazoles; Nitrosamines; Oxazoles; Oxazolidinones; Peroxides; Pyrazines; Pyrazoles; Pyridazines; Pyridines; Pyridones; Pyrimidinones; Thiophenes; Triazoles	2016
Favipiravir: Pharmacokinetics and Concerns About Clinical Trials for 2019-nCoV Infection. Clinical pharmacology and therapeutics, 2020, Volume: 108, Issue:2 Topics: Acetaminophen; Amides; Animals; Antiviral Agents; Clinical Trials as Topic; Coronavirus Infections; COVID-19 Drug Treatment; Drug Interactions; Humans; Pyrazines	2020

Article

Year

Biotransformation and bioactivation reactions - 2015 literature highlights.

Drug metabolism reviews, 2016, Volume: 48, Issue:2

Topics: Acetaminophen; Allylbenzene Derivatives; Aniline Compounds; Animals; Anisoles; Benzbromarone; Biotransformation; Humans; Imidazoles; Niacinamide; Nitroimidazoles; Nitrosamines; Oxazoles; Oxazolidinones; Peroxides; Pyrazines; Pyrazoles; Pyridazines; Pyridines; Pyridones; Pyrimidinones; Thiophenes; Triazoles

2016

Favipiravir: Pharmacokinetics and Concerns About Clinical Trials for 2019-nCoV Infection.

Clinical pharmacology and therapeutics, 2020, Volume: 108, Issue:2

Topics: Acetaminophen; Amides; Animals; Antiviral Agents; Clinical Trials as Topic; Coronavirus Infections; COVID-19 Drug Treatment; Drug Interactions; Humans; Pyrazines

2020

Trials

1 trial(s) available for pyrazines and acetaminophen

Article	Year
Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen. British journal of clinical pharmacology, 2015, Volume: 80, Issue:5 Topics: Acetaminophen; Adult; Amides; Analgesics, Non-Narcotic; Antiviral Agents; Drug Interactions; Female; Humans; In Vitro Techniques; Inhibitory Concentration 50; Male; Middle Aged; Pyrazines; Young Adult	2015

Other Studies

6 other study(ies) available for pyrazines and acetaminophen

Article	Year
Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. I. Lack of dependence on glutathione. Toxicology and applied pharmacology, 1991, Jun-01, Volume: 109, Issue:1 Topics: Acetaminophen; Animals; Cricetinae; Glutathione; Glutathione Disulfide; Liver; Male; Mesocricetus; Oxidation-Reduction; Pyrazines; Schistosomicides; Thiones; Thiophenes	1991
Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. II. Competitive shunt in metabolism via glucuronidation. Toxicology and applied pharmacology, 1991, Jun-01, Volume: 109, Issue:1 Topics: Acetaminophen; Animals; Cricetinae; Glutathione; Liver; Male; Mesocricetus; Models, Biological; Pyrazines; Schistosomicides; Thiones; Thiophenes; Uridine Diphosphate Glucuronic Acid	1991
Metabolic changes of acetaminophen after intravenous administration to rats pretreated with 2-(allylthio)pyrazine. Biopharmaceutics & drug disposition, 1998, Volume: 19, Issue:4 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Inactivation, Metabolic; Male; Pyrazines; Rats; Rats, Sprague-Dawley	1998
Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:3 Topics: Acetaminophen; Analgesics; Animals; Blotting, Western; Catalysis; Cells, Cultured; Chromatography, High Pressure Liquid; Enzyme Induction; Glucuronosyltransferase; Hepatocytes; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Molecular Sequence Data; Pyrazines; Rats; Rats, Gunn; Rats, Sprague-Dawley; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Thiones; Thiophenes	2002
Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:9 Topics: Acetaminophen; Allyl Compounds; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile; Blotting, Western; Branched DNA Signal Amplification Assay; Drug Resistance, Multiple; Kidney; Liver; Male; Mitochondrial Proteins; Phenobarbital; Pyrazines; Rats; Rats, Sprague-Dawley; Ribosomal Proteins; RNA, Messenger; Saccharomyces cerevisiae Proteins; Stilbenes; Sulfides; Thiones; Thiophenes; Time Factors	2003
Acetaminophen-induced hepatocyte injury: C2-ceramide and oltipraz intervention, hepatocyte nuclear factor 1 and glutathione S-transferase A1 changes. Journal of applied toxicology : JAT, 2019, Volume: 39, Issue:12 Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Cell Culture Techniques; Cell Proliferation; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gene Expression; Glutathione Transferase; Hep G2 Cells; Hepatocyte Nuclear Factor 1; Hepatocytes; Humans; Pyrazines; Sphingosine; Thiones; Thiophenes	2019